Catalog No.
Product Name
Application
Product Information
Citations
-
PROTAC linker
N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It provides a versatile approach for researchers developing PROTACs, facilitating targeted protein degradation in various biological applications. -
PROTAC Linkers
Azido-PEG4-nitrile functions as a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide group that enables engagement in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, Azido-PEG4-nitrile can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) using dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) moieties. This versatility makes it valuable for researchers aiming to develop targeted degradation strategies in chemical biology. -
PROTAC Linkers
Mal-amido-PEG8-TFP ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of covalent bonds between proteins, thereby enabling targeted protein degradation. It is essential for researchers developing PROTACs aimed at modulating protein levels in various biological systems. -
PROTAC Linker
Ethyl-trans-4-benzylcyclohexane-1-carboxylate is a versatile PROTAC linker that plays a critical role in targeted protein degradation applications. This compound facilitates the conjugation of ligands to E3 ligase, promoting the ubiquitination and subsequent degradation of specific target proteins. Its structural features enable the development of efficient PROTAC molecules for various biological research studies, including drug discovery and mechanistic investigations of protein homeostasis. -
PROTAC Linker
Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl compounds, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN-modified molecules. Its versatile reactivity makes it a valuable tool for researchers in the development of targeted protein degradation strategies. -
PROTAC Linker
Bis-PEG3-t-butyl ester serves as a PEG-based linker specifically designed for PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound facilitates targeted protein degradation by connecting the E3 ligase to the protein of interest, thereby enabling efficient manipulation of cellular protein levels. Its structural features enhance solubility and biocompatibility, making it an essential tool for research into targeted therapies and protein regulation in various biological contexts. -
PROTAC Linker
N-(Azido-PEG3)-N-bis(PEG3-acid) is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound features an azide group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions utilizing DBCO or BCN groups. Its versatility in click chemistry enables efficient labeling and tissue targeting, making it a valuable tool for drug discovery and protein degradation studies. -
PROTAC Linkers
N-(Mal-PEG6)-N-bis(PEG3-amine) is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation. It plays a crucial role in the development of targeted protein degradation strategies, making it valuable for research in cellular signaling and disease therapeutics. -
PROTAC Linkers
m-PEG3-S-PEG1-C2-Boc is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTAC constructs, thereby improving their biological activity in target protein degradation studies. Its functionality supports research applications in targeted protein degradation, enabling researchers to explore novel therapeutic strategies in various diseases. -
PROTAC Linkers
Trityl-PEG10-azide is a PEG-based linker specifically designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Trityl-PEG10-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for chemical biology applications in PROTAC development. -
PROTAC Linker
Propargyl-PEG3-methyl ester is a PEG-based linker designed for use in the synthesis of PROTACs, utilizing its alkyne functionality. This compound can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing molecules. Its structural properties make it suitable for advancing studies in targeted protein degradation and related therapeutic applications, enhancing the versatility and efficacy of PROTAC design. -
PROTAC Linkers
Amino-PEG7-acid is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis targeting chimeras (PROTACs). This compound enhances the solubility and bioavailability of PROTACs while facilitating efficient target degradation. Its applications are particularly relevant in drug discovery and development, particularly for studies focused on targeted protein degradation and therapeutic interventions. -
PROTAC Linker
Benzyl-PEG2-amine is a polyethylene glycol (PEG)-based linker designed for proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing their specificity for ubiquitination and subsequent degradation. It is instrumental in the development of PROTACs for targeted protein depletion studies and therapeutic applications in various diseases, including cancer. -
PROTAC Linker
Phthalamide-PEG3-azide is a PEG-based linker designed for PROTAC synthesis. This compound features an azide moiety, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Its utility in these chemical reactions makes it a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linker
Propargyl-PEG2-urea-C3-triethoxysilane is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, enabling efficient conjugation. This reagent is essential for researchers developing targeted protein degradation strategies and studying protein-protein interactions. -
PROTAC Linker
Benzyl-PEG6-Ots serves as a polyethylene glycol (PEG)-based linker for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the design and development of PROTACs, enabling targeted protein degradation through recruitment of E3 ligases. It is instrumental in enhancing drug efficacy and selectivity in chemical biology and therapeutic research applications. -
PROTAC Linker
Benzyl-PEG4-Azido is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimera (PROTAC) compounds. This reagent features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. The versatility of Benzyl-PEG4-Azido makes it an essential component for researchers employing PROTAC technology to modulate protein degradation pathways in biochemical studies. -
