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P131

PROTAC BTK Degrader

P131 is a PROTAC molecule that targets Bruton's tyrosine kinase (BTK) for degradation through the Cereblon ligase complex. This compound is effective in degrading both wild-type and C481S mutant BTK with nanomolar potencies. P131 is utilized in research applications focused on the modulation of BTK activity, providing insights into its role in various B-cell malignancies and related signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2360561-66-4
Applications	PROTAC BTK Degrader
Formula	C₄₆H₄₈N₁₂O₉
Molecular Weight	912.95
SMILES	NC1=NC=NC2=C1C(C3=CC=C(C=C3)OC4=CC=CC=C4)=NN2[C@@H]5CCCN(C5)C(C6=CN(N=N6)CCOCCOCCOCCNC7=C8C(N(C(C8=CC=C7)=O)C9CCC(NC9=O)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.