Pralatrexate

Catalog No.: A11522

DHFR inhibitor

Pralatrexate Chemical Structure

CAS NO. 146464-95-1

Pralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$200.00
25 mg
$400.00
10mM * 1mL in DMSO
$174.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Pralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells.
Targets
DHFR
In vitro DMSO 28 mg/mL (58.64 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.94 mL 104.72 mL 209.44 mL
0.5 mM 4.19 mL 20.94 mL 41.89 mL
1 mM 2.09 mL 10.47 mL 20.94 mL
5 mM 0.42 mL 2.09 mL 4.19 mL

*The above data is based on the productmolecular weight 477.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11522
Actions Inhibitor
M. Wt 477.47
Formula C23H23N7O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 146464-95-1
Synonyms PDX, 10-Propargyl-10-deazaaminopterin, D05589
SMILES C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)O

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