Catalog No.
Product Name
Application
Product Information
Citations
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Apoptosis Inducer
EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) specifically designed to target the triple mutant EGFRL858R/T790M/C797S, exhibiting an IC50 of 18 nM. This compound effectively suppresses EGFR phosphorylation, thereby inducing apoptosis and causing cell cycle arrest at the G0/G1 phase. It serves as a valuable tool for research into cancer therapies focused on overcoming resistance in EGFR-mutated tumor cells. -
Survivin Dimerization Inhibitor
LQZ-7F is a potent survivin dimerization inhibitor that promotes spontaneous apoptosis in prostate cancer cells. It demonstrates dose-dependent cytotoxicity against PC-3 and C4-2 cell lines, with IC50 values of 2.99 µM and 2.47 µM, respectively. Additionally, LQZ-7F exhibits synergistic effects when combined with Docetaxel, making it valuable for research into therapeutic strategies targeting survivin in cancer treatment. -
Apoptosis Inducer
Carubicin hydrochloride is an apoptosis inducer that targets cancer cell proliferation. Derived from microbial sources, it effectively inhibits the growth of VHL-defective clear cell renal cell carcinoma (CCRCC) cells. Notably, carubicin hydrochloride induces apoptosis through mechanisms that are independent of p53 and hypoxia-inducible factor HIF2. This compound holds significant potential for research applications in cancer biology. -
Mutant p53 Reactivator
SLMP53-2 is a mutant p53 reactivator that restores the wild-type conformation and DNA-binding capabilities of the mutp53-Y220C variant by enhancing its interaction with Hsp70. This mechanism reestablishes p53 transcriptional activity, contributing to important biological processes such as cell cycle arrest, apoptosis, and endoplasmic reticulum (ER) stress. SLMP53-2 demonstrates significant antitumor activity, making it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Flavokawain C is a natural chalcone derived from Kava root, functioning as an apoptosis inducer. It demonstrates cytotoxic effects against human cancer cell lines, specifically exhibiting an IC50 value of 12.75 μM for HCT 116 cells. This compound is of significant interest in cancer research for its potential therapeutic applications in inducing programmed cell death in malignancies. -
Apoptosis Inducer
Euscaphic acid is a triterpene derived from the root of R. alceaefolius Poir, functioning as an apoptosis inducer. This compound inhibits DNA polymerases, specifically calf DNA polymerase α and rat DNA polymerase β, with IC50 values of 61 μM and 108 μM, respectively. Euscaphic acid's ability to induce apoptosis makes it a valuable reagent for research focused on cancer biology and cell death pathways. -
Apoptosis Inducer
Damnacanthal is an anthraquinone that primarily functions as an apoptosis inducer through selective inhibition of p56lck tyrosine kinase activity. Demonstrating significant anticancer properties, Damnacanthal effectively inhibits p56lck autophosphorylation and the phosphorylation of exogenous substrates, with IC50 values of 46 nM and 220 nM, respectively. Additionally, Damnacanthal exhibits antinociceptive and anti-inflammatory effects in murine models, along with antifungal activity against Candida albicans. This compound is valuable for research into cancer biology and related therapeutic pathways. -
p53Y220C Transcriptional Activator
TRAP-1 is a selective p53Y220C transcriptional activator that engages with p53Y220C and BRD4 to form a ternary complex, leading to enhanced transcription of mutant p53 target genes. It effectively upregulates p21 and other p53 target genes in pancreatic cell lines harboring the p53Y220C mutation. Notably, TRAP-1 demonstrates significant antiproliferative effects, exhibiting IC50 values of 0.531 μM in BxPC-3 cells (p53Y220C) compared to 3.94 μM in A549 cells (p53WT). TRAP-1 is a valuable tool for investigating cancer associated with the p53Y220C mutation. -
Survivin/XIAP Modulator
UC-112 is a selective modulator of survivin and XIAP, with notable anticancer properties. It induces the degradation of survivin through the ubiquitin-mediated proteasomal pathway, while also decreasing XIAP levels in in vivo tumor models. This compound activates caspase-3/7 and caspase-9, promoting apoptosis in cancer cells. UC-112 is relevant for research into melanoma, prostate cancer, and various cancer-related studies. -
