Catalog No.
Product Name
Application
Product Information
Citations
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Tyrosinase inhibitor
Aloin (Barbaloin) is a yellow crystalline substance obtained from aloe and is reported to be a potent inhibitors of tyrosinase. -
Tyrosinase inhibitor
Arbutin is a glycosylated hydroquinone used in traditional Chinese medicine (TCM). Arbutin inhibits melanin formation due to its tyrosinase inhibitory activity.
- 4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM.
- Hydroxyacetic acid is a dermatologic agent. It has also been used as a plant-tissue based biosensor and chemiluminescence flow sensor.
- Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation.
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COX-1/HDAC/Tyrosinase Inhibitor
Gnetol is a bioactive phenolic compound isolated from the root of *Gnetum montanum* with diverse pharmacological properties. It potently inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 0.78 μM and exhibits histone deacetylase (HDAC) inhibitory activity. Gnetol is also a strong tyrosinase inhibitor, with an IC₅₀ of 4.5 μM against murine tyrosinase, leading to suppression of melanin biosynthesis. In addition to its antioxidant, antiproliferative, anticancer, and hepatoprotective effects, Gnetol modulates metabolic enzymes in a concentration-dependent manner, including α-amylase, α-glucosidase, and adipogenesis pathways, making it a promising candidate for research in oncology, dermatology, and metabolic disorders. -
Tyrosinase Inhibitor
Norartocarpetin is a potent tyrosinase inhibitor, demonstrating significant inhibition with an IC50 value of 0.47 μM. This compound serves as an effective antibrowning agent for food systems research and exhibits notable anticancer activity against lung carcinoma cells (NCI-H460) with an IC50 of 22 μM. Its antiproliferative effects are mediated through targeting the Ras/Raf/MAPK signaling pathway, inducing mitochondrial-mediated apoptosis, causing S-phase cell cycle arrest, and inhibiting cell migration and invasion in human lung carcinoma cells. -
Tyrosinase Inhibitor
2-Ketoglutaric Acid Potassium is a reversible and orally active inhibitor of tyrosinase, exhibiting an IC50 value of 15 mM. As a key intermediate in the Krebs cycle, it plays a role in ATP and GTP production and serves as a major carbon skeleton for nitrogen-assimilatory reactions. In addition to its enzymatic inhibition, 2-Ketoglutaric Acid Potassium has demonstrated the ability to suppress abnormal intestinal permeability and the expression of TNFα, both in vitro and in vivo. Its therapeutic applications extend to alleviating symptoms of inflammatory bowel disease (IBD) and rebalance of gut microbiota. -
Tyrosinase Inhibitor
Deoxyarbutin is a potent tyrosinase inhibitor, primarily utilized in dermatological and cancer research. It promotes apoptosis in melanoma cells and enhances the vitality of mouse acinar cells, exhibiting significant skin whitening effects and anti-tumor activity. This compound is valuable for studies focused on skin disorders and melanoma treatment strategies. -
Mushroom Tyrosinase Inhibitor
Dihydroaltenuene B is a potent inhibitor of mushroom tyrosinase, exhibiting an IC50 of 38.33 µM. This compound interacts with active site residues, including His244, Met280, and Gly281, through hydrogen bonding with its 3-OH and 4'-OH groups. Dihydroaltenuene B serves as a valuable reagent for investigating tyrosinase-related enzymatic processes and offers potential applications in skin-whitening agents and studies on melanin biosynthesis inhibition. -
Tyrosinase Inhibitor
Aloesin is a potent tyrosinase inhibitor known for its diverse biological activities, including anti-inflammatory effects and ultraviolet protection. Additionally, it exhibits antibacterial properties and has been shown to induce apoptosis in various cancer cell lines, making it a valuable compound for research in ovarian cancer and related studies. Its multifunctional profile provides a broad spectrum of applications in both dermatological and oncology research. -
Tyrosinase Inhibitor
Dalbergioidin is a potent tyrosinase inhibitor that demonstrates significant activity through its ability to modulate enzymatic processes related to melanin biosynthesis. This compound has been shown to ameliorate renal fibrosis induced by doxorubicin by suppressing the TGF-β signaling pathway. Dalbergioidin's potential applications include studies focused on skin disorders and the regulation of pigmentation. -
Tyrosinase Inhibitor
AP736 is a potent inhibitor of tyrosinase, exhibiting an IC50 value of 0.9 μM, and demonstrates significant anti-melanogenesis activity in normal human melanocytes with an IC50 of 0.11 μM. By inhibiting the cAMP-PKA-CREB signaling pathway, AP736 effectively reduces the expression of tyrosinase and TRP-1/2, leading to a decrease in microphthalmia-associated transcription factor (MITF) transcripts and proteins. This compound is suitable for investigations into melanogenesis and the underlying mechanisms of hyperpigmentation. -
