Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-720 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimeras), enabling targeted protein degradation. It is useful in research applications involving ubiquitin-proteasome system modulation and has potential implications in therapeutic discovery. -
Ligand for E3 Ligase
CRBN ligand-210 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, thereby enabling the construction of a PROTAC. Such applications are valuable for targeted protein degradation studies, offering insights into protein function and regulation in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-537 is a specific ligand for the E3 ubiquitin ligase, cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of proteolysis-targeting chimeras (PROTACs). This compound is valuable in research applications focused on investigating protein ubiquitination and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-365 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling targeted protein degradation via the ubiquitin-proteasome system. This compound serves as a crucial component for the development of PROTACs (Proteolysis Targeting Chimeras) by facilitating the recruitment of CRBN to a specific target protein. This functionality makes CRBN ligand-365 a valuable tool for investigating protein homeostasis and therapeutic interventions in various biological pathways and diseases. -
Ligand for E3 Ligase
CRBN ligand-693 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to specific target proteins, enabling the formation of PROTACs (proteolysis-targeting chimeras). It is suitable for use in research applications focused on targeted protein degradation and the modulation of protein levels within various cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-433 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling the design of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation. This compound is valuable for research applications focused on understanding cellular protein regulation and developing novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-299 serves as an E3 ubiquitin ligase ligand that selectively recruits the cereblon (CRBN) protein. This compound can be utilized to conjugate with target protein ligands through a linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation studies. As such, it is valuable for research focused on modulating protein levels and studying cellular processes influenced by ubiquitination pathways. -
Thalidomide Analog
5-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione is a Thalidomide analog that possesses a hydroxy group allowing for potential derivatization. This compound functions as an E3 ligase activator, facilitating the ubiquitinylation of target proteins. Its biological activity makes it valuable for research in drug development, particularly in studies focused on protein degradation and cellular signaling pathways. -
Ligand for E3 Ligase
CRBN ligand-306 is a ligand designed for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to connect with target protein ligands through a linker, forming a proteolysis-targeting chimera (PROTAC). Its applications include targeted protein degradation research, offering a pathway for studying and modulating protein levels in cellular systems. -
Ligand for E3 Ligase
CRBN ligand-890 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN for targeted protein degradation. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis targeting chimera) for selective degradation of proteins of interest. Its application in research includes investigations into protein homeostasis and therapeutic strategies for diseases linked to aberrant protein levels. -
Ligand for E3 Ligase
CRBN ligand-630 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be effectively coupled with target protein ligands via a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-630 is valuable in studies of targeted protein degradation and the modulation of cellular processes through ubiquitin-mediated pathways. -
Ligand for E3 Ligase
CRBN ligand-346 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-346 is instrumental in studies involving targeted protein degradation, offering insights into mechanisms of action in cellular processes and potential therapeutic applications. -
Ligand for E3 Ligase
CRBN ligand-736 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the construction of PROTACs (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a linker. CRBN ligand-736 serves as a valuable tool for studies involving targeted protein degradation and therapeutic development in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-586 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in targeted protein degradation applications. This compound can be conjugated with a target-specific ligand through a suitable linker to create a PROTAC, enabling the degradation of proteins of interest. CRBN ligand-586 is valuable for research in the fields of cancer biology and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-490 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-490 is valuable for studies in targeted protein degradation and therapeutic research applications related to modulating cellular protein levels. -
Ligand for E3 Ligase
CRBN ligand-479 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be conjugated to a specific target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimeric (PROTAC) molecule. CRBN ligand-479 is essential for studies in targeted protein degradation and has applications in drug discovery and development. -
Ligand for E3 Ligase
CRBN ligand-457 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound serves as a valuable tool for the development of PROTACs by linking CRBN to target protein ligands through a suitable linker. Its utility in targeted protein degradation research makes it an essential reagent for studies in drug discovery and cellular biology. -
Ligand for E3 Ligase
CRBN ligand-658 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in cellular systems. It is designed for the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands via a suitable linker. This compound is useful in investigating ubiquitin-proteasome pathway mechanisms and advancing targeted protein degradation research. -
Ligand for E3 Ligase
CRBN ligand-513 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its primary application lies in targeted protein degradation studies, contributing to research on cellular regulation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-763 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. It serves as a valuable tool in drug discovery and therapeutic research aimed at modulating protein levels within cells. -
Ligand for E3 Ligase
CRBN ligand-236 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling the development of proteolysis-targeting chimeras (PROTACs). CRBN ligand-236 serves as a valuable tool for studying protein degradation pathways and exploring new therapeutic strategies in cellular biology and drug discovery. -
Ligand for E3 Ligase
CRBN ligand-628 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to effectively recruit the CRBN protein. It can be utilized to conjugate with a target protein ligand through a linker, facilitating the formation of PROTACs (proteolysis-targeting chimeras). This compound serves as a valuable tool in targeted protein degradation research, enabling the investigation of protein function and regulation in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-521 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. It can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. This reagent is valuable for research applications in drug discovery and development, particularly in the study of protein homeostasis and therapeutic intervention. -
Ligand for E3 Ligase
CRBN ligand-358 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker, enabling targeted protein degradation. Its applications in chemical biology research include studying protein homeostasis and dissecting cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-671 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling the development of targeted protein degradation strategies through the formation of PROTACs (Proteolysis Targeting Chimeras). CRBN ligand-671 is instrumental in research applications focusing on protein regulation and cellular signaling pathways. -
Ligand for E3 Ligase
