Antibody-drug Conjugates (ADC)

Biotin-TEG-ATFBA is a click chemistry reagent featuring a perfluorophenylazide moiety. This compound is known for forming a highly stable azene intermediate, facilitating insertion and addition reactions with moderate to good yields following photolysis. It possesses an azide functional group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Biotin-TEG-ATFBA can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN-tagged substrates, making it a valuable tool for bioconjugation and labeling applications in chemical biology.

Br-PEG4-C2-Boc is a cleavable 4-unit polyethylene glycol (PEG) linker specifically designed for use in antibody-drug conjugates (ADCs). This reagent facilitates the conjugation of drugs to antibodies, enabling targeted delivery and enhanced therapeutic efficacy. Its versatile chemical structure allows for efficient drug release in response to specific cleavage mechanisms, making it suitable for research applications in ADC development and optimization.

Fmoc-NH-PEG8-CH2COOH is a cleavable linker optimized for antibody-drug conjugates (ADCs) and serves as a PEG-based linker for PROTAC synthesis. This compound facilitates effective conjugation of biomolecules while enabling targeted degradation of specific proteins, making it essential for drug development and therapeutic research. Its application spans the design of innovative ADCs and the advancement of PROTAC technology in cellular studies.

22-(tert-Butoxy)-22-oxodocosanoic acid serves as a non-cleavable linker for antibody-drug conjugates (ADCs), facilitating the stable attachment of cytotoxic agents to antibodies. This compound is integral for enhancing the therapeutic efficacy of ADCs by ensuring a robust conjugation without premature release. Additionally, it functions as an alkyl chain-based PROTAC linker, enabling targeted protein degradation applications in chemical biology research.

DBCO-PEG2-DBCO is a versatile click chemistry reagent featuring two terminal dibenzocyclooctyne (DBCO) groups connected by a polyethylene glycol (PEG) linker. This compound is engineered for efficient, copper-free click reactions, making it particularly valuable in the development of antibody-drug conjugates (ADCs). Its unique chemical properties promote strong and selective labeling, enabling researchers to explore novel therapeutic applications and enhance drug delivery systems in biomedical research. This reagent is intended for research use only.

NHS-SS-biotin is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This reagent features an N-hydroxysuccinimide (NHS) ester that facilitates efficient conjugation to amino groups on antibodies, while its disulfide bond allows for controlled release of the drug upon internalization. NHS-SS-biotin is crucial for applications in targeted therapy research and the development of novel ADC formulations.

N-Boc-diethanolamine is a cleavable linker based on an alkyl/ether structure, primarily utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound facilitates the conjugation of therapeutic agents to antibodies, enhancing targeted delivery and efficacy. Its application in PROTAC technology allows for the selective degradation of target proteins, making it a valuable tool in drug discovery and development.

N3Ac-OPhOMe is an azide-containing click chemistry reagent that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and ring strain-promoted alkyne-azide cycloaddition (SPAAC). Its utility in conjugating biomolecules allows for diverse applications in biochemical research, including the labeling and tracking of proteins, nucleic acids, and complex biomolecular interactions. This compound serves as a valuable tool in chemical biology and biomaterials development.

Fmoc-Val-Ala-aminomethyl acetate is a versatile ADC linker that facilitates the synthesis of antibody-drug conjugates (ADCs). This compound plays a crucial role in enhancing the stability and efficacy of conjugated therapeutics. It is essential for researchers developing targeted therapies in cancer and other diseases, providing a means for precise drug delivery.

BCN-PEG3-OH is a non-cleavable linker specifically designed for antibody-drug conjugate (ADC) synthesis. As a click chemistry reagent, it features a bicyclo[6.1.0]nonyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound supports robust conjugation strategies, enhancing the delivery of cytotoxic agents in targeted cancer therapies. Its efficiency makes it an invaluable tool in the development of ADCs for various research applications.

SPDMV is a glutathione-cleavable linker utilized in antibody-drug conjugate (ADC) applications. It promotes the targeted release of cytotoxic agents upon intracellular reduction, enhancing therapeutic efficacy and minimizing off-target effects. SPDMV is ideal for research focused on the development and optimization of ADCs in cancer therapy.

