Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Azido-PEG1-Boc is a PEG-based linker designed for use in the synthesis of PROTACs, functioning primarily through click chemistry. It contains an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups, facilitating the development of targeted protein degradation technologies in various biological research applications. -
PROTAC Linker
Tetraethylene glycol monohexadecyl ether serves as a PEG-based linker in the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the design of bifunctional molecules that can engage specific target proteins for degradation. Its hydrophilic-hydrophobic balance is crucial for optimizing cell permeability and enhancing target selectivity, making it a valuable reagent in chemical biology and therapeutic research applications focused on protein modulation. -
PROTAC Linker
S-acetyl-PEG3-alcohol is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the conjugation of target proteins to E3 ligase ligands, enabling the targeted degradation of specific proteins within cellular systems. This reagent is essential for researchers investigating targeted protein degradation and developing innovative therapeutic strategies in drug discovery. -
PROTAC Linker
Tos-PEG2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of specific proteins within cellular environments. Tos-PEG2-Boc is ideal for researchers exploring targeted protein degradation pathways and developing novel therapeutics based on PROTAC technology. -
PROTAC Linkers
Bis(m-PEG4)-N-OH is a PEG-based linker designed for the assembly of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective conjugation of ligands, enhancing the solubility and bioavailability of the resulting PROTACs. Its unique structure promotes targeted protein degradation, making it a valuable tool for researchers investigating novel therapeutic strategies and protein modulation in various biological contexts. -
PROTAC Linkers
DBCO-C-PEG1 is a PEG-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). It features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent enables precise conjugation and enhances the development of targeted protein degradation studies, contributing to advancements in therapeutic applications and cellular biology research. -
PROTAC linker
NH-bis(C2-PEG1-azide) is a versatile PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties. This compound is essential for developing targeted protein degradation strategies and is widely applicable in chemical biology and drug discovery research. -
PROTAC Linkers
Hydroxy-PEG4-methylamine is a polyethylene glycol (PEG) based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to an E3 ubiquitin ligase, enhancing targeted protein degradation. Its application is critical in the development of innovative therapeutic strategies in cellular and molecular biology research. -
PROTAC Linker
Azido-PEG9-azide is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-bearing compounds. This reagent is instrumental in the development of targeted protein degradation strategies, promoting innovative research in drug discovery and protein regulation. -
PROTAC Linkers
Benzyl-PEG7-azide is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide functional group, it facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. This compound plays a crucial role in drug discovery and development by enabling the selective degradation of target proteins. -
PROTAC Linkers
C2-Bis-phosphoramidic acid diethyl ester is a specialized linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This alkyl chain-based reagent facilitates the formation of heterobifunctional molecules, enabling targeted protein degradation. It is valuable in the development of novel therapeutic strategies that leverage the ubiquitin-proteasome system for selective protein modulation in cellular research. -
PROTAC Linker
Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite functions as a PEG-based linker in the synthesis of PROTACs. This compound features an alkyne moiety enabling its application in click chemistry, specifically facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is particularly useful in targeted protein degradation studies and other research applications requiring precise molecular assembly. -
PROTAC Linkers
m-PEG3-S-PEG2-OH is a polyethylene glycol (PEG)-based linker designed for the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of specific proteins in cellular assays. Its application is critical for researchers investigating targeted protein modulation and related therapeutic strategies in drug discovery and development. -
PROTAC Linkers
m-PEG4-(CH2)6-Phosphonic acid is a PEG-based linker utilized in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound features a phosphonic acid moiety that enhances hydrophilicity and improves solubility, contributing to the design of effective targeted protein degradation systems. Its applications extend to studies focusing on protein modulation and degradation, providing valuable tools for therapeutic development in various diseases. -
PROTAC Linkers
(R)-TCO-OH is a click chemistry reagent designed for use as a linker in PROTAC (proteolysis-targeting chimeras) synthesis. This compound features a trans-cyclooctene (TCO) moiety, which allows it to undergo an inverse electron-demand Diels-Alder (iEDDA) reaction with tetrazine-containing partners, facilitating selective protein degradation. Its application is critical in the development of targeted protein degradation strategies for various biological and therapeutic research areas. -
PROTAC Linker
Acid-PEG4-S-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimeras) synthesis. This compound facilitates the formation of a novel therapeutic modality that harnesses the ubiquitin-proteasome system for targeted protein degradation. Its unique structure enhances solubility and connectivity, making it a valuable tool for researchers investigating selective protein modulation and degradation pathways. -
PROTAC Linker
