Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) is a PEG-based linker specifically designed for proteolysis-targeting chimeras (PROTACs). This compound enables the conjugation of a biotin moiety for enhanced target engagement and recruitment of E3 ligases. It is a valuable tool for researchers working on targeted protein degradation and therapeutic applications in cellular biology. -
PROTAC Linker
Boc-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione is a versatile linker designed for the synthesis of PROTACs, specifically utilized in the development of BRD4 Degrader-26. This compound enables the assembly of targeted protein degraders, facilitating the selective ubiquitination and subsequent degradation of BRD4 protein. Its application in chemical biology research supports the exploration of targeted therapies and novel approaches to modulate protein levels in various disease contexts. -
PROTAC Linker
N-Boc-N-bis(PEG3-NHS ester) functions as a PEG-based PROTAC linker, facilitating the design and synthesis of PROTAC molecules. This compound enhances the solubility and stability of PROTACs, thereby improving their efficacy in targeted protein degradation studies. Its unique structure allows for the formation of stable conjugates, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Propargyl-PEG3-phosphonic acid diethyl ester is a versatile PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This reagent features an alkyne group that enables its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the efficient conjugation of azide-containing molecules. The incorporation of this linker enhances the stability and bioactivity of resulting PROTACs, making it valuable in targeted protein degradation studies and related research applications. -
PROTAC Linkers
THP-PEG8-OH is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). This compound facilitates the formation of PROTACs by providing a flexible and hydrophilic spacer, enhancing the efficacy and solubility of the resultant bioconjugates. THP-PEG8-OH is primarily employed in chemical biology research to study targeted protein degradation and to develop novel therapeutics. -
PROTAC Linkers
Bis-PEG25-TFP ester is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features a TFP (trifluoroethyl phthalimide) moiety that facilitates the conjugation of target proteins to ubiquitin ligases, promoting their degradation via the cellular ubiquitin-proteasome system. Bis-PEG25-TFP ester is essential for the development of targeted protein degradation therapies and supports various applications in chemical biology and drug discovery research. -
PROTAC Linkers
Mal-amido-PEG9-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of proteins by connecting ligands to E3 ubiquitin ligases, thereby enhancing the selectivity and efficacy of PROTAC molecules. Its effective application in chemical biology allows researchers to investigate protein function and develop new therapeutic strategies. -
PROTAC Linker
N-Boc-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of proteins or small molecules, enhancing their solubility and stability. Its primary applications include drug development and targeted degradation research, making it a valuable tool for investigations into protein regulation and cellular mechanisms. -
PROTAC Linker
PEG2-Cl is a polyethylene glycol-based PROTAC linker designed to facilitate the synthesis of targeted proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and solubility of PROTACs, allowing for improved cellular uptake and efficacy. PEG2-Cl is pivotal in the development of novel therapeutic agents aimed at modulating protein degradation for various research applications in drug discovery and development. -
PROTAC Linker
Thiol-C9-PEG7 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates target protein degradation by enabling the conjugation of ligands to E3 ligases, thereby promoting the selective ubiquitination of specific proteins. Its application is essential in research focused on targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
Tos-PEG3-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. Its flexible structure and solubility make it suitable for various research applications in drug discovery and development, particularly in investigating protein interactions and cellular pathways. -
PROTAC Linker
1-Isothiocyanato-PEG4-alcohol is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins with E3 ligases, thereby enhancing proteolytic degradation pathways. It is suitable for applications involving targeted protein degradation research and the development of novel therapeutic agents. -
PROTAC Linker
DBCO-NH-Boc is a PROTAC linker featuring a dibenzocyclooctyne (DBCO) moiety that enables efficient synthesis of PROTACs through click chemistry. This compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, providing a versatile approach for targeted protein degradation research. Its unique structure enhances connectivity and stability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linkers
Methyl-PEG4-acyl chloride is a PEG-derived compound that serves as an effective linker for PROTAC (proteolysis-targeting chimera) synthesis. Its primary mechanism involves facilitating the assembly of bifunctional molecules designed to induce targeted protein degradation. This reagent is essential for researchers developing PROTACs to explore the modulation of protein function and cellular pathways in various biological contexts. -
PROTAC Linkers
Br-PEG7-NHBoc is a PEG-based PROTAC linker designed for the synthesis of proteolysis targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, facilitating their application in targeted protein degradation studies. It can be utilized in various research contexts, including drug discovery and novel therapeutic development, targeting specific proteins for degradation. -
PROTAC Linker
