Catalog No.
Product Name
Application
Product Information
Citations
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ADC/PROTAC Linker
Propargyl-PEG8-bromide is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This non-cleavable linker includes an alkyne group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc). Its versatility makes it a valuable tool for researchers in the development of targeted therapeutics and for probing protein degradation mechanisms. -
PROTAC Linkers
m-PEG10-acid is a polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs (Proteolysis Targeting Chimeras). This non-cleavable 10-unit PEG linker enhances solubility and stability, facilitating effective delivery of therapeutic agents to targeted cells. The compound is instrumental in chemical biology applications, aiding in the development of novel targeted therapies and research into protein degradation mechanisms. -
PROTAC Linkers
N-Bromoacetyl-β-alanine is a versatile PROTAC linker that functions through targeted protein degradation pathways. This compound facilitates the synthesis of PROTACs, enabling the development of novel therapeutic strategies. Additionally, N-Bromoacetyl-β-alanine serves as a cleavable linker for antibody-drug conjugates (ADCs), enhancing the delivery of cytotoxic agents to specific cancer cells. Its utility in these applications makes it a valuable tool in chemical biology research. -
PROTAC Linker
β-D-tetraacetylgalactopyranoside-PEG1-N3 serves as a cleavable linker in PROTAC (proteolysis-targeting chimera) research, facilitating the synthesis of antibody-drug conjugates (ADCs). This compound features an azide group that allows for click chemistry applications, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with partners containing DBCO or BCN moieties, making it a versatile tool for bioconjugation and targeted drug delivery studies. -
ADC/PROTAC Linker
m-PEG8-MS is a polyethylene glycol (PEG)-based linker designed for use in antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). This cleavable linker facilitates the effective synthesis of ADCs, enhancing drug delivery specificity and potency. Its versatile applications in chemical biology allow for targeted degradation of selected proteins, making it a valuable tool in therapeutic development and research. -
ADC/PROTAC Linker
Propargyl-PEG1-SS-PEG1-C2-Boc is a versatile alkyl/ether-based linker with applications in PROTAC and antibody-drug conjugate (ADC) synthesis. This cleavable linker features an alkyne group, enabling its use in click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc). Propargyl-PEG1-SS-PEG1-C2-Boc is instrumental in the development of targeted therapeutic strategies, making it valuable for researchers in drug design and bioconjugation studies. -
PROTAC Linker
Tr-PEG8-OH is a non-cleavable linker composed of an 8 unit polyethylene glycol (PEG) chain, primarily utilized in the synthesis of PROTACs (proteolysis-targeting chimeras) and antibody-drug conjugates (ADCs). This PEG-based linker facilitates the development of optimized bioconjugates, enhancing their pharmacokinetic profiles and therapeutic efficacy. Tr-PEG8-OH is particularly valuable for research applications focusing on targeted protein degradation and drug delivery systems. -
ADC/PROTAC Linker
Propargyl-PEG4-thiol is a PEG-based linker specifically designed for use in the synthesis of PROTACs and non-cleavable antibody-drug conjugates (ADCs). This compound features an alkyne functional group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating precise conjugation with azide-containing molecules. Propargyl-PEG4-thiol is essential for advancing research in targeted protein degradation and therapeutic antibody development. -
ADC/PROTAC Linker
m-PEG7-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker facilitates the development of targeted therapeutics by enabling controlled release of active compounds. Its versatile application supports research in targeted protein degradation and drug delivery systems, making it an essential reagent for advancing science in cancer therapy and other diseases. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-NHS ester is a versatile linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This PEG/alkyl/ether-based compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its cleavable nature enhances the functionality and targeting capabilities of therapeutic agents, making it essential for researchers involved in drug development and bioconjugation applications. -
ADC/PROTAC Linker