Azide-PEG3-L-alanine-Fmoc is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its azide functionality. This compound is capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules and can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds. Its unique properties make it a valuable tool for researchers working on targeted protein degradation and related applications in chemical biology. -
PROTAC Linker
Azido-PEG4-hydrazide-Boc is a PEG-based linker designed for use in the synthesis of PROTACs, functioning primarily as a tool for targeted protein degradation. This compound features an azide group that facilitates click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it suitable for various bioconjugation applications in chemical biology and drug discovery research. -
PROTAC Linker
BnO-PEG1-CH2CO2tBu is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras) molecules. This linker facilitates the conjugation of ligands to an E3 ligase, promoting targeted protein degradation. It plays a crucial role in advancing research in therapeutic applications that leverage the degradation of specific proteins within cellular pathways. -
PROTAC Linkers
S-acetyl-PEG3-phosphonic acid ethyl ester is a polyethylene glycol (PEG) based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the development of bifunctional molecules that target specific proteins for ubiquitin-mediated degradation. Its application in research includes cellular studies of protein turnover and the exploration of targeted therapy strategies in various disease models. -
PROTAC Linker
SCO-PEG8-COOH is a PROTAC linker that facilitates the formation of targeted protein degraders by connecting target proteins to E3 ligases. This polyethylene glycol (PEG) derivative features a maleimide moiety for conjugation with amino groups, particularly lysine residues, enhancing the specificity and efficiency of protein interactions. Its versatility in modifying biomolecules makes it a valuable tool for studies in targeted protein degradation and therapeutic development in chemical biology. -
PROTAC Linkers
TCO-PEG8-amine is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis targeting chimeras). It facilitates the formation of bifunctional molecules by covalently linking target proteins to E3 ligases, enabling targeted protein degradation. This reagent is essential for researchers exploring innovative therapeutic strategies in cancer, neurodegenerative diseases, and other pathologies through targeted modulation of protein levels. -
PROTAC Linkers
HO-PEG15-OH is a polyethylene glycol (PEG) based PROTAC linker that plays a critical role in the development of proteolysis-targeting chimeras (PROTACs). This reagent facilitates the selective degradation of target proteins by linking E3 ligases to the desired substrates, enhancing the functionality of PROTACs in therapeutic research. Its biocompatibility and flexible structure make it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linker
DBCO-C2-SulfoNHS ester serves as a key PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound incorporates a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing partners. It plays a crucial role in the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
Propargyl-PEG6-SH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its efficient conjugation capabilities make it a valuable tool for researchers investigating targeted protein degradation and related therapeutic applications. -
PROTAC Linkers
Benzyl-PEG12-alcohol is a polyethylene glycol (PEG) based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). Its structure facilitates effective conjugation of E3 ligase ligands to target proteins, enhancing targeted protein degradation pathways. This compound is valuable for researchers focusing on the development of novel therapeutics that leverage targeted degradation mechanisms. -
PROTAC Linker
Azido-PEG4-(CH2)3-methyl ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds. This compound is ideal for applications in targeted protein degradation research. -
PROTAC Linker
Bromo-PEG5-phosphonic acid diethyl ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted degradation pathways in cellular contexts. Its unique structure allows for increased solubility and improved pharmacokinetic profiles, making it a valuable tool for research in drug development and protein regulation studies. -
PROTAC Linker
Benzyloxy carbonyl-PEG3-NHS ester is a PEG-based linker that facilitates the synthesis of PROTACs (proteolysis-targeting chimeras) by reacting with amine-containing compounds. This versatile reagent enables the conjugation of ligands to E3 ligases, enhancing target degradation pathways. Its application is crucial in biochemical research focused on targeted protein degradation and the development of novel therapeutic strategies. -
PROTAC Linkers
m-PEG10-T-Butyl ester is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of PROTACs by providing a stable and soluble connection between the target protein and E3 ligase. Its unique structure enhances the efficiency of targeted protein degradation, making it a valuable tool in drug discovery and chemical biology research. -
PROTAC Linker
Br-PEG6-CH2COOtBu is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the connection between a target protein ligand and an E3 ligase ligand, enhancing targeted protein degradation. Its primary application lies in drug discovery and development, particularly in the design of novel therapeutics that harness the ubiquitin-proteasome system. -
PROTAC Linker
Bromo-PEG5-phosphonic acid is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking inhibitors to E3 ligases, enhancing their therapeutic potential. It serves as a valuable tool in the development of targeted protein degradation strategies for various research applications, including cancer therapeutics and cellular signaling studies. -
PROTAC Linkers
1,3-Bis-aminooxy propane is an alkyl chain-based PROTAC linker that facilitates the construction of Proteolysis Targeting Chimeras (PROTACs). This compound is designed to enhance the selective degradation of target proteins through the ubiquitin-proteasome system. Its application in chemical biology research aids in exploring cellular pathways and the development of novel therapeutic agents. -