Hydroxy-PEG2-C2-sulfonic acid is a PEG-based linker designed specifically for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the targeted degradation of specific proteins within cells, enabling researchers to explore the role of these proteins in various biological processes. Hydroxy-PEG2-C2-sulfonic acid is essential for developing novel therapeutic strategies that harness the power of targeted protein degradation in disease models. -
PROTAC Linkers
Mal-PEG5-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound facilitates the conjugation of E3 ligases to target proteins, enhancing the degradation of specific proteins through the ubiquitin-proteasome pathway. Its structural attributes make it suitable for a variety of research applications focused on targeted protein degradation and therapeutic development. -
PROTAC Linker
Propargyl-PEG10-Boc is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group that facilitates the copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for efficient conjugation with azide-containing molecules. Its application is essential for advancing research in targeted protein degradation and drug discovery. -
PROTAC Linker
Lipoamido-PEG4-acid is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases, thereby promoting targeted degradation of specific proteins within cells. Its design enhances solubility and stability, making it a valuable tool in chemical biology and drug discovery applications focused on targeted protein degradation. -
PROTAC linker
N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It provides a versatile approach for researchers developing PROTACs, facilitating targeted protein degradation in various biological applications. -
PROTAC Linkers
Azido-PEG4-nitrile functions as a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide group that enables engagement in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, Azido-PEG4-nitrile can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) using dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) moieties. This versatility makes it valuable for researchers aiming to develop targeted degradation strategies in chemical biology. -
PROTAC Linkers
Mal-amido-PEG8-TFP ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of covalent bonds between proteins, thereby enabling targeted protein degradation. It is essential for researchers developing PROTACs aimed at modulating protein levels in various biological systems. -
PROTAC Linker
Ethyl-trans-4-benzylcyclohexane-1-carboxylate is a versatile PROTAC linker that plays a critical role in targeted protein degradation applications. This compound facilitates the conjugation of ligands to E3 ligase, promoting the ubiquitination and subsequent degradation of specific target proteins. Its structural features enable the development of efficient PROTAC molecules for various biological research studies, including drug discovery and mechanistic investigations of protein homeostasis. -
PROTAC Linker
Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl compounds, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN-modified molecules. Its versatile reactivity makes it a valuable tool for researchers in the development of targeted protein degradation strategies. -
PROTAC Linker
Bis-PEG3-t-butyl ester serves as a PEG-based linker specifically designed for PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound facilitates targeted protein degradation by connecting the E3 ligase to the protein of interest, thereby enabling efficient manipulation of cellular protein levels. Its structural features enhance solubility and biocompatibility, making it an essential tool for research into targeted therapies and protein regulation in various biological contexts. -
PROTAC Linker
N-(Azido-PEG3)-N-bis(PEG3-acid) is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound features an azide group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions utilizing DBCO or BCN groups. Its versatility in click chemistry enables efficient labeling and tissue targeting, making it a valuable tool for drug discovery and protein degradation studies. -
PROTAC Linkers
N-(Mal-PEG6)-N-bis(PEG3-amine) is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation. It plays a crucial role in the development of targeted protein degradation strategies, making it valuable for research in cellular signaling and disease therapeutics. -
PROTAC Linkers
m-PEG3-S-PEG1-C2-Boc is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTAC constructs, thereby improving their biological activity in target protein degradation studies. Its functionality supports research applications in targeted protein degradation, enabling researchers to explore novel therapeutic strategies in various diseases. -
PROTAC Linkers
Trityl-PEG10-azide is a PEG-based linker specifically designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Trityl-PEG10-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for chemical biology applications in PROTAC development. -
PROTAC Linker
Propargyl-PEG3-methyl ester is a PEG-based linker designed for use in the synthesis of PROTACs, utilizing its alkyne functionality. This compound can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing molecules. Its structural properties make it suitable for advancing studies in targeted protein degradation and related therapeutic applications, enhancing the versatility and efficacy of PROTAC design. -
PROTAC Linkers
Amino-PEG7-acid is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis targeting chimeras (PROTACs). This compound enhances the solubility and bioavailability of PROTACs while facilitating efficient target degradation. Its applications are particularly relevant in drug discovery and development, particularly for studies focused on targeted protein degradation and therapeutic interventions. -
PROTAC Linker
Benzyl-PEG2-amine is a polyethylene glycol (PEG)-based linker designed for proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing their specificity for ubiquitination and subsequent degradation. It is instrumental in the development of PROTACs for targeted protein depletion studies and therapeutic applications in various diseases, including cancer. -
PROTAC Linker
