Dihydrofolate reductase (DHFR)

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  1. Inhibitor (2)


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Catalog No. Product Name Product Information
A10021

Methotrexate (Abitrexate)

Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis.
A10655

NSC 131463 (DAMPA)

NSC 131463 is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM.
A10707

Pemetrexed (Alimta)

Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase.
A12796

Trimetrexate

Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.

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