Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
tert-Butyl 7-aminoheptanoate is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the covalent attachment of ligand components, enhancing the overall efficacy of targeted protein degradation. Its application in research contributes to the development of novel therapeutics aimed at specific disease-related proteins, supporting advancements in targeted drug discovery. -
PROTAC Linker
tert-Butyl cis-4-(methylamino)cyclohexyl)carbamate is a PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases for targeted protein degradation, enabling researchers to investigate the modulation of protein levels in various biological processes. Its utility in drug discovery and development makes it a valuable tool for studying protein function and cellular pathways. -
PROTAC Linker
2-(2-(tert-Butoxycarbonyl)-2-azaspiro[3.5]nonan-7-yl)acetic acid is a PROTAC linker that plays a critical role in targeted protein degradation strategies. This compound facilitates the synthesis of PROTACs, enhancing their efficacy in biological research. Its unique chemical structure allows for optimal interaction with E3 ligases, making it a valuable tool in drug discovery and therapeutic development focused on modulating protein levels within cells. -
PROTAC Linker
tert-Butyl (7-bromoheptyl)carbamate serves as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins through the ubiquitin-proteasome system, making it a valuable tool in targeted protein degradation research. Its utility extends to the development of novel therapeutic strategies in various biological applications. -
PROTAC Linker
Methyl 6-oxospiro[3.3]heptane-2-carboxylate is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by bridging an E3 ligase and the protein of interest. It plays a critical role in expanding drug discovery applications, particularly in the fields of targeted therapy and cellular protein regulation. -
PROTAC Linker
5-Bromopentanoyl chloride is a versatile PROTAC linker primarily utilized in the synthesis of PROTACs, facilitating the targeted degradation of specific proteins. This compound serves as a key component in the design of PROTAC ATR degrader-2, promoting efficient target protein ubiquitination and subsequent proteasomal degradation. Its application in chemical biology research supports the development of innovative therapeutic strategies aimed at regulating protein levels within cells. -
PROTAC Linker
Bromo-PEG8-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases to target proteins, enabling targeted protein degradation. Its flexibility and solubility characteristics make it suitable for various research applications in drug development and cellular biology. -
PROTAC Linker
Amino-PEG9-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). It facilitates the ubiquitination and subsequent degradation of target proteins by linking E3 ligases with the protein of interest. This reagent is essential for researchers aiming to develop novel targeted protein degradation strategies in various biological contexts. Its hydrophilic nature enhances solubility, contributing to improved performance in cellular applications. -
PROTAC Linker
Acid-PEG5-C2-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the recruitment of E3 ligases, promoting targeted protein degradation. Its versatile properties make it suitable for constructing PROTACs aimed at various therapeutic targets in chemical biology and drug discovery research. -
PROTAC Linkers
Mal-amido-PEG2-C2-acid is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of protein-targeting ligands to E3 ligase ligands, enabling targeted protein degradation. Its application is crucial in the development of therapeutics that modulate protein levels and function in biological research. -
PROTAC Linker
Iodoacetamide-PEG3-azide is a PEG-based linker specifically designed for the synthesis of PROTACs (proteolysis targeting chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. These versatile chemical reactions enhance the molecular engineering capabilities for targeted protein degradation studies in various biological research applications. -
PROTAC Linker
tert-Butyl 9-aminononanoate functions as a PROTAC linker, facilitating the development of targeted protein degraders. It plays a crucial role in the synthesis of PROTAC sEH-degrader-1, enabling selective degradation of specific proteins within cellular pathways. This compound is valuable for researchers exploring protein modulation and therapeutic interventions through targeted degradation technology. -
PROTAC Linkers
Propargyl-PEG2-OH is a PEG-based PROTAC linker that facilitates the synthesis of Thalidomide-O-PEG2-propargyl. This compound contains an alkyne functional group, enabling efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in research allows for the development of targeted protein degradation strategies, making it a valuable tool for studies in therapeutic intervention and cellular regulation. -
PROTAC Linker
Amino-PEG2-(CH2)3COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation of specific proteins within cells. Amino-PEG2-(CH2)3COOH is instrumental in advancing drug discovery and therapeutic development through selective modulation of protein levels. -
PROTAC Linkers
Bis-PEG5-acid is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs. As a critical component for creating bifunctional molecules, Bis-PEG5-acid facilitates the targeted degradation of Cdc20 through the formation of the CP5V PROTAC. This compound is instrumental in studying protein degradation pathways and advancing therapeutic strategies in cancer research. -
PROTAC Linkers
Dodecaethylene glycol is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of targeted protein degradation strategies by linking E3 ligase to the protein of interest. Its hydrophilic properties enhance solubility and can improve the pharmacological profiles of PROTAC molecules, making it a valuable tool for researchers investigating protein regulation and degradation mechanisms. -
PROTAC Linker
Biotin-PFP ester is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This alkyl/ether-based compound enhances molecular recognition through biotinylation, enabling selective degradation of target proteins via the ubiquitin-proteasome pathway. Its utility in the development of targeted protein degradation strategies makes it valuable for research applications in cancer biology and therapeutic discovery. -
