Catalog No.
Product Name
Application
Product Information
Citations
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Self-assembling Octapeptide
FEFEFKFK is a self-assembling octapeptide known for its ability to form fibrillar structures. At concentrations exceeding 7 mg/mL, FEFEFKFK exhibits gelation properties that are instrumental in investigating the mechanisms of amyloid fibril formation. This compound is particularly relevant for research into protein misfolding diseases, including Alzheimer's disease and Parkinson's disease, providing valuable insights into disease pathology and potential therapeutic approaches. -
Fluorescent Substrate Peptide
Mca-SEVNLDAEFK(Dnp) is a fluorescent substrate peptide specifically designed for the estimation of Beta-secretase 1 (BACE-1) activity. Featuring the 'Swedish' mutation of the amyloid precursor protein (APP) β-secretase cleavage site, this substrate undergoes cleavage at the -Leu-Asp- bond, releasing the highly fluorescent 7-methoxycoumarin (Mca) fragment. This release results in a significant increase in fluorescence intensity due to the removal of the quenching effect from the 2,4-dinitrophenyl (Dnp) moiety, making it a valuable tool for research applications in Alzheimer’s disease and related studies of amyloid pathology. -
Peptide
BACE1 (485-501) is a peptide corresponding to the carboxyl terminal region of Beta-site APP cleaving enzyme 1 (BACE1). This peptide serves as an effective antigen for the generation of anti-BACE1-C antibodies, facilitating the study of BACE1's role in Alzheimer's disease and other neurodegenerative conditions. Its utility in immunological assays aids researchers in elucidating the biochemical pathways associated with amyloid precursor protein processing. -
Calcium/calmodulin-dependent Protein Kinase I Peptide
CaMKI (299-320) is a peptide derived from the calcium/calmodulin-dependent protein kinase I, encompassing residues 299 to 320. This peptide exhibits a high-affinity interaction with Ca2+-calmodulin (Kd ≤ 1 nM) and is capable of phosphorylating target substrate proteins, thus modulating their biological activity. Due to its functional domains, including the calmodulin-binding and self-inhibition domains, CaMKI (299-320) is a valuable tool for investigating cellular physiological processes such as proliferation, differentiation, and apoptosis. -
CaMKII Active Peptide
[Ala286]-Calmodulin-Dependent Protein Kinase II (281-302) is a modified peptide fragment of calcium/calmodulin-dependent protein kinase II (CaMKII), featuring an alanine substitution at position 286. This alteration enhances its functional characteristics, making it a valuable tool for the development of potent CaMKII inhibitors. It is primarily used in research applications focused on understanding CaMKII's regulatory roles in cellular processes and signaling pathways. -
CaMKII Inhibitor
CaMKII inhibitory peptide KIIN is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). This peptide effectively disrupts CaMKII activity, making it a valuable tool for studying CaMKII-dependent signaling pathways. Its use in various research applications includes investigating cellular processes such as synaptic plasticity, memory formation, and cardiac function. -
Small Peptides
SP-10 is a small peptide that specifically targets the interaction between the spike (S) protein of SARS-CoV and the angiotensin-converting enzyme 2 (ACE2) receptor, exhibiting an IC50 value of 1.88 nM. This compound is valuable for research on SARS-CoV, particularly in studies investigating viral entry mechanisms and the development of therapeutic agents aimed at inhibiting this critical interaction. Its potent activity makes it an essential tool for exploring antiviral strategies. -
Polyglutamine Inhibitor
Polyglutamine binding peptide 1 (QBP1) is a peptide inhibitor that specifically targets polyglutamine sequences. It effectively inhibits polyQ protein aggregation in vitro and demonstrates the ability to suppress polyQ-induced cell death in cell culture models. This reagent is valuable for research focused on neurodegenerative disorders associated with polyglutamine expansion, providing insights into potential therapeutic interventions. -
Bioactive Peptide
LKBtide is a bioactive peptide that serves as a substrate for Serine/Threonine kinase 11 (STK11), also known as LKB1. This peptide is derived from the sucrose non-fermenting 1 (SNF1) protein kinase and plays a crucial role in the LKB1/AMP-activated protein kinase (AMPK) signaling pathway. LKBtide is commonly utilized in research focused on cellular energy regulation, metabolic signaling, and cancer biology. -
