Azido-PEG3-SS-NHS is a cleavable polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when paired with alkyne, DBCO, or BCN moieties. Its versatility in click chemistry enhances the development of targeted therapies by facilitating the precise attachment of cytotoxic agents to antibodies for efficient delivery and therapeutic action.
Azido-PEG3-SS-NHS is a cleavable polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when paired with alkyne, DBCO, or BCN moieties. Its versatility in click chemistry enhances the development of targeted therapies by facilitating the precise attachment of cytotoxic agents to antibodies for efficient delivery and therapeutic action.
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