Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
2-[3-(Methoxycarbonyl)bicyclo[1.1.1]pentan-1-yl]acetic acid functions as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficacy of targeted protein degradation by linking E3 ligases to the target proteins, allowing for precise modulation of cellular pathways. It is a valuable tool for researchers investigating the mechanisms of protein degradation and developing novel therapeutic interventions in various diseases. -
PROTAC Linker
tert-Butyl ((4-oxocyclohexyl)methyl)carbamate functions as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Its structural features enhance target specificity and binding efficiency, making it an essential component in the development of targeted protein degradation strategies. This chemical is widely utilized in research focused on protein regulation and therapeutic development. -
PROTAC Linker
2-[2-(tert-Butoxy)-2-oxoethoxy]acetic acid serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the synthesis of targeted protein degraders, enabling the selective modulation of protein levels within cellular environments. It is valuable for researchers engaged in the exploration of targeted therapy and drug discovery. -
PROTAC Linker
4-Hydroxybicyclo[2.2.2]octane-1-carboxylic acid serves as a versatile PROTAC linker. It facilitates the design and synthesis of PROTAC molecules aimed at targeted protein degradation. This compound is instrumental in advancing research in targeted therapies and elucidating cellular processes through the modulation of specific protein levels. -
PROTAC Linker
Z-Glycinol is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the targeted degradation of selected proteins within cellular systems. Its application in PROTAC development enables innovative approaches in drug discovery and therapeutic intervention. -
PROTAC Linker
tert-Butyl 4-(methylamino)butanoate hydrochloride serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the development of targeted protein degradation strategies, enabling researchers to investigate protein functions and develop novel therapeutic interventions. Its unique structural features contribute to linker stability and optimal binding specificity in PROTAC applications. -
PROTAC Linker
tert-Butyl (E)-4-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)piperidine-1-carboxylate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the conjugation of ligands to proteins, enhancing the targeted degradation of specific proteins in cellular systems. Its application is crucial in drug discovery and development, particularly in oncology and therapeutic resistance research. -
PROTAC Linker
3-(4-Bromophenyl)propanoic acid functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs, enabling the targeted degradation of specific proteins. Its unique chemical properties make it valuable in research focused on protein modulation and therapeutic intervention in various diseases. -
PROTAC Linker
AMCA (4-(Aminomethyl)-1-cyclohexanecarboxylic acid) serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation compounds. It is utilized in the synthesis of the PROTAC molecule YB-3–17, which plays a significant role in studying protein degradation pathways and therapeutic interventions. This reagent is essential for researchers focusing on the design and implementation of PROTAC-based strategies in molecular biology and drug discovery. -
PROTAC Linker
m-PEG6-CH2CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by connecting an E3 ligase ligand to a target protein ligand, aiding in the development of innovative therapeutic strategies. It is particularly valuable in drug discovery and development for the modulation of protein levels in cellular and animal models. -
PROTAC Linker
NH-bis(PEG4-acid) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances solubility and flexibility, facilitating efficient ubiquitination and degradation of target proteins. NH-bis(PEG4-acid) is ideal for researchers developing novel PROTAC molecules in various therapeutic applications, including targeted protein degradation and drug discovery. -
PROTAC Linkers
Tetraethyl octane-1,8-diylbis(phosphonate) is an alkyl chain-based linker designed for the development of PROTACs (proteolysis targeting chimeras). This compound facilitates the assembly of protein-targeting small molecules, promoting targeted degradation of specific proteins within cells. Its structural properties support the formation of efficient PROTACs, making it a valuable tool in chemical biology and therapeutic research for investigating protein functions and therapeutic interventions. -
PROTAC Linker
Bromo-PEG1-CH2COOH is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables selective degradation of target proteins by linking an E3 ligase ligand to a target protein binder through a PEG spacer. Its application is crucial in drug discovery and development, particularly for studies focused on targeted protein degradation and novel therapeutic interventions. -
PROTAC Linkers
Amino-PEG4-C1-Boc is a polyethylene glycol (PEG)-based linker specifically designed for Protein Targeting Chimeras (PROTACs). This compound facilitates the synthesis of PROTACs by providing a flexible and biocompatible spacer that enhances solubility and stability. Its application is vital in the field of targeted protein degradation research, enabling the development of novel therapeutics that modulate protein function through ubiquitin-proteasome pathway engagement. -
PROTAC Linkers
Boc-NH-PEG15-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of covalent bonds between target proteins and E3 ligases, enhancing targeted degradation of specific proteins within cells. Its PEG structure provides increased solubility and improved pharmacokinetic properties, making it valuable in chemical biology and drug development applications focused on targeted protein degradation. -
PROTAC Linker
NH2-PEG3-C6-Cl is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the assembly of targeting warheads and E3 ligase recruiters, enhancing the degradation of specific proteins within cells. Its application in PROTAC development supports research into targeted protein degradation, offering potential therapeutic advantages in various diseases. -
PROTAC Linker Chemical
