Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
THP-PEG7-alcohol is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient creation of PROTACs by connecting target proteins to E3 ligases, enabling targeted protein degradation. It plays a crucial role in drug development research focused on selective protein modulation and therapeutic interventions. -
PROTAC Linker
Acid-PEG6-C2-Boc is a polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound enhances solubility and stability, facilitating the development of innovative drugs that target specific proteins for degradation. Its application in PROTACs supports research in targeted therapy and protein degradation mechanisms. -
PROTAC Linker
Lenalidomide-acetylene-Br serves as a PROTAC linker, integral to the design of HJM-561, which is a selective and orally bioavailable inhibitor targeting EGFR. This compound effectively addresses Osimertinib-resistant EGFR triple mutations, making it a valuable tool for research into cancer therapies that overcome resistance mechanisms. Its application in PROTAC-mediated protein degradation offers potential for advancing targeted therapeutic strategies in oncology. -
PROTAC Linker
APN-C3-NH-Boc is an alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functional group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its versatility makes APN-C3-NH-Boc an essential reagent for researchers exploring targeted protein degradation and related biochemistry applications. -
PROTAC linker
N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN moieties, facilitating efficient conjugation in chemical biology research applications. -
PROTAC Linker
Propargyl-PEG4-CH2-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation, making it a valuable tool in chemical biology research and drug discovery efforts. -
PROTAC Linkers
Mal-C2-cyclohexylcarboxyl-hydrazide TFA is a versatile linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyl chain structure that facilitates the conjugation of target proteins and E3 ligases, enabling selective degradation of specific proteins within biological systems. It is a valuable tool for researchers exploring targeted protein degradation as a therapeutic strategy. -
PROTAC Linkers
Benzyl-PEG1-MS is a polyethylene glycol (PEG)-based linker designed specifically for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. It serves as a valuable tool in drug discovery and development, particularly in studies involving protein modulation and degradation pathways. -
PROTAC Linker
Propargyl-PEG1-THP is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an alkyne functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This linker facilitates the development of targeted protein degradation strategies, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
N-Mal-N-bis(PEG2-amine) is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This versatile linker facilitates the targeted degradation of proteins by promoting the ubiquitination process. It is essential for researchers engaged in studying protein regulation and developing novel therapeutic strategies that harness the ubiquitin-proteasome system. -
PROTAC Linker
Benzyl-PEG2-MS is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligase, promoting ubiquitination and subsequent degradation of the target. It plays a crucial role in chemical biology and drug discovery, enabling the development of novel therapeutic strategies. -
PROTAC Linker Chemical
Br-C2-PEG3-OTs is a PEG-derived PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its structural properties facilitate the effective assembly of PROTACs, enhancing their ability to degrade targeted proteins through the ubiquitin-proteasome system. This compound is suitable for applications in drug development and research focused on targeted protein degradation mechanisms. -
PROTAC Linker
2-(4-Aminophenyl)ethanol serves as a versatile PROTAC linker, crucial for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the design of targeted therapies by linking E3 ligase recruiters with protein targets, thereby promoting selective degradation of specified proteins. Its application is significant in drug discovery and development, particularly in studying protein homeostasis and the modulation of cellular processes. -
PROTAC Linker
Folate-PEG3-alkyne is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Folate-PEG3-alkyne is essential for developing targeted therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linker
m-PEG2-amido-Ph-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of stable PROTAC molecules by enabling conjugation to target proteins, thereby promoting targeted degradation via the ubiquitin-proteasome system. Its properties make it valuable for research applications in drug discovery and protein regulation studies. -
PROTAC Linkers
Mal-amido-PEG9-NH-Boc is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins for selective degradation via the ubiquitin-proteasome system. It is suitable for applications in drug development and targeted protein degradation research, providing enhanced solubility and stability in biological assays. -
PROTAC Linker
Aminooxy-PEG3-C2-NH-Boc is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an aminooxy functional group that facilitates the conjugation of PROTACs to target proteins, enabling selective degradation. Its structure enhances solubility and biocompatibility, making it suitable for a variety of chemical biology applications in targeted protein degradation research. -
PROTAC Linkers
Boc-N-PEG2-MS is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the creation of bifunctional molecules that can selectively target and degrade specific proteins within the cell. Its PEGylated structure enhances solubility and stability, making it a valuable tool for researchers investigating targeted protein degradation and related therapeutic applications. -
PROTAC Linkers
