CL2A-SN-38

Catalog No.: A18392

DNA Topoisomerase I inhibitor

CL2A-SN-38

CL2A-SN-38 Chemical Structure

CAS NO. 1279680-68-0

CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 6.75 mL 33.77 mL 67.54 mL
0.5 mM 1.35 mL 6.75 mL 13.51 mL
1 mM 0.68 mL 3.38 mL 6.75 mL
5 mM 0.14 mL 0.68 mL 1.35 mL

*The above data is based on the productmolecular weight 1480.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18392
Actions Inhibitor
M. Wt 1480.61
Formula C73H97N11O22
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1279680-68-0
SMILES O=C(O[[email protected]](C1=C(CO2)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C1)=O)(CC)C2=O)OCC6=CC=C(NC([[email protected]](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC(CNC(C8CCC(CN9C(C=CC9=O)=O)CC8)=O)=C7)=O)=O)=O)C=C6

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