Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
PEG4-sulfonic acid is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of PROTACs, enhancing their efficacy in targeting and degrading specific proteins within cellular environments. PEG4-sulfonic acid's unique structure provides solubility and stability, making it suitable for various biochemical applications in drug discovery and therapeutic research. -
ADC/PROTAC Linker
Propargyl-PEG5-azide is a PEG-based linker designed for antibody-drug conjugate (ADC) and PROTAC applications. This compound features an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Propargyl-PEG5-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile and effective tool for chemical biologists developing targeted therapeutics. -
PROTAC Linker
N-(Boc-PEG3)-N-bis(PEG2-alcohol) is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of heterobifunctional molecules that promote targeted protein degradation. Its unique structure enhances solubility and bioavailability, making it suitable for various applications in chemical biology and drug development. -
PROTAC Linkers
Phthalimide-PEG3-C2-OTs is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a phthalimide moiety connected by a polyethylene glycol (PEG) chain, enabling effective linkage between ligands that bind to E3 ubiquitin ligases and target proteins. By harnessing the ubiquitin-proteasome system, PROTACs equipped with Phthalimide-PEG3-C2-OTs promote selective degradation of specific proteins, making it a valuable tool for targeted protein modulation in various biological research applications. -
PROTAC Linker
BCN-PEG4-acid is a PEG-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring a bicyclononyne (BCN) moiety, this compound is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its use facilitates the development of targeted protein degradation strategies, enhancing the versatility and effectiveness of drug discovery research. -
PROTAC Linkers
Mal-PEG12-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances cellular permeability and stability, facilitating the efficient targeting and degradation of specific proteins within cells. Its application in the development of PROTACs paves the way for innovative research in targeted protein degradation and the modulation of cellular pathways. -
PROTAC Linker
N-Biotin-N-bis(PEG4-acid) serves as a PEG-based linker specifically designed for the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates efficient conjugation of target proteins to E3 ligases, promoting selective degradation pathways. It is applicable in the synthesis of novel PROTAC molecules aimed at elucidating protein interactions and studying cellular pathways. -
PROTAC Linker
S-Acetyl-PEG8-OH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the development of novel biopharmaceuticals by enabling targeted protein degradation. Its biocompatibility and flexibility make it suitable for research applications in drug discovery and development, particularly in the study of protein interactions and turnover. -
PROTAC Linker
Azido-PEG3-Sulfone-PEG4-acid is a PEG-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group that enables its application in click chemistry, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when combined with DBCO or BCN groups, making it a versatile tool in chemical biology and drug development research. -
PROTAC Linker
Lipoamido-PEG2-OH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of covalent linkages between target proteins and E3 ligases, enhancing the selective degradation of specific proteins within cellular systems. Lipoamido-PEG2-OH serves as a crucial tool in the development of targeted therapeutic strategies and the exploration of protein functions in various biological research applications. -
PROTAC Linkers
TCO-PEG3-amide-C3-triethoxysilane is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. Its triethoxysilane group facilitates conjugation to various surfaces or substrates, enhancing the development of targeted protein degradation strategies. This compound serves as a crucial tool for researchers investigating targeted therapies and protein modulation. -
PROTAC Linkers
m-PEG6-2-methylacrylate is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables effective coupling of target proteins to E3 ligases, facilitating targeted protein degradation. Its unique structural properties make it suitable for various applications in chemical biology and drug development. -
PROTAC Linker
Ald-Ph-PEG4-NH-Boc is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTAC constructs, enabling effective targeting of specific proteins for degradation. Its unique structure provides versatility in the development of novel therapeutic agents for various research applications in targeted protein degradation. -
PROTAC Linkers
Boc-PEG1-Boc is a bifunctional linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This alkyl/ether-based compound facilitates the conjugation of target proteins with E3 ligases, enabling the targeted degradation of specific proteins within cellular contexts. Its application is essential for researchers developing novel PROTACs for therapeutic interventions in various diseases, including cancer and neurodegenerative disorders. -
PROTAC Linkers
Sulfone-Bis-PEG4-acid is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the assembly of bifunctional molecules that promote targeted protein degradation, making it valuable in biological research and drug discovery applications. Its unique structural properties enhance solubility and optimize the pharmacokinetic profiles of PROTACs. -
PROTAC Linker
Boc-PEG4-phosphonic acid ethyl ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of a target protein ligand to an E3 ligase ligand, enabling selective protein degradation. Its unique structure enhances solubility and stability, making it a valuable tool in the development of targeted protein degradation research. -
PROTAC Linker
m-PEG8-succinimidyl carbonate is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances solubility and stability, facilitating the effective assembly of targeted protein degradation systems. Its application in chemical biology and drug discovery research allows for the selective modulation of protein levels, providing valuable insights into protein function and potential therapeutic interventions. -
