Antibody-drug Conjugates (ADC)

Dolastatin 10 (DLS 10) is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.

SPDB-DM4 is a drug-linker conjugate for ADC by using the maytansinebased payload (DM4, a tubulin inhibitor) via a SPDB linker, exhibiting potent anti-tumor activity.

Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM.

DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate.

SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).

SPB is a drug-linker conjugate for ADC with potent anti-inflammatory activity by using Xanthotoxol, linked via the ADC linker.

Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-drug resistant cell lines.

NAMPT inhibitor-linker 2 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker.

NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker.

C-11 is a tubulin inhibitor and acts as a ADC cytotoxin, displays cytotoxicity for carcinoma cell lines.

Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

Tesirine is a pyrrolobenzodiazepine (PBD) dimer used as a payload in antibody-drug conjugates (ADCs), primarily targeting cancer cells. It exhibits remarkable antitumor efficacy through its ability to cross-link DNA at the minor groove, leading to potent cytotoxic effects. Tesirine’s favorable hydrophobicity and improved conjugation properties make it an effective component for developing targeted cancer therapies. Its released warhead, SG3199, demonstrates picomolar activity across various cancer cell lines, highlighting its potential in cancer research and therapeutic applications.

BS2G Crosslinker Disodium is an amine-reactive homobifunctional crosslinker that targets amine groups on proteins and peptides. This reagent facilitates the stable conjugation of proteins, peptides, and biomolecules, making it valuable in the development of antibody-drug conjugates (ADCs). Its application extends to various biochemical research and therapeutic studies, where precise linkage is essential for functionality.

DBCO-HS-PEG2-VA-PABC-SG3199 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It features a SG3199-based DNA small channel crosslinker combined with a cleavable linker, facilitating targeted delivery of therapeutic agents. This reagent is suitable for the synthesis of ADCs, enabling enhanced efficacy in drug-based cancer therapies and other biomedical research applications.

DBCO-NHS ester is a non-cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs). It serves as a click chemistry reagent, featuring a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is essential for bioconjugation applications, allowing for the stable attachment of therapeutics to antibodies, thereby enhancing the efficacy and specificity of targeted drug delivery in cancer research.

Sulfo-SMCC sodium is a hetero-bifunctional ADC linker that features both an N-hydroxysuccinimide (NHS) ester and a maleimide functional group. It facilitates efficient coupling by selectively reacting with primary amines and sulfhydryl groups, forming stable noncleavable linkages. This reagent is widely employed in the development of antibody-drug conjugates (ADCs), enabling targeted delivery of therapeutic agents for enhanced efficacy in cancer treatment and other diseases.

Desthiobiotin-Iodoacetamide functions primarily as an antibody-drug conjugate (ADC) linker, facilitating targeted drug delivery in therapeutic applications. It exhibits a strong affinity for biotin-binding proteins, making it useful in the labeling and detection of proteins in various biological assays. Additionally, this compound can be utilized as a probe for studying Oridonin-treated cell lysis, enhancing the understanding of cellular responses in drug treatment studies.

DOTA-NHS-ester is a labeling agent that facilitates the conjugation of affibody molecules for applications in molecular imaging. It is commonly utilized in small animal positron emission tomography (PET), single-photon emission computed tomography (SPECT), and computed tomography (CT). This reagent effectively labels radiotherapeutic agents or imaging probes, aiding in the detection and characterization of tumors.

15-Azido-pentadecanoic acid is an azide-containing compound widely utilized in click chemistry applications. This reagent is particularly effective for labeling and characterizing post-translationally palmitylated proteins through a straightforward two-step labeling process. Additionally, it can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-functionalized molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, providing versatile approaches for conjugation in chemical biology research.

N-Hydroxysulfosuccinimide sodium serves as a non-cleavable linker for antibody-drug conjugates (ADCs). By enabling stable covalent attachment of cytotoxic drugs to antibodies, it plays a crucial role in enhancing targeted cancer therapy. This reagent is widely utilized in the development and optimization of ADC formulations for improved therapeutic efficacy.

Azido-PEG2-C2-amine is a PEG-based linker designed for use in PROTAC synthesis. This compound features an azide moiety that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, facilitating conjugation with alkyne-bearing molecules. Additionally, Azido-PEG2-C2-amine serves as a non-cleavable linker for the development of antibody-drug conjugates (ADCs), making it a versatile tool in chemical biology and drug discovery applications.