PROTAC linker
N-methyl-N'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTAC molecules. This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing partners. Its unique chemical properties make it a valuable tool in the development of targeted protein degraders, enhancing research applications in drug discovery and cellular biology. -
PROTAC Linkers
Folate-PEG1-mal is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. By incorporating a folate moiety, it enhances cellular uptake through folate receptor-mediated endocytosis. This linker serves as a valuable tool in research applications focused on developing novel therapeutic strategies in cancer and other diseases by enabling the selective modulation of target protein levels. -
PROTAC Linker
1-(Piperidin-4-ylmethyl)piperazine is a specialized linker used in the development of PROTAC (Proteolysis Targeting Chimeras) molecules. It plays a critical role in facilitating targeted protein degradation, enabling the design of innovative therapeutic agents, including PROTAC EGFR degrader 13. This compound is essential for researchers focusing on drug discovery and protein modulation studies. -
PROTAC Linkers
t-Boc-N-amido-PEG10-Br is a PEG-based linker designed for the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enhancing the specificity and efficacy of targeted protein degradation. It is utilized in biochemical research applications aimed at manipulating protein levels and studying protein function in various cellular contexts. -
PROTAC Linker
Benzyl-PEG5-Ots is a polyethylene glycol (PEG) linker specifically designed for use in synthesizing PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the selective degradation of proteins of interest. Its efficacy makes it a valuable tool in drug discovery and development, particularly in the modulation of biological pathways through targeted protein degradation. -
PROTAC Linker
Methylamino-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation of specific proteins. Its versatility makes it suitable for applications in drug discovery and targeted protein degradation research. -
PROTAC Linker
Fmoc-NH-PEG25-CH2CH2COOH is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the selective degradation of proteins in cellular systems. It is particularly useful in the development of novel therapeutics aimed at regulating protein levels for research in cancer biology, neurodegeneration, and other disease models. -
PROTAC Linkers
m-PEG2-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) compounds. By facilitating the conjugation of E3 ligases to target proteins, this linker plays a crucial role in the selective degradation of proteins within cells. m-PEG2-MS is essential for research applications focused on targeted protein degradation to investigate protein function and develop therapeutic strategies. -
PROTAC Linker
N3-PEG8-CH2COOH is a PEG-based linker designed for PROTAC synthesis, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN group-containing compounds. This compound serves as a versatile tool in chemical biology for the development of targeted protein degradation strategies. -
PROTAC Linkers
m-PEG12-COO-propanoic acid is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTAC molecules. Its unique chemical structure facilitates the effective conjugation of target proteins, enabling targeted protein degradation through the recruitment of E3 ligases. This versatile linker is ideal for research applications focused on the development of novel therapeutics targeting specific disease-associated proteins. -
PROTAC linker
DSPE-PEG5-propargyl is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties enable efficient assembly of targeted protein degraders, making it a crucial tool for research in protein modulation and therapeutic development. -
PROTAC Linker
AZD-CO-C2-Ph-amido-Ph-azide is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties. This compound is essential for facilitating targeted protein degradation and advancing research in therapeutic development. -
PROTAC Linkers
Bis-PEG13-acid is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of targeting moieties to E3 ligase ligands, enabling targeted protein degradation. Its application is crucial in the development of new therapeutic agents that harness the ubiquitin-proteasome system for selective protein modulation in various biological research fields. -
PROTAC Linkers
Boc-PEG4-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides a flexible and hydrophilic spacer, facilitating the formation of PROTACs that target and degrade specific proteins within cellular systems. Its unique structure enhances the solubility and bioavailability of PROTAC molecules, making it a valuable tool for researchers focused on targeted protein degradation and therapeutic interventions. -
PROTAC Linker
PEG4-sulfonic acid is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of PROTACs, enhancing their efficacy in targeting and degrading specific proteins within cellular environments. PEG4-sulfonic acid's unique structure provides solubility and stability, making it suitable for various biochemical applications in drug discovery and therapeutic research. -
ADC/PROTAC Linker
Propargyl-PEG5-azide is a PEG-based linker designed for antibody-drug conjugate (ADC) and PROTAC applications. This compound features an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Propargyl-PEG5-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile and effective tool for chemical biologists developing targeted therapeutics. -
PROTAC Linker
N-(Boc-PEG3)-N-bis(PEG2-alcohol) is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of heterobifunctional molecules that promote targeted protein degradation. Its unique structure enhances solubility and bioavailability, making it suitable for various applications in chemical biology and drug development. -
PROTAC Linkers
