MC-Gly-Gly-Phe-Gly-PAB-PNP

Catalog No.: A42650
ADC Linker
MC-Gly-Gly-Phe-Gly-PAB-PNP is a chemically engineered linker specifically designed for the synthesis of antibody-drug conjugates (ADCs) targeting human epidermal growth factor receptor (EGFR). This compound facilitates the stable attachment of therapeutic agents to antibodies, enhancing selective delivery to tumor cells while minimizing off-target effects. Its structural properties contribute to improved pharmacokinetics and therapeutic efficacy in cancer research applications.
Grouped product items
Size Price Stock Qty
5mg
$115.00
In stock
10mg
$185.00
In stock
25mg
$385.00
In stock
50mg
$605.00
In stock
100mg
$950.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMC-Gly-Gly-Phe-Gly-PAB-PNP is a chemically engineered linker specifically designed for the synthesis of antibody-drug conjugates (ADCs) targeting human epidermal growth factor receptor (EGFR). This compound facilitates the stable attachment of therapeutic agents to antibodies, enhancing selective delivery to tumor cells while minimizing off-target effects. Its structural properties contribute to improved pharmacokinetics and therapeutic efficacy in cancer research applications.
Product Information
Catalog NumA42650
FormulaC39H41N7O12
Molecular Weight799.78
CAS Number2632342-16-4
SMILESO=[N+]([O-])C(C=C1)=CC=C1OC(OCC(C=C2)=CC=C2NC(CNC([C@@H](NC(CNC(CNC(CCCCCN3C(C=CC3=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O
Useful Calculator

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