Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Tetrazine-Ph-NHS ester is a key PROTAC linker utilized in the synthesis of protein-targeting chimeras. This compound features a Tetrazine moiety capable of participating in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO)-modified entities. Its application is vital for the development of targeted protein degradation strategies in chemical biology research, enabling the selective modulation of protein levels within cells. -
PROTAC Linkers
Bis-Tos-PEG6 is a polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of PROTACs by enabling the effective conjugation of E3 ligase recruiters and target proteins, enhancing targeted protein degradation. Its versatile structure allows for increased solubility and improved pharmacokinetic properties, making it an essential tool in chemical biology and drug discovery research. -
PROTAC Linkers
Thiol-C2-PEG2-OH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC synthesis. This compound facilitates the development of PROTACs by enabling the efficient conjugation of target proteins, thereby enhancing the specificity and stability of the resulting compounds. Its application is crucial in studies focused on targeted protein degradation and drug discovery, providing researchers with a valuable tool for investigating proteomic interactions. -
PROTAC Linker
TCO-amine (hydrochloride) is an alkyl chain-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound contains a TCO moiety, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. TCO-amine (hydrochloride) serves as a crucial tool in targeted protein degradation research, facilitating the development of novel therapeutic agents. -
PROTAC Linker
Acid-PEG5-mono-methyl ester functions as a PEG-based linker for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the targeted degradation of specific proteins by linking an E3 ligase ligand to a target protein ligand. Its utility in generating PROTACs highlights its significance in drug discovery and development, particularly for addressing challenging therapeutic targets. -
PROTAC Linker
Bpin-Cyclohexene-COOEt is a powerful PROTAC linker that facilitates targeted protein degradation through the formation of bifunctional PROTAC molecules. This reagent enables the efficient synthesis of PROTACs, which harness the ubiquitin-proteasome system to selectively degrade proteins of interest. Its structural characteristics optimize binding affinities and enhance cellular uptake, making it a valuable tool in drug discovery and molecular biology research. -
PROTAC Linker
tert-Butyl 11-aminoundecanoate serves as a versatile PROTAC linker, facilitating the synthesis of a variety of PROTAC molecules. By connecting a ligand for an E3 ubiquitin ligase with a ligand specific for the target protein, it enables the selective degradation of proteins through the ubiquitin-proteasome pathway. This compound is instrumental for researchers aiming to manipulate protein levels and study the dynamics of protein degradation in cellular contexts. -
PROTAC Linkers
m-PEG12-OTs is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). By providing a flexible and hydrophilic interface, m-PEG12-OTs enhances the solubility and stability of PROTAC constructs. This linker is essential in research applications focusing on targeted protein degradation and the development of novel therapeutic strategies. -
PROTAC Linker
Mal-PEG4-propargyl is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its application in PROTAC development provides a valuable tool for targeted protein degradation studies in various biological research contexts. -
PROTAC Linker
exo BCN-O-PNB is a versatile alkyl/ether-based PROTAC linker designed for the synthesis of PROTAC molecules. As a click chemistry reagent, it features a BCN group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This mechanism facilitates the creation of stable and efficient bifunctional molecules, aiding in targeted protein degradation research applications. -
PROTAC Linker
11-Bromoundecan-1-ol serves as a PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound is pivotal in the synthesis of various PROTACs, including PROTAC GPX4 degrader-4. Its structure enhances the efficiency of degradation pathways, making it a valuable tool for research in targeted therapeutics and protein regulation studies. -
PROTAC Linker
Bromo-PEG2-bromide is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the generation of bifunctional molecules that induce targeted protein degradation, thereby modulating protein levels within cellular systems. Its properties make it a valuable tool for researchers investigating selective protein degradation and developing new therapeutic strategies in cancer and other diseases. -
PROTAC Linkers
Nonaethylene glycol monomethyl ether is a polyethylene glycol (PEG) derivative utilized as a linker in protein degradation targeting chimeras (PROTACs). Its structure facilitates the synthesis of novel PROTACs by providing optimal solubility and flexibility, enhancing cellular delivery. This reagent is essential for researchers engaged in studying targeted protein degradation mechanisms and developing therapeutics based on the PROTAC technology. -
PROTAC Linker
tert-Butyl 3-(2-iodoethoxy)propanoate serves as a crucial PROTAC linker, facilitating the creation of targeted protein degradation tools. This compound is instrumental in synthesizing PROTAC FAK degrader 1, contributing to advancements in research focused on protein modulation and degradation pathways. Its unique structural properties enhance the efficacy and specificity of PROTAC assemblies, making it a valuable reagent for chemical biology applications. -
PROTAC Linkers
CH2COOH-PEG3-CH2COOH is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of proteins within cells. It is particularly useful in chemical biology studies aimed at developing novel therapeutic strategies for various diseases through targeted protein degradation. -
PROTAC Linkers
Hydroxy-PEG6-Boc is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins and E3 ligases, enabling selective degradation of proteins through the ubiquitin-proteasome system. This reagent is essential for research applications focused on targeted protein degradation and drug development. -