Substrate Peptide Of Cathepsin S
Ac-KQKLR-AMC TFA is a substrate peptide for Cathepsin S, conjugated with the fluorescent indicator AMC (Excitation/Emission = 354 nm/442 nm). This reagent facilitates the measurement of Cathepsin S activity, enabling researchers to study proteolytic processes and assess enzyme function in various biological contexts. Its application is crucial for investigations into the role of Cathepsin S in physiological and pathological conditions. -
Bioactive Peptide
MeO-Suc-Arg-Pro-Tyr-pNA is a bioactive peptide that serves as a substrate for chymotrypsin. This compound is utilized in studies involving proteolytic enzyme activity and can be instrumental in understanding protease function in various biological processes. Its application extends to biochemical assays aimed at investigating protein digestion and regulation of enzymatic activity. -
Polypeptide
Activated Protein C (390-404), human is a polypeptide fragment derived from the vitamin K-dependent serine protease activated protein C (APC). This fragment specifically inhibits the anticoagulant function of APC by blocking its ability to inactivate factor Va. It serves as a valuable tool in studies of coagulation pathways and the regulation of anticoagulant mechanisms, contributing to research in thrombosis and hemostasis. -
Dipeptide
L-Isoleucyl-L-valine is a dipeptide that serves as a specific inducer of the transition from bovine trypsinogen to trypsin. This compound is significant in studying proteolytic enzyme activation and can be utilized in various biochemical assays focused on enzymology and protein processing. Its role in facilitating the conversion process makes it valuable for research into digestive enzyme activation mechanisms. -
Peptide
Eglin c (41-49) is a peptide fragment that acts as a potent inhibitor of cathepsin G and α-chymotrypsin, exhibiting Ki values of 42 μM and 20 μM, respectively. This compound is crucial for studies exploring protease inhibition and the regulation of inflammatory responses. Its specificity and efficacy make it an important tool for biochemical research involving serine proteases. -
Peptide
Pancreastatin (swine) is a 49-residue peptide that primarily inhibits glucose-induced insulin release by targeting pancreatic beta cells. This peptide is derived from the porcine pancreas and plays a significant role in the regulation of glucose metabolism and insulin secretion. It is useful in research applications focused on diabetes, metabolic disorders, and the physiological roles of peptide hormones. -
Cell-penetrating Peptide
(Arg)9, also known as Nona-L-arginine, functions as a cell-penetrating peptide due to its composition of nine arginine residues. This peptide acts as an inhibitor of the serine endoprotease Furin and demonstrates significant neuroprotective activity, with an IC50 of 0.78 μM in glutamic acid-induced models. (Arg)9 is valuable in research applications targeting cellular delivery systems and neuroprotection studies. -
Prion Peptide Fragment
PrP (106-126) is a synthetic peptide corresponding to the amyloidogenic region of the prion protein (PrP). This fragment exhibits biochemical properties similar to the infectious form of prion protein, making it crucial for the study of prion diseases. It is commonly utilized in research applications involving prion biology, amyloid formation, and the mechanisms underlying neurodegenerative disorders. -
Peptide Mimics
ccβ is a 17-amino acid peptide designed to mimic the conformational transition of proteins from α-helix to β-sheet. This transition is crucial in the aggregation of proteins linked to various neurodegenerative diseases, including Alzheimer's disease and prion diseases. ccβ serves as a valuable tool for investigating mechanisms of protein aggregation and its implications in disease pathology. -
Tau fragment R2
Tau Peptide (275-305) targets the second repeat domain of the tau protein, which plays a critical role in microtubule binding and is implicated in Alzheimer's disease. This peptide specifically interacts with group IIB metal ions (Zn²⁺, Cd²⁺, Hg²⁺), facilitating conformational changes and promoting pathological accumulation. Research applications include investigating the effects of heavy metals on tau protein dynamics and their contributions to neurodegenerative disease mechanisms. -
Tau Fragment
