Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC/ADC Linker
NH2-PEG2-C2-Boc is a PEG-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This non-cleavable linker comprises two PEG units, facilitating efficient conjugation while ensuring stability in biological systems. Its application is crucial in the development of targeted therapeutics, enabling precise modulation of protein degradation and enhancing the efficacy of ADCs in research and therapeutic contexts. -
ADC/PROTAC Linker
m-PEG5-CH2COOH is a non-cleavable linker designed for use in antibody-drug conjugates (ADCs) and PEG-based PROTACs. It facilitates the synthesis of ADCs by enabling stable connectivity between the antibody and the cytotoxic drug. Additionally, m-PEG5-CH2COOH serves as an effective linker for the development of PROTACs, thereby supporting targeted protein degradation research. Its chemical properties enhance the overall efficacy and stability of conjugated compounds in biological applications. -
ADC/PROTAC Linker
DBCO-PEG4-DBCO is a PEG-based linker primarily designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This compound features a dibenzocyclooctyne (DBCO) group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its versatile reactivity enables the development of targeted therapeutics, enhancing specificity and efficacy in research applications focused on protein degradation and targeted delivery systems. -
ADC/PROTAC Linker
m-PEG2-Amine is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis and antibody-drug conjugate (ADC) development. This cleavable linker facilitates the integration of therapeutic agents with antibodies, enhancing cellular uptake and stability. m-PEG2-Amine is essential for researchers focusing on targeted protein degradation and ADC formulations in therapeutic development. -
PROTAC Linkers
Fmoc-NH-PEG4-CH2COOH is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This PEG-based compound facilitates the development of targeted protein degradation strategies by enabling the construction of functional PROTACs. Its structural attributes support precise conjugation while maintaining stability in various biological environments, making it suitable for innovative therapeutic applications in chemical biology research. -
PROTAC Linker
Bis-PEG6-NHS ester is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables efficient conjugation to target proteins, allowing for selective degradation in cellular systems. Additionally, Bis-PEG6-NHS ester serves as a cleavable linker in the development of antibody-drug conjugates (ADCs), enhancing the therapeutic potential of these targeted delivery systems. Its versatility makes it an essential tool for research in drug development and targeted therapies. -
ADC/PROTAC Linker
Azido-PEG6-NHS ester is a cleavable 6-unit polyethylene glycol (PEG) linker designed for antibody-drug conjugate (ADC) synthesis. This compound serves as a versatile linker for PROTAC applications due to its ability to participate in click chemistry through the azide group. It can facilitate copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it an essential tool for chemical biology research. -
PROTAC/ADC Linker
NH2-PEG6-Boc is a PEG-based linker primarily designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras) and serves as a non-cleavable 6 unit PEG linker for antibody-drug conjugates (ADCs). It plays a critical role in optimizing the stability and efficacy of targeted therapeutics by facilitating the selective degradation of specific proteins. This compound is valuable in research applications focused on drug development and the exploration of targeted protein degradation mechanisms. -
ADC/PROTAC Linker
Aminooxy-PEG3-azide is a non-cleavable, three-unit PEG linker primarily used for the synthesis of antibody-drug conjugates (ADCs) and as a PEG-based linker in PROTAC development. This compound features an azide functionality that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-functionalized compounds, making it a versatile tool for chemical biology applications. -
ADC/PROTAC Linker
Bis-PEG13-NHS ester is a polyethylene glycol (PEG) based linker primarily utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound features a cleavable NHS ester that facilitates effective conjugation to target molecules, enhancing the delivery of therapeutic agents. Its application in constructing PROTACs allows for targeted protein degradation, making it a powerful tool in drug development and cancer research. -
PROTAC Linkers
Fmoc-NH-PEG6-CH2COOH is a cleavable linker that targets PROTAC applications, facilitating the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This PEG-based compound enhances the solubility and bioavailability of therapeutic agents. Its unique structure allows for selective cleavage, making it suitable for drug development and targeted protein degradation studies in various research settings. -
ADC/PROTAC Linker
Bis-PEG21-NHS ester is a polyethylene glycol (PEG) based linker with a primary mechanism as a cleavable ADC and PROTAC linker. This compound facilitates the synthesis of PROTACs and antibody-drug conjugates (ADCs) by providing a stable yet versatile connecting moiety. Its unique properties support targeted drug delivery and enhance the specificity of therapeutic applications in chemical biology research. -
PROTAC Linker
Azide-PEG3-Tos is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This non-cleavable linker consists of a three-unit polyethylene glycol (PEG) structure, making it suitable for the development of antibody-drug conjugates (ADCs). Azide-PEG3-Tos acts as a click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its versatile reactivity and stability make it a valuable tool in chemical biology research and drug development. -
