Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
Lipoamido-PEG12-acid is a PEG-derived linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This chemical reagent facilitates the construction of bifunctional molecules that can selectively target and degrade specific proteins, offering significant potential in advancing targeted protein degradation research. Its unique structure enhances solubility and bioavailability, making it an essential tool for studies involving protein manipulation and therapeutic development in cancer and other diseases. -
PROTAC Linker
N-(Amino-PEG3)-N-bis(PEG3-Boc) is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of bifunctional molecules that enhance targeted protein degradation, making it a valuable tool in protein engineering and therapeutic research. Its structural characteristics allow for improved solubility and stability, optimizing the effectiveness of PROTACs in biological applications. -
PROTAC Linkers
m-PEG12-NH-C2-acid is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enhancing targeted protein degradation. It plays a crucial role in the development of innovative therapeutic strategies for various diseases by enabling selective modulation of protein levels. -
PROTAC Linker
I-PEG5-OH is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTAC molecules. This linker facilitates the effective conjugation of ligands to E3 ligases, enabling targeted protein degradation. It is suitable for research applications focusing on the development of small-molecule-based therapies for various diseases by modulating protein levels within cellular systems. -
PROTAC Linker
Mal-PEG1-PFP ester is a versatile PROTAC linker featuring an alkyl/ether backbone. It facilitates the synthesis of PROTACs by providing a stable linkage between the target protein and the E3 ubiquitin ligase. This compound is essential for the development of targeted protein degradation strategies in chemical biology and therapeutic research. -
PROTAC Linkers
Fmoc-aminooxy-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of protein-targeting moieties to E3 ligase recruiters, enhancing the efficacy of targeted protein degradation approaches. Its application in the development of PROTACs supports research in targeted therapeutics and protein regulation mechanisms. -
PROTAC Linker
m-PEG3-S-PEG4-propargyl is a PEG-based PROTAC linker designed for synthesizing PROTACs. This compound features an alkyne functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its utility in generating bifunctional degraders makes it a valuable tool in targeted protein degradation research and drug development applications. -
PROTAC Linker
Propargyl-PEG4-S-PEG4-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs. Its alkyne functionality allows for the efficient formation of links through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing compounds. This compound is crucial for facilitating targeted protein degradation, making it an essential tool in chemical biology and drug discovery research. -
PROTAC Linker
m-PEG3-phosphonic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of ligands to E3 ligases, enabling targeted degradation of specific proteins in cellular studies. Its flexible structure enhances solubility and improves cellular uptake, making it a valuable tool for researchers investigating targeted protein degradation pathways. -
PROTAC Linkers
Benzyl-PEG5-azide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities bearing DBCO or BCN groups. The versatility and efficiency of Benzyl-PEG5-azide make it a valuable tool in the development of targeted protein degradation strategies and related chemical biology applications. -
PROTAC Linkers
Benzyl-PEG4-Boc is a PEG-based PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, enabling efficient protein degradation in cellular systems. It serves as a versatile building block in chemical biology research aimed at targeted protein modulation and therapeutic applications. -
PROTAC Linkers
THP-PEG9-OH is a polyethylene glycol (PEG) based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It serves as a key component in creating bifunctional molecules that facilitate targeted protein degradation. This compound is instrumental in researchers' efforts to harness the cellular ubiquitin-proteasome system for selective protein removal, making it valuable for studies in drug development and therapeutic applications. -
PROTAC Linker
Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted ubiquitination and degradation of specific proteins. Its application in PROTAC development supports advancements in targeted protein modulation and therapeutic strategies in various disease models. -
PROTAC Linkers
Tetraethyl butane-1,4-diylbis(phosphonate) serves as an alkyl chain-based linker for PROTAC (Proteolysis Targeting Chimeras) synthesis, facilitating targeted protein degradation. This reagent's structural features enhance the specificity and efficacy of PROTACs, making it valuable in the study of protein turnover and cellular regulation mechanisms. Its applications include developing novel therapeutics and exploring the dynamics of protein interactions within various biological contexts. -
PROTAC Linker
Azido-PEG7-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Azido-PEG7-CH2COOH can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Its versatility as a click chemistry reagent makes it valuable for targeted protein degradation studies and related research applications. -
PROTAC Linkers
N-PEG3-N'-(azide-PEG3)-Cy5 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this linker can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical biology and drug development research. Its application in PROTAC technology supports studies targeting protein degradation pathways for therapeutic discovery. -
PROTAC linker
N-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. This versatile linker enhances the design of targeted protein degradation pathways, making it valuable for research applications in drug discovery and biotechnology. -
PROTAC Linkers