Apoptosis Inducer
Glycidyl methacrylate is an apoptosis inducer that demonstrates concentration-dependent cytotoxicity and genotoxicity in human peripheral blood lymphocytes and CCRF-CEM leukemia cells. It induces DNA strand breaks and base oxidative damage through mechanisms associated with oxidative stress, although cellular repair systems can effectively mitigate the damage within two hours. This compound also has applications in the development of dental composite restorative materials. -
Apoptosis Inducer
8-Hydroxyefavirenz is a potent apoptosis inducer through a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Its ability to trigger programmed cell death positions it as a valuable tool in cancer research. Additionally, 8-Hydroxyefavirenz features an alkyne group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), enhancing its utility in click chemistry applications. -
Apoptosis Inducer
Taccalonolide A is a microtubule stabilizer derived from the plant Tacca chantrieri, known for its ability to induce apoptosis. This compound demonstrates significant cytotoxic effects, particularly in cancer cell lines, including those that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7). Taccalonolide A initiates apoptosis through mechanisms such as G2-M phase cell cycle accumulation and Bcl-2 phosphorylation, exhibiting an IC50 of 622 nM against SK-OV-3 cells. Its distinct properties make it a valuable tool for research in cancer biology and drug resistance. -
Apoptosis Inducer
Chaetoglobosin A is a potent apoptosis inducer derived from the extract of Penicillium aquamarinium and belongs to the cytochalasan family. It selectively targets filamentous actin in chronic lymphocytic leukemia (CLL) cells, leading to cell-cycle arrest and inhibition of membrane ruffling and cell migration. This compound is valuable for research in apoptosis mechanisms and cancer therapeutics. -
Apoptosis Inducer
Justicidin A is a natural compound isolated from Justicia procumbens that acts as an apoptosis inducer. It induces programmed cell death by decreasing Ku70 levels, which facilitates the translocation of Bax from the cytosol to the mitochondria. Justicidin A is valuable for researching cancer mechanisms and therapeutic strategies targeting apoptosis pathways. -
Apoptosis Inducer
Beta-Zearalanol is a mycotoxin derived from the Fusarium species, known for its role as an apoptosis inducer. This compound induces oxidative stress in mammalian reproductive cells, making it a valuable reagent for studies focused on cellular apoptosis and reproductive toxicology. Its ability to conjugate with glucuronic acid further supports its relevance in biochemical and pharmacological research. -
Apoptosis Inducer
5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole) acts as an apoptosis inducer, demonstrating the capacity to inhibit DNA lesion replication caused by Temozolomide. This artificial nucleoside promotes apoptosis in cancer cells and effectively halts the cell cycle at the G0 phase. In preclinical studies, 5-NIdR has been shown to enhance the anti-tumor efficacy of Temozolomide in murine models of glioblastoma, providing valuable insights for cancer therapeutics research. -
Apoptosis Inducer
Tetrahydroxyquinone, a redox-active benzoquinone, primarily induces apoptosis through the generation of reactive oxygen species (ROS). By participating in a redox cycle with semiquinone radicals, Tetrahydroxyquinone enhances oxidative stress within cells, making it a valuable tool for studying cellular mechanisms related to cell death and oxidative damage. Its ability to trigger apoptotic pathways positions it as a relevant compound for research in cancer biology and oxidative stress-related studies. -
Apoptosis Inducer
Rubropunctatin is an orange azaphilone pigment that functions as an apoptosis inducer. Isolated from Monascus pilosus-fermented rice, it displays notable anti-inflammatory, immunosuppressive, and antioxidative properties. Additionally, Rubropunctatin has demonstrated anti-tumor activity, making it a promising candidate for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Citreoviridin is a potent apoptosis inducer derived from Penicillium citreoviride NRRL 2579, primarily targeting Na+/K+-ATPase in brain synaptosomes. This compound exhibits a dose-dependent inhibition of cell proliferation and promotes apoptosis in human umbilical vein endothelial cells. Its unique mechanism of action and effects on ATPase activities make it a valuable reagent for research applications studying cellular apoptotic pathways and endothelial cell function. -