m-PEG9-phosphonic acid ethyl ester is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of proteins to E3 ligases, enabling targeted protein degradation, which is crucial for the modulation of protein levels in various biological pathways. Its application in PROTAC development makes it a valuable tool for researchers investigating novel therapeutic strategies in cancer and other diseases. -
PROTAC Linker
Azido-PEG8-propargyl is a PEG-linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group and an alkyne moiety, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. It also demonstrates reactivity through strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Azido-PEG8-propargyl is an effective tool for creating targeted protein degradation systems in chemical biology research. -
PROTAC Linkers
NH-bis-PEG3 is a polyethylene glycol (PEG) based linker designed for synthesizing PROTACs (Proteolysis Targeting Chimeras). Its bifunctional nature facilitates the effective conjugation of target ligands and E3 ligase recruiters, enhancing the intracellular degradation of specific proteins. This linker is instrumental in the development of targeted protein degradation strategies, making it valuable for various research applications in drug discovery and therapeutics. -
PROTAC Linker
Propargyl-PEG4-O-C1-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne moiety, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its design is particularly beneficial for research applications in targeted protein degradation, allowing for the precise engineering of therapeutic agents. -
PROTAC Linker
Bis-PEG9-PFP ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, enhancing their degradation via the ubiquitin-proteasome system. This compound is particularly valuable in chemical biology for developing targeted protein degradation strategies, enabling researchers to explore novel therapeutic approaches in disease models. -
PROTAC Linker
C-NH-Boc-C-Bis-(C-PEG1-Boc) is a versatile PROTAC linker known for its alkyl/ether composition. This compound facilitates the design and synthesis of PROTACs, enabling targeted protein degradation. Its unique structure enhances solubility and stability, making it suitable for a range of chemical biology applications and research into targeted therapeutics. -
PROTAC Linker
N-Methyl-N-(t-Boc)-PEG4-acid is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enhances the solubility and stability of PROTAC molecules, facilitating their assembly and improving target specificity. It is suitable for research applications focused on targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
Propanol-PEG3-CH2OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of bifunctional molecules that promote targeted protein degradation, thus enabling the study of protein function and modulation in various biological pathways. Its unique structure offers enhanced solubility and flexibility, making it suitable for diverse applications in drug discovery and chemical biology. -
PROTAC Linkers
Hexaethylene glycol dimethyl ether is a polyethylene glycol (PEG)-based linker widely utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the binding of E3 ligases and target proteins, enhancing the selective degradation of target proteins in cellular assays. Its favorable solubility and biocompatibility make it a valuable tool for researchers in the fields of drug discovery and targeted protein degradation. -
PROTAC Linker
m-PEG5-sulfonic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. This reagent is suitable for applications in chemical biology and drug discovery research, particularly in the development of novel therapeutics that exploit cellular proteolytic pathways. -
PROTAC Linker
SCO-PEG8-NHS is a PROTAC linker that facilitates the assembly of targeted protein degradation complexes. It features a polyethylene glycol (PEG) chain and includes both SCO and NHS ester functionalities, allowing for covalent attachment to amino groups. This compound is utilized for enhancing the selectivity and efficacy of proteolysis-targeting chimeras (PROTACs) by reacting with amino acid residues, especially lysine, in proteins or peptides, driving the development of novel therapeutic strategies in chemical biology research. -
PROTAC Linker
Pyrene-PEG5-alcohol is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the construction of bifunctional molecules that can target specific proteins for degradation via the ubiquitin-proteasome system. Its unique structure allows for enhanced solubility and effective protein engagement, making it suitable for various research applications in drug development and protein engineering. -
PROTAC Linkers
m-PEG5-2-methylacrylate is a polyethylene glycol (PEG) and alkyl/ester-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the construction of PROTACs by enabling effective conjugation between target proteins and E3 ligases, thereby enhancing the degradation of specific proteins in cellular contexts. It is of particular interest for researchers studying targeted protein degradation and therapeutic applications in cancer and other diseases. -
PROTAC Linker
TCO-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as an effective spacer, facilitating the coupling of E3 ligase recruiters and target proteins, thereby enhancing the degradation of specific proteins in cellular assays. Its application in PROTAC development supports investigations into targeted protein degradation and therapeutic strategies in various diseases. -
PROTAC Linkers
Lipoamido-PEG12-acid is a PEG-derived linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This chemical reagent facilitates the construction of bifunctional molecules that can selectively target and degrade specific proteins, offering significant potential in advancing targeted protein degradation research. Its unique structure enhances solubility and bioavailability, making it an essential tool for studies involving protein manipulation and therapeutic development in cancer and other diseases. -