PROTAC Linkers
Aminooxy-PEG2-azide is a PEG-based PROTAC linker that facilitates the synthesis of protein degraders. This non-cleavable 2-unit PEG linker is also utilized in the preparation of antibody-drug conjugates (ADCs). As a versatile click chemistry reagent, it features an azide group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its applications are essential in advancing targeted protein degradation and ADC development. -
PROTAC Linker
Bis-sulfone-PEG3-Azide is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. Its versatility makes it a valuable tool in research applications focused on protein degradation and targeted delivery of therapeutic agents. -
PROTAC/ADC Linker
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG linker designed for use in antibody-drug conjugates (ADCs) and PROTACs. Its unique structure facilitates the stable attachment of drugs to antibodies while preserving the ability to release the active compound upon internalization. This reagent is essential for researchers developing targeted therapies, enabling more efficient delivery and controlled release of therapeutic agents. Its versatility as both an ADC linker and PROTAC linker supports advancements in drug design and development workflows. -
ADC/PROTAC Linker
m-PEG4-Amine is a PEG-based linker primarily utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound features a cleavable link, enabling the targeted delivery of therapeutic agents while providing controlled release upon cellular internalization. Its application is pivotal in advancing research in targeted protein degradation and therapeutic modalities, enhancing drug efficacy and specificity in various biological systems. -
PROTAC Linkers
m-PEG7-CH2CH2COOH is a PEG-based PROTAC linker designed to facilitate the synthesis of targeted protein degraders. It serves as a non-cleavable linker in the development of antibody-drug conjugates (ADCs), enhancing the delivery of therapeutic agents. This compound is crucial for researchers working on PROTAC technology and ADC chemistry, enabling better modulation of protein levels in various biological systems. Its unique structure supports effective conjugation and stability for experimental applications in drug development. -
PROTAC/ADC Linker
Propargyl-PEG2-acid is a non-cleavable linker targeting the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This PEG-based compound facilitates the conjugation process through click chemistry, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It serves as a vital tool for researchers in the development of innovative therapeutic strategies involving ADCs and targeted protein degradation applications. -
ADC/PROTAC Linker
N-Boc-PEG5-bromide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras) and antibody-drug conjugates (ADCs). This cleavable linker facilitates the efficient conjugation of therapeutic agents to antibodies, enabling targeted delivery and enhanced therapeutic efficacy. Its application extends to various research areas in bioconjugation and drug development, making it a valuable tool for advancing therapeutic strategies in cancer and other diseases. -
ADC/PROTAC Linker
Bis-PEG25-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras) and antibody-drug conjugates (ADCs). Featuring a cleavable NHS ester moiety, this compound enables precise conjugation and release of biomolecules, facilitating targeted therapeutic strategies. Its versatility makes it suitable for a variety of applications in chemical biology and drug development, particularly in enhancing the selectivity and efficacy of therapeutic agents. -
PROTAC Linkers
BCN-PEG4-NHS ester is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves the BCN group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is essential for enabling targeted protein degradation and enhancing the therapeutic potential of PROTACs in chemical biology research. Additionally, it serves as an effective tool for bioconjugation applications, expanding the versatility of synthetic approaches in drug discovery. -
PROTAC/ADC Linker
Azido-PEG8-acid is a non-cleavable linker composed of eight polyethylene glycol (PEG) units, specifically designed for use in antibody-drug conjugates (ADCs) and PROTACs. It serves as a versatile click chemistry reagent due to its azide functionality, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when interacting with DBCO or BCN groups. This compound is essential for researchers focusing on the development of targeted therapeutic agents and protein degradation strategies. -
PROTAC Linkers
Boc-Hyp-OMe is a non-cleavable linker that serves as an essential component in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. Its alkyl chain structure facilitates the conjugation of therapeutic agents, enabling targeted delivery and improved therapeutic efficacy. Boc-Hyp-OMe is valuable for researchers focusing on drug development and molecular biology, particularly in studies involving targeted protein degradation and the design of innovative therapeutic modalities. -
PROTAC Linker
Azido-PEG5-acid is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This non-cleavable linker facilitates the development of conjugates and antibody-drug conjugates (ADCs) through its azide functionality. Azido-PEG5-acid participates in click chemistry, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates, and can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its versatility makes it valuable for various applications in chemical biology and drug discovery. -
ADC/PROTAC Linker