Tyrosinase-Resistant Mimetic
3,5-Difluoro-L-tyrosine is a functional mimetic of tyrosine that exhibits resistance to tyrosinase. This compound is utilized to investigate the substrate specificity of protein tyrosine phosphatases (PTPs), making it valuable for research into tyrosine phosphorylation pathways and their regulatory mechanisms. -
Tyrosinase Inhibitor
Swertiajaponin is a potent tyrosinase inhibitor that interacts with the enzyme's binding pocket through hydrogen bonding and hydrophobic interactions, exhibiting an IC50 of 43.47 μM. It effectively inhibits oxidative stress-mediated MAPK/MITF signaling pathways, resulting in a reduction of tyrosinase protein levels. Additionally, Swertiajaponin demonstrates strong anti-oxidative activity and suppresses melanin accumulation, making it a valuable tool for research aimed at understanding pigmentation disorders and oxidative stress. -
Tyrosinase Antagonist
Tyrosinase-IN-22 is a potent inhibitor of the enzyme tyrosinase, effectively targeting its substrates L-tyrosine and L-DOPA with IC50 values of 60 nM and 30 nM, respectively. This compound exhibits significant antioxidant and anti-melanogenic properties, making it valuable for research in skin pigmentation disorders and oxidative stress studies. Its ability to modulate tyrosinase activity positions it as a useful tool in the investigation of melanin synthesis and related biological pathways. -
Tyrosinase Inhibitor
Tyrosinase-IN-12 is a potent non-competitive inhibitor of tyrosinase, demonstrating an IC50 value of 49.33 ± 2.64 µM and a Ki value of 31.25 ± 0.25 µM. This compound exhibits strong radical scavenging activity, effectively reducing the production of reactive oxygen species (ROS) with an IC50 of 25.39 ± 0.77 µM. Tyrosinase-IN-12 is applicable in research focusing on the mitigation of browning in food products and agricultural applications. -
Tyrosinase Inhibitor
2-Hydroxy-4-methoxybenzaldehyde is a potent inhibitor of the enzyme tyrosinase, which is crucial in melanin biosynthesis. This compound plays a significant role in research pertaining to pigmentation disorders and skin-related applications. Additionally, it can be utilized as a precursor for the synthesis of Urolithin M7, expanding its utility in biochemical studies. -
Tyrosinase Inhibitor
Polyphyllin C is a spirostanol saponin that acts as a tyrosinase inhibitor. It demonstrates mild inhibitory activity against tyrosinase with an IC50 of 36.87 µM. Additionally, Polyphyllin C exhibits moderate antileishmanial effects, with an IC50 of 1.59 µg/mL, making it a candidate for research in skin pigmentation disorders and leishmaniasis treatment. -
Tyrosinase Inhibitor
p-Coumaric Acid Ethyl Ester serves as a non-competitive, reversible inhibitor of tyrosinase, with an IC50 value of 4.89 μg/mL and a Ki of 1.83 μg/mL. This compound quells the intrinsic fluorescence of the enzyme and alters the binding affinity of L-tyrosine by inducing conformational changes within the catalytic domain without interfering with the copper ion binding. p-Coumaric Acid Ethyl Ester has applications in the development of pharmaceuticals, cosmetics, and fruit preservation products. -
Tyrosinase Inhibitor
Cepharadione B is a natural tyrosinase inhibitor derived from the leaves of Piper sanctum, exhibiting an IC50 value of 170 μM. This compound demonstrates significant inhibitory effects on cell growth in various cancer cell lines, including A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15. Cepharadione B is valuable for research exploring pigmentation processes, melanoma, and potential therapeutic interventions against cancer. -
Tyrosinase Inhibitor
(E)-2-Methoxycinnamaldehyde is a potent inhibitor of tyrosinase, demonstrating an IC50 of 0.42 mM for mushroom tyrosinase. Isolated from the twigs of Cinnamomum cassia, this compound is relevant in the study of melanin biosynthesis as well as potential applications in skin depigmentation. Additionally, (E)-2-Methoxycinnamaldehyde has been investigated for its role in Parkinson's disease research, providing insights into neuroprotective strategies. -
Tyrosinase Inhibitor
Isobutylamido thiazolyl resorcinol is a selective inhibitor of human tyrosinase with an IC50 of 1.1 μM, demonstrating notable efficacy against melanin production. This compound also shows an IC50 of 108 μM against mushroom tyrosinase, highlighting its specificity. Isobutylamido thiazolyl resorcinol effectively mitigates pigmentation induced by UVB exposure and significantly reduces the visibility of hyperpigmentation related to acne. Its applications in dermatological research make it a valuable tool for studying skin pigmentation processes and developing treatments for skin discoloration disorders. -
Tyrosinase Inhibitor
