ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is a potent tyrosinase inhibitor that effectively reduces melanin synthesis. Isolated from Pteris fern, this compound targets the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF), modulating melanin production. Key structural features including the 11α-OH, 15-oxo, and 16-en functionalities contribute to its inhibitory effects on melanin synthesis, while the 19-COOH moiety may help mitigate cytotoxicity associated with related compounds. This reagent is valuable in research focused on skin pigmentation and potential therapeutic applications for hyperpigmentation disorders.
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is a potent tyrosinase inhibitor that effectively reduces melanin synthesis. Isolated from Pteris fern, this compound targets the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF), modulating melanin production. Key structural features including the 11α-OH, 15-oxo, and 16-en functionalities contribute to its inhibitory effects on melanin synthesis, while the 19-COOH moiety may help mitigate cytotoxicity associated with related compounds. This reagent is valuable in research focused on skin pigmentation and potential therapeutic applications for hyperpigmentation disorders.
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