CC-647 is a molecular glue modulator that targets the Cereblon (CRBN) E3 ubiquitin ligase. It enhances the interaction between CRBN and ZBTB16, along with its oncogenic fusion protein RARα-ZBTB16, with a DC50 of 103 nM. CC-647 is particularly valuable for the investigation of ZBTB16-RARα-associated acute promyelocytic leukemia (APL) and offers potential insights into therapeutic strategies for this malignancy.
CC-647 is a molecular glue modulator that targets the Cereblon (CRBN) E3 ubiquitin ligase. It enhances the interaction between CRBN and ZBTB16, along with its oncogenic fusion protein RARα-ZBTB16, with a DC50 of 103 nM. CC-647 is particularly valuable for the investigation of ZBTB16-RARα-associated acute promyelocytic leukemia (APL) and offers potential insights into therapeutic strategies for this malignancy.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