PROTAC Linkers
Diethyl 12-bromododecylphosphonate is a phosphonate compound designed as a versatile linker for PROTAC (PROteolysis TArgeting Chimeras) synthesis. It facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of specific proteins through the ubiquitin-proteasome pathway. This compound is essential for researchers developing novel PROTACs to study protein regulation and degradation in various biological systems. -
PROTAC Linkers
Tri(t-butoxycarbonylethoxymethyl) ethanol is a versatile PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This alkyl/ether-based compound enhances the modulation of target proteins by providing optimal spatial arrangements for target engagement and ubiquitination. Its application is critical in advancing drug discovery and development in the fields of cancer therapy and cellular regulation. -
PROTAC Linkers
Bis-PEG3-sulfonic acid is a PEG-based PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the solubility and versatility of PROTACs, allowing for improved degradation of target proteins in cellular systems. Its application in drug discovery makes it a valuable tool for researchers focusing on targeted protein degradation and the development of novel therapeutic agents. -
PROTAC Linker
Triethylene glycol monodecyl ether serves as a PEG-based linker in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of targeted protein degradation systems by linking E3 ligase and target proteins effectively. It is essential for researchers investigating novel therapeutic strategies that employ targeted protein modulation. -
PROTAC Linker
Azido-PEG3-S-PEG4-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs, targeting the degradation of specific proteins. This versatile reagent features an azide and an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules. Its applications include facilitating targeted protein degradation and the development of novel therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linkers
Amino-PEG24-alcohol is a PEG-based linker specifically designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the formation of robust and effective PROTACs by providing a flexible linker that enhances target engagement and proteasomal degradation. It is applicable in various research studies involving targeted protein degradation and the development of novel therapeutic strategies. -
PROTAC Linkers
Boc-Gly-amido-C-PEG3-C3-amine is a PEG-based linker designed for the development of PROTAC (Proteolysis Targeting Chimeras) molecules. Its amido and PEG3 components enhance solubility and facilitate the effective conjugation of the target protein and E3 ligase. This linker is essential for constructing complex PROTACs, enabling the targeted degradation of specific proteins in biochemical research and therapeutic applications. -
PROTAC Linkers
MS-PEG4-t-butyl ester is a PEG-derived linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of proteins in cellular studies. Its unique structure promotes solubility and versatility in the development of targeted protein degradation research applications. -
PROTAC Linker
Propargyl-PEG6-N3 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. Propargyl-PEG6-N3 is an essential tool for researchers focused on advancing targeted protein degradation studies. -
PROTAC Linkers
TCO-PEG3-TCO is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and solubility of PROTACs while effectively linking E3 ligases to target proteins, thereby promoting targeted protein degradation. Its applications are vital in research focused on elucidating protein functions and developing novel therapeutic strategies in cancer and other diseases. -
PROTAC linker
N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride functions as a PEG-based PROTAC linker, facilitating the synthesis of PROTACs. This compound features an azide functional group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a versatile tool for chemical biology applications in targeted protein degradation studies. -
PROTAC Linker
S-acetyl-PEG6-Tos serves as a PEG-based linker for the development of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby enabling selective protein degradation. It is designed to enhance the pharmacokinetic properties and solubility of PROTACs, making it a valuable tool in targeted protein degradation research and therapeutic development. -
PROTAC Linkers
Biotin-PEG7-thiourea is a versatile PROTAC linker featuring a biotin moiety and a polyethylene glycol (PEG) chain. It facilitates the assembly of PROTACs by linking target proteins to E3 ubiquitin ligases, enabling targeted protein degradation. This reagent is ideal for applications in drug discovery and research focused on modulating cellular protein levels through proteolysis. -
PROTAC Linkers
DBCO-PEG2-amine is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a dibenzocyclooctyne (DBCO) moiety that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG2-amine facilitates the development of PROTACs for targeted protein degradation applications, making it valuable in chemical biology and therapeutic research. -
PROTAC Linkers
Mal-amido-PEG10-acid is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by connecting ligands to E3 ligase, enhancing the efficacy of targeted protein degradation in biochemical research. It is an essential tool for researchers investigating protein regulation and potential therapeutic interventions. -
PROTAC Linker
Azido-PEG8-TFP ester is a PEG-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functionality that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool in chemical biology for targeted protein degradation studies. -
PROTAC Linker
3-(2-(4-Methylpiperazin-1-yl)ethyl)azetidin-3-ol serves as a versatile linker in PROTAC applications, specifically designed for the targeted degradation of BRD4, exemplified by the BRD4 PROTAC BD-9136. This compound facilitates the formation of bifunctional molecules that promote the ubiquitination and subsequent proteasomal degradation of BRD4. Its structural features enable efficient engagement with target proteins, making it valuable in research focused on protein regulation and therapeutic discovery. -
