Catalog No.
Product Name
Application
Product Information
Citations
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Tyrosinase Inhibitor
Tyrosinase-IN-1 is a potent inhibitor of the enzyme tyrosinase, a copper-containing metalloenzyme integral to melanin biosynthesis and enzymatic browning processes. This compound demonstrates significant biological activity as a tyrosinase inhibitor, making it a valuable tool for research into skin whitening agents and food preservation applications. Its effectiveness in modulating tyrosinase activity positions it as a key reagent for studies aimed at understanding pigmentation mechanisms and enhancing food shelf life. -
Tyrosinase Inhibitor
Phaeosphaone D is a thiodiketopiperazine alkaloid that demonstrates strong inhibitory activity against tyrosinase, an enzyme critical in melanin biosynthesis. Isolated from the endophytic fungus Phaeosphaeria fuckelii, Phaeosphaone D exhibits an IC50 value of 33.2 μM, indicating its potency. This compound is valuable for research applications focused on skin pigmentation, melanoma, and potential therapeutic strategies for hyperpigmentation disorders. -
Tyrosinase Inhibitor
Tyrosinase-IN-7 is a potent inhibitor of tyrosinase, exhibiting an IC50 value of 1.57 µM. This compound demonstrates effective inhibition of cell growth while maintaining low cytotoxicity, making it suitable for research applications focused on melanin synthesis and related disorders. Its unique properties position it as a valuable tool in the study of pigmentation mechanisms and potential therapeutic interventions. -
Tyrosinase Inhibitor
6-Acetylnimbandiol is a non-cytotoxic tyrosinase inhibitor that demonstrates an IC50 value of 69.85 μM, effectively reducing melanin production and MITF expression. This compound is valuable for investigating the mechanisms of pigmentation and has potential applications in melanoma research. -
Tyrosinase Inhibitor
2,3-Dihydroisoginkgetin is a biflavonoid that functions as a potent inhibitor of tyrosinase, exhibiting a 36.84% inhibition rate at a concentration of 0.1 mM. This compound demonstrates reduced cytotoxicity in human epidermal melanocyte (HEMn) cells, with an IC50 value of 86.16 μM. 2,3-Dihydroisoginkgetin is valuable for research applications focused on skin pigmentation, melanin production, and potential therapeutic strategies for hyperpigmentation disorders. -
Tyrosinase Inhibitor
Tyrosinase-IN-4 is a potent inhibitor of the enzyme tyrosinase, a copper-containing metalloenzyme that catalyzes the rate-limiting step in melanin biosynthesis, which is essential for pigmentation in various biological systems. This compound has significant implications for research in skin whitening agents and food preservation, making it a valuable tool for studies focused on reducing pigmentation and preventing enzymatic browning in food products. -
Mushroom Tyrosinase Diphenolase Inhibitor
Tyrosinase-IN-33 is a pyridine-based compound that acts as a potent inhibitor of mushroom tyrosinase diphenolase activity. It effectively reduces enzyme activity, with an IC50 value of 9.0 μM, making it a valuable tool for research into melanogenesis and related disorders. This compound is suitable for studies investigating enzymatic inhibition and the regulation of pigmentation processes. -
Tyrosinase Inhibitor
Tyrosinase-IN-44 is a potent inhibitor of tyrosinase, exhibiting IC50 values of 0.47 μM for monophenolase activity and 0.53 μM for diphenolase activity. This compound demonstrates significant antioxidant properties through its glutathione peroxidase-like catalytic function and DPPH radical scavenging ability. Tyrosinase-IN-44 effectively prevents browning in fruit juices, particularly in banana and apple, by inhibiting polyphenol oxidase (PPO). Its applications extend to redox regulation and food preservation, making it a valuable reagent in biochemical research. -
Tyrosinase Inhibitor
Cardanol diene is a phenolic compound that acts as an inhibitor of tyrosinase, exhibiting an IC50 value of 52.5 μM in vitro. It is utilized in research aimed at exploring pigmentation processes and has applications in the synthesis of cardanol-metal complexes, which have been shown to inhibit biofilm formation by uropathogenic E. coli. -
Tyrosinase Inhibitor
