HGC652 is a molecular glue degrader that specifically targets TRIM21, facilitating the disruption of nuclear membrane integrity through a TRIM21-dependent mechanism. By binding with high affinity to the PRY-SPRY domain of TRIM21, HGC652 promotes the interaction between TRIM21 and NUP98, enhancing E3 ligase activity. This results in the polyubiquitination and subsequent proteasomal degradation of nucleoporins such as NUP155 and GLE1, leading to altered nuclear morphology, enhanced genomic instability, and ultimately, cancer cell death. HGC652 serves as a valuable tool for investigating nuclear envelope dynamics and the role of TRIM21 in cancer research.
HGC652 is a molecular glue degrader that specifically targets TRIM21, facilitating the disruption of nuclear membrane integrity through a TRIM21-dependent mechanism. By binding with high affinity to the PRY-SPRY domain of TRIM21, HGC652 promotes the interaction between TRIM21 and NUP98, enhancing E3 ligase activity. This results in the polyubiquitination and subsequent proteasomal degradation of nucleoporins such as NUP155 and GLE1, leading to altered nuclear morphology, enhanced genomic instability, and ultimately, cancer cell death. HGC652 serves as a valuable tool for investigating nuclear envelope dynamics and the role of TRIM21 in cancer research.
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