XMU-MP-8 is a potent molecular glue degrader that targets the oncoprotein SKP2. It binds to the F-box domain of SKP2 and the N-terminal TPR domain of the E3 ligase STUB1, facilitating the formation of a stable SKP2-SKPer1-STUB1 ternary complex. This interaction leads to SKP2 ubiquitination and subsequent proteasomal degradation, selectively eliminating SKP2-expressing cancer cells. XMU-MP-8 demonstrates significant tumor suppression and favorable safety profiles in vivo, making it a valuable tool for cancer research, particularly in studies related to non-small cell lung adenocarcinoma (NSCLC) and prostatic adenocarcinoma.
XMU-MP-8 is a potent molecular glue degrader that targets the oncoprotein SKP2. It binds to the F-box domain of SKP2 and the N-terminal TPR domain of the E3 ligase STUB1, facilitating the formation of a stable SKP2-SKPer1-STUB1 ternary complex. This interaction leads to SKP2 ubiquitination and subsequent proteasomal degradation, selectively eliminating SKP2-expressing cancer cells. XMU-MP-8 demonstrates significant tumor suppression and favorable safety profiles in vivo, making it a valuable tool for cancer research, particularly in studies related to non-small cell lung adenocarcinoma (NSCLC) and prostatic adenocarcinoma.
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