3',4'-Dihydroxyacetophenone is a potent tyrosinase inhibitor, demonstrating a strong inhibitory effect on enzyme activity with an IC50 value of 10 μM. Isolated from Picea schrenkiana needles, this compound also exhibits antioxidant properties and vasoactive effects, making it valuable for research applications in skin pigmentation and melanogenesis. Its ability to modulate tyrosinase activity positions it as a useful tool in studies related to pigmentation disorders and cosmetic formulations. -
Tyrosinase Inhibitor
(R)-Trolox is a vitamin E analogue and a competitive inhibitor of tyrosinase, exhibiting a Ki value of 0.83 mM and an ID50 of 1.88 mM. This compound demonstrates a greater affinity for tyrosinase compared to its (S) enantiomer, which has a Ki value of 0.61 mM. (R)-Trolox is valuable for research focused on skin pigmentation, oxidative stress, and potential therapeutic applications in disorders related to hyperpigmentation. -
Tyrosinase Inhibitor
Mulberroside F acts as a potent tyrosinase inhibitor, primarily derived from the mulberry plant (Morus alba L.). This compound effectively inhibits tyrosinase activity, leading to a reduction in melanin formation, making it valuable in research related to hyperpigmentation and skin disorders. Additionally, Mulberroside F demonstrates superoxide scavenging activity, contributing to its protective effects against oxidative stress. -
Tyrosinase Inhibitor
4-Bromobenzoic acid is a potent inhibitor of tyrosinase, with an IC50 range of 0-0.3 mg/mL. This compound plays a significant role in the study of melanin biosynthesis and is applicable in research focused on cosmetic whitening and pigmentation disorders. Its metabolism via the protocatechuic acid (PCA) pathway provides additional insights into its biochemical interactions and potential therapeutic benefits. -
Tyrosinase Inhibitor
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound that acts as an effective inhibitor of the enzyme tyrosinase, exhibiting an IC50 of 29.75 μM. This compound plays a significant role in regulating melanin production and is of interest in research applications related to skin pigmentation disorders and cosmetic formulations. Its inhibitory effect on tyrosinase makes it a valuable reagent for studies exploring pigmentary conditions and related therapeutic interventions. -
Tyrosinase Inhibitor
5-Feruloylquinic acid is a potent inhibitor of tyrosinase, an enzyme involved in melanin biosynthesis. Isolated from green coffee beans, this hydroxycinnamic acid derivative exhibits significant antioxidant properties and has demonstrated anticancer activity against various cancer types, including lymphoma, oral epidermal cancer, and breast cancer. Its ability to modulate enzymatic activity and protect against oxidative stress makes it a valuable compound for research in cancer biology and metabolic studies. -
Tyrosinase Inhibitor
Mirificin, a tyrosinase inhibitor derived from Puerariae Lobatae Radix, demonstrates inhibitory activity with an IC50 of 12.66 μM. This isoflavone is of particular interest in studies related to pigmentation disorders and skin hyperpigmentation, offering a potential therapeutic avenue for regulating melanin synthesis. Its ability to modulate tyrosinase activity underscores its relevance in chemical and pharmacological research applications. -
Tyrosinase Inhibitor
2-Methoxycinnamic acid is a noncompetitive inhibitor of tyrosinase, an enzyme critical in melanin biosynthesis. This compound effectively reduces melanin production, making it valuable in studies focused on pigmentation disorders and skin whitening applications. Its ability to modulate tyrosinase activity positions it as a significant reagent for research in dermatology and cosmetic science. -
Tyrosinase Iinhibitor
Dihydromorin is a natural flavanonol compound that acts as a potent inhibitor of tyrosinase. Its inhibitory activity on this enzyme is significant for research applications focused on regulating melanin production, offering potential insights into hyperpigmentation disorders and skin-related studies. Dihydromorin can serve as an important tool for investigating mechanisms of skin pigmentation and the effects of natural compounds on melanin synthesis. -
Tyrosinase Inhibitor
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound that serves as an effective inhibitor of tyrosinase, with an IC50 value of 1.64 μM. This compound is derived from Morus nigra root and exhibits significant potential for applications in studies related to pigmentation and skin disorders. Its inhibitory action on tyrosinase makes it a valuable tool for research in cosmetic and dermatological fields. -
Tyrosinase Inhibitor
Neorauflavane is a potent inhibitor of tyrosinase, exhibiting an IC50 of 30 nM for monophenolase activity and 500 nM for diphenolase activity. Derived from Campylotropis hirtella, this compound effectively reduces melanin content in B16 melanoma cells. Neorauflavane serves as a valuable tool for research in pigmentation disorders and skin biology. -
Tyrosinase Inhibitor
