Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
tert-Butyl 4-(4-(piperazin-1-ylmethyl)piperidin-1-yl)benzoate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound is instrumental in synthesizing PROTAC AR Degrader-6, enabling targeted degradation of specific proteins. Its application is valuable in cellular studies and drug discovery involving targeted protein degradation. -
PROTAC Linkers
m-PEG6-(CH2)6-Phosphonic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its phosphonic acid moiety enhances the stability and solubility of PROTACs, facilitating efficient target degradation through the ubiquitin-proteasome system. This compound is essential for researchers focusing on the development of targeted protein degradation strategies in therapeutic applications. -
PROTAC Linker
Azido-PEG8-NHBoc is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it a versatile tool for chemical biology applications and targeted protein degradation research. -
PROTAC Linker
N-(Biotin)-N-bis(PEG1-alcohol) is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of biotin and a target protein, enabling targeted degradation through the ubiquitin-proteasome system. Its application in research supports the development of innovative therapeutic strategies for selective protein modulation in various biological contexts. -
PROTAC Linker
Piperidine-C2-piperazine-Boc is a PROTAC linker designed to facilitate the development of targeted protein degradation strategies. It plays a critical role in the synthesis of PROTACs by enabling the efficient conjugation of E3 ligase ligands and target proteins. This compound is valuable for research applications aimed at understanding protein homeostasis and developing therapeutics that leverage the cellular ubiquitin-proteasome system. -
PROTAC Linker
Aminooxy-PEG7-methane is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins and E3 ligases, promoting targeted degradation pathways in cellular systems. It is valuable for researchers developing PROTAC-based therapeutics and studying protein turnover and degradation mechanisms. -
PROTAC Linkers
PC-PEG11-Azide is a PEG-based linker designed for use in PROTAC synthesis, facilitating targeted protein degradation. It features an Azide group that enables copper-catalyzed azide-alkyne cycloaddition reactions with alkyne-containing compounds. Additionally, PC-PEG11-Azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) derivatives. This versatility makes it a valuable tool for chemical biology and drug discovery applications. -
PROTAC Linker
endo-BCN-PEG2-PFP ester serves as a PEG-based linker in the synthesis of PROTACs, functioning primarily through its BCN group. This compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, thereby enabling precise protein degradation applications. Its utility extends to various research areas, including targeted protein modulation and therapeutic development strategies. -
PROTAC Linkers
Hydroxy-PEG4-C2-nitrile is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates effective protein degradation by allowing the conjugation of target proteins to E3 ligases, thereby enhancing the cellular activity of PROTACs. Its biocompatibility and flexibility make it suitable for diverse applications in chemical biology and targeted protein degradation studies. -
PROTAC Linkers
Azido-PEG6-C1-Boc is a PEG-based linker primarily designed for use in the synthesis of PROTACs. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, as well as those containing DBCO or BCN groups. Its unique properties make it an effective tool for advancing research in targeted protein degradation and other chemical biology applications. -
PROTAC Linkers
Fmoc-NH-PEG11-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in protein-targeted degradation (PROTAC) applications. This compound features a Fmoc (Fluorenylmethyloxycarbonyl) protective group and is suitable for the synthesis of bifunctional PROTACs, facilitating the conjugation of targeting moieties to E3 ligase recruiters. It enables enhanced solubility and stability in biological environments, making it valuable for studies in targeted protein degradation and drug discovery. -
PROTAC Linker
Boc-NH-PEG7-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs by leveraging its azide group. It enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-functionalized compounds and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized molecules. This linker is essential for the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
NH2-C2-amido-C2-Boc is a selective PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of various PROTACs, enhancing the delivery of E3 ligases to target proteins. Its structural properties support the development of novel therapeutic strategies, including those targeting CDK2/9, thus broadening research avenues in oncology and other disease areas. -
PROTAC Linkers
Hydroxy-PEG11-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a hydroxyl functionality, which enhances conjugation efficiency and enables flexibility in target protein degradation applications. Hydroxy-PEG11-Boc serves as an essential building block in the development of novel therapeutics aimed at modulating protein levels in various biological contexts. -
PROTAC Linker
N-(Hydroxy-PEG3)-N-bis(PEG4-Boc) is a polyethylene glycol (PEG)-based linker designed for Proteolysis Targeting Chimeras (PROTACs) synthesis. This compound facilitates the conjugation of target proteins with E3 ligases, promoting ubiquitination and subsequent degradation. Its unique structural properties make it suitable for developing targeted therapeutics in chemical biology and drug discovery. -
PROTAC Linker
Mal-PEG3-PFP ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates efficient conjugation between the target protein and an E3 ligase, enhancing the degradation of specific proteins within cells. Researchers can leverage Mal-PEG3-PFP ester in drug discovery and development processes focusing on targeted protein degradation pathways. -
PROTAC Linker
