Salusin-α

Catalog No.: A73884
Endogenous Bioactive Peptide
Salusin-α is an endogenous bioactive peptide that modulates hemodynamic responses and promotes cell proliferation. It effectively stimulates the proliferation of quiescent vascular smooth muscle cells (VSMCs) and fibroblasts, resulting in a notable decrease in blood pressure and heart rate. Although its effects are less potent than those of Salusin-β, Salusin-α holds significant potential for applications in cardiovascular disease research and therapeutic exploration.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSalusin-α is an endogenous bioactive peptide that modulates hemodynamic responses and promotes cell proliferation. It effectively stimulates the proliferation of quiescent vascular smooth muscle cells (VSMCs) and fibroblasts, resulting in a notable decrease in blood pressure and heart rate. Although its effects are less potent than those of Salusin-β, Salusin-α holds significant potential for applications in cardiovascular disease research and therapeutic exploration.
Product Information
Catalog NumA73884
FormulaC114H192N40O30
Molecular Weight2602.99
CAS Number624735-22-4
SequenceSer-Gly-Ala-Leu-Pro-Pro-Ala-Pro-Ala-Ala-Pro-Arg-Pro-Ala-Leu-Arg-Ala-Gln-Arg-Ala-Gly-Pro-Ala-Gly-Pro-Gly-Ala-Lys-NH2
Sequence shorteningSGALPPAPAAPRPALRAQRAGPAGPGAK-NH2
SMILESC(=O)([C@H]1N(C([C@@H](NC([C@@H](NC(CNC([C@H](CO)N)=O)=O)C)=O)CC(C)C)=O)CCC1)N2[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@H](C(=O)N5[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(=O)N6[C@H](C(N[C@H](C(NCC(=O)N7[C@H](C(NCC(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)C)=O)=O)CCC7)=O)C)=O)CCC6)=O)C)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)C)=O)CCCNC(=N)N)=O)CC(C)C)=O)C)=O)CCC5)CCCNC(=N)N)=O)CCC4)C)=O)C)=O)CCC3)C)=O)CCC2
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