Propargyl-PEG5-amine is a non-cleavable linker utilized in antibody-drug conjugates (ADCs) and PROTAC synthesis. This PEG-based compound features an alkyne functional group, enabling efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Propargyl-PEG5-amine is valuable for researchers developing innovative therapeutic strategies involving targeted protein degradation and selective delivery of cytotoxic agents. -
ADC/PROTAC Linker
Bis-PEG7-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). Its NHS ester functionality facilitates conjugation, enabling the attachment of therapeutic agents to targeting antibodies or protein degradation components. This versatility supports research applications in targeted therapy and protein modulation, making it a valuable tool in drug development and protein engineering studies. -
ADC/PROTAC Linker
Propargyl-PEG3-NHS ester is a PEG-based linker designed for use in the development of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker features an alkyne group, allowing for efficient synthesis through click chemistry. It specifically enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it a valuable tool for researchers in the fields of drug conjugation and targeted protein degradation. -
PROTAC Linkers
Amino-PEG6-alcohol is a non-cleavable linker composed of a six-unit polyethylene glycol (PEG) chain, primarily utilized in the formulation of antibody-drug conjugates (ADCs) and PROTACs (proteolysis-targeting chimeras). This versatile PEG-based linker enhances the solubility and stability of the final conjugate, facilitating targeted therapeutic applications. It is essential for researchers working on the development of innovative therapeutic strategies in cancer and other diseases through the use of ADCs and PROTACs. -
ADC/PROTAC Linker
TCO-PEG12-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras) and antibody-drug conjugates (ADCs). This cleavable linker facilitates the conjugation of therapeutics, enabling targeted degradation of specific proteins via the ubiquitin-proteasome pathway. Its unique properties make it suitable for advancing research in targeted therapies and optimizing drug delivery systems. -
PROTAC Linkers
Boc-NH-PEG4-CH2COOH is a cleavable linker designed for use in antibody-drug conjugates (ADCs) and PEG-based PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the construction of PROTACs by providing a flexible and stable linkage that enhances biological activity. Its applications include targeted protein degradation research and the development of innovative therapeutic strategies in oncology and other diseases. -
ADC/PROTAC Linker
Propargyl-PEG3-acid is a versatile non-cleavable linker designed for antibody-drug conjugates (ADCs) and PEG-based PROTAC applications. Its structure includes a three-unit polyethylene glycol (PEG) moiety and an alkyne group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This reagent is key in the synthesis of advanced bioconjugates, such as 6-OHDA-PEG3-yne, combining the bioactivity of 6-OHDA with the stability of the linker for targeted therapeutic applications. -
PROTAC Linkers
Azido-PEG6-alcohol is a PEG-based linker designed for use in PROTAC synthesis, enhancing the development of targeted protein degradation strategies. This compound functions as a non-cleavable linker for antibody-drug conjugates, facilitating effective delivery of therapeutics. As a versatile click chemistry reagent, Azido-PEG6-alcohol features an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. Its applications extend to the fields of drug delivery and bioconjugation in chemical biology research. -
ADC/PROTAC Linker
Propargyl-PEG4-Br is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs, facilitating effective targeted delivery of therapeutic agents. This non-cleavable linker integrates an alkyne group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Propargyl-PEG4-Br is essential for the synthesis of advanced bioconjugates to enhance therapeutic efficacy and specificity in research applications. -
ADC/PROTAC Linker
m-PEG12-amine is a polyethylene glycol (PEG)-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This non-cleavable 12-unit PEG linker enhances the stability and solubility of ADCs, facilitating targeted delivery of therapeutic agents. Its application in PROTAC development aids in the effective degradation of specific target proteins, thus advancing research in targeted protein modulation and therapeutic interventions. -
ADC/PROTAC Linker
DBCO-PEG4-amine is a PEG-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This versatile cleavable linker allows for efficient conjugation through its DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its applications extend to the creation of homobifunctional cross-linkers, such as FPM-PEG4-DBCO, facilitating advanced drug delivery and targeted degradation strategies in chemical biology research. -
PROTAC Linker
m-PEG6-NHS ester is a non-cleavable linker designed for applications in PROTAC synthesis. This 6-unit polyethylene glycol (PEG) linker plays a crucial role in the construction of antibody-drug conjugates (ADCs), enabling effective cellular delivery of therapeutic agents. Its unique structure facilitates the conjugation of various biomolecules, making it a valuable tool for researchers in the fields of targeted drug delivery and protein degradation studies. -
ADC/PROTAC Linker
Propargyl-PEG5-NHS ester is a cleavable linker primarily used in the synthesis of antibody-drug conjugates (ADCs) and PROTAC molecules. This PEG/alkyl/ether-based compound features an alkyne functionality, facilitating click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing partners. Its versatility makes it suitable for various applications in targeted protein degradation and the development of ADCs, supporting advanced research in drug delivery and molecular biology. -
