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Tat-βsyn-degron

Catalog No.: A79436
α-Synuclein Knockdown Peptide
Tat-βsyn-degron is an α-synuclein knockdown peptide that promotes the degradation of α-synuclein through the proteasome pathway. This compound demonstrates significant efficacy in reducing α-synuclein protein levels in primary rat cortical neuron cultures. Additionally, Tat-βsyn-degron has shown potential in alleviating parkinsonian toxin-induced neuronal damage and movement disorders in a Parkinson's mouse toxicity model, making it a valuable tool for research into neurodegenerative diseases.
Tat-βsyn-degron 2816095-52-8 α-Synuclein Knockdown Peptide
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTat-βsyn-degron is an α-synuclein knockdown peptide that promotes the degradation of α-synuclein through the proteasome pathway. This compound demonstrates significant efficacy in reducing α-synuclein protein levels in primary rat cortical neuron cultures. Additionally, Tat-βsyn-degron has shown potential in alleviating parkinsonian toxin-induced neuronal damage and movement disorders in a Parkinson's mouse toxicity model, making it a valuable tool for research into neurodegenerative diseases.
Product Information
Catalog NumA79436
FormulaC132H237N59O31
Molecular Weight3146.67
CAS Number2816095-52-8
SequenceTyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Thr-Lys-Ser-Gly-Val-Tyr-Leu-Val-Gly-Arg-Arg-Arg-Gly
Sequence shorteningYGRKKRRQRRRRTKSGVYLVGRRRG
SMILES[C@H](CC1=CC=C(O)C=C1)(C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(NCC(O)=O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)C(C)C)=O)CC(C)C)=O)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC2=CC=C(O)C=C2)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)[C@@H](C)O)=O)CCCCN)=O)CO)=O)=O)C(C)C)=O
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