VcMMAE

Catalog No.: A14362

VcMMAE

VcMMAE Chemical Structure

CAS NO. 646502-53-6

VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).

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1 mg
$70.00
2 mg
$120.00
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Biological Activity

VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
In vitro DMSO 92 mg/mL (69.87 mM)
Water Insoluble
Ethanol 92 mg/mL (69.87 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 7.6 mL 37.98 mL 75.95 mL
0.5 mM 1.52 mL 7.6 mL 15.19 mL
1 mM 0.76 mL 3.8 mL 7.6 mL
5 mM 0.15 mL 0.76 mL 1.52 mL

*The above data is based on the productmolecular weight 1316.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14362
CAS No. 646502-53-6
Formula C68H105N11O15
M. Wt 1316.63
Purity >98%
Synonyms Vedotin
SMILES CC[[email protected]](C)[[email protected]@H]([[email protected]@H](CC(=O)N1CCC[[email protected]]1[[email protected]@H]([[email protected]@H](C)C(=O)N[[email protected]](C)[[email protected]](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](C(C)C)N(C)C(=O)OCC3=CC=C(C=C3)NC(=O)[[email protected]](CCCNC(=O)N)NC(=O)[[email protected]](C(C)C)NC(=O)CCCCCN4C(=O)C=CC4=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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