Broussoflavonol F is a modulator of the HER2-RAS-MEK-ERK signaling pathway and an inhibitor of mushroom tyrosinase, exhibiting an IC50 of 82.3 μM against the latter. This compound effectively reduces protein expression levels of RAS, HER2, phosphorylated BRAF, phosphorylated MEK, and phosphorylated ERK, leading to the induction of apoptosis and G0/G1 phase cell cycle arrest. It demonstrates notable cytotoxicity against colon cancer cells, making it a valuable tool for research focused on colon cancer and related signaling pathways.
Broussoflavonol F is a modulator of the HER2-RAS-MEK-ERK signaling pathway and an inhibitor of mushroom tyrosinase, exhibiting an IC50 of 82.3 μM against the latter. This compound effectively reduces protein expression levels of RAS, HER2, phosphorylated BRAF, phosphorylated MEK, and phosphorylated ERK, leading to the induction of apoptosis and G0/G1 phase cell cycle arrest. It demonstrates notable cytotoxicity against colon cancer cells, making it a valuable tool for research focused on colon cancer and related signaling pathways.
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