PROTAC Linkers
HOOCCH2O-PEG4-CH2COOH is a symmetric polyethylene glycol (PEG) linker designed for use in PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of Homo-PROTACs, enabling targeted protein degradation in cellular systems. Its unique structure enhances solubility and biocompatibility, making it a valuable tool in drug development and biochemical research focused on modulating protein levels. -
PROTAC Linker
PC-Biotin-PEG4-NHS carbonate is a PEG-based linker designed for use in the synthesis of PROTACs. This compound functions as a bifunctional reagent to facilitate the conjugation of biotin to target proteins. Its utility in PROTAC development enables researchers to enhance protein degradation pathways for the study of cellular processes and disease mechanisms. This linker is essential for applications in targeted protein degradation and therapeutic research. -
PROTAC Linkers
DNP-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting targeted protein degradation pathways. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules, as well as with those bearing DBCO or BCN groups. Its utility in click chemistry enables precise conjugation strategies essential for advancing research in therapeutic protein modulation. -
PROTAC Linkers
Fmoc-PEG12-NHS ester is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This NHS ester form facilitates the conjugation of the PROTAC moiety to target proteins, enabling targeted degradation pathways. It is ideal for applications in drug discovery and development, particularly for those exploring targeted protein degradation mechanisms. -
PROTAC Linkers
Decaethylene glycol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligands and protein target moieties, enabling the effective targeted degradation of specific proteins within cells. It supports research into protein regulation and therapeutic development in various biological contexts, contributing to advancements in drug discovery and regenerative medicine. -
PROTAC Linkers
m-PEG9-acid is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the development of targeted protein degradation strategies by enhancing solubility and specificity. This compound is essential for researchers focusing on targeted protein modulation and therapeutic applications in cancer and other diseases through the PROTAC approach. -
PROTAC Linker
Biotin-PEG4-amide-Alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functionality that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its unique properties facilitate targeted protein degradation research, making it a valuable tool for bioconjugation and drug discovery applications. -
PROTAC Linker
Mal-amido-PEG4-acid is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the formation of PROTACs by connecting an E3 ligase ligand to a targeted protein ligand, enhancing the degradation of specific proteins within cells. Its application is critical in drug discovery and development, particularly for targeting hard-to-drug proteins in various therapeutic areas. -
PROTAC Linker
Fmoc-NH-PEG5-C2-NH2 is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of bifunctional molecules that engage the ubiquitin-proteasome system for targeted protein degradation. Its structure enhances solubility and biocompatibility, making it suitable for a variety of research applications in drug discovery and targeted therapy studies. -
PROTAC Linker
9-Bromononanoic acid functions as a PROTAC linker, facilitating the synthesis of targeted protein degradation agents. This compound is particularly suitable for constructing PROTACs aimed at FGFR1, enabling the selective degradation of this oncogenic protein. Its utility in the development of innovative therapeutic strategies underscores its importance in chemical biology and drug discovery. -
PROTAC Linker
Boc-N-PEG1-C2-NHS ester is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its NHS ester moiety facilitates efficient conjugation to target proteins, thereby enabling the construction of compounds that promote targeted protein degradation. This reagent is essential for advancing research in therapeutic strategies that leverage the ubiquitin-proteasome system for improved selective degradation of proteins. -
PROTAC Linkers
Thiol-PEG8-acid is a PEG-based linker designed for use in proteolysis-targeting chimera (PROTAC) synthesis. Its thiol functional group facilitates conjugation with target proteins, while the polyethylene glycol (PEG) moiety enhances solubility and bioavailability. This compound is essential for researchers developing PROTACs aimed at selective degradation of specific proteins, advancing studies in targeted protein modulation and therapeutic applications. -
PROTAC Linker
UV Cleavable Biotin-PEG2-Azide is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its UV-cleavable properties make it particularly useful for studying protein interactions and degradation pathways in cellular contexts. -
PROTAC Linkers
Biotin-PEG8-NHS ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of covalent bonds with targeted proteins, enhancing the selective degradation of specific cellular targets. It is instrumental in research applications involving targeted protein degradation, providing a versatile tool for advancing drug discovery and therapeutic strategies. -
PROTAC Linker
Amino-PEG3-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). This compound features an amino group that facilitates conjugation with targeting ligands and an acidic carboxylic group that enhances solubility. Amino-PEG3-CH2COOH is instrumental in the development of targeted protein degradation strategies, making it valuable for research in cancer therapeutics and other diseases involving aberrant protein levels. -
PROTAC Linker
DBCO-PEG4-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs. It features a dibenzocyclooctyne (DBCO) moiety, enabling reaction via strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is essential for the development of targeted protein degradation strategies, facilitating precise modular assembly in therapeutic research applications. -
PROTAC Linker