t-Boc-Aminooxy-PEG7-bromide is a polyethylene glycol (PEG)-derived linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an aminooxy functional group that facilitates conjugation to target proteins and E3 ligases, thereby promoting targeted protein degradation. It is particularly useful in research applications focused on investigating protein interactions and developing novel therapeutic strategies. -
PROTAC Linkers
HS-PEG11-CH2CH2N3 is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, HS-PEG11-CH2CH2N3 can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities containing DBCO or BCN functional groups. This versatility makes it a valuable tool for advancing proteomic research and targeted protein degradation studies. -
PROTAC Linker
2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane is a PEG-based linker designed for use in the synthesis of PROTACs, which facilitates targeted protein degradation. Its azide functionality enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This versatile chemical is essential for researchers focusing on protein modulation and therapeutic applications involving PROTAC technology. -
PROTAC Linker
m-PEG5-phosphonic acid ethyl ester is a polyethylene glycol (PEG) derived PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This reagent enables the generation of novel bifunctional molecules that can specifically target and induce degradation of selected proteins, making it valuable for research in targeted protein degradation and biopharmaceutical development. Its application supports investigations in various fields, including cancer research and cellular signaling pathways. -
PROTAC Linker
Fluorescein-thiourea-PEG4-azide is a PROTAC linker designed for the synthesis of proteolysis-targeting chimera (PROTAC) molecules. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This reagent is critical for studies focused on targeted protein degradation and can facilitate the development of innovative therapeutic strategies in chemical biology and pharmacology. -
PROTAC Linkers
N-Boc-PEG12-alcohol is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of proteins within cells. Its hydrophilic nature improves solubility and bioavailability, making it a valuable tool in drug discovery and development, particularly in the field of targeted protein degradation research. -
PROTAC Linker
Propargyl-PEG4-S-PEG4-Boc is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its alkyne functional group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This reagent is essential for advancing research in targeted protein degradation and connectivity studies in chemical biology. -
PROTAC Linker
Propargyl-PEG10-amine is a PEG-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Exhibiting a primary mechanism as a click chemistry reagent, it features an alkyne group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. This functionality is crucial for generating targeted therapeutic strategies by facilitating the development of bifunctional molecules for protein degradation studies. Its versatile application makes it a valuable tool in chemical biology research. -
PROTAC linker
N-(m-PEG9)-N'-(propargyl-PEG8)-Cy5 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features an alkyne functional group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its applications are pivotal in targeted protein degradation research, facilitating the development of novel therapeutic strategies. -
PROTAC Linker
7-Iodohept-1-yne is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs), enabling targeted degradation of specific proteins. Its distinctive chemical structure supports effective conjugation to both target proteins and E3 ligases, enhancing the efficacy of PROTAC-mediated protein degradation. This compound is essential for research applications focused on cellular regulation, protein homeostasis, and drug discovery. -
PROTAC Linker
Benzyl-PEG5-MS is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted protein degradation by linking E3 ligases to ubiquitinated proteins, thus enabling selective modulation of cellular targets. Its structural properties support the development of effective PROTACs for research applications in targeted therapeutics and protein degradation studies. -
PROTAC Linker
Mal-PEG1-bromide is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound plays a crucial role in facilitating the degradation of target proteins by joining an E3 ligase and the target protein through a linker, enhancing proteolysis efficiency. Its application is vital in the development of novel therapeutic strategies for targeted protein degradation in various research fields, including cancer biology and drug discovery. -
PROTAC Linkers
N-Boc-PEG23-bromide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the attachment of target proteins to E3 ligases, enabling targeted protein degradation. Its hydrophilic properties enhance solubility and improve pharmacokinetic properties, making it suitable for diverse applications in drug discovery and development. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG4-alcohol is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the reversible conjugation of ligands to target proteins, promoting their ubiquitination and subsequent degradation through the proteasome pathway. It is an invaluable tool for researchers studying targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linker
Bis-propargyl-PEG10 is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring an alkyne moiety, this compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-functionalized molecules. Its utility in forming stable linkages enhances the development of targeted protein degradation strategies in therapeutic research applications. -
PROTAC Linker
Boc-Aminooxy-PEG3-azide is a versatile PEG-based linker utilized in the synthesis of PROTACs (proteolysis targeting chimeras). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) derivatives. Its application in PROTAC development enables efficient targeting and degradation of specific proteins, making it valuable for research in targeted protein degradation and related fields. -
PROTAC Linker