1-Bromo-6-chlorohexane is a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). Its chemical structure is designed to promote the efficient recruitment of E3 ubiquitin ligases, enhancing targeted protein degradation. This compound is essential for researchers investigating the regulation of protein homeostasis and the therapeutic potential of targeted protein degradation strategies. -
PROTAC Linkers
DBCO-PEG5-DBCO is a PEG-based linker specifically designed for synthesizing PROTACs. Featuring a dibenzocyclooctyne (DBCO) moiety, this reagent enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its versatility makes it an invaluable tool in the development of targeted protein degradation strategies, facilitating research into novel therapeutic approaches in various biological systems. -
PROTAC Linkers
Azido-PEG5-CH2CO2-NHS is a PEG-based linker designed for use in the synthesis of PROTACs through click chemistry. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkynes and molecules containing DBCO or BCN moieties. Its unique properties make it a valuable tool for researchers in protein degradation studies and other chemical biology applications. -
PROTAC Linker
3,9-Dimethyl-3,9-diazaspiro[5.5]undecane is a rigid linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation, exemplified by its application in creating potent IRAK4 PROTAC degraders, such as FIP22, which demonstrate efficacy in conditions like atopic dermatitis. Its structural characteristics enhance the stability and specificity of PROTAC development, making it a valuable tool in chemical biology research. -
PROTAC Linkers
Amino-PEG12-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This linker facilitates the conjugation of targeting moieties and E3 ligase recruiters, enhancing the development of targeted protein degradation strategies. Its hydrophilic properties and adjustable length make it particularly suitable for optimizing PROTAC pharmacokinetics and efficacy in various biological applications. -
PROTAC Linker
BnO-PEG4-OH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) applications. This reagent facilitates the synthesis of PROTACs, enabling targeted protein degradation through the recruitment of E3 ligases. Its structure enhances hydrophilicity and solubility, making it suitable for diverse chemical modifications and applications in drug discovery and molecular biology research. -
PROTAC Linker
Aminooxy-PEG4-propargyl is a PEG-based PROTAC linker featuring an alkyne functionality that facilitates the synthesis of targeted protein degraders. This compound enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups, making it a versatile tool for chemical biology applications. It is particularly useful in the development of PROTACs aimed at regulating protein levels in a controlled manner. -
PROTAC linker
Boc-NH-PEG7-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs, leveraging its ability to facilitate targeted protein degradation. This compound features an alkyne functionality that enables its engagement in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application enhances the versatility and efficiency of PROTAC development, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
Bromo-PEG6-azide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. This compound features an azide group enabling its functionality as a click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized entities, facilitating efficient conjugation in various chemical biology applications. -
PROTAC linker
DSPE-PEG5-azide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, enabling its application in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing molecules. Its versatility in click chemistry facilitates the efficient construction of targeted degradation units for therapeutic research and development. -
PROTAC Linker
Sulfo DBCO-amine is a versatile PROTAC linker designed to facilitate the synthesis of PROTACs. This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, allowing for efficient and selective conjugation. Its application in chemical biology is crucial for developing targeted protein degraders, thereby advancing research in protein modulation and therapeutic intervention. -
PROTAC Linkers
Azido-PEG4-Thiol is a PEG-based linker designed specifically for PROTAC (Proteolysis Targeting Chimera) synthesis. Functioning through click chemistry, it features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG4-Thiol can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds bearing DBCO or BCN groups. This compound serves as a valuable tool in the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Boc-Aminooxy-PEG2-C2-amine is a PEG-based linker designed for proteolysis-targeting chimera (PROTAC) applications. This compound facilitates the synthesis of PROTACs, which are used to promote targeted protein degradation, thereby enabling the study of protein function and regulation. Its unique structure enhances cellular permeability and stability, making it suitable for a variety of biological research applications in drug discovery and development. -
PROTAC Linker
Bromo-PEG5-azide is a PEG-based linker specifically designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This reagent features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds that possess DBCO or BCN groups. Its versatility makes it a valuable tool for advancing protein degradation studies and optimizing PROTAC design. -
PROTAC Linkers
m-PEG24-azide is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, DBCO, or BCN groups. Its unique reactivity enables the efficient conjugation of various biomolecules, facilitating the development of targeted degradation strategies in cellular research. -
PROTAC linker
N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based linker designed for PROTAC synthesis, functioning primarily through click chemistry. Featuring a DBCO moiety, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent enhances the development of targeted protein degradation strategies, proving valuable in various biochemical applications and studies aimed at modulating protein levels within cellular systems. -
PROTAC Linker
Amino-PEG5-CH2COOH is a polyethylene glycol (PEG)-derived PROTAC linker designed for the construction of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, thereby promoting ubiquitination and subsequent degradation in cellular assays. The linker’s specific chemical properties enhance solubility and biocompatibility, making it suitable for various applications in protein degradation research and drug development. -
PROTAC linker
