Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
Bis-PEG3-sulfonic acid is a PEG-based PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the solubility and versatility of PROTACs, allowing for improved degradation of target proteins in cellular systems. Its application in drug discovery makes it a valuable tool for researchers focusing on targeted protein degradation and the development of novel therapeutic agents. -
PROTAC Linker
Triethylene glycol monodecyl ether serves as a PEG-based linker in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of targeted protein degradation systems by linking E3 ligase and target proteins effectively. It is essential for researchers investigating novel therapeutic strategies that employ targeted protein modulation. -
PROTAC Linker
Azido-PEG3-S-PEG4-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs, targeting the degradation of specific proteins. This versatile reagent features an azide and an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules. Its applications include facilitating targeted protein degradation and the development of novel therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linkers
Amino-PEG24-alcohol is a PEG-based linker specifically designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the formation of robust and effective PROTACs by providing a flexible linker that enhances target engagement and proteasomal degradation. It is applicable in various research studies involving targeted protein degradation and the development of novel therapeutic strategies. -
PROTAC Linkers
Boc-Gly-amido-C-PEG3-C3-amine is a PEG-based linker designed for the development of PROTAC (Proteolysis Targeting Chimeras) molecules. Its amido and PEG3 components enhance solubility and facilitate the effective conjugation of the target protein and E3 ligase. This linker is essential for constructing complex PROTACs, enabling the targeted degradation of specific proteins in biochemical research and therapeutic applications. -
PROTAC Linkers
MS-PEG4-t-butyl ester is a PEG-derived linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of proteins in cellular studies. Its unique structure promotes solubility and versatility in the development of targeted protein degradation research applications. -
PROTAC Linker
Propargyl-PEG6-N3 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. Propargyl-PEG6-N3 is an essential tool for researchers focused on advancing targeted protein degradation studies. -
PROTAC Linkers
TCO-PEG3-TCO is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and solubility of PROTACs while effectively linking E3 ligases to target proteins, thereby promoting targeted protein degradation. Its applications are vital in research focused on elucidating protein functions and developing novel therapeutic strategies in cancer and other diseases. -
PROTACT Linker
N-(7-Aminoheptyl)-2-bromoacetamide functions as a linker in the PROTAC (proteolysis-targeting chimera) technology. This compound facilitates the synthesis of PROTAC molecules, which are designed to selectively target and degrade specific proteins within cells. Its versatility makes it an essential component in research applications focused on targeted protein degradation and therapeutic development. -
PROTAC linker
N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride functions as a PEG-based PROTAC linker, facilitating the synthesis of PROTACs. This compound features an azide functional group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a versatile tool for chemical biology applications in targeted protein degradation studies. -
PROTAC Linker
S-acetyl-PEG6-Tos serves as a PEG-based linker for the development of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby enabling selective protein degradation. It is designed to enhance the pharmacokinetic properties and solubility of PROTACs, making it a valuable tool in targeted protein degradation research and therapeutic development. -
PROTAC Linkers
Biotin-PEG7-thiourea is a versatile PROTAC linker featuring a biotin moiety and a polyethylene glycol (PEG) chain. It facilitates the assembly of PROTACs by linking target proteins to E3 ubiquitin ligases, enabling targeted protein degradation. This reagent is ideal for applications in drug discovery and research focused on modulating cellular protein levels through proteolysis. -
PROTAC Linkers
DBCO-PEG2-amine is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a dibenzocyclooctyne (DBCO) moiety that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG2-amine facilitates the development of PROTACs for targeted protein degradation applications, making it valuable in chemical biology and therapeutic research. -
PROTAC Linkers
Mal-amido-PEG10-acid is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by connecting ligands to E3 ligase, enhancing the efficacy of targeted protein degradation in biochemical research. It is an essential tool for researchers investigating protein regulation and potential therapeutic interventions. -
PROTAC Linker
Azido-PEG8-TFP ester is a PEG-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functionality that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool in chemical biology for targeted protein degradation studies. -
PROTAC Linker
3-(2-(4-Methylpiperazin-1-yl)ethyl)azetidin-3-ol serves as a versatile linker in PROTAC applications, specifically designed for the targeted degradation of BRD4, exemplified by the BRD4 PROTAC BD-9136. This compound facilitates the formation of bifunctional molecules that promote the ubiquitination and subsequent proteasomal degradation of BRD4. Its structural features enable efficient engagement with target proteins, making it valuable in research focused on protein regulation and therapeutic discovery. -
PROTAC Linker
Bis-PEG6-t-butyl ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target ligands to E3 ubiquitin ligases, enabling the selective degradation of proteins of interest. Its incorporation into PROTAC structures enhances solubility and stability, making it a valuable tool for researchers studying targeted protein degradation mechanisms in cellular and molecular biology. -