Fmoc-Lys-OH hydrochloride is a cleavable linker for antibody-drug conjugates (ADCs), facilitating targeted delivery of cytotoxic agents to cancer cells. This compound is instrumental in the synthesis of ADCs, providing a functional group for conjugation. Additionally, Fmoc-Lys-OH hydrochloride serves as an alkyl chain-based linker in the development of PROTACs, enhancing selective protein degradation pathways for therapeutic applications.

Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable linker utilized in the development of antibody-drug conjugates (ADCs), demonstrating significant versatility in chemical synthesis. This alkyl chain-based compound serves as a valuable PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras (PROTACs). Its structured design enhances the efficiency of targeted protein degradation, making it an essential tool for researchers in the field of drug discovery and therapeutic development.

N3-C4-NHS ester is a noncleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), specifically targeting azide groups. This compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, enabling efficient conjugation. Additionally, N3-C4-NHS ester can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it highly versatile for bioconjugation applications in chemical biology and therapeutic development.

Biotin-PEG4-PFP ester is a cleavable linker designed for use in PROTAC (Proteolysis Targeting Chimera) technology, facilitating the synthesis of antibody-drug conjugates (ADCs). This 4 unit PEG linker enhances solubility and stability, which are vital for effective drug delivery. Its unique structure enables selective conjugation while maintaining biological activity, making it an essential tool for researchers developing targeted therapies in cancer and other disease models.

m-PEG12-OH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras) and antibody-drug conjugates (ADCs). This non-cleavable linker consists of a 12-unit polyethylene glycol chain, facilitating stable conjugation in bioconjugation applications. Its properties enable efficient delivery of biologically active drugs to target cells, making it suitable for research in targeted therapy and drug development.

PC Biotin-PEG3-NHS ester is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This highly soluble pegylated compound allows for efficient conjugation to antibodies, enhancing stability and facilitating targeted delivery of cytotoxic agents. Its primary applications include the development of ADCs for cancer therapeutics and research into targeted treatment strategies.

MC-AAA-NHCH2OCH2COOH is a cleavable linker designed for use in antibody-drug conjugates (ADCs). This compound facilitates the targeted delivery of cytotoxic agents to specific cells, enhancing therapeutic efficacy while minimizing off-target effects. Its unique structure enables effective release of the drug payload in the tumor microenvironment, making it suitable for various oncology research applications.

2-Azidoethyl β-D-lactoside is a versatile click chemistry reagent designed for the selective conjugation of biomolecules. It features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, offering high efficiency and specificity. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives. This reagent is useful in various biological research applications, including the labeling and tracking of nucleic acids, proteins, and lipids within complex biological systems.

Propargyl-PEG5-acid is a non-cleavable polyethylene glycol (PEG) linker designed for antibody-drug conjugate (ADC) applications. It facilitates the synthesis of ADCs targeting Galectin-3 and serves as a versatile PROTAC linker. This compound features an alkyne functional group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool for click chemistry in chemical biology research. Researchers can utilize Propargyl-PEG5-acid in various applications, including drug conjugation and the development of therapeutic agents.

Propargyl-Tos is a cleavable linkers designed for use in the synthesis of antibody-drug conjugates (ADCs). Featuring an alkyne group, Propargyl-Tos facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This property makes it valuable for constructing complex bioconjugates, enhancing the therapeutic efficacy of ADCs in targeted cancer therapy research.

Mal-NH-ethyl-SS-propionic acid is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the selective release of the cytotoxic drug upon internalization, enhancing therapeutic efficacy. Its application in ADC development enables targeted delivery of therapeutic agents, making it valuable in various cancer research studies and the advancement of targeted therapies.

Mal-PEG1-Val-Cit-PABC-OH is a cleavable polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This linker facilitates the attachment of cytotoxic agents to antibodies while maintaining stability in circulation. Upon reaching the target site, the linker can be cleaved, releasing the therapeutic payload and enhancing cytotoxic efficacy. This compound is valuable for research applications focusing on ADC development and optimization.

Tr-PEG2-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This non-cleavable linker, featuring a two-unit PEG structure, facilitates the development of antibody-drug conjugates (ADCs). Its key biological activity includes promoting targeted protein degradation and enhancing the solubility and pharmacokinetics of conjugated molecules, making it a valuable tool in chemical biology and therapeutic research applications.

