DHFR

Inhibitory Selectivity
Catalog No.Inhibitor Name DHFROther
A10707Pemetrexed
****
TS,GARFT
A15207Pemetrexed Disodium Hydrate
****
TS,GARFT
A10021Methotrexate
A11522Pralatrexate

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A10021 SALE

Methotrexate (Abitrexate)

DHFR inhibitor
Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis.
A10707 SALE

Pemetrexed (Alimta)

-
Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase.
A11787 SALE

Aminopterin

-
Aminopterin is an antineoplastic drug. It works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase.
A12668

Pemetrexed disodium

DHFR inhibitor
Pemetrexed disodium is a novel antifolate with multiple targets
A12796

Trimetrexate

-
Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.
A10655

NSC 131463 (DAMPA)

DHFR inhibitor
NSC 131463 is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM.
A11522 SALE

Pralatrexate

DHFR inhibitor
Pralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells.
A15207

Pemetrexed disodium hemipenta hydrate

-
Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

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