PROTAC Linker
Bis-PEG6-t-butyl ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target ligands to E3 ubiquitin ligases, enabling the selective degradation of proteins of interest. Its incorporation into PROTAC structures enhances solubility and stability, making it a valuable tool for researchers studying targeted protein degradation mechanisms in cellular and molecular biology. -
PROTAC Linkers
Benzenedimethanamine-diethylamine is a PROTAC linker featuring an alkyl chain structure. This compound facilitates the development of PROTACs by connecting the target protein to E3 ligases, thereby influencing proteasomal degradation pathways. It is utilized in chemical biology research and drug discovery to enhance the specificity and efficacy of targeted protein degradation strategies. -
PROTAC Linker
Lipoamido-PEG3-OH is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the creation of stable PROTAC molecules that engage target proteins for selective degradation through the ubiquitin-proteasome pathway. Additionally, Lipoamido-PEG3-OH is instrumental in developing dendronized gold nanoparticle (AuNP)-based drug delivery systems, enhancing the efficacy and stability of therapeutic agents. -
PROTAC Linkers
Mal-PEG3-Boc is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound effectively enhances the solubility and stability of drug conjugates while maintaining the functional integrity required for targeted protein degradation. It is ideal for researchers developing innovative PROTAC-based therapeutic strategies. -
PROTAC Linker
MS-PEG1-THP is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of target proteins to E3 ligases, enhancing the targeted degradation of proteins of interest. MS-PEG1-THP is ideal for researchers aiming to develop PROTACs for applications in drug discovery and the study of protein regulation mechanisms. -
PROTAC Linker
Chloroacetamido-PEG4-NHS ester is a polyethylene glycol (PEG)-derived PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of covalent bonds with target proteins through the NHS ester moiety, enhancing the specificity and efficacy of the resulting PROTAC. It is employed in various research applications, including targeted protein degradation studies and drug discovery initiatives. -
PROTAC Linker
m-PEG8-(CH2)12-phosphonic acid ethyl ester serves as a PEG-based linker for PROTAC synthesis, facilitating the design of bifunctional molecules that target and degrade specific proteins via the ubiquitin-proteasome system. Its structural attributes enhance solubility and bioavailability, making it suitable for application in various drug discovery and developmental research. This linker allows researchers to explore targeted protein degradation as a therapeutic strategy, thus advancing the field of targeted therapies and precision medicine. -
PROTAC Linker
Ald-Ph-amido-PEG3-C2-NH2 is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of bifunctional molecules that promote the targeted degradation of proteins via the ubiquitin-proteasome system. Its unique structure enhances the solubility and stability of PROTAC constructs, making it a valuable tool for researchers exploring protein modulation and degradation pathways in cellular studies. -
PROTAC linker
N-(m-PEG4)-N'-(azide-PEG3)-Cy5 serves as a PEG-based linker for PROTAC technology, facilitating the synthesis of targeted protein degraders. This compound features an azide functional group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it a versatile tool for researchers in the field of chemical biology and drug development. -
PROTAC Linkers
Azido-PEG36-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with substrates containing DBCO or BCN groups, making it suitable for various chemical biology applications, including targeted protein degradation studies. -
PROTAC linker
N-(Amino-PEG1)-N-bis(PEG2-propargyl) serves as a PEG-based linker for PROTAC (proteolysis targeting chimera) synthesis. This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties enable efficient conjugation in the development of targeted protein degradation strategies, making it a valuable tool for chemical biology research. -
PROTAC Linkers
NH2-O-C5-COOH hydrobromide is an alkyl chain-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the creation of PROTACs by connecting target proteins to E3 ligases, enabling targeted degradation pathways. Its application is pivotal in guiding research aimed at developing novel therapeutic strategies in cancer and other diseases. -
PROTAC Linker
N-(Azido-PEG2)-N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker designed for synthesizing bifunctional molecules. This compound features an azide moiety, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it is capable of undergoing strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN functionalized molecules, making it a versatile tool for chemical biology applications, including targeted protein degradation studies. -
PROTAC Linker
PEG5-bis-(Ethyl phosphonate) is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the selective degradation of target proteins through the recruitment of E3 ligases, making it valuable for therapeutic research and protein modulation studies. Its hydrophilic properties enhance solubility and biocompatibility, essential for effective PROTAC development. -
PROTAC Linkers
Boc-Aminooxy-PEG5-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an aminooxy group that facilitates the conjugation of target ligands to E3 ligase ligands, enhancing the targeted degradation of specific proteins. This reagent is suitable for applications in drug discovery and biochemical research focused on protein regulation and degradation mechanisms. -
PROTAC Linker
Benzyl-PEG5-THP is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of targeting moieties to E3 ligase, enhancing the efficacy of targeted protein degradation. Its application in chemical biology research allows for the development of novel therapeutics and provides insights into protein regulation mechanisms.