Propargyl-PEG8-acid is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. It features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing biomolecules. Its utility in creating cleavable linkers makes it valuable for targeted drug delivery applications, particularly against Gram-negative bacterial infections. This versatile reagent supports the development of innovative therapeutic strategies in chemical biology and drug discovery.

Tetrazine-PEG4-amine hydrochloride functions as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs). This compound features a tetrazine group, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) functionalized molecules. It is essential for the development of targeted therapies, facilitating the selective delivery of cytotoxic agents to cancer cells while minimizing off-target effects.

Ald-Ph-amido-PEG4-C2-NHS ester is a non-cleavable linker specifically designed for antibody-drug conjugation (ADC) applications. Comprising a four-unit polyethylene glycol (PEG) structure, it facilitates stable attachment of therapeutic agents to antibodies, enhancing the efficacy of targeted therapies. This reagent is suitable for use in research focused on developing advanced ADC formulations with improved pharmacokinetics and therapeutic index.

Hydroxy-PEG3-(CH2)2-Boc is an uncleavable linker employed in the synthesis of antibody-drug conjugates (ADCs). This compound enhances the stability of ADCs, facilitating the targeted delivery of cytotoxic agents to tumor cells. Additionally, Hydroxy-PEG3-(CH2)2-Boc can serve as a valuable component in the development of PROTACs, expanding its utility in targeted protein degradation research.

H-cis-Hyp-OMe hydrochloride is a non-cleavable linker designed for use in antibody-drug conjugates (ADCs). This compound provides stability and efficacy in the development of ADCs by ensuring prolonged circulation time and effective drug delivery. Additionally, H-cis-Hyp-OMe hydrochloride serves as an alkyl chain-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras for targeted protein degradation research applications.

Tetraethylene glycol monotosylate is a versatile cleavable linker primarily utilized in the synthesis of antibody-drug conjugates (ADCs). Its acylhydrazone moiety facilitates targeted drug delivery while enabling controlled release of cytotoxic agents. In addition to ADC applications, this compound can also serve as a linker in the development of proteolysis-targeting chimera (PROTAC) molecules, enhancing the specificity and efficacy of targeted protein degradation studies.

SIA Crosslinker is a non-cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). It facilitates stable conjugation between antibodies and cytotoxic drugs, ensuring effective delivery and controlled therapeutic activity. This reagent is essential for research focused on targeted cancer therapies and ADC development, providing robust stability in diverse biological environments.

Mal-PEG1-acid is a non-cleavable linker derived from polyethylene glycol (PEG) that serves as an effective reagent for antibody-drug conjugates (ADCs) and PROTAC synthesis. This compound facilitates the construction of PROTACs by providing a flexible linker that enhances target protein degradation through ubiquitin-proteasome pathways. Its application is crucial for developing novel therapeutics that utilize the PROTAC strategy in chemical biology and drug discovery.

Bis-PEG10-NHS ester is a cleavable linker designed for use in antibody-drug conjugate (ADC) and PROTAC synthesis. The compound features a polyethylene glycol (PEG) structure that enhances solubility and stability while promoting efficient drug delivery. Its primary mechanism involves facilitating the conjugation of drugs to antibodies or target proteins, making it essential in developing targeted therapies. Bis-PEG10-NHS ester is suitable for research applications aimed at improving therapeutic efficacy and specificity in drug development.

TCO-NHS Ester (axial) is a versatile click chemistry reagent primarily used for site-specific labeling in amine reactions. The compound features TCO groups that participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. It is valuable in bioconjugation and molecular imaging applications, enabling researchers to construct complex biomolecular structures.

Gly-Gly-Gly-PEG3-TCO is a polyethylene glycol (PEG) linker featuring a TCO moiety, primarily utilized in the synthesis of antibody-drug conjugates (ADCs). This compound facilitates click chemistry through its ability to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. Its application in ADC development enhances targeted delivery and therapeutic efficacy in the treatment of various diseases.

tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable linker utilized in the development of antibody-drug conjugates (ADCs). This compound serves as an alkyl chain-based PROTAC linker, enabling the synthesis of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation studies. Its unique structural properties make it a valuable tool for enhancing the efficacy of bioconjugates in therapeutic applications.

Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable 2 unit polyethylene glycol (PEG) linker designed for use in antibody-drug conjugate (ADC) synthesis. This linker facilitates the selective release of cytotoxic agents upon internalization of the ADC by target cells, enhancing therapeutic efficacy. Its unique structural features support various research applications in the development of targeted cancer therapies.

Spermine(N3BBB) is an azide-containing click chemistry reagent designed for bioconjugation applications. It facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This versatility makes Spermine(N3BBB) a valuable tool for biochemical studies involving targeted labeling and cross-linking in various biological systems.

H-Hyp-OMe hydrochloride is a non-cleavable linker designed for use in antibody-drug conjugates (ADCs) and also serves as an alkyl chain-based PROTAC linker. This versatile compound facilitates the synthesis of PROTACs, enabling the targeted degradation of specific proteins through the ubiquitin-proteasome system. H-Hyp-OMe hydrochloride is valuable in the development of therapeutic strategies aimed at selectively modulating protein function in various biological research applications.

Sulfo-LC-SPDP sodium is a cleavable linker specifically designed for the development of antibody-drug conjugates (ADCs). Its chemical structure enables the selective attachment of drugs to antibodies, facilitating targeted delivery. This reagent is essential for creating ADCs that exhibit enhanced stability and improved therapeutic efficacy in various cancer research applications.

Mal-PEG4-bis-PEG4-propargyl is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), targeting efficient drug delivery. This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it suitable for click chemistry applications. Its structure supports the development of stable and effective ADCs, enhancing the therapeutic potential in various biomedical research fields.

BCN-SS-NHS is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This reagent features a BCN group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. Its unique properties enhance the targeting and delivery of therapeutic agents, making it a valuable tool in the development of ADCs for various cancer research applications.

DBCO-PEG2-Val-Cit-PAB-MMAE is an antibody-drug conjugate (ADC) linker that employs a DBCO group for efficient click chemistry with azide moieties. This reagent incorporates a Val-Cit dipeptide, which is cleavable by proteases, facilitating the targeted release of the MMAE warhead within cells through an elimination mechanism. Its design is optimized for applications in targeted cancer therapy, enhancing the specificity and efficacy of drug delivery systems.

Hydroxy-PEG4-acid is a non-cleavable linker featuring a four-unit polyethylene glycol (PEG) moiety, primarily utilized in the development of antibody-drug conjugates (ADCs). This linker is also applicable in the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating targeted degradation of specific proteins. Its biocompatibility and structural versatility make it valuable in various chemical biology applications, particularly in therapeutic development and research focusing on targeted protein modulation.

N-Boc-cis-4-Hydroxy-D-proline serves as a non-cleavable linker for antibody-drug conjugates (ADCs), facilitating the conjugation of therapeutic agents to antibodies. This compound also functions as an alkyl chain-based PROTAC linker, making it useful for the synthesis of both ADCs and PROTACs. Its structural attributes enhance the stability and efficacy of conjugated therapies, supporting research efforts in targeted drug delivery and protein degradation.

Azido-PEG9-acid is a non-cleavable 9-unit polyethylene glycol (PEG) linker designed for use in antibody-drug conjugate (ADC) synthesis. This reagent facilitates the creation of conjugates through its azide functionality, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG9-acid supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for bioconjugation applications in chemical and molecular biology research.

Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). Its structure facilitates the controlled release of cytotoxic agents upon internalization, enhancing therapeutic efficacy. This compound is essential for research applications focusing on the development and optimization of ADC therapies in targeted cancer treatments.

Propargyl-PEG2-NHBoc is a cleavable linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This PEG-based linker features an alkyne group, allowing for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties support robust applications in drug development and targeted protein degradation research, making it a valuable tool for chemical biology studies.

Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 is a branched linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the conjugation of therapeutic agents to antibodies, enhancing their delivery and efficacy in targeting specific cells. Its unique structure allows for improved stability and solubility, making it an essential component in ADC development for cancer therapy and other applications in targeted drug delivery research.

Bis-PEG8-acid is a polyethylene glycol-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This bifunctional linker facilitates the formation of PROTACs by providing a cleavable connection between the target protein and an E3 ligase. Additionally, Bis-PEG8-acid serves as a linker in the development of antibody-drug conjugates (ADCs), enhancing their stability and efficacy. Its application in chemical biology and therapeutic research supports innovative approaches in targeted protein degradation and drug delivery systems.