Tyrosinase-IN-11 is a potent inhibitor of tyrosinase, exhibiting IC50 values of 50 nM for L-tyrosinase and 64 nM for L-dopa. This compound demonstrates significant antioxidant properties and low cytotoxicity, making it suitable for biological assays. Tyrosinase-IN-11 is particularly relevant for research into skin hyperpigmentation and related dermatological applications. -
Mushroom Tyrosinase Inhibitor
Sanggenon O is a potent inhibitor of mushroom tyrosinase, demonstrating an IC50 value of 1.15 μM. This compound, derived from Morus nigra, is valuable for research applications focused on enzymatic activity modulation, particularly in studies related to melanin biosynthesis and skin pigmentation. Its inhibitory effects on tyrosinase make it a useful tool in cosmetic and therapeutic research aimed at addressing hyperpigmentation and related conditions. -
Tyrosinase Inhibitor
Obtusifolin-2-O-glucoside is a potent inhibitor of tyrosinase, demonstrating an IC50 value of 9.2 μM. This compound, which can be isolated from cassia seed, has significant implications in the study of melanogenesis and skin pigmentation. Its inhibitory properties make it a valuable tool for research into hyperpigmentation disorders and skin-lightening agents. -
Tyrosinase Inhibitor
Viscumneoside III is a dihydroflavone O-glycoside that functions as a potent inhibitor of tyrosinase, exhibiting an IC50 value of 0.5 mM. This compound demonstrates significant anti-angina pectoris activity, making it a valuable reagent for research into melanogenesis and cardiovascular health. Its ability to modulate tyrosinase activity further supports its applications in studies related to pigmentation disorders and metabolic conditions. -
Tyrosinase Inhibitor
Isolindleyin is a butyrophenone that acts as a potent inhibitor of tyrosinase, exhibiting a Kd of 54.8 μM in human tyrosinase assays. This compound demonstrates notable anti-inflammatory, analgesic, and anti-melanogenic activities, making it valuable for research in skin-related disorders and the modulation of pigmentation processes. Its multifunctional properties position it as a significant tool for studying enzyme inhibition and related biological pathways. -
Tyrosinase Inhibitor
Chimonanthine is an alkaloid derived from Chimonanthus praecox, known for its ability to inhibit tyrosinase activity. This compound also reduces the expression of tyrosine-related protein-1 mRNA, leading to the suppression of melanogenesis. Due to its mechanism of action, Chimonanthine is valuable in research focused on pigmentation disorders and potential therapeutic applications in hyperpigmentation conditions. -
Tyrosinase Inhibitor
Kojic acid dipalmitate is a derivative of kojic acid and functions as a reversible competitive inhibitor of tyrosinase. This compound is primarily studied for its skin-lightening properties due to its ability to inhibit melanin production. It is frequently utilized in research applications aiming to understand pigmentation mechanisms and the development of cosmetic agents targeting hyperpigmentation disorders. -
Tyrosinase Inhibitor
6-Hydroxykaempferol is a competitive inhibitor of tyrosinase, exhibiting an IC50 value of 124 μM. This flavonoid demonstrates a Ki value of 148 μM when L-DOPA serves as the substrate, effectively inhibiting the enzymatic activity by binding to the active site. Its inhibitory properties make it a valuable tool for research in skin pigmentation, cosmetic formulations, and enzymatic activity studies related to melanogenesis. -
Tyrosinase Inhibitor
Tyrosinase-IN-16 is a potent inhibitor of tyrosinase, exhibiting a Ki value of 470 nM. This compound demonstrates significant cytotoxicity against B16F10 melanoma cells, achieving over 90% inhibition at a concentration of 20 μM. Tyrosinase-IN-16 is valuable for studies investigating mechanisms of melanin synthesis and potential therapeutic applications in pigmentary disorders and melanoma research. -
Tyrosinase Inhibitor
Tyrosinase-IN-3 is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme that catalyzes the rate-limiting step in melanin biosynthesis and enzymatic browning processes. This compound exhibits significant biological activity in mitigating melanin production, making it valuable for research into skin whitening agents and food preservatives. Its application potential extends to various fields requiring modulation of pigmentation and oxidative reactions. -
Tyrosinase Inhibitor
4-Prenyloxyresveratrol is a derivative of oxyresveratrol that functions as a potent inhibitor of tyrosinase, exhibiting an IC50 of 0.90 μM. This compound demonstrates significant biological activity in inhibiting melanin production, making it valuable in research applications related to pigmentation disorders, skin protection, and potential therapeutic interventions in hyperpigmentation. -
Tyrosinase Inhibitor
Tyrosinase-IN-5 is a highly potent inhibitor of tyrosinase, exhibiting an IC50 value of 0.02 μM. This compound effectively suppresses melanogenesis while demonstrating minimal cytotoxicity to cells. Tyrosinase-IN-5 is applicable in research focused on skin pigmentation disorders and the development of skin-lightening agents.