Broussonin C is a competitive inhibitor of tyrosinase, a key enzyme involved in melanin biosynthesis. Isolated from Broussonetia kazinoki, Broussonin C exhibits potent inhibitory activity with IC50 values of 0.43 μM for monophenolase and 0.57 μM for diphenolase. This compound is valuable for research applications focused on skin pigmentation, oxidative stress, and potential therapeutic interventions in hyperpigmentation disorders. -
tyrosinase Inhibitor
Tyrosinase-IN-27 is a selective tyrosinase (TYR) inhibitor with an IC50 value of 0.88 μM. This compound acts by binding to TYR, resulting in a decrease in α-helical content and altering the enzyme's secondary structure, leading to reduced enzymatic activity. Tyrosinase-IN-27 has potential applications in the food industry, specifically for preventing enzymatic browning in products such as lotus root slices. -
Tyrosinase Inhibitor
7-Methoxy obtusifolin acts as a competitive inhibitor of tyrosinase, exhibiting an IC50 value of 7.0 μM. This compound is utilized in studies focused on melanogenesis and pigmentation disorders, making it a valuable tool for research in skin biology and potential therapeutic development for hyperpigmentation conditions. -
Tyrosinase Inhibitor
Tyrosinase-IN-2 is a selective inhibitor of the enzyme tyrosinase, a copper-containing metalloenzyme that catalyzes the critical step in melanin biosynthesis and contributes to enzymatic browning. This compound demonstrates significant inhibitory activity, making it a valuable tool for research in skin whitening agents and food preservation applications. Its ability to modulate melanin production positions Tyrosinase-IN-2 as a promising candidate for studies focused on pigmentation and related processes. -
Tyrosinase Inhibitor
Tyrosinase-IN-10 is a partially competitive inhibitor of tyrosinase, exhibiting an IC50 of 1.6 μM against tyrosinase activity in human melanoma cell lysates. This compound is valuable for research applications focused on melanin production and skin disorders, as well as for studying the biochemical pathways associated with tyrosinase. Its specific inhibition properties make it a useful tool for exploring potential therapeutic strategies in pigmentation-related conditions. -
Tyrosinase Inhibitor
Glabrene is an isoflavene derived from licorice root, functioning primarily as a tyrosinase inhibitor with an IC50 of 3.5 μM. It exhibits estrogen-like activity and is utilized in research investigating skin pigmentation, melanogenesis, and potential therapeutic applications in hyperpigmentation disorders. Its ability to modulate enzymatic activity makes it a valuable reagent for studies related to skin biology and pigmentation regulation. -
Tyrosinase inhibitor
Allamandicin is an iridoid lactone that acts as a potent inhibitor of tyrosinase. Isolated from the roots of Allamanda cathartica, Allamandicin exhibits significant biological activity by effectively reducing melanin production. This compound is valuable in research applications focused on skin pigmentation, cosmetics, and potential therapeutic strategies for conditions related to hyperpigmentation. -
Tyrosinase Inhibitor
Persiconin is a potent inhibitor of tyrosinase, an enzyme crucial for melanin synthesis. Isolated from Prunus persica, Persiconin exhibits a notable tyrosinase inhibitory activity, achieving an inhibition of 46% at a concentration of 500 μM. This compound is particularly valuable in research applications focused on skin whitening and pigmentation modulation. -
Tyrosinase Inhibitor
Tyrosinase-IN-17 is a potent inhibitor of tyrosinase, exhibiting a lipophilic nature and skin permeability with a pIC50 value of 4.99. This compound demonstrates non-cytotoxic properties, making it suitable for in vitro studies. Tyrosinase-IN-17 is primarily employed in research related to melanin synthesis and disorders, including melanoma and other melanogenesis-related diseases. -
Tyrosinase Inhibitor
Tyrosinase-IN-31 is a selective inhibitor of tyrosinase, targeting both monophenolase (IC50=70.44 μM) and diphenolase (IC50=1.89 μM) activities. This compound effectively inhibits tyrosinase and melanogenesis, demonstrating potential applications in skin depigmentation research. Additionally, Tyrosinase-IN-31 exhibits the ability to penetrate the blood-brain barrier, allowing it to enter the central nervous system, where it may confer neuroprotective effects and improve symptoms related to Parkinson's disease. -
Tyrosinase Inhibitor