Biotin-PEG4-OH is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and pharmacokinetic properties of PROTACs, enabling efficient target protein degradation. Biotin-PEG4-OH is particularly useful in the study of protein regulation and therapeutic development, providing significant applications in drug discovery and cellular biology research. -
PROTAC Linkers
Hydroxy-PEG4-C2-methyl ester is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). Its primary mechanism involves enhancing the solubility and bioavailability of PROTAC compounds, thereby facilitating the targeted degradation of specific proteins within a cellular context. This reagent is valuable for researchers studying protein turnover and developing novel therapeutic strategies through targeted protein modulation. -
PROTAC Linkers
(2-Pyridyldithio)-PEG4-propargyl is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) development. It facilitates the conjugation of target proteins with E3 ligases, enabling targeted protein degradation. This compound is ideal for researchers working on targeted therapies and studying protein regulation mechanisms. -
PROTAC Linker
Bromoacetamido-PEG3-C2-Boc is a PEG-based linker designed for the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enabling targeted protein degradation. It is particularly useful in chemical biology research focused on exploring new therapeutic strategies and studying protein dynamics within cellular systems. -
PROTAC Linker
NH-bis(PEG4-Boc) is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation molecules. This compound facilitates the development of PROTACs by enhancing solubility and promoting protein-targeting capabilities. It enables researchers to explore the therapeutic potential of targeted protein modulation in various biological systems. -
PROTAC Linker
Biotinyl-NH-PEG3-C3-amido-C3-COOH is a PEG-based PROTAC linker that facilitates the formation of proteolysis-targeting chimeras (PROTACs). This compound effectively promotes targeted protein degradation by linking an E3 ligase to a specific protein of interest. It is instrumental in drug discovery and development, enabling researchers to explore novel therapeutic approaches for modulating protein levels in various biological pathways. -
PROTAC Linker
t-Butyl acetate-PEG2-CH2COOH serves as a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the effective synthesis of PROTACs, enabling targeted protein degradation for therapeutic research. Its structure promotes solubility and stability, making it a valuable tool in the development of innovative treatments for various diseases by modulating protein function. -
PROTAC Linkers
(±)15-HETE is an alkyl chain-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent plays a crucial role in facilitating the targeted degradation of proteins, enhancing the effectiveness of therapeutic applications. Its structural properties make it suitable for various research applications, particularly in the field of drug development and protein regulation studies. -
PROTAC Linker
Hydroxy-PEG4-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the construction of bifunctional molecules that target specific proteins for degradation via the ubiquitin-proteasome system. Hydroxy-PEG4-CH2-Boc is ideal for research applications involving targeted protein modulation and therapeutic development. -
PROTAC Linker
N-Boc-PEG5-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides a flexible and hydrophilic spacer, facilitating efficient target protein degradation through the recruitment of E3 ligases. N-Boc-PEG5-alcohol is valuable in studies focused on targeted therapy and drug development, particularly in addressing challenges related to selective degradation of specific proteins in cellular systems. -
PROTAC Linkers
HO-PEG24-OH is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the selective degradation of target proteins by simultaneously binding to an E3 ubiquitin ligase and a protein of interest. Its versatile application in PROTAC development supports research in targeted protein degradation and therapeutic interventions in various diseases. -
PROTAC Linkers
Hydroxy-PEG1-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTACs by providing the necessary structural components for effective target protein degradation. Its hydrophilic characteristics enhance solubility and stability, making it suitable for various biochemical studies aimed at investigating targeted protein degradation pathways. -
PROTAC Linker
Bis-propargyl-PEG4 is a versatile PEG-based linker designed for use in PROTAC synthesis. This compound facilitates the generation of PROTACs through its alkyne functionality, enabling efficient click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application extends to the synthesis of demethylvancomycin dimers, highlighting its significance in drug development and biochemical research. -
PROTAC Linker
Bis-Tos-PEG4 is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the development of bifunctional molecules that can selectively target and degrade specific proteins via the ubiquitin-proteasome system. Its versatility makes it valuable for research applications in targeted protein degradation and drug development. -
PROTAC Linker
3,6,9-Trioxaundecanedioic acid is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of proteins by linking ligands to E3 ligase components. Its versatile structure enhances compound solubility and allows for effective bioconjugation, making it valuable in chemical biology and drug discovery applications focused on targeted protein modulation. -
PROTAC Linker
Amino-PEG10-amine is a polyethylene glycol (PEG)-based PROTAC linker designed to facilitate the conjugation of two mono diethylstilbestrol (DES)-based ligands. This compound serves as a pivotal tool for developing selective and potent estrogen receptor antagonists, enhancing therapeutic efficacy in endocrine therapies for breast cancer. Its structure promotes improved targeting and activity, making it an essential component for researchers focused on advanced cancer treatment strategies. -
PROTAC Linker
Mal-C6-amine TFA is a versatile PROTAC linker featuring a hexyl chain structure, designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the development of targeted protein degradation strategies, enabling selective modulation of protein levels in cellular contexts. Its efficacy in connecting ligands to E3 ligases makes it a valuable tool in chemical biology and drug discovery applications.