PROTAC Linker
PEG5-Tos is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by linking a warhead to an E3 ligase, enabling effective modulation of protein levels within cellular systems. PEG5-Tos is an essential tool for researchers investigating protein function and developing novel therapeutic strategies in cancer and other diseases. -
PROTAC Linkers
Azido-PEG1-azide is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO- or BCN-modified compounds. Azido-PEG1-azide is invaluable for researchers developing novel targeted protein degradation strategies. -
PROTAC Linkers
Bromo-PEG6-bromide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This reagent facilitates targeted protein degradation by connecting a ligand for the target protein and an E3 ligase, thereby promoting the ubiquitination and subsequent degradation of the target. Bromo-PEG6-bromide is essential for researchers exploring the modulation of protein levels and pathways in various biological contexts, including cancer research and therapeutic development. -
PROTAC Linkers
Biotin-PEG8-acid is a biotin-conjugated, polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of PROTACs by providing a flexible and hydrophilic spacer that enhances solubility and target engagement. It is ideally suited for research applications focusing on targeted protein degradation and the development of novel therapeutic strategies. -
PROTAC linker
N-(Azido-PEG3)-N-bis(PEG4-acid) is a versatile PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide functional group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, enhancing the potential for modular design in chemical biology applications. -
PROTAC Linker
Fmoc-N-PEG7-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This linker facilitates the conjugation of target proteins to E3 ligases, enabling targeted degradation of specific proteins in cellular contexts. Its structure enhances solubility, stability, and bioavailability, making it suitable for various research applications in drug discovery and protein modulation studies. -
PROTAC Linker
Fmoc-NH-PEG10-acid is a polyethylene glycol (PEG) based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligand moieties to E3 ligase recruitments, enhancing the development of targeted protein degradation strategies. It serves as a crucial tool for researchers in the fields of chemical biology and drug discovery, enabling the exploration of novel therapeutic pathways. -
PROTAC Linker
Bis-propargyl-PEG3 is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. This compound plays a crucial role in generating zinc-dipicolylamine (ZnDPA) complexes, which exhibit antiplasmodial activity. As a click chemistry reagent, Bis-propargyl-PEG3 features an alkynyl group allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it a valuable tool for targeted protein degradation and compound conjugation studies. -
PROTAC Linker
Octaethylene glycol monomethyl ether functions as a PEG-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances solubility and stability while promoting the efficient degradation of target proteins. It is applicable in various biochemical research settings that explore targeted protein degradation mechanisms. -
PROTAC Linkers
Iodo-PEG3-N3 is a PEG-based PROTAC linker designed for synthesizing Proteolysis Targeting Chimeras (PROTACs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Iodo-PEG3-N3 can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized molecules, making it highly versatile for chemical biology applications in targeted protein degradation research. -
PROTAC Linker
Boc-NH-PEG12-CH2CH2COOH is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound enables the effective conjugation of target proteins to E3 ligases, facilitating the targeted degradation of specific proteins. It is an essential reagent for researchers developing novel therapeutics through targeted protein degradation strategies. -
PROTAC Linkers
Mal-amido-PEG12-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary mechanism involves forming covalent bonds with target proteins to facilitate their ubiquitination and subsequent degradation. This compound plays a crucial role in advancing research related to targeted protein degradation, enabling the development of innovative therapeutic strategies for various diseases. Its versatile application in PROTAC chemistry is valuable for researchers exploring the modulation of protein levels in cellular studies. -
PROTAC Linkers
Bis-aminooxy-PEG1 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an aminooxy functional group that facilitates the covalent bonding of target proteins for targeted degradation. Its design enhances solubility and stability in biological environments, making it suitable for various research applications, including drug discovery and cellular assays aimed at exploring protein degradation pathways. -
PROTAC Linker
Hydroxy-PEG9-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enables the formation of stable covalent linkages essential for targeted protein degradation. Its structural properties facilitate enhanced solubility and bioavailability, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Propargyl-PEG2-bromide is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound features an alkyne group that facilitates click chemistry, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for efficient conjugation with azide-containing molecules. Its application in PROTAC development supports targeted protein degradation research, making it a valuable tool for advancing therapeutic strategies. -
PROTAC Linker
Ald-CH2-PEG4-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the development of PROTACs by providing the necessary structural stability and flexibility for targeted protein degradation. It is particularly useful in drug discovery and development applications focused on modulating protein levels through the ubiquitin-proteasome pathway. -
PROTAC Linker
Bromo-PEG1-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the construction of bifunctional molecules that can selectively recruit E3 ligases, leading to targeted protein degradation. Its utility in chemical biology research includes the development of novel therapeutic agents that manipulate protein levels in cellular environments. -