PROTAC Linkers
Benzenedimethanamine-diethylamine is a PROTAC linker featuring an alkyl chain structure. This compound facilitates the development of PROTACs by connecting the target protein to E3 ligases, thereby influencing proteasomal degradation pathways. It is utilized in chemical biology research and drug discovery to enhance the specificity and efficacy of targeted protein degradation strategies. -
PROTAC Linker
Lipoamido-PEG3-OH is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the creation of stable PROTAC molecules that engage target proteins for selective degradation through the ubiquitin-proteasome pathway. Additionally, Lipoamido-PEG3-OH is instrumental in developing dendronized gold nanoparticle (AuNP)-based drug delivery systems, enhancing the efficacy and stability of therapeutic agents. -
PROTAC Linkers
Mal-PEG3-Boc is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound effectively enhances the solubility and stability of drug conjugates while maintaining the functional integrity required for targeted protein degradation. It is ideal for researchers developing innovative PROTAC-based therapeutic strategies. -
PROTAC Linker
MS-PEG1-THP is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of target proteins to E3 ligases, enhancing the targeted degradation of proteins of interest. MS-PEG1-THP is ideal for researchers aiming to develop PROTACs for applications in drug discovery and the study of protein regulation mechanisms. -
PROTAC Linker
Chloroacetamido-PEG4-NHS ester is a polyethylene glycol (PEG)-derived PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of covalent bonds with target proteins through the NHS ester moiety, enhancing the specificity and efficacy of the resulting PROTAC. It is employed in various research applications, including targeted protein degradation studies and drug discovery initiatives. -
PROTAC Linker
m-PEG8-(CH2)12-phosphonic acid ethyl ester serves as a PEG-based linker for PROTAC synthesis, facilitating the design of bifunctional molecules that target and degrade specific proteins via the ubiquitin-proteasome system. Its structural attributes enhance solubility and bioavailability, making it suitable for application in various drug discovery and developmental research. This linker allows researchers to explore targeted protein degradation as a therapeutic strategy, thus advancing the field of targeted therapies and precision medicine. -
PROTAC Linker
Ald-Ph-amido-PEG3-C2-NH2 is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of bifunctional molecules that promote the targeted degradation of proteins via the ubiquitin-proteasome system. Its unique structure enhances the solubility and stability of PROTAC constructs, making it a valuable tool for researchers exploring protein modulation and degradation pathways in cellular studies. -
PROTAC linker
N-(m-PEG4)-N'-(azide-PEG3)-Cy5 serves as a PEG-based linker for PROTAC technology, facilitating the synthesis of targeted protein degraders. This compound features an azide functional group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it a versatile tool for researchers in the field of chemical biology and drug development. -
PROTAC Linkers
Azido-PEG36-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with substrates containing DBCO or BCN groups, making it suitable for various chemical biology applications, including targeted protein degradation studies. -
PROTAC linker
N-(Amino-PEG1)-N-bis(PEG2-propargyl) serves as a PEG-based linker for PROTAC (proteolysis targeting chimera) synthesis. This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties enable efficient conjugation in the development of targeted protein degradation strategies, making it a valuable tool for chemical biology research. -
PROTAC Linkers
NH2-O-C5-COOH hydrobromide is an alkyl chain-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the creation of PROTACs by connecting target proteins to E3 ligases, enabling targeted degradation pathways. Its application is pivotal in guiding research aimed at developing novel therapeutic strategies in cancer and other diseases. -
PROTAC Linker
N-(Azido-PEG2)-N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker designed for synthesizing bifunctional molecules. This compound features an azide moiety, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it is capable of undergoing strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN functionalized molecules, making it a versatile tool for chemical biology applications, including targeted protein degradation studies. -
PROTAC Linker
PEG5-bis-(Ethyl phosphonate) is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the selective degradation of target proteins through the recruitment of E3 ligases, making it valuable for therapeutic research and protein modulation studies. Its hydrophilic properties enhance solubility and biocompatibility, essential for effective PROTAC development. -
PROTAC Linkers
Boc-Aminooxy-PEG5-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an aminooxy group that facilitates the conjugation of target ligands to E3 ligase ligands, enhancing the targeted degradation of specific proteins. This reagent is suitable for applications in drug discovery and biochemical research focused on protein regulation and degradation mechanisms. -
PROTAC Linker
Benzyl-PEG5-THP is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of targeting moieties to E3 ligase, enhancing the efficacy of targeted protein degradation. Its application in chemical biology research allows for the development of novel therapeutics and provides insights into protein regulation mechanisms. -
PROTAC Linker
tert-Butyl 4-(4-(piperazin-1-ylmethyl)piperidin-1-yl)benzoate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound is instrumental in synthesizing PROTAC AR Degrader-6, enabling targeted degradation of specific proteins. Its application is valuable in cellular studies and drug discovery involving targeted protein degradation. -
PROTAC Linkers