N3-PEG4-C2-NHS ester is a non-cleavable 4-unit polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN functionalities. Due to its unique properties, N3-PEG4-C2-NHS ester is a valuable tool for the development of targeted therapeutics.

Maleimide-DOTA is a non-cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). It facilitates stable attachment of therapeutic agents to antibodies, ensuring effective delivery to target cells while maintaining the drug's biological activity. This compound plays a crucial role in ADC development for targeted cancer therapies and related research applications.

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This linker facilitates the selective release of cytotoxic agents in targeted cancer therapies, enhancing therapeutic efficacy while minimizing off-target effects. Its structured design supports optimal stability and effective drug delivery, making it a valuable component in ADC research and development.

3-Azidopropylamine is a click chemistry reagent designed for efficient bioconjugation through its azide functional group. It facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and ring strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules, including those with DBCO or BCN groups. This reagent is particularly useful in applications involving complexation and transfection of plasmid DNA, making it valuable for molecular biology and materials science research.

Fmoc-NH-PEG4-CH2CH2COOH is a cleavable linker designed for antibody-drug conjugates (ADCs), facilitating the targeted delivery of cytotoxic agents to cancer cells. This compound serves as a PEG-based PROTAC linker, enabling the construction of proteolysis-targeting chimeras (PROTACs) for efficient degradation of specific proteins in various biological contexts. It is suitable for applications in drug development and biochemical research, particularly in the fields of oncology and targeted therapeutics.

6-Azido-hexylamine is a versatile cleavable linker utilized in the development of antibody-drug conjugates (ADCs). It features an azide functional group that participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. This compound is essential for the precise attachment of cytotoxic agents to antibodies, facilitating targeted cancer therapies.

DBCO-PEG4-Maleimide is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. It is essential for applications in targeted drug delivery, enhancing the therapeutic efficacy of ADCs while minimizing off-target effects.

Mal-PEG4-NHS ester is a non-cleavable ADC linker that facilitates the conjugation of biomolecules, particularly linking Quantum dots (QDs) with PEGylated liposomes. This compound exhibits key biological activity by enhancing the stability and solubility of the assembled conjugates. It is primarily utilized in antibody-drug conjugate (ADC) development, nanomedicine, and for improving drug delivery systems in research applications.

DBCO-PEG5-NHS ester is a cleavable linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This PEG/alkyl/ether-based reagent facilitates the formation of stable covalent bonds through strain-promoted alkyne-azide cycloaddition (SPAAC), targeting azide-functionalized molecules. Its defined structure enhances the efficacy and specificity of therapeutic compounds, making it a valuable tool for researchers in the development of targeted therapies.

Fmoc-3VVD-OH is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the stable attachment of cytotoxic agents to antibodies, enabling targeted delivery to cancer cells. Its hydrolyzable nature allows for efficient release of the drug in the desired cellular environment, making it a valuable tool in cancer research and therapeutic development.

Gly-Gly-Gly-PEG4-DBCO is a polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs). Featuring a dibenzocyclooctyne (DBCO) functional group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing compounds. Its high stability and efficiency make it an essential tool in the development of targeted therapeutics for improved delivery of cytotoxic drugs.

Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable linker primarily utilized in the development of antibody-drug conjugates (ADCs). Its PEG-based structure also allows for incorporation in the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating targeted degradation of specific proteins. This reagent provides a functional handle for the attachment of theranostic payloads, enhancing the efficacy and specificity of therapeutic agents in chemical biology research.

Azidoacetic Acid is a versatile click chemistry reagent characterized by its azide group functionality. It serves as a valuable tool for the synthesis of protein-targeting chimeras, such as PROTACs. Azidoacetic Acid can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, as well as ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties, enabling the rapid assembly of bioconjugates and labeled biomolecules for various research applications.

Kdo Azide is a click chemistry reagent that features an azide functional group, allowing it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynyl compounds. Additionally, Kdo Azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions in the presence of DBCO or BCN moieties. This reagent is valuable for metabolic labeling applications and various bioconjugation strategies in chemical biology research.

β-D-glucuronide-pNP-carbonate is a cleavable linker specifically designed for use in antibody-drug conjugates (ADCs). It facilitates the release of cytotoxic drugs in targeted therapeutic applications, thereby enhancing the efficacy of treatment while minimizing off-target effects. This compound is valuable for researchers focusing on the development of ADCs aimed at improving precision in cancer therapies and other diseases.