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is a potent tyrosinase inhibitor that effectively reduces melanin synthesis. Isolated from Pteris fern, this compound targets the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF), modulating melanin production. Key structural features including the 11α-OH, 15-oxo, and 16-en functionalities contribute to its inhibitory effects on melanin synthesis, while the 19-COOH moiety may help mitigate cytotoxicity associated with related compounds. This reagent is valuable in research focused on skin pigmentation and potential therapeutic applications for hyperpigmentation disorders. -
Tyrosinase Inhibitor
Tyrosinase-IN-35 is a potent inhibitor of human tyrosinase, exhibiting an IC50 of 2.09 μM, significantly surpassing the efficacy of Kojic Acid, which has an IC50 of 16.38 μM. This compound effectively reduces melanin content in B16F10 melanoma cells in vitro at concentrations of 4 μM and 8 μM. Tyrosinase-IN-35 serves as a valuable tool for research in pigmentation disorders and related therapeutic applications. -
Mushroom Tyrosinase Inhibitor
Chetoseminudin B is a potent inhibitor of mushroom tyrosinase, exhibiting an IC50 value of 31.7 μM. This compound is significant for research applications focused on melanin biosynthesis, pigmentation disorders, and potential cosmetic formulations aimed at skin lightening. Its ability to modulate enzymatic activity makes it valuable for investigating the role of tyrosinase in various biological processes. -
Tyrosinase Inhibitor
Sorocein H is a potent inhibitor of tyrosinase, demonstrating an IC50 value of 6.49 μM. This compound effectively reduces melanin synthesis and serves as a valuable tool in the study of pigment-related disorders. Research applications include investigations into skin pigmentation and related pathological conditions. -
Tyrosinase Inhibitor
Aspochalasin I is a potent tyrosinase inhibitor that effectively suppresses melanogenesis, achieving an IC50 of 22.4 μM. This compound also demonstrates cytotoxic effects against various cancer cell lines, including NCI-H460, MCF-7, and SF-268, with IC50 values of 22.1, 33.4, and 19.9 μM, respectively. Due to its role in inhibiting melanin production, Aspochalasin I can be utilized in research aimed at developing skin whitening agents and exploring therapeutic avenues in cancer treatment. -
Tyrosinase
Tyrosinase-IN-6 is a potent inhibitor of the enzyme tyrosinase, exhibiting an IC50 value of 3.80 μM. This compound demonstrates notable antioxidant activity, making it valuable for research applications focused on pigmentation pathways and oxidative stress. Tyrosinase-IN-6 can be utilized in studies aimed at understanding skin disorders, melanin production, and developing cosmetic or therapeutic agents targeting hyperpigmentation. -
Tyrosinase Inhibitor
Dodoviscin A is a potent tyrosinase inhibitor that can be derived from the aerial parts of Dodonaea viscosa. It effectively reduces melanin production in B16-F10 melanoma cells and significantly suppresses mushroom tyrosinase activity. In addition, Dodoviscin A inhibits the phosphorylation of cAMP response element binding protein, which is stimulated by 3-isobutyl-1-methylxanthine and forskolin, making it a valuable tool for research applications focused on pigmentation and related signaling pathways. -
Tyrosinase Inhibitor
Tyrosinase-IN-37 is a potent inhibitor of tyrosinase, displaying an IC50 of 1.02 μM, significantly more effective than kojic acid, which has an IC50 of 14.74 μM. This compound demonstrates the capability to prevent browning in Rosa roxburghii and offers broader applications by inhibiting browning processes independent of tyrosinase activity. Its efficacy makes Tyrosinase-IN-37 a valuable tool in research focused on pigmentation and enzymatic regulation. -
Tyrosinase Inhibitor
Azo-resveratrol is a potent inhibitor of tyrosinase, demonstrating an IC50 value of 36.28 μM. This compound is particularly relevant for research applications focused on melanogenesis, skin pigmentation disorders, and potential therapeutic interventions for hyperpigmentation. Azo-resveratrol's ability to modulate tyrosinase activity highlights its significance in biochemical studies related to melanin synthesis. -
Tyrosinase Inhibitor