Phthalimide-PEG3-C2-OTs is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a phthalimide moiety connected by a polyethylene glycol (PEG) chain, enabling effective linkage between ligands that bind to E3 ubiquitin ligases and target proteins. By harnessing the ubiquitin-proteasome system, PROTACs equipped with Phthalimide-PEG3-C2-OTs promote selective degradation of specific proteins, making it a valuable tool for targeted protein modulation in various biological research applications. -
PROTAC Linker
BCN-PEG4-acid is a PEG-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring a bicyclononyne (BCN) moiety, this compound is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its use facilitates the development of targeted protein degradation strategies, enhancing the versatility and effectiveness of drug discovery research. -
PROTAC Linkers
Mal-PEG12-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances cellular permeability and stability, facilitating the efficient targeting and degradation of specific proteins within cells. Its application in the development of PROTACs paves the way for innovative research in targeted protein degradation and the modulation of cellular pathways. -
PROTAC Linker
N-Biotin-N-bis(PEG4-acid) serves as a PEG-based linker specifically designed for the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates efficient conjugation of target proteins to E3 ligases, promoting selective degradation pathways. It is applicable in the synthesis of novel PROTAC molecules aimed at elucidating protein interactions and studying cellular pathways. -
PROTAC Linker
S-Acetyl-PEG8-OH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the development of novel biopharmaceuticals by enabling targeted protein degradation. Its biocompatibility and flexibility make it suitable for research applications in drug discovery and development, particularly in the study of protein interactions and turnover. -
PROTAC Linker
Azido-PEG3-Sulfone-PEG4-acid is a PEG-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group that enables its application in click chemistry, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when combined with DBCO or BCN groups, making it a versatile tool in chemical biology and drug development research. -
PROTAC Linker
Lipoamido-PEG2-OH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of covalent linkages between target proteins and E3 ligases, enhancing the selective degradation of specific proteins within cellular systems. Lipoamido-PEG2-OH serves as a crucial tool in the development of targeted therapeutic strategies and the exploration of protein functions in various biological research applications. -
PROTAC Linkers
TCO-PEG3-amide-C3-triethoxysilane is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. Its triethoxysilane group facilitates conjugation to various surfaces or substrates, enhancing the development of targeted protein degradation strategies. This compound serves as a crucial tool for researchers investigating targeted therapies and protein modulation. -
PROTAC Linkers
m-PEG6-2-methylacrylate is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables effective coupling of target proteins to E3 ligases, facilitating targeted protein degradation. Its unique structural properties make it suitable for various applications in chemical biology and drug development. -
PROTAC Linker
Ald-Ph-PEG4-NH-Boc is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTAC constructs, enabling effective targeting of specific proteins for degradation. Its unique structure provides versatility in the development of novel therapeutic agents for various research applications in targeted protein degradation. -
PROTAC Linkers
Boc-PEG1-Boc is a bifunctional linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This alkyl/ether-based compound facilitates the conjugation of target proteins with E3 ligases, enabling the targeted degradation of specific proteins within cellular contexts. Its application is essential for researchers developing novel PROTACs for therapeutic interventions in various diseases, including cancer and neurodegenerative disorders. -
PROTAC Linkers
Sulfone-Bis-PEG4-acid is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the assembly of bifunctional molecules that promote targeted protein degradation, making it valuable in biological research and drug discovery applications. Its unique structural properties enhance solubility and optimize the pharmacokinetic profiles of PROTACs. -
PROTAC Linker
Boc-PEG4-phosphonic acid ethyl ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of a target protein ligand to an E3 ligase ligand, enabling selective protein degradation. Its unique structure enhances solubility and stability, making it a valuable tool in the development of targeted protein degradation research. -
PROTAC Linker
m-PEG8-succinimidyl carbonate is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances solubility and stability, facilitating the effective assembly of targeted protein degradation systems. Its application in chemical biology and drug discovery research allows for the selective modulation of protein levels, providing valuable insights into protein function and potential therapeutic interventions. -
PROTAC Linkers
Diethyl 12-bromododecylphosphonate is a phosphonate compound designed as a versatile linker for PROTAC (PROteolysis TArgeting Chimeras) synthesis. It facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of specific proteins through the ubiquitin-proteasome pathway. This compound is essential for researchers developing novel PROTACs to study protein regulation and degradation in various biological systems. -
PROTAC Linkers
Tri(t-butoxycarbonylethoxymethyl) ethanol is a versatile PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This alkyl/ether-based compound enhances the modulation of target proteins by providing optimal spatial arrangements for target engagement and ubiquitination. Its application is critical in advancing drug discovery and development in the fields of cancer therapy and cellular regulation.