Tau Peptide (273-284) is a truncated fragment of the Tau protein, primarily involved in neurofibrillary tangles associated with tauopathies. This peptide is valuable for studying the molecular mechanisms of Alzheimer's disease and other related neurodegenerative disorders. It serves as a tool for elucidating Tau aggregation processes and investigating potential therapeutic interventions targeting Tau-related pathologies. -
Polypeptide
Tau Peptide (255-314) (Repeat 2 Domain) (human) is a polypeptide derived from the Tau-F protein, specifically the 255-314 fragment of this key isoform. This peptide encompasses critical aggregation sequences PHF6* (275-280, VQIINK) and PHF6 (306-311, VQIVYK), which play a significant role in Tau aggregation. It spans the C-terminal half of the repeat domain R1, the entire repeat domain R2, and the N-terminal half of repeat domain R3, making it vital for studies on Tau-related neurodegenerative processes and microtubule dynamics. -
Tau fragment
Tau Peptide (244-274) targets the Repeat 1 domain of the tau protein, a key player in neurodegenerative diseases such as Alzheimer's. This peptide fragment is commonly utilized in research to study tau pathology, including phosphorylation and aggregation processes associated with tau-mediated toxicity. Its role in modulating tau interactions makes it a valuable tool for investigating tau-related mechanisms in various cellular models. -
Tau fragment
Tau Peptide (245-274) (Repeat 1 Domain) is a specific fragment of the Tau protein that serves as a crucial target in neurodegenerative research. This peptide is involved in the formation of neurofibrillary tangles, which are characteristic of Alzheimer's disease and other tauopathies. It can be used in studies investigating tau aggregation and toxicity, as well as in the development of therapeutics aimed at modulating tau pathology. -
Tau fragment
Tau Peptide (294-305) (human) is a biologically active fragment of the Tau protein that plays a critical role in neurodegenerative diseases, particularly in Alzheimer’s disease. This peptide is instrumental in studying tau pathology, including tau aggregation and neurofibrillary tangles. It serves as an important tool for researchers investigating the mechanisms of tau-related neurodegeneration and developing potential therapeutic approaches. -
Tau fragment
Tau Peptide (45-73) (Exon 2/Insert 1 Domain) is a fragment of the Tau protein that plays a crucial role in stabilizing microtubules. This peptide is often used in research studies focusing on neurodegenerative diseases, particularly Alzheimer's disease, where Tau pathology is implicated. It serves as a valuable tool for investigating Tau aggregation, cellular interactions, and the effects of post-translational modifications on Tau function. -
Polypeptide
Tau Peptide (274-288) is a polypeptide that plays a significant role in neurobiology through its interaction with tau protein. This peptide is widely utilized in research applications focused on protein-protein interactions, functional analyses, and epitope mapping. It serves as a valuable tool in the exploration of tau-related pathologies, aiding in the understanding of neurodegenerative diseases such as Alzheimer's. -
Tau fragment
Tau Peptide (306-336) (Repeat 3 Domain) targets the Tau protein, specifically the repeat domain that plays a crucial role in microtubule stabilization. This peptide fragment facilitates studies on Tau's involvement in neurodegenerative diseases, particularly Alzheimer's disease, by helping to elucidate the mechanisms of Tau aggregation and function. It serves as a valuable tool for researchers investigating Tau-related pathology and potential therapeutic interventions. -
Tau fragment
Tau Peptide (379-408) is a specific fragment of the tau protein, which is integral to neurodegenerative research, particularly in the study of tauopathies. This peptide serves as a crucial tool for understanding tau aggregation, neurofibrillary tangles formation, and synaptic dysfunction. Its applications include investigating mechanisms of tau-related pathologies and evaluating therapeutic interventions targeting tau misfolding and toxicity. -
Tau Peptide
Acetyl-PHF5 amide is a tau peptide that demonstrates amyloidogenic properties, facilitating the polymerization into filamentous structures. This compound is valuable for research into tau-related pathologies, such as Alzheimer's disease, and is used to study the mechanisms of tau aggregation and neurodegeneration. Its ability to replicate key features of tau protein behavior makes it an essential tool for investigating therapeutic strategies targeting tauopathies. -