N-Boc-N-bis(PEG4-OH) is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This cleavable linker also serves as a versatile component for the development of antibody-drug conjugates (ADCs). Due to its unique structure, it facilitates targeted drug delivery and enhances the efficacy of therapeutic agents in various biological applications. -
PROTAC Linkers
Bis-PEG7-acid is a polyethylene glycol (PEG) based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enhances the solubility and stability of the PROTAC molecules, facilitating targeted protein degradation. Its application in chemical biology supports research focused on developing novel therapeutics through targeted ubiquitination pathways. -
ADC/PROTAC Linker
Propargyl-PEG9-bromide is a PEG-based linker utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This non-cleavable linker facilitates the targeted delivery of therapeutics through its unique click chemistry capabilities, featuring an alkyne group suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAc). Its applications extend to enhancing drug efficacy and specificity in chemical biology and therapeutic development. -
PROTAC Linkers
m-PEG4-Boc is a cleavable polyethylene glycol (PEG) linker with four ethylene glycol units, designed for use in the synthesis of antibody-drug conjugates (ADCs) and Proteolysis Targeting Chimeras (PROTACs). This versatile linker facilitates the development of ADCs by enabling site-specific conjugation, while also serving as a crucial component in PROTAC design for targeted protein degradation. Its functional properties contribute to the effectiveness and stability of various bioconjugates in chemical biology research. -
PROTAC linker
Boc-gly-PEG3-endo-BCN is a cleavable PEG-based linker designed for targeted protein degradation applications through PROTAC technology. Its biocompatible structure facilitates the synthesis of antibody-drug conjugates (ADCs) by serving as a versatile linker. The presence of a bicyclo[6.1.0]nonyne (BCN) group allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules, making it a valuable reagent for click chemistry in biological research. -
ADC/PROTAC Linker
m-PEG5-MS is a PEG-based linker designed for antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). This cleavable linker facilitates the synthesis of PROTACs, enabling targeted degradation of specific proteins. Its key applications include drug development and cellular regulation studies, making it a versatile tool in therapeutic research and protein modulation. -
PROTAC Linker
Amino-PEG11-OH is a non-cleavable linker composed of an 11-unit polyethylene glycol (PEG) moiety designed for use in antibody-drug conjugates (ADCs) and PROTAC (Proteolysis Targeting Chimera) synthesis. This PEG-based linker facilitates the conjugation of drugs to antibodies, enhancing therapeutic efficacy while maintaining stability. Additionally, it serves as an effective component in the development of PROTACs, enabling targeted protein degradation for advanced molecular research applications. -
ADC/PROTAC Linker
Propargyl-PEG7-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker features an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its versatility and efficiency make it a valuable tool in the development of targeted therapeutics and bioconjugates for cancer research and drug delivery applications. -
ADC/PROTAC Linker
N-Boc-N-bis(PEG2-OH) is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This cleavable linker facilitates the precise attachment of therapeutic agents to antibodies, enhancing targeted drug delivery while minimizing off-target effects. Its structure allows for efficient conjugation and release of the active component, making it suitable for a variety of applications in drug development and molecular biology research. -
ADC/PROTAC Linker
Bis-PEG2-PFP ester is a non-cleavable linker that comprises two units of polyethylene glycol (PEG) and is essential for the synthesis of antibody-drug conjugates (ADCs). Its unique structure makes it suitable for use in peptide-based PROTACs (Proteolysis Targeting Chimeras), facilitating targeted degradation of specific proteins. This reagent supports advanced research in the fields of targeted therapy and protein regulation. -
ADC/PROTAC Linker
m-PEG9-Amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker facilitates the attachment of biomolecules, enabling targeted protein degradation and precise delivery of therapeutic agents. m-PEG9-Amine is essential for advancing research in targeted therapy and bioconjugation applications. -