CRBN ligand-439 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker to form a PROTAC, enabling the modulation of protein levels and function in various biological contexts. It serves as a valuable tool for researchers investigating targeted protein degradation pathways and the role of CRBN in cellular processes. -
Ligand for E3 Ligase
CRBN ligand-657 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. CRBN ligand-657 is valuable for investigating the mechanisms of targeted protein degradation and exploring therapeutic possibilities in various diseases. -
Ligand for E3 Ligase
CRBN ligand-343 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning primarily to recruit the CRBN protein. This compound can be conjugated to target protein ligands through a linker, facilitating the formation of PROTACs (proteolysis-targeting chimeras). It is valuable in research applications focused on targeted protein degradation and modulation of cellular protein levels, contributing to novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-536 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the design of PROTACs by linking it to a specific target protein ligand through a suitable linker, enabling targeted protein degradation. CRBN ligand-536 is instrumental for research applications in the fields of targeted therapy and proteomics. -
Ligand for E3 Ligase
CRBN ligand-701 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create PROTAC molecules, enabling targeted protein degradation. Its applications extend to research in targeted therapy and the study of protein regulation within cellular systems. -
Ligand for E3 Ligase
CRBN ligand-424 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in PROTAC (Proteolysis Targeting Chimeras) development by linking to target protein ligands through a suitable linker. Its capacity to modulate protein degradation pathways makes it valuable for research in targeted protein degradation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-683 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is particularly valuable for the development of PROTAC (Proteolysis Targeting Chimeras) by linking to target protein ligands through a suitable linker. CRBN ligand-683 is instrumental in studies of targeted protein degradation and may be harnessed in various research applications related to proteostasis and disease modulation. -
Ligand for E3 Ligase
CRBN ligand-510 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC. It plays a significant role in targeted protein degradation research, providing valuable insights for drug development and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-696 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of cereblon to specific target proteins. By linking CRBN ligand-696 to a target protein ligand through a suitable linker, it enables the formation of proteolysis-targeting chimeras (PROTACs), which are valuable tools for targeted protein degradation studies and therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-308 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to chemically link to a target protein ligand through a suitable linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its ability to modulate protein degradation pathways makes it a valuable tool for studying protein turnover and the therapeutic potential of targeted protein degradation in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-412 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the formation of proteolysis-targeting chimeras (PROTACs). This compound is essential for studies focused on targeted protein degradation and therapeutic applications in cancer research and other diseases. -
Ligand for E3 Ligase
CRBN ligand-578 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be conjugated to target protein ligands through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). This compound is valuable for studies in targeted protein degradation and cellular protein modulation, making it useful in therapeutic research and drug development. -
Ligand for E3 Ligase
CRBN ligand-455 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be utilized to create proteolysis-targeting chimeras (PROTACs) by linking to a target protein ligand through a suitable linker, enabling targeted protein degradation. It serves as a valuable tool for exploring protein function and regulation, particularly in the context of drug discovery and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-392 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of CRBN to specific target proteins. This compound is utilized in the development of proteolysis-targeting chimeras (PROTACs) when covalently linked to a target protein ligand through a suitable linker, enabling selective degradation of the target protein. Research applications include targeted protein degradation studies and exploring novel therapeutic approaches in cellular biology. -
Ligand for E3 Ligase
CRBN ligand-391 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). It plays a significant role in targeted protein degradation research and drug discovery applications, contributing to advancements in therapeutic strategies for various diseases. -
Ligand for E3 Ligase
CRBN ligand-626 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This molecule can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Researchers can utilize CRBN ligand-626 in studies exploring targeted protein degradation and the modulation of various biological pathways. -
Ligand for E3 Ligase
CRBN ligand-757 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimeric molecule (PROTAC). CRBN ligand-757 serves as a valuable tool in chemical biology and therapeutic development, particularly in studies focused on targeted protein degradation. -
Ligand for E3 Ligase
CRBN ligand-535 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is suitable for use in the development of PROTACs, enabling targeted protein degradation through an innovative bifunctional mechanism. Its ability to bridge ligands to target proteins makes it valuable for researchers studying ubiquitin-proteasome system modulation and therapeutic protein degradation strategies. -
Ligand for E3 Ligase
CRBN ligand-443 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the development of PROTAC (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation supports innovative research in therapeutic development and cellular regulation. -
Ligand for E3 Ligase
CRBN ligand-484 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to target protein ligands through a linker, enabling the development of PROTACs that promote targeted protein degradation. Its utility in research includes exploring the mechanisms of ubiquitin-proteasome system modulation and protein homeostasis in cellular contexts. -
Ligands for E3 Ligase
(S,S,S)-AHPC is a specific ligand for E3 ligases, serving as a crucial component in targeted protein degradation applications. It is utilized for the synthesis of PROTAC AH081, which can facilitate the degradation of specific proteins within cells. This compound is an important tool in research focused on understanding protein interactions and developing novel therapeutic strategies through modulation of E3 ligase activity. -
Ligand for E3 Ligase
CRBN ligand-488 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its utility in targeted protein elimination makes it an important tool for investigating cellular processes and therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-741 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon, enabling the formation of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand via a suitable linker. This compound is valuable for studies in targeted protein degradation, offering potential applications in drug development and cancer research. -
Ligand for E3 Ligase
CRBN ligand-307 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). CRBN ligand-307 is valuable in research applications focused on targeted protein degradation and the modulation of cellular protein levels, making it an essential tool for studies in drug discovery and therapeutic development. -
Ligands for E3 Ligase
CRBN ligand-45 functions as a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation through the proteolysis-targeting chimera (PROTAC) technology. This compound is essential for research applications focused on investigating ubiquitination pathways and developing novel therapeutic strategies that harness the ubiquitin-proteasome system. Its ability to selectively engage E3 ligases makes it a valuable tool in the study of cellular protein homeostasis and degradation mechanisms.