Tau fragment
Tau Peptide (1-16) (human) is a fragment of the Tau protein, primarily targeting Tau-mediated pathways involved in neurodegenerative diseases. This peptide is crucial for studying the role of Tau in processes such as microtubule stabilization and neurofibrillary tangle formation. It serves as an important tool for research applications focused on Alzheimer's disease and other tauopathies. -
Tau fragment
Tau Peptide (74-102) (Exon 3/Insert 2 Domain) is a specific fragment of the tau protein that plays a crucial role in stabilizing microtubules in neurons. This peptide is instrumental in research focusing on tauopathies, including Alzheimer’s disease, where tau aggregation and dysfunction are key pathological features. By utilizing this peptide, researchers can investigate tau-related mechanisms and develop potential therapeutic strategies for neurodegenerative disorders. -
α-Synuclein Knockdown Peptide
Tat-βsyn-degron is an α-synuclein knockdown peptide that promotes the degradation of α-synuclein through the proteasome pathway. This compound demonstrates significant efficacy in reducing α-synuclein protein levels in primary rat cortical neuron cultures. Additionally, Tat-βsyn-degron has shown potential in alleviating parkinsonian toxin-induced neuronal damage and movement disorders in a Parkinson's mouse toxicity model, making it a valuable tool for research into neurodegenerative diseases. -
Peptide
Thioether-cyclized helix B peptide, CHBP, targets the mTOR signaling pathway to modulate autophagy. This peptide enhances metabolic stability and exhibits renoprotective effects by inhibiting mTORC1 while activating mTORC2. Its unique properties make it a valuable reagent for researching cellular metabolism and kidney protection mechanisms. -
E3 Ligase Peptide Ligand
ErbB2 peptide is a ligand for E3 ubiquitin ligase that specifically targets the PI3K pathway. This peptide is crucial for the development of peptide-based PROTACs, enabling selective degradation of proteins involved in various cellular processes. It is valuable for research applications focused on targeted protein degradation and signaling pathway modulation. -
Small Metal Chelating Peptide
Phytochelatin 3 (PC 3) is a small metal chelating peptide that effectively binds heavy metals, facilitating their detoxification. Derived from the sulfur-rich molecule glutathione, PC 3 is synthesized by various organisms, including plants, fungi, algae, and bacteria, as a protective response to metal stress. This peptide plays a crucial role in metal homeostasis and detoxification in plants, making it valuable for research in environmental science and plant physiology. -
Bombesin-Like Neuropeptide
Neuromedin C (porcine) is a bombesin-like neuropeptide derived from porcine spinal cord. It demonstrates significant contractile activity on rat uterine tissue, consistent with the effects of bombesin. This peptide holds promise for research into neurological disorders and related biological investigations. -
peptides
Valylleucine TFA is a polypeptide known for its role in peptide screening applications. This reagent serves as a valuable tool for identifying active peptides through immunoassay techniques. It is particularly useful in the study of protein interactions, functional analysis, and epitope mapping, contributing significantly to research and development efforts in agent discovery. -
Peptide Nucleic Acid
Fmoc-PNA-A(Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer that incorporates an adenine base. Featuring Fmoc and benzhydryloxycarbonyl (Bhoc) protecting groups, it serves as a fundamental building block for solid-phase PNA synthesis. This monomer is ideal for the development of PNA-based sequence-specific hybridization probes, which have extensive applications in molecular biology, including studies related to HER2-expressing tumors for disease diagnosis and mechanism exploration. -
Neurotrophic Polypeptide
Nerve Growth Factor 2.5S, murine submaxillary gland, is a neurotrophic polypeptide that plays a critical role in the growth and development of sympathetic and embryonic sensory neurons, as well as specific cholinergic neurons in the central nervous system. Comprising solely the β-subunit, this factor exhibits significant nerve growth-promoting activity. It is widely used in research applications focusing on neural development, neurodegenerative diseases, and cellular signaling pathways involving neuronal survival and differentiation. -