ADC/PROTAC Linker
Bis-PEG17-NHS ester is a PEG-based linker designed for efficient conjugation in both PROTAC and antibody-drug conjugate (ADC) synthesis. Its NHS ester functionality allows for selective coupling to amine-containing molecules, facilitating the development of targeted therapies. This reagent is particularly useful in the development of PROTACs for targeted protein degradation and in the construction of ADCs that deliver cytotoxic agents to specific cancer cells. -
ADC/PROTAC Linker
N-Boc-PEG9-alcohol is a polyethylene glycol (PEG)-based linker utilized in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This cleavable linker facilitates the conjugation of bioactive molecules, enhancing the pharmacokinetic properties of ADCs. Its application extends to the development of targeted degraders, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linkers
N-Succinimidyl 3-(Bromoacetamido)propionate is a versatile PEG-based linker designed for PROTAC (proteolysis-targeting chimeras) synthesis. This compound facilitates the effective conjugation of small molecules to target proteins, enabling targeted protein degradation. Additionally, it serves as a cleavable linker for the development of antibody-drug conjugates (ADCs), enhancing therapeutic efficacy in cancer research. This reagent is essential for studies focused on protein modulation and targeted therapies. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-acid is a PEG-based linker designed for application in antibody-drug conjugates (ADCs) and PROTAC synthesis. This linker features a DBCO group that participates in strain-promoted alkyne-azide cycloaddition (SPAAC), facilitating selective conjugation with azide-containing molecules. Its chemical properties make it ideal for developing targeted therapeutics that can modulate protein levels in biological research, enhancing experimental outcomes in drug discovery and development. -
PROTAC Linker
5-Hydroxypentanoic acid serves as a versatile PROTAC linker, playing a crucial role in targeted protein degradation technology. This compound facilitates the synthesis of PROTAC AR-V7 degrader-1, contributing to innovative research in protein regulation and therapeutic development. Its structural characteristics enhance the design of bifunctional molecules for selective protein degradation, making it a valuable reagent in life sciences research. -
ADC/PROTAC Linker
Amino-PEG10-OH is a non-cleavable, 10-unit polyethylene glycol (PEG) linker primarily utilized in the development of antibody-drug conjugates (ADCs). This versatile linker also serves a critical role in the synthesis of proteolysis-targeting chimeras (PROTACs). Its hydrophilic properties enhance solubility and stability, making it suitable for diverse applications in chemical biology and therapeutic development. -
SKP2 Molecular Glue Degrader
XMU-MP-8 is a potent molecular glue degrader that targets the oncoprotein SKP2. It binds to the F-box domain of SKP2 and the N-terminal TPR domain of the E3 ligase STUB1, facilitating the formation of a stable SKP2-SKPer1-STUB1 ternary complex. This interaction leads to SKP2 ubiquitination and subsequent proteasomal degradation, selectively eliminating SKP2-expressing cancer cells. XMU-MP-8 demonstrates significant tumor suppression and favorable safety profiles in vivo, making it a valuable tool for cancer research, particularly in studies related to non-small cell lung adenocarcinoma (NSCLC) and prostatic adenocarcinoma. -
TRIM21 Molecular Glue
HGC652 is a molecular glue degrader that specifically targets TRIM21, facilitating the disruption of nuclear membrane integrity through a TRIM21-dependent mechanism. By binding with high affinity to the PRY-SPRY domain of TRIM21, HGC652 promotes the interaction between TRIM21 and NUP98, enhancing E3 ligase activity. This results in the polyubiquitination and subsequent proteasomal degradation of nucleoporins such as NUP155 and GLE1, leading to altered nuclear morphology, enhanced genomic instability, and ultimately, cancer cell death. HGC652 serves as a valuable tool for investigating nuclear envelope dynamics and the role of TRIM21 in cancer research. -
Molecular Glue
CC-647 is a molecular glue modulator that targets the Cereblon (CRBN) E3 ubiquitin ligase. It enhances the interaction between CRBN and ZBTB16, along with its oncogenic fusion protein RARα-ZBTB16, with a DC50 of 103 nM. CC-647 is particularly valuable for the investigation of ZBTB16-RARα-associated acute promyelocytic leukemia (APL) and offers potential insights into therapeutic strategies for this malignancy. -