m-PEG6-(CH2)6-Phosphonic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its phosphonic acid moiety enhances the stability and solubility of PROTACs, facilitating efficient target degradation through the ubiquitin-proteasome system. This compound is essential for researchers focusing on the development of targeted protein degradation strategies in therapeutic applications. -
PROTAC Linker
Azido-PEG8-NHBoc is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it a versatile tool for chemical biology applications and targeted protein degradation research. -
PROTAC Linker
N-(Biotin)-N-bis(PEG1-alcohol) is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of biotin and a target protein, enabling targeted degradation through the ubiquitin-proteasome system. Its application in research supports the development of innovative therapeutic strategies for selective protein modulation in various biological contexts. -
PROTAC Linker
Piperidine-C2-piperazine-Boc is a PROTAC linker designed to facilitate the development of targeted protein degradation strategies. It plays a critical role in the synthesis of PROTACs by enabling the efficient conjugation of E3 ligase ligands and target proteins. This compound is valuable for research applications aimed at understanding protein homeostasis and developing therapeutics that leverage the cellular ubiquitin-proteasome system. -
PROTAC Linker
Aminooxy-PEG7-methane is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins and E3 ligases, promoting targeted degradation pathways in cellular systems. It is valuable for researchers developing PROTAC-based therapeutics and studying protein turnover and degradation mechanisms. -
PROTAC Linkers
PC-PEG11-Azide is a PEG-based linker designed for use in PROTAC synthesis, facilitating targeted protein degradation. It features an Azide group that enables copper-catalyzed azide-alkyne cycloaddition reactions with alkyne-containing compounds. Additionally, PC-PEG11-Azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) derivatives. This versatility makes it a valuable tool for chemical biology and drug discovery applications. -
PROTAC Linker
endo-BCN-PEG2-PFP ester serves as a PEG-based linker in the synthesis of PROTACs, functioning primarily through its BCN group. This compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, thereby enabling precise protein degradation applications. Its utility extends to various research areas, including targeted protein modulation and therapeutic development strategies. -
PROTAC Linkers
Hydroxy-PEG4-C2-nitrile is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates effective protein degradation by allowing the conjugation of target proteins to E3 ligases, thereby enhancing the cellular activity of PROTACs. Its biocompatibility and flexibility make it suitable for diverse applications in chemical biology and targeted protein degradation studies. -
PROTAC Linkers
Azido-PEG6-C1-Boc is a PEG-based linker primarily designed for use in the synthesis of PROTACs. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, as well as those containing DBCO or BCN groups. Its unique properties make it an effective tool for advancing research in targeted protein degradation and other chemical biology applications. -
PROTAC Linkers
Fmoc-NH-PEG11-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in protein-targeted degradation (PROTAC) applications. This compound features a Fmoc (Fluorenylmethyloxycarbonyl) protective group and is suitable for the synthesis of bifunctional PROTACs, facilitating the conjugation of targeting moieties to E3 ligase recruiters. It enables enhanced solubility and stability in biological environments, making it valuable for studies in targeted protein degradation and drug discovery. -
PROTAC Linker
Boc-NH-PEG7-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs by leveraging its azide group. It enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-functionalized compounds and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized molecules. This linker is essential for the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
NH2-C2-amido-C2-Boc is a selective PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of various PROTACs, enhancing the delivery of E3 ligases to target proteins. Its structural properties support the development of novel therapeutic strategies, including those targeting CDK2/9, thus broadening research avenues in oncology and other disease areas. -
PROTAC Linkers
Hydroxy-PEG11-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a hydroxyl functionality, which enhances conjugation efficiency and enables flexibility in target protein degradation applications. Hydroxy-PEG11-Boc serves as an essential building block in the development of novel therapeutics aimed at modulating protein levels in various biological contexts. -
PROTAC Linker
N-(Hydroxy-PEG3)-N-bis(PEG4-Boc) is a polyethylene glycol (PEG)-based linker designed for Proteolysis Targeting Chimeras (PROTACs) synthesis. This compound facilitates the conjugation of target proteins with E3 ligases, promoting ubiquitination and subsequent degradation. Its unique structural properties make it suitable for developing targeted therapeutics in chemical biology and drug discovery. -
PROTAC Linker
Mal-PEG3-PFP ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates efficient conjugation between the target protein and an E3 ligase, enhancing the degradation of specific proteins within cells. Researchers can leverage Mal-PEG3-PFP ester in drug discovery and development processes focusing on targeted protein degradation pathways. -
PROTAC Linker
Fluorescein-thiourea-PEG6-acid is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of targeted protein degradation systems by linking the E3 ligase recruitment component with the target protein. Its fluorescent properties enable tracking and visualization in biological assays, making it a valuable tool for chemical biology research and drug development. -
PROTAC Linker
Benzyl-PEG10-alcohol is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the efficient conjugation of targeting ligands to E3 ligase recruiters, enabling the selective degradation of target proteins. Its application is crucial in advancing research in targeted protein degradation and therapeutic development.