Capspase-4 Fluorogenic Substrate Peptide
Ac-LEVD-AFC is a fluorogenic substrate peptide specifically designed for the activity assays of caspase-4. This compound exhibits key biological activity by releasing a fluorescent signal upon cleavage by caspase-4, making it a valuable tool for studying apoptosis and inflammatory processes. It is suitable for various research applications, including cell death studies and the evaluation of caspase activity in different biological systems. -
Dipeptide
Valylhistidine is a dipeptide comprising valine and histidine (Val-His) that has been studied for its ability to form complexes with Cu (II), mimicking the structure of superoxide dismutase. Although it demonstrates a structural similarity to this enzyme, Valylhistidine does not exhibit catalytic activity. This compound serves as a valuable tool in research related to oxidative stress and the design of metalloproteins. -
Dipeptide
(Fmoc-Cys-OtBu)2 (disulfide bridge) is a cystine dipeptide connected by an oxidized disulfide bond. This compound serves as a versatile building block in the synthesis of cleavable disulfide linkers, enabling targeted release in biochemical applications. Its unique properties make it valuable for research involving peptide modifications and drug delivery systems. -
Cosmetic Peptide
2-Ethylhexyl palmitate is an ester derived from palmitic acid, primarily functioning as an emollient and skin conditioning agent. It is widely utilized in cosmetic formulations, particularly in the development of UV sunscreen products, where it enhances skin absorption and provides moisturizing properties. Research applications include studies on the efficacy and stability of sunscreen formulations, as well as skin permeation assessments. -
Fluorinated Peptide
3,4-Difluorophenylalanine is a fluorinated amino acid that serves as a building block in peptide synthesis. Its unique fluorination enhances gelation properties, making it useful in the development of novel hydrogels and biomaterials. This compound is instrumental in studies focused on peptide-based drug delivery systems and tissue engineering applications. -
Peptide
H-Glu(Met-OH)-OH, a peptide compound, is known to induce oxidative stress through the generation of hydroxyl radicals. Its ability to modulate redox dynamics makes it a valuable tool for investigating oxidative damage and related biological processes. This peptide is applicable in studies focused on cellular responses to oxidative stress and the mechanisms underlying various diseases. -
Self-assembling Peptide
MAX1 is a self-assembling peptide that forms hydrogels through molecular interaction. This compound exhibits key biological activity in biomaterial applications, providing a scaffold for tissue engineering and drug delivery systems. Its tunable properties make it suitable for various research applications in regenerative medicine and cellular studies. MAX1 offers a versatile platform for investigating peptide-based hydrogel formation and optimization. -
Tag Peptide
Cys-V5 Peptide is a tag peptide featuring an N-terminal cysteine modification. This peptide facilitates the labeling of proteins, enhancing detection and purification methods in various biochemical assays. Its applications are particularly relevant in studies involving protein interaction, expression analysis, and the development of recombinant proteins. -
Active Peptide
N-Acetyl semax amidate is a biologically active peptide that primarily targets neuroprotective mechanisms. It exhibits potential cognitive enhancement and neurogenic effects, making it valuable for research in neurobiology and cognitive disorders. This compound is utilized in studies exploring the modulation of stress responses and memory enhancement. -
Tripeptide
H-Gly-Gly-Tyr-OH is a tripeptide known for its involvement in various biochemical pathways. This compound serves as a valuable tool in pharmaceutical research and biochemistry, contributing to the understanding of peptide interactions and biological functions. It may also be utilized in studies related to drug design and therapeutic development. -
Peptide
LSD is a peptide that specifically targets lymphatics associated with C8161 melanoma, demonstrating no binding affinity for normal tissues or tumor blood vessels. When conjugated with pro-apoptotic peptides, LSD effectively decreases the presence of tumor lymphatics. This compound is valuable for research in targeted therapies and the diagnostic evaluation of tumor lymphatics.