PROTAC Linker
N-(Amino-PEG3)-N-bis(PEG3-Boc) is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of bifunctional molecules that enhance targeted protein degradation, making it a valuable tool in protein engineering and therapeutic research. Its structural characteristics allow for improved solubility and stability, optimizing the effectiveness of PROTACs in biological applications. -
PROTAC Linkers
m-PEG12-NH-C2-acid is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enhancing targeted protein degradation. It plays a crucial role in the development of innovative therapeutic strategies for various diseases by enabling selective modulation of protein levels. -
PROTAC Linker
I-PEG5-OH is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTAC molecules. This linker facilitates the effective conjugation of ligands to E3 ligases, enabling targeted protein degradation. It is suitable for research applications focusing on the development of small-molecule-based therapies for various diseases by modulating protein levels within cellular systems. -
PROTAC Linker
Mal-PEG1-PFP ester is a versatile PROTAC linker featuring an alkyl/ether backbone. It facilitates the synthesis of PROTACs by providing a stable linkage between the target protein and the E3 ubiquitin ligase. This compound is essential for the development of targeted protein degradation strategies in chemical biology and therapeutic research. -
PROTAC Linkers
Fmoc-aminooxy-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of protein-targeting moieties to E3 ligase recruiters, enhancing the efficacy of targeted protein degradation approaches. Its application in the development of PROTACs supports research in targeted therapeutics and protein regulation mechanisms. -
PROTAC Linker
m-PEG3-S-PEG4-propargyl is a PEG-based PROTAC linker designed for synthesizing PROTACs. This compound features an alkyne functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its utility in generating bifunctional degraders makes it a valuable tool in targeted protein degradation research and drug development applications. -
PROTAC Linker
Propargyl-PEG4-S-PEG4-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs. Its alkyne functionality allows for the efficient formation of links through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing compounds. This compound is crucial for facilitating targeted protein degradation, making it an essential tool in chemical biology and drug discovery research. -
PROTAC Linker
m-PEG3-phosphonic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of ligands to E3 ligases, enabling targeted degradation of specific proteins in cellular studies. Its flexible structure enhances solubility and improves cellular uptake, making it a valuable tool for researchers investigating targeted protein degradation pathways. -
PROTAC Linkers
Benzyl-PEG5-azide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities bearing DBCO or BCN groups. The versatility and efficiency of Benzyl-PEG5-azide make it a valuable tool in the development of targeted protein degradation strategies and related chemical biology applications. -
PROTAC Linkers
Benzyl-PEG4-Boc is a PEG-based PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, enabling efficient protein degradation in cellular systems. It serves as a versatile building block in chemical biology research aimed at targeted protein modulation and therapeutic applications. -
PROTAC Linkers
THP-PEG9-OH is a polyethylene glycol (PEG) based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It serves as a key component in creating bifunctional molecules that facilitate targeted protein degradation. This compound is instrumental in researchers' efforts to harness the cellular ubiquitin-proteasome system for selective protein removal, making it valuable for studies in drug development and therapeutic applications. -
PROTAC Linker
Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted ubiquitination and degradation of specific proteins. Its application in PROTAC development supports advancements in targeted protein modulation and therapeutic strategies in various disease models. -
PROTAC Linkers
Tetraethyl butane-1,4-diylbis(phosphonate) serves as an alkyl chain-based linker for PROTAC (Proteolysis Targeting Chimeras) synthesis, facilitating targeted protein degradation. This reagent's structural features enhance the specificity and efficacy of PROTACs, making it valuable in the study of protein turnover and cellular regulation mechanisms. Its applications include developing novel therapeutics and exploring the dynamics of protein interactions within various biological contexts. -
PROTAC Linker
Azido-PEG7-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Azido-PEG7-CH2COOH can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Its versatility as a click chemistry reagent makes it valuable for targeted protein degradation studies and related research applications. -
PROTAC Linkers
N-PEG3-N'-(azide-PEG3)-Cy5 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this linker can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical biology and drug development research. Its application in PROTAC technology supports studies targeting protein degradation pathways for therapeutic discovery. -
PROTAC linker
N-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. This versatile linker enhances the design of targeted protein degradation pathways, making it valuable for research applications in drug discovery and biotechnology. -
PROTAC Linkers
t-Boc-Aminooxy-PEG7-bromide is a polyethylene glycol (PEG)-derived linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an aminooxy functional group that facilitates conjugation to target proteins and E3 ligases, thereby promoting targeted protein degradation. It is particularly useful in research applications focused on investigating protein interactions and developing novel therapeutic strategies.