Fluorescein-thiourea-PEG6-acid is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of targeted protein degradation systems by linking the E3 ligase recruitment component with the target protein. Its fluorescent properties enable tracking and visualization in biological assays, making it a valuable tool for chemical biology research and drug development. -
PROTAC Linker
Benzyl-PEG10-alcohol is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the efficient conjugation of targeting ligands to E3 ligase recruiters, enabling the selective degradation of target proteins. Its application is crucial in advancing research in targeted protein degradation and therapeutic development. -
PROTAC Linkers
THP-PEG7-alcohol is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient creation of PROTACs by connecting target proteins to E3 ligases, enabling targeted protein degradation. It plays a crucial role in drug development research focused on selective protein modulation and therapeutic interventions. -
PROTAC Linker
Acid-PEG6-C2-Boc is a polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound enhances solubility and stability, facilitating the development of innovative drugs that target specific proteins for degradation. Its application in PROTACs supports research in targeted therapy and protein degradation mechanisms. -
PROTAC Linker
Lenalidomide-acetylene-Br serves as a PROTAC linker, integral to the design of HJM-561, which is a selective and orally bioavailable inhibitor targeting EGFR. This compound effectively addresses Osimertinib-resistant EGFR triple mutations, making it a valuable tool for research into cancer therapies that overcome resistance mechanisms. Its application in PROTAC-mediated protein degradation offers potential for advancing targeted therapeutic strategies in oncology. -
PROTAC Linker
APN-C3-NH-Boc is an alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functional group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its versatility makes APN-C3-NH-Boc an essential reagent for researchers exploring targeted protein degradation and related biochemistry applications. -
PROTAC linker
N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN moieties, facilitating efficient conjugation in chemical biology research applications. -
PROTAC Linker
Propargyl-PEG4-CH2-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation, making it a valuable tool in chemical biology research and drug discovery efforts. -
PROTAC Linkers
Mal-C2-cyclohexylcarboxyl-hydrazide TFA is a versatile linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyl chain structure that facilitates the conjugation of target proteins and E3 ligases, enabling selective degradation of specific proteins within biological systems. It is a valuable tool for researchers exploring targeted protein degradation as a therapeutic strategy. -
PROTAC Linkers
Benzyl-PEG1-MS is a polyethylene glycol (PEG)-based linker designed specifically for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. It serves as a valuable tool in drug discovery and development, particularly in studies involving protein modulation and degradation pathways. -
PROTAC Linker
Propargyl-PEG1-THP is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an alkyne functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This linker facilitates the development of targeted protein degradation strategies, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
N-Mal-N-bis(PEG2-amine) is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This versatile linker facilitates the targeted degradation of proteins by promoting the ubiquitination process. It is essential for researchers engaged in studying protein regulation and developing novel therapeutic strategies that harness the ubiquitin-proteasome system. -
PROTAC Linker
Benzyl-PEG2-MS is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligase, promoting ubiquitination and subsequent degradation of the target. It plays a crucial role in chemical biology and drug discovery, enabling the development of novel therapeutic strategies. -
PROTAC Linker Chemical
Br-C2-PEG3-OTs is a PEG-derived PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its structural properties facilitate the effective assembly of PROTACs, enhancing their ability to degrade targeted proteins through the ubiquitin-proteasome system. This compound is suitable for applications in drug development and research focused on targeted protein degradation mechanisms. -
PROTAC Linker
2-(4-Aminophenyl)ethanol serves as a versatile PROTAC linker, crucial for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the design of targeted therapies by linking E3 ligase recruiters with protein targets, thereby promoting selective degradation of specified proteins. Its application is significant in drug discovery and development, particularly in studying protein homeostasis and the modulation of cellular processes. -
PROTAC Linker
Folate-PEG3-alkyne is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Folate-PEG3-alkyne is essential for developing targeted therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linker
m-PEG2-amido-Ph-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of stable PROTAC molecules by enabling conjugation to target proteins, thereby promoting targeted degradation via the ubiquitin-proteasome system. Its properties make it valuable for research applications in drug discovery and protein regulation studies. -
PROTAC Linkers
Mal-amido-PEG9-NH-Boc is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins for selective degradation via the ubiquitin-proteasome system. It is suitable for applications in drug development and targeted protein degradation research, providing enhanced solubility and stability in biological assays. -
PROTAC Linker
Aminooxy-PEG3-C2-NH-Boc is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an aminooxy functional group that facilitates the conjugation of PROTACs to target proteins, enabling selective degradation. Its structure enhances solubility and biocompatibility, making it suitable for a variety of chemical biology applications in targeted protein degradation research. -
