Dihydrofolate reductase (DHFR)



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Catalog No. Product Name Application Product Information
A10021 SALE

Methotrexate (Abitrexate)

DHFR inhibitor
Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis.
A10655

NSC 131463 (DAMPA)

DHFR inhibitor
NSC 131463 is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM.
A10707 SALE

Pemetrexed (Alimta)

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Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase.
A12796

Trimetrexate

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Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.

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