E3 Ligase Ligand
E3 Ligase Ligand 36 is a potent E3 ligase ligand that serves as a key substrate for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates targeted protein degradation and has been utilized in the development of PROTAC BRM/BRG1 degrader-1. This compound provides valuable tools for research in protein regulation and therapeutic applications in various diseases. -
Molecular Glues
MG Degrader 3 is a molecular glue that targets the CRBN protein, inducing targeted protein degradation. It exhibits potent anti-proliferative activity in multiple myeloma cell line MM.1S, with an IC50 of 8.7 nM. This compound is valuable for studies investigating protein degradation mechanisms and therapeutic approaches in cancer research. -
E3 Ligase Ligand-Linker Conjugate
Ethanolamine-Thalidomide-4-OH is an E3 ligase ligand-linker conjugate designed to facilitate targeted protein degradation via the proteolysis targeting chimera (PROTAC) approach. This compound combines a cereblon (CRBN) ligand with a linker, enabling the synthesis of various PROTACs, such as PROTAC BTK Degrader-13. It serves as a crucial tool for researchers investigating selective protein degradation mechanisms and developing novel therapeutic strategies. -
PROTAC Linker
Azido-PEG2-C2-amine is a PEG-based linker designed for use in PROTAC synthesis. This compound features an azide moiety that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, facilitating conjugation with alkyne-bearing molecules. Additionally, Azido-PEG2-C2-amine serves as a non-cleavable linker for the development of antibody-drug conjugates (ADCs), making it a versatile tool in chemical biology and drug discovery applications. -
ADC/PROTAC Linker
DBCO-PEG5-NHS ester is a cleavable linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This PEG/alkyl/ether-based reagent facilitates the formation of stable covalent bonds through strain-promoted alkyne-azide cycloaddition (SPAAC), targeting azide-functionalized molecules. Its defined structure enhances the efficacy and specificity of therapeutic compounds, making it a valuable tool for researchers in the development of targeted therapies. -
PROTAC Linkers
Bromo-PEG2-C2-azide is a versatile PROTAC linker featuring a bromo group and an azide moiety, designed for the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This compound functions effectively in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Bromo-PEG2-C2-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it a valuable tool for targeted protein degradation and bioconjugation strategies in chemical biology research. -
PROTAC Linker
Azido-PEG4-C2-acid is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. It serves as a non-cleavable linker in the synthesis of antibody-drug conjugates (ADCs) and is integral to the development of compounds such as vRucaparib-TP4. This compound features an azide group that enables the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, and it also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile reagent for chemical biology research. -
ADC/PROTAC Linker
Bis-PEG9-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs (proteolysis-targeting chimeras). This cleavable linker facilitates the attachment of drugs to antibodies, enhancing selective delivery and activity. Its application in PROTAC synthesis allows for targeted protein degradation, making it a valuable tool in drug discovery and development. -
PROTAC Linker
N3-PEG3-CH2CH2COOH is a PEG-based PROTAC linker that facilitates selective protein degradation by enabling the synthesis of specific PROTACs, including BI-3663 and BI-4216. This compound contains an azide group, allowing it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-containing molecules. N3-PEG3-CH2CH2COOH is also applicable as a non-cleavable ADC linker in the development of antibody-drug conjugates, making it a versatile reagent for chemical biology research. -
ADC/PROTAC Linker
N-Boc-PEG1-bromide is a versatile cleavable linker targeting ADCs and PROTACs. This PEG/alkyl/ether-based reagent facilitates the synthesis of antibody-drug conjugates (ADCs) and enhances the design of proteolysis-targeting chimeras (PROTACs). Its unique properties allow for effective conjugation and release mechanisms, making it suitable for various applications in chemical biology and drug development research. -
ADC/PROTAC Linker