PROTAC Linkers
Boc-N-PEG2-MS is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the creation of bifunctional molecules that can selectively target and degrade specific proteins within the cell. Its PEGylated structure enhances solubility and stability, making it a valuable tool for researchers investigating targeted protein degradation and related therapeutic applications. -
PROTAC Linkers
m-PEG9-phosphonic acid ethyl ester is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of proteins to E3 ligases, enabling targeted protein degradation, which is crucial for the modulation of protein levels in various biological pathways. Its application in PROTAC development makes it a valuable tool for researchers investigating novel therapeutic strategies in cancer and other diseases. -
PROTAC Linker
Azido-PEG8-propargyl is a PEG-linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group and an alkyne moiety, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. It also demonstrates reactivity through strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Azido-PEG8-propargyl is an effective tool for creating targeted protein degradation systems in chemical biology research. -
PROTAC Linkers
NH-bis-PEG3 is a polyethylene glycol (PEG) based linker designed for synthesizing PROTACs (Proteolysis Targeting Chimeras). Its bifunctional nature facilitates the effective conjugation of target ligands and E3 ligase recruiters, enhancing the intracellular degradation of specific proteins. This linker is instrumental in the development of targeted protein degradation strategies, making it valuable for various research applications in drug discovery and therapeutics. -
PROTAC Linker
Propargyl-PEG4-O-C1-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne moiety, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its design is particularly beneficial for research applications in targeted protein degradation, allowing for the precise engineering of therapeutic agents. -
PROTAC Linker
Bis-PEG9-PFP ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, enhancing their degradation via the ubiquitin-proteasome system. This compound is particularly valuable in chemical biology for developing targeted protein degradation strategies, enabling researchers to explore novel therapeutic approaches in disease models. -
PROTAC Linker
C-NH-Boc-C-Bis-(C-PEG1-Boc) is a versatile PROTAC linker known for its alkyl/ether composition. This compound facilitates the design and synthesis of PROTACs, enabling targeted protein degradation. Its unique structure enhances solubility and stability, making it suitable for a range of chemical biology applications and research into targeted therapeutics. -
PROTAC Linker
N-Methyl-N-(t-Boc)-PEG4-acid is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enhances the solubility and stability of PROTAC molecules, facilitating their assembly and improving target specificity. It is suitable for research applications focused on targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
Propanol-PEG3-CH2OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of bifunctional molecules that promote targeted protein degradation, thus enabling the study of protein function and modulation in various biological pathways. Its unique structure offers enhanced solubility and flexibility, making it suitable for diverse applications in drug discovery and chemical biology. -
PROTAC Linkers
Hexaethylene glycol dimethyl ether is a polyethylene glycol (PEG)-based linker widely utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the binding of E3 ligases and target proteins, enhancing the selective degradation of target proteins in cellular assays. Its favorable solubility and biocompatibility make it a valuable tool for researchers in the fields of drug discovery and targeted protein degradation. -
PROTAC Linker
m-PEG5-sulfonic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. This reagent is suitable for applications in chemical biology and drug discovery research, particularly in the development of novel therapeutics that exploit cellular proteolytic pathways. -
PROTAC Linker
SCO-PEG8-NHS is a PROTAC linker that facilitates the assembly of targeted protein degradation complexes. It features a polyethylene glycol (PEG) chain and includes both SCO and NHS ester functionalities, allowing for covalent attachment to amino groups. This compound is utilized for enhancing the selectivity and efficacy of proteolysis-targeting chimeras (PROTACs) by reacting with amino acid residues, especially lysine, in proteins or peptides, driving the development of novel therapeutic strategies in chemical biology research. -
PROTAC Linker
Pyrene-PEG5-alcohol is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the construction of bifunctional molecules that can target specific proteins for degradation via the ubiquitin-proteasome system. Its unique structure allows for enhanced solubility and effective protein engagement, making it suitable for various research applications in drug development and protein engineering. -
PROTAC Linkers
m-PEG5-2-methylacrylate is a polyethylene glycol (PEG) and alkyl/ester-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the construction of PROTACs by enabling effective conjugation between target proteins and E3 ligases, thereby enhancing the degradation of specific proteins in cellular contexts. It is of particular interest for researchers studying targeted protein degradation and therapeutic applications in cancer and other diseases. -
PROTAC Linker
TCO-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as an effective spacer, facilitating the coupling of E3 ligase recruiters and target proteins, thereby enhancing the degradation of specific proteins in cellular assays. Its application in PROTAC development supports investigations into targeted protein degradation and therapeutic strategies in various diseases.