Phthalamide-PEG3-azide is a PEG-based linker designed for PROTAC synthesis. This compound features an azide moiety, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Its utility in these chemical reactions makes it a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linker
Propargyl-PEG2-urea-C3-triethoxysilane is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, enabling efficient conjugation. This reagent is essential for researchers developing targeted protein degradation strategies and studying protein-protein interactions. -
PROTAC Linker
Benzyl-PEG6-Ots serves as a polyethylene glycol (PEG)-based linker for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the design and development of PROTACs, enabling targeted protein degradation through recruitment of E3 ligases. It is instrumental in enhancing drug efficacy and selectivity in chemical biology and therapeutic research applications. -
PROTAC Linker
Benzyl-PEG4-Azido is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimera (PROTAC) compounds. This reagent features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. The versatility of Benzyl-PEG4-Azido makes it an essential component for researchers employing PROTAC technology to modulate protein degradation pathways in biochemical studies. -
PROTAC linker
N-methyl-N'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTAC molecules. This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing partners. Its unique chemical properties make it a valuable tool in the development of targeted protein degraders, enhancing research applications in drug discovery and cellular biology. -
PROTAC Linkers
Folate-PEG1-mal is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. By incorporating a folate moiety, it enhances cellular uptake through folate receptor-mediated endocytosis. This linker serves as a valuable tool in research applications focused on developing novel therapeutic strategies in cancer and other diseases by enabling the selective modulation of target protein levels. -
PROTAC Linker
1-(Piperidin-4-ylmethyl)piperazine is a specialized linker used in the development of PROTAC (Proteolysis Targeting Chimeras) molecules. It plays a critical role in facilitating targeted protein degradation, enabling the design of innovative therapeutic agents, including PROTAC EGFR degrader 13. This compound is essential for researchers focusing on drug discovery and protein modulation studies. -
PROTAC Linkers
t-Boc-N-amido-PEG10-Br is a PEG-based linker designed for the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enhancing the specificity and efficacy of targeted protein degradation. It is utilized in biochemical research applications aimed at manipulating protein levels and studying protein function in various cellular contexts. -
PROTAC Linker
Benzyl-PEG5-Ots is a polyethylene glycol (PEG) linker specifically designed for use in synthesizing PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the selective degradation of proteins of interest. Its efficacy makes it a valuable tool in drug discovery and development, particularly in the modulation of biological pathways through targeted protein degradation. -
PROTAC Linker
Methylamino-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation of specific proteins. Its versatility makes it suitable for applications in drug discovery and targeted protein degradation research. -
PROTAC Linker
Fmoc-NH-PEG25-CH2CH2COOH is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the selective degradation of proteins in cellular systems. It is particularly useful in the development of novel therapeutics aimed at regulating protein levels for research in cancer biology, neurodegeneration, and other disease models. -
PROTAC Linkers
m-PEG2-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) compounds. By facilitating the conjugation of E3 ligases to target proteins, this linker plays a crucial role in the selective degradation of proteins within cells. m-PEG2-MS is essential for research applications focused on targeted protein degradation to investigate protein function and develop therapeutic strategies. -
PROTAC Linker
N3-PEG8-CH2COOH is a PEG-based linker designed for PROTAC synthesis, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN group-containing compounds. This compound serves as a versatile tool in chemical biology for the development of targeted protein degradation strategies. -
PROTAC Linkers
m-PEG12-COO-propanoic acid is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTAC molecules. Its unique chemical structure facilitates the effective conjugation of target proteins, enabling targeted protein degradation through the recruitment of E3 ligases. This versatile linker is ideal for research applications focused on the development of novel therapeutics targeting specific disease-associated proteins. -
PROTAC linker
DSPE-PEG5-propargyl is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties enable efficient assembly of targeted protein degraders, making it a crucial tool for research in protein modulation and therapeutic development. -
PROTAC Linker
AZD-CO-C2-Ph-amido-Ph-azide is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties. This compound is essential for facilitating targeted protein degradation and advancing research in therapeutic development. -
PROTAC Linkers
Bis-PEG13-acid is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of targeting moieties to E3 ligase ligands, enabling targeted protein degradation. Its application is crucial in the development of new therapeutic agents that harness the ubiquitin-proteasome system for selective protein modulation in various biological research fields. -
PROTAC Linkers
Boc-PEG4-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides a flexible and hydrophilic spacer, facilitating the formation of PROTACs that target and degrade specific proteins within cellular systems. Its unique structure enhances the solubility and bioavailability of PROTAC molecules, making it a valuable tool for researchers focused on targeted protein degradation and therapeutic interventions.