PROTAC Linker
m-PEG6-Br is a polyethylene glycol (PEG)-based PROTAC linker designed to facilitate the synthesis of PROTAC molecules. This compound enhances the solubility and stability of the resulting bifunctional ligands, allowing for improved target degradation efficiency. m-PEG6-Br is essential in studies focusing on the development of targeted protein degradation strategies in chemical biology and therapeutic applications. -
PROTAC Linker
NH2-PEG7 is a polyethylene glycol (PEG) linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. It facilitates the synthesis of targeted protein degraders, including the PARP1 degrader iRucaparib-AP6. This linker enhances the solubility and bioavailability of the resultant PROTAC molecules, making it valuable in drug discovery and development aimed at modulating protein levels in cellular systems. -
PROTAC Linkers
Azido-PEG6-CH2COOH is a PEG-based linker that facilitates the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide group enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with dienophile groups such as DBCO or BCN. This versatile reagent is essential for the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Boc-NH-PEG3-NHS ester is a polyethylene glycol (PEG)-derived PROTAC linker that facilitates the conjugation of target proteins to E3 ligases, enhancing proteasome-mediated degradation. This compound is essential in the development of PROTACs designed to manipulate protein levels within cells, offering significant potential for therapeutic applications in cancer and other diseases. Its ability to provide solubility and favorable pharmacokinetics makes it a valuable tool in chemical biology research. -
PROTAC Linkers
m-PEG11-NHS ester is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTACs. It serves as a reactive moiety that enables the conjugation of targeting ligands to ubiquitin ligases, allowing for the development of targeted protein degradation strategies. This compound is instrumental in creating bifunctional molecules that promote the selective degradation of specific proteins, making it valuable for chemical biology and therapeutic research applications. -
PROTAC Linker
Boc-Piperazine-OH is a PROTAC linker that facilitates the targeted degradation of proteins through the ubiquitin-proteasome system. This compound plays a crucial role in drug discovery, particularly in the design and development of PROTACs aimed at modulating protein levels within cellular contexts. Its unique structural features enable effective conjugation to target proteins, enhancing the specificity and efficacy of therapeutic interventions. -
PROTAC Linkers
Tos-PEG2-NH-Boc is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTAC molecules by providing the necessary structural framework for target protein degradation. Its unique properties enhance the efficiency and specificity of PROTAC development, making it an essential tool for drug discovery and development research. -
PROTAC Linkers
Mal-PEG10-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the conjugation of a target ligand to an E3 ligase, promoting the degradation of specific proteins within cells. Mal-PEG10-NHS ester is essential for developing novel protein degradation strategies in drug discovery and chemical biology research. -
PROTAC Linkers
Oleic-DBCO is a versatile PROTAC linker featuring an alkyl chain structure. It serves as a click chemistry reagent, incorporating a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This property makes Oleic-DBCO valuable for the synthesis of targeted protein degradation compounds in chemical biology research, enabling the study of protein function and drug development. -
PROTAC Linker
Desthiobiotin-PEG4-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-modified molecules. Its unique properties make it a valuable tool for researchers investigating protein interactions and degradation pathways in various biological contexts. -
PROTAC Linkers
DBCO-PEG1-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It facilitates the development of targeted protein degradation strategies, making it valuable in research applications focused on therapeutic interventions targeting specific proteins. -
PROTAC Linker
Azido-PEG3-SS-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting the ubiquitin-proteasome system. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynyl-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-functionalized compounds, facilitating the development of versatile PROTAC constructs for targeted protein degradation studies. -
PROTAC Linkers
Mal-PEG2-NHS is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, enabling targeted degradation of specific proteins within cells. This compound is essential in the development of therapeutics that harness the ubiquitin-proteasome system for selective protein modulation in various biological research applications. -
PROTAC Linker
Amino-PEG3-C2-sulfonic acid is a polyethylene glycol (PEG)-derived linker designed for the synthesis of PROTAC (proteolysis-targeting chimeras). This compound facilitates the selective degradation of target proteins by connecting ligands to E3 ubiquitin ligases. Utilized in chemical biology and drug discovery, Amino-PEG3-C2-sulfonic acid enhances the stability and solubility of PROTAC molecules, advancing research in targeted protein degradation. -
PROTAC Linkers
1,2-Bis(2-iodoethoxy)ethane is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the development of potent BTK (Bruton's tyrosine kinase) degraders, such as MT802 and SJF620, which exhibit degradation capabilities with DC50 values of 1 nM and 7.9 nM, respectively. Its application extends to advancing research in targeted protein degradation, offering a valuable tool for studies in cancer and autoimmune diseases. -
PROTAC Linker
Propargyl-PEG7-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation, making it a valuable tool for researchers studying protein interactions and cellular pathways. -
PROTAC Linker
Azido-PEG4-beta-D-glucose is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized partners, making it a versatile tool for chemical biologists in targeted protein degradation studies.
