Dxd

Catalog No.: A21517

DNA topoisomerase I inhibitor

Dxd

Dxd Chemical Structure

CAS NO. 1599440-33-1

Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).

Availability: In stock

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1 mg

Regular Price: $468.00

Special Price $374.40

5 mg

Regular Price: $1,404.00

Special Price $1,123.20

10 mg

Regular Price: $2,392.00

Special Price $1,913.60

50 mg

Regular Price: $7,176.00

Special Price $5,740.80

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Biological Activity

Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.26 mL 101.32 mL 202.64 mL
0.5 mM 4.05 mL 20.26 mL 40.53 mL
1 mM 2.03 mL 10.13 mL 20.26 mL
5 mM 0.41 mL 2.03 mL 4.05 mL

*The above data is based on the productmolecular weight 493.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21517
Actions Inhibitor
CAS No. 1599440-33-1
Formula C26H24FN3O6
M. Wt 493.48
Purity >98%
Synonyms Exatecan derivative for ADC
SMILES O=C1[[email protected]](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[[email protected]@H]5NC(CO)=O)C(C)=C(F)C=C6N=C4C3=C2)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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