RNF5-IN-1 is a selective RNF5 degrader that targets the RNF5 E3 ubiquitin ligase, inhibiting its activity and facilitating its proteasomal degradation via endoplasmic reticulum-associated degradation (ERAD). It demonstrates significant biological activity by inhibiting α-1-antitrypsin dislocation with an IC50 value of 2.7 μM. This compound is valuable for research into conditions such as cystic fibrosis, acute myeloid leukemia, and various viral infections.
RNF5-IN-1 is a selective RNF5 degrader that targets the RNF5 E3 ubiquitin ligase, inhibiting its activity and facilitating its proteasomal degradation via endoplasmic reticulum-associated degradation (ERAD). It demonstrates significant biological activity by inhibiting α-1-antitrypsin dislocation with an IC50 value of 2.7 μM. This compound is valuable for research into conditions such as cystic fibrosis, acute myeloid leukemia, and various viral infections.
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