PROTAC Linker
THP-PEG9-THP is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient and selective degradation of target proteins through CRBN-mediated ubiquitination. It is essential for researchers exploring targeted protein degradation strategies in various cellular and in vivo models. -
PROTAC Linker
Propargyl-PEG3-phosphonic acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its utility in connecting target proteins with E3 ligases makes it valuable for researchers exploring targeted protein degradation pathways. -
PROTAC Linkers
Tos-PEG13-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the creation of bifunctional molecules that selectively target and degrade specific proteins within cells. Its application is crucial for therapeutic development in cancer research and the study of protein regulation mechanisms. -
PROTAC Linker
N-(Boc-PEG5)-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of PROTAC molecules by providing solubility and stability, enhancing their effectiveness in targeted protein degradation studies. Its application spans the design of innovative therapeutic agents aimed at modulating specific protein interactions within cellular systems. -
PROTAC Linkers
CHO-C-PEG2-C-CHO is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective recruitment of E3 ligases and enhances the targeted degradation of specific proteins, making it a valuable tool in drug development and protein modulation studies. Its unique structure allows for flexibility and stability in the formation of bifunctional agents, supporting various research applications in targeted protein degradation and cellular signaling pathways. -
PROTAC Linker
Acid-PEG2-ethyl propionate is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of PROTACs by enhancing the solubility and stability of the resultant conjugates. It is ideal for research focused on targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
t-Boc-aminooxy-PEG6-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne group that enables its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, making it a versatile tool in chemical biology. Its ability to efficiently link various functional groups broadens its applications in drug discovery and development. -
PROTAC Linker
Ald-Ph-amido-PEG2-C2-Boc is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. This compound facilitates the conjugation of small molecules to E3 ligases, enabling efficient ubiquitination and subsequent proteasomal degradation of specific proteins. Its application in PROTAC development supports research in targeted therapy and drug discovery by enhancing the specificity and efficacy of protein modulation. -
PROTAC Linker
Bis-PEG4-t-butyl ester is a PEG-based linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of targeting ligands to E3 ligases, enabling the selective degradation of target proteins. Its unique structure enhances the pharmacokinetic properties of resulting PROTACs, making it a valuable tool for research in targeted protein degradation and drug discovery. -
PROTAC Linker
Methyltetrazine-propylamine is a versatile PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This linker features an alkyl chain structure, enhancing the stability and functionality of the resulting conjugates. It is ideal for researchers focusing on targeted protein degradation and the development of innovative therapeutic modalities for various diseases. -
PROTAC Linkers
Ms-PEG6-MS is a PEG-based PROTAC linker designed for facilitating the synthesis of PROTAC molecules. This compound enables the efficient conjugation of target-binding moieties to E3 ligase recognition elements, thereby promoting targeted protein degradation. It is commonly utilized in chemical biology research to study protein interactions and develop novel therapeutic agents that harness the ubiquitin-proteasome system. -
PROTAC Linkers
NH-bis-PEG5 is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). Its unique structure facilitates the construction of bifunctional molecules that selectively target proteins for ubiquitination and subsequent degradation. This compound is instrumental in advancing research in targeted protein degradation therapies and investigating cellular processes involving protein modulation. -
PROTAC Linkers
Bis-PEG7-t-butyl ester is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. This compound facilitates the development of novel PROTACs by providing a flexible and soluble linker that enhances target protein degradation. It is valuable in drug discovery and development research, particularly in studies focused on targeted protein modulation and therapeutic strategies. -
PROTAC Linkers
Bis-PEG25-acid is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of innovative therapeutics by enhancing the solubility and stability of the resulting PROTACs. Its ability to connect ligands and promote targeted protein degradation makes it a valuable tool in drug discovery and chemical biology research. -
PROTAC Linker
m-PEG16-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs that enable targeted protein degradation, thereby providing a valuable tool for dissecting protein function and understanding disease mechanisms. Its application is particularly relevant in the development of novel therapeutic strategies for various biomedical research fields, including cancer and neurodegenerative disorders. -
PROTAC Linkers
Mal-amide-PEG2-oxyamine-Boc is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. It facilitates the conjugation of target proteins for degradation, enabling specific modulation of protein levels in cellular contexts. This compound is essential for developing targeted protein degradation strategies in drug discovery and therapeutic applications. -
PROTAC Linkers
Hydroxy-PEG24-Boc is a poly(ethylene glycol)-based linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the solubility and cellular uptake of PROTAC molecules, facilitating targeted protein degradation. Its application is crucial in the development of innovative therapies aimed at modulating protein levels within various biological pathways.