PROTAC/ADC Linker
Azido-PEG5-CH2CO2H is a cleavable 5-unit PEG linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and efficiently functions as a PEG-based PROTAC linker. This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its versatile reactivity positions Azido-PEG5-CH2CO2H as a valuable tool in chemical biology, particularly in targeted therapeutics and drug delivery systems. -
PROTAC Linker
Bromoacetamido-PEG4-acid is a PEG-based linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound exhibits crucial properties for the development of targeted protein degradation strategies. In addition, it serves as a cleavable linker in antibody-drug conjugate (ADC) technology, facilitating the conjugation of therapeutic agents to antibodies for improved specificity and efficacy in cancer treatment. Its versatile applications make it essential for advancements in targeted therapies and drug delivery systems. -
PROTAC Linkers
Fmoc-NH-PEG8-CH2COOH is a cleavable linker optimized for antibody-drug conjugates (ADCs) and serves as a PEG-based linker for PROTAC synthesis. This compound facilitates effective conjugation of biomolecules while enabling targeted degradation of specific proteins, making it essential for drug development and therapeutic research. Its application spans the design of innovative ADCs and the advancement of PROTAC technology in cellular studies. -
ADC/PROTAC Linker
N-Boc-diethanolamine is a cleavable linker based on an alkyl/ether structure, primarily utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound facilitates the conjugation of therapeutic agents to antibodies, enhancing targeted delivery and efficacy. Its application in PROTAC technology allows for the selective degradation of target proteins, making it a valuable tool in drug discovery and development. -
PROTAC Linkers
Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable linker utilized in the development of antibody-drug conjugates (ADCs), demonstrating significant versatility in chemical synthesis. This alkyl chain-based compound serves as a valuable PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras (PROTACs). Its structured design enhances the efficiency of targeted protein degradation, making it an essential tool for researchers in the field of drug discovery and therapeutic development. -
PROTAC Linker
Biotin-PEG4-PFP ester is a cleavable linker designed for use in PROTAC (Proteolysis Targeting Chimera) technology, facilitating the synthesis of antibody-drug conjugates (ADCs). This 4 unit PEG linker enhances solubility and stability, which are vital for effective drug delivery. Its unique structure enables selective conjugation while maintaining biological activity, making it an essential tool for researchers developing targeted therapies in cancer and other disease models. -
ADC/PROTAC Linker
m-PEG12-OH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras) and antibody-drug conjugates (ADCs). This non-cleavable linker consists of a 12-unit polyethylene glycol chain, facilitating stable conjugation in bioconjugation applications. Its properties enable efficient delivery of biologically active drugs to target cells, making it suitable for research in targeted therapy and drug development. -
PROTAC Linker
Tr-PEG2-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This non-cleavable linker, featuring a two-unit PEG structure, facilitates the development of antibody-drug conjugates (ADCs). Its key biological activity includes promoting targeted protein degradation and enhancing the solubility and pharmacokinetics of conjugated molecules, making it a valuable tool in chemical biology and therapeutic research applications. -
ADC/PROTAC Linker
Propargyl-PEG8-acid is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. It features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing biomolecules. Its utility in creating cleavable linkers makes it valuable for targeted drug delivery applications, particularly against Gram-negative bacterial infections. This versatile reagent supports the development of innovative therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linkers
Mal-PEG1-acid is a non-cleavable linker derived from polyethylene glycol (PEG) that serves as an effective reagent for antibody-drug conjugates (ADCs) and PROTAC synthesis. This compound facilitates the construction of PROTACs by providing a flexible linker that enhances target protein degradation through ubiquitin-proteasome pathways. Its application is crucial for developing novel therapeutics that utilize the PROTAC strategy in chemical biology and drug discovery. -
ADC/PROTAC Linker
Bis-PEG10-NHS ester is a cleavable linker designed for use in antibody-drug conjugate (ADC) and PROTAC synthesis. The compound features a polyethylene glycol (PEG) structure that enhances solubility and stability while promoting efficient drug delivery. Its primary mechanism involves facilitating the conjugation of drugs to antibodies or target proteins, making it essential in developing targeted therapies. Bis-PEG10-NHS ester is suitable for research applications aimed at improving therapeutic efficacy and specificity in drug development. -
PROTAC Linkers
H-Hyp-OMe hydrochloride is a non-cleavable linker designed for use in antibody-drug conjugates (ADCs) and also serves as an alkyl chain-based PROTAC linker. This versatile compound facilitates the synthesis of PROTACs, enabling the targeted degradation of specific proteins through the ubiquitin-proteasome system. H-Hyp-OMe hydrochloride is valuable in the development of therapeutic strategies aimed at selectively modulating protein function in various biological research applications.