Fmoc-Gly-NH-CH2-acetyloxy is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the stable attachment of cytotoxic drugs to antibodies while allowing for selective release in target cells. Its application is critical in developing advanced therapeutics that improve the efficacy and safety of cancer treatments through targeted drug delivery.

Maleimide is a versatile compound primarily utilized as an ADC linker in cancer research. It is instrumental in the development of antibody-drug conjugates, facilitating targeted delivery of cytotoxic agents to cancer cells. Additionally, Maleimide can be employed in the synthesis of fluorogenic probes, enabling the specific detection and quantification of thiol-containing analytes in various biological samples.

Bromo-PEG2-C2-azide is a versatile PROTAC linker featuring a bromo group and an azide moiety, designed for the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This compound functions effectively in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Bromo-PEG2-C2-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it a valuable tool for targeted protein degradation and bioconjugation strategies in chemical biology research.

Mal-PEG2-NHS ester is a non-cleavable antibody-drug conjugate (ADC) linker that features a maleimide group, a two-unit polyethylene glycol (PEG) spacer, and an N-hydroxysuccinimide (NHS) ester. This compound is essential for the efficient conjugation of cytotoxic agents to antibodies, facilitating targeted delivery in cancer therapy. Mal-PEG2-NHS ester enhances the stability and solubility of ADCs, making it suitable for research applications in drug development and discovery.

DBCO-Maleimide is a non-cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). As a click chemistry reagent, it features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This property enables seamless conjugation and enhances the therapeutic efficacy of ADCs, making DBCO-Maleimide an essential tool in bioconjugation and targeted drug delivery research.

Boc-NH-PEG4-CH2CH2NH2 is a cleavable five-unit polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This linker facilitates the conjugation of therapeutic agents to antibodies, enhancing target specificity and therapeutic efficacy. Additionally, Boc-NH-PEG4-CH2CH2NH2 serves as a PEG-based linker in the development of PROTACs, contributing to the targeted degradation of proteins in various research applications.

Azido-PEG4-C2-acid is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. It serves as a non-cleavable linker in the synthesis of antibody-drug conjugates (ADCs) and is integral to the development of compounds such as vRucaparib-TP4. This compound features an azide group that enables the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, and it also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile reagent for chemical biology research.

Fmoc-Gly-Gly-Phe-OH is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the selective release of therapeutic agents in targeted cancer treatment, enhancing the efficacy of the conjugated drug while minimizing systemic exposure. Its utility in ADC formulation makes it a valuable tool for researchers developing innovative cancer therapeutics.

MAC glucuronide linker-2 is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This linker facilitates the targeted delivery of cytotoxic agents to tumor cells, allowing for enhanced efficacy while minimizing off-target effects. It is particularly valuable in research applications focused on ADC development and optimization, contributing to advancements in targeted cancer therapies.

Azido-PEG8-NHS ester is a cleavable 8-unit polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that enables it to participate in click chemistry, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its unique properties make it valuable for the efficient synthesis of ADCs and the development of novel PROTACs.

N3-PEG2-C2-NHS ester is a non-cleavable 2-unit PEG linker designed for the synthesis of antibody-drug conjugates (ADCs). Featuring an azide functional group, it serves as a click chemistry reagent capable of facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, N3-PEG2-C2-NHS ester participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for conjugation applications in bioconjugate chemistry.

N3-C5-NHS ester is a noncleavable ADC linker designed for the synthesis of antibody-drug conjugates (ADCs). It features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds. This reagent is essential for enhancing the efficacy and specificity of targeted therapeutic agents in chemical biology research.

Bis-PEG9-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs (proteolysis-targeting chimeras). This cleavable linker facilitates the attachment of drugs to antibodies, enhancing selective delivery and activity. Its application in PROTAC synthesis allows for targeted protein degradation, making it a valuable tool in drug discovery and development.

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC linker designed for the synthesis of drug-linker conjugates in antibody-drug conjugate (ADC) applications. This compound facilitates the construction of targeted therapeutics, enhancing the specificity and efficacy of drug delivery. It is particularly relevant in the development of complex conjugates such as Deruxtecan, providing researchers with a reliable tool for advancing ADC-based therapies.