Hedgehog



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Catalog No. Product Name Application Product Information
A10249

Cyclopamine

Hedgehog signaling inhibitor
Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
A11442

GANT 58

GLI antagonist
A13252 SALE

GANT61

GLI antagonist
GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
A10258 SALE

GDC-0449 (Vismodegib)

Hedgehog antagonist
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
A12920

Hh-Ag1.5

Hedgehog inhibitor
Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM.
A12418

HhAntag

-
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway.
A11048 SALE

LY2940680 (Taladegib)

SMO Antagonist
LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein.
A16111

MK-4101

Hedgehog inhibitor
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway.
A13095 SALE

SANT-1

Sonic hedgehog inhibitor
SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
A11351

TAK-441

Hedgehog inhibitor
TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor.

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