CL2A-SN-38

Catalog No.: A18392

DNA Topoisomerase I inhibitor

CL2A-SN-38

CL2A-SN-38 Chemical Structure

CAS NO. 1279680-68-0

CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 6.75 mL 33.77 mL 67.54 mL
0.5 mM 1.35 mL 6.75 mL 13.51 mL
1 mM 0.68 mL 3.38 mL 6.75 mL
5 mM 0.14 mL 0.68 mL 1.35 mL

*The above data is based on the productmolecular weight 1480.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18392
Actions Inhibitor
CAS No. 1279680-68-0
Formula C73H97N11O22
M. Wt 1480.61
Purity >98%
SMILES O=C(O[[email protected]](C1=C(CO2)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C1)=O)(CC)C2=O)OCC6=CC=C(NC([[email protected]](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC(CNC(C8CCC(CN9C(C=CC9=O)=O)CC8)=O)=C7)=O)=O)=O)C=C6
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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