S-acetyl-PEG3-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. Its acetylated form enhances solubility and biocompatibility, making it suitable for targeted protein degradation studies. This linker facilitates the development of novel therapeutic agents by optimizing the delivery and efficacy of PROTACs in various biological applications. -
PROTAC Linkers
Tetraethyl heptane-1,7-diylbis(phosphonate) is a versatile linker utilized in the development of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound features an alkyl chain structure that facilitates the construction of bifunctional PROTACs, allowing for targeted protein degradation. It is instrumental in studies of targeted therapy and has applications in various drug discovery research efforts aimed at modulating protein levels within cellular systems. -
PROTAC Linkers
Benzyl-PEG6-t-butyl ester serves as a PEG-based linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides a flexible and stable connection between the ligand and E3 ligase components, facilitating the efficient degradation of target proteins. Its utilization in research supports the development of innovative therapeutic strategies through targeted protein degradation. -
PROTAC Linker
PEG4-bis(phosphonic acid diethyl ester) is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) applications. Its primary mechanism involves facilitating the conjugation of targeting moieties to E3 ligases, enhancing the proteolytic degradation of target proteins. This compound is instrumental in the development of innovative therapeutics through targeted protein degradation strategies, making it an essential reagent for research in drug discovery and cellular mechanisms. -
PROTAC Linker
Propargyl-PEG3-CH2COOH is a PEG-based linker specifically designed for PROTAC synthesis. This compound features an alkyne functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloadditions (CuAAc) with azide-containing molecules. Its key biological activity facilitates the development of targeted protein degradation strategies, making it suitable for various chemical biology applications in the study of protein regulation and therapeutic interventions. -
PROTAC Linker
3,4-Dibromo-Mal-PEG2-amine is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of targeted protein degradation strategies by linking E3 ligases to substrates. Its application is crucial in studies focusing on protein modulation in various disease contexts, including cancer and neurodegenerative disorders. -
PROTAC Linker
Pyrene-amido-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). It features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have DBCO or BCN functionalities, making it a versatile tool for targeted protein degradation studies. -
PROTAC Linkers
DBCO-PEG1-amine is a polyethylene glycol (PEG) based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) functional group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG1-amine enhances the modularity and functionality of PROTACs, making it instrumental in targeted protein degradation research and therapeutic applications. -
PROTAC Linkers
t-Boc-Amido-PEG23-Amine is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of targeting and warhead moieties to enhance the selective degradation of proteins. Its hydrophilic nature aids in improving solubility and bioavailability, making it an essential tool for researchers in drug discovery and protein regulation studies. -
PROTAC Linker
Fluorescein-PEG5-acid is a polyethylene glycol (PEG) linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that can engage target proteins for ubiquitination and degradation. Its fluorescent properties also enable monitoring and tracking of PROTAC activity in biological assays, making it a valuable tool for research focused on targeted protein degradation and cellular processes. -
PROTAC Linker
Mal-NH-PEG2-CH2CH2COOPFP ester is a PEG-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the covalent attachment of target proteins to E3 ligases, enabling targeted protein degradation. Its application is crucial in research focused on therapeutic interventions that harness the ubiquitin-proteasome system for modulating protein levels in various disease contexts. -
PROTAC Linkers
2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound features an azide functional group which allows for versatile click chemistry reactions, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It is instrumental in the synthesis of targeted protein degraders, facilitating effective drug development and biological research studies. -
PROTAC Linker
PEG3-bis-(ethyl phosphonate) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting selective degradation of specific proteins through the ubiquitin-proteasome pathway. Its application extends to various research fields, including drug discovery and functional proteomics, aiding in the development of targeted therapies. -
PROTAC Linker
Azido-PEG5-S-methyl ethanethioate functions as a versatile linker in the synthesis of PROTACs, utilizing its PEG-based structure to enhance solubility and stability. This reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne moieties and entities containing DBCO or BCN groups, respectively. Its utility in PROTAC development makes it an essential tool for researchers investigating targeted protein degradation mechanisms. -
PROTAC Linker
HO-CONH-C3-PEG3-NH2 is a versatile linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This reagent enhances the stability and solubility of PROTACs, facilitating the targeted degradation of specific proteins. Its application is pivotal in studies focused on protein homeostasis, cancer therapeutics, and the development of novel drug modalities. -
PROTAC Linker
DNP-NH-PEG2-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enhances cellular permeability and stability of PROTAC molecules. Its application facilitates the targeted degradation of specific proteins, supporting research in protein interaction and therapeutic development. -
PROTAC Linkers
m-PEG5-nitrile is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that engage E3 ubiquitin ligases, enhancing targeted protein degradation. Its use is critical in drug development, particularly in studies focused on innovative therapeutic strategies for the modulation of protein levels in various biological contexts.