NH-bis(PEG3-azide) is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules. Additionally, NH-bis(PEG3-azide) can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized partners, making it a versatile tool in chemical biology and drug discovery research applications. -
PROTAC Linker
Mal-amido-PEG6-NHS ester is a PEGylated linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of proteins in cellular systems. Its high solubility and stability make it an ideal choice for developing novel therapeutic agents in targeted protein degradation research. -
PROTAC Linker
THP-PEG1-alcohol is a polyethylene glycol (PEG) based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its unique structure facilitates efficient conjugation between target proteins and E3 ligases, enhancing the targeted degradation of specific cellular proteins. This reagent is essential for researchers exploring targeted protein degradation and developing novel therapeutic strategies in cancer and other diseases. -
PROTAC Linkers
m-PEG6-thiol is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the assembly of PROTACs by providing solubility and stability, enhancing target protein degradation. Its primary applications include drug discovery and development within targeted protein degradation research. -
PROTAC Linker
m-PEG8-Br is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of target proteins and E3 ligases, thereby enhancing the specificity and efficacy of targeted protein degradation. Its application is crucial in cancer research and drug discovery, enabling the development of novel therapeutics aimed at selectively degrading undesirable proteins in various biological contexts. -
PROTAC Linker
Bromo-PEG6-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of novel protein degraders by enabling the recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent degradation. Its utility in chemical biology and drug discovery makes it a valuable tool for researchers focused on targeted protein modulation and therapeutic interventions. -
PROTAC Linker
Mal-amido-PEG12-NHS ester is a PEGylated linker specifically designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of various ligands to E3 ubiquitin ligases, thereby enabling targeted degradation of specific proteins within cells. Key applications include studies of protein regulation and degradation mechanisms, as well as development of novel therapeutic strategies in cancer and other diseases. -
PROTAC Linker
Boc-aminoxy-PEG4-acid is a polyethylene glycol (PEG) derivative designed as a linker for PROTAC (Proteolysis Targeting Chimera) systems. It facilitates the conjugation of E3 ligase ligands and target proteins, thereby enhancing the efficiency of targeted protein degradation. This versatile linker is crucial for researchers developing PROTAC-based therapeutics and studying the principles of targeted protein modulation. Its PEG structure contributes to increased solubility and improved pharmacokinetic properties in biological applications. -
PROTAC Linker
endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. Featuring a bicyclo[6.1.0]nonyne (BCN) group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its robust click chemistry properties make it suitable for applications in protein degradation research and therapeutic development. -
PROTAC Linkers
TCO-PEG8-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enabling targeted degradation of proteins thought unsuitable for classical small-molecule approaches. It is a valuable tool for researchers investigating protein regulation, cellular signaling pathways, and therapeutic interventions through targeted protein degradation. -
PROTAC Linker
Biotin-PEG3-Mal is a biotin-conjugated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the selective degradation of target proteins by linking E3 ubiquitin ligases to the target proteins of interest. With its biotin moiety, Biotin-PEG3-Mal enables efficient capture and purification of PROTAC compounds, making it a valuable tool for drug discovery and cellular investigations into protein regulation. -
PROTAC Linker
Propargyl-PEG9-amine is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne group, enabling selective conjugation through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Propargyl-PEG9-amine enhances the bioconjugation process, facilitating the development of targeted protein degradation tools for various biological research applications. -
PROTAC Linkers
m-PEG4-SH is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligase, enabling targeted protein degradation. m-PEG4-SH is crucial for researchers seeking to develop novel PROTACs for applications in drug discovery and cellular protein regulation studies. -
PROTAC Linker
Mal-PEG2-NH2 TFA is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides a versatile approach for enhancing the solubility and pharmacokinetic properties of PROTACs, facilitating targeted protein degradation. Mal-PEG2-NH2 TFA is essential for researchers aiming to develop selective degraders for therapeutic applications in diverse biological systems. -
PROTAC Linker
Fmoc-amino-PEG5-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a fluoromethoxycarbonyl (Fmoc) protecting group, facilitating the incorporation of amino acids into the PROTAC design. Its PEG linker enhances solubility and promotes cellular uptake, making it valuable for research applications focused on targeted protein degradation and therapeutic development. -
PROTAC Linkers
Amino-PEG2-CH2CH2-SH hydrochloride is a polyethylene glycol (PEG) linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the development of bifunctional molecules, enabling targeted protein degradation with precision. Its biocompatible structure enhances solubility and stability, making it suitable for a variety of applications in chemical biology and drug discovery, particularly in the creation of novel therapies for previously intractable targets. -
PROTAC Linker
Dde Biotin-PEG4-alkyne is a PEG-based PROTAC linker featuring an alkyne group, facilitating the synthesis of PROTACs. This compound serves as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in the design of bifunctional molecules allows for enhanced targeted degradation of proteins, making it a valuable tool in chemical biology and therapeutic research.