Mycosporine 2 glycine is a selective inhibitor of tyrosinase-related protein 1 (TYRP1), demonstrating strong binding affinity and stability. This compound exhibits biological activity that can modulate melanogenesis, making it valuable in research focused on hyperpigmentation disorders. Additionally, Mycosporine 2 glycine is commonly utilized in sunscreen formulations due to its protective properties against UV-induced skin damage. -
Tyrosinase Inhibitor
Tyrosinase-IN-42 is a potent inhibitor of tyrosinase, exhibiting an IC50 of 1.363 µM. This compound demonstrates significant anti-browning effects in fresh-cut apples and exhibits antioxidant properties through scavenging of DPPH and ABTS free radicals, with IC50 values of 57.90 µM and 45.64 µM, respectively. Tyrosinase-IN-42 is useful in research applications focused on food preservation and the study of oxidative stress. -
Tyrosinase Inhibitor
Taraxinic acid is a potent inhibitor of tyrosinase, an enzyme crucial for melanin biosynthesis. Derived from the roots of Taraxacum flavostylum and Taraxacum lucidum, it exhibits a dose-dependent inhibition of tyrosinase activity, achieving approximately 54.5% inhibition at 50 μg/mL. Additionally, Taraxinic acid demonstrates cytotoxic effects against melanoma cell lines A375 and HTB140 with an IC50 of 83.2 μM, and WM793 with an IC50 of 60.4 μM, indicating significant potential for applications in anticancer research. -
Tyrosinase Activator
5-epi-Arvestonate A is a sesquiterpenoid that acts as a tyrosinase activator, enhancing melanogenesis through the activation of the microphthalmia-associated transcription factor (MITF) and genes within the tyrosinase family. This compound furthermore exhibits anti-inflammatory properties by inhibiting the expression of interferon-gamma (IFN-γ)-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells. Its biological activity makes it a valuable reagent for research in dermatological studies and pigmentation processes. -
Tyrosinase Inhibitor
FQ is a potent tyrosinase inhibitor, specifically designed to inhibit the diphenolase activity of mushroom tyrosinase, with an IC50 value of 120 μM. This reagent is valuable for research applications focusing on pigmentation processes, allowing investigators to explore the biochemical pathways associated with melanin synthesis and regulation. Its ability to modulate tyrosinase activity makes FQ a critical tool in dermatological and cosmetic research. -
Tyrosinase Inhbitor
Tyrosinase-IN-20 is a potent inhibitor of tyrosinase, exhibiting an IC50 of 28.50 μM. This compound effectively dampens melanin production by inhibiting the enzymatic activity of tyrosinase, making it valuable for research into pigmentation disorders and skin-related applications. Its ability to modulate melanin synthesis allows for exploration in fields such as dermatology and cosmetic formulations. -
HER2-RAS-MEK-ERK signaling pathway Modulator, mushroom tyrosinase Inhibitor
Broussoflavonol F is a modulator of the HER2-RAS-MEK-ERK signaling pathway and an inhibitor of mushroom tyrosinase, exhibiting an IC50 of 82.3 μM against the latter. This compound effectively reduces protein expression levels of RAS, HER2, phosphorylated BRAF, phosphorylated MEK, and phosphorylated ERK, leading to the induction of apoptosis and G0/G1 phase cell cycle arrest. It demonstrates notable cytotoxicity against colon cancer cells, making it a valuable tool for research focused on colon cancer and related signaling pathways. -
Tyrosinase Inhibitor
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is a potent tyrosinase inhibitor known for its ability to reduce melanin production, making it a valuable agent in skin lightening applications. This compound is of significant interest in research surrounding hyperpigmentation disorders, various cancer types, central nervous system disorders, osteoporosis, and diabetes, offering potential therapeutic insights into these conditions. Its mechanism of action provides a basis for exploring innovative treatments and understanding skin-related pathologies. -
Tyrosinase Inhibitor
Methyl cinnamate (Methyl 3-phenylpropenoate) is an effective tyrosinase inhibitor, primarily utilized to prevent enzymatic browning in food products. In addition to its role in food applications, it demonstrates antimicrobial properties and exhibits antiadipogenic effects, partly mediated by the CaMKK2-AMPK signaling pathway. This compound is valuable for researchers exploring therapeutic strategies in skin pigmentation disorders and metabolic regulation.