Bis-PEG5-NHS ester is a polyethylene glycol (PEG) based linker that targets protein degradation for the development of PROTACs (proteolysis targeting chimeras) and serves as a cleavable linker in antibody-drug conjugates (ADCs). This compound facilitates the conjugation of bioactive molecules with antibodies, enhancing the targeted delivery of therapeutic agents. Its versatile application in synthesizing both PROTACs and ADCs makes it valuable for advancing research in targeted therapies and drug delivery systems. -
PROTAC Linker
Amino-PEG4-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This linker facilitates the assembly of heterobifunctional molecules and enables targeted degradation of proteins within cellular systems. Additionally, Amino-PEG4-alcohol serves as a non-cleavable 4-unit PEG linker for the development of antibody-drug conjugates (ADCs), enhancing the delivery of therapeutic agents. It is suitable for applications in chemical biology and drug development research. -
ADC/PROTAC Linker
Azido-PEG7-amine is a non-cleavable 7-unit polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs (Proteolysis Targeting Chimeras). This versatile linker features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Azido-PEG7-amine serves as an important tool for the development of advanced bioconjugates in chemical research. -
PROTAC Linker
Boc-NH-PEG4-CH2CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras), facilitating targeted degradation of specific proteins. Additionally, this compound serves as a cleavable linker for antibody-drug conjugates (ADCs), enhancing the delivery of therapeutic agents to specific cellular targets. Its versatile applications make it a valuable tool in chemical biology and drug development research. -
ADC/PROTAC Linker
N-Boc-PEG4-bromide is a PEG-based linker that functions as a cleavable agent in antibody-drug conjugates (ADCs) and PROTACs. This compound facilitates the synthesis of PROTACs by providing a flexible and hydrophilic connector, enhancing solubility and biological activity. Its functional bromide group allows for effective conjugation to various biomolecules, making it a valuable tool in drug development research. -
PROTAC Linkers
Azido-PEG5-alcohol functions as a non-cleavable linker in the synthesis of antibody-drug conjugates (ADCs) and as a versatile PEG-based linker for PROTAC (proteolysis-targeting chimeras) development. It is characterized by its azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne, DBCO, or BCN-functionalized molecules. This reagent is instrumental in creating stable linkages for targeted protein degradation and therapeutic antibody conjugation, enhancing the efficacy of research applications in drug development. -
PROTAC Linkers
Azido-PEG6-amine is a PEG-based PROTAC linker featuring an azide functional group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-bearing and DBCO or BCN-containing molecules. This compound plays a crucial role in the synthesis of PROTACs, facilitating targeted protein degradation. Additionally, it serves as a non-cleavable linker in the development of antibody-drug conjugates (ADCs), providing significant versatility for researchers engaged in drug development and therapeutic applications. -
PROTAC Linker
Bis-PEG3-NHS ester is a non-cleavable linker that features a three-unit polyethylene glycol (PEG) structure, designed for use in the construction of PROTACs (proteolysis-targeting chimeras). This reagent facilitates the effective conjugation of antibodies to various agents, enhancing their therapeutic potential. Its unique properties make it suitable for applications in targeted drug delivery and protein degradation studies. -
Azide Compound
DBCO-PEG2-NHS ester is a click chemistry reagent with an azide group, designed to facilitate bioconjugation through reactions with primary amines, such as lysine side chains or aminosilane-coated surfaces. This PEG-based compound features an NHS ester, which enables the formation of stable covalent bonds under neutral to slightly basic conditions. The hydrophilic polyethylene glycol (PEG) spacer enhances solubility and adds flexibility, reducing steric hindrance during ligation. DBCO-PEG2-NHS ester is ideal for applications in copper-free Click Chemistry and other bioconjugation studies. -
ADC/PROTAC Linker
N-Boc-PEG2-bromide is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. Its PEG-based structure facilitates enhanced solubility and flexibility, contributing to improved therapeutic efficacy. This reagent is essential for researchers focused on developing targeted drug delivery systems and studying protein degradation pathways.