Apoptosis Inducer
Falcarinol is a natural compound that functions as an apoptosis inducer, primarily through its inhibition of the heat shock protein 90 (Hsp90) in both the N-terminal and C-terminal regions. Its selective mechanism showcases limited toxicity, making it a valuable tool for studying apoptotic pathways. Additionally, Falcarinol contains an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc), which enables its use in click chemistry applications for the conjugation of azide-containing compounds. -
Apoptosis Inducer
Ganglioside GD3 diammonium is an acidic glycosphingolipid that serves as an effective apoptosis inducer through its interaction with the mitochondrial permeability transition pore (PTPC). This compound inhibits the proliferation of cancer cells and activates the caspase family, facilitating apoptosis. Ganglioside GD3 diammonium is valuable for research into cancer biology and neurodegenerative diseases, providing insights into cell death mechanisms and potential therapeutic interventions. -
Apoptosis Inducer
Diffractaic acid is a proapoptotic compound primarily derived from Usnea longissima. It is recognized for its ability to induce apoptosis in various cellular models, making it relevant for research in cell death and related disorders. Additionally, diffractaic acid exhibits analgesic and antipyretic properties, contributing to its potential applications in neurobiology and anti-inflammatory studies. -
p53 Activator
Condurango glycoside A is a potent p53 activator that initiates reactive oxygen species (ROS) generation and up-regulates p53 expression. This compound effectively induces apoptosis and promotes premature senescence associated with DNA damage in HeLa cells. Its biological activity makes it a valuable tool for research focused on cellular stress responses and cancer biology. -
Apoptosis Inducer
Rabeprazole-d4 is a deuterated derivative of Rabeprazole, primarily acting as an apoptosis inducer through its irreversible inhibition of gastric H+/K+-ATPase. This second-generation proton pump inhibitor also functions as a uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole-d4 is valuable for research focused on gastric ulcerations and gastroesophageal reflux diseases, facilitating studies on its mechanisms of action and therapeutic potential. -
Apoptosis Inducer
XL44 is an apoptosis inducer that targets hRpn13, facilitating hRpn13-dependent programmed cell death. This compound reduces cell viability through a PCLAF-dependent mechanism, promoting the ubiquitin-dependent degradation of hRpn13Pru and the ubiquitin-independent degradation of specific proteins containing KEN boxes. XL44 is utilized in research applications focused on understanding apoptosis pathways and protein degradation mechanisms. -
Apoptosis Inducer
Chrysosplenol D is a methoxy flavonoid that functions as an apoptosis inducer, specifically targeting ERK1/2 signaling pathways in triple-negative human breast cancer cells. In addition to its pro-apoptotic effects, Chrysosplenol D displays anti-inflammatory properties and moderate antitrypanosomal activity, making it a valuable candidate for cancer research and studies focused on inflammation and parasitic infections. -
MDM2-p53 Interaction Inhibitor
MI-1061 TFA is a potent inhibitor of the MDM2-p53 interaction, exhibiting an IC50 of 4.4 nM and a Ki of 0.16 nM. This orally bioavailable and chemically stable compound effectively activates p53, leading to apoptosis in SJSA-1 xenograft tumor tissues in murine models. MI-1061 TFA demonstrates significant anti-tumor activity, making it a valuable tool for cancer research focused on the modulation of the p53 signaling pathway. -
Apoptosis Inducer
Genistein 8-c-glucoside (G8CG) acts as an apoptosis inducer by promoting mitochondrial membrane depolarization. This compound facilitates programmed cell death, making it a valuable tool for research applications focused on cancer biology and therapeutic interventions. G8CG’s mechanisms can be explored in various cellular models to better understand apoptosis and its regulation. -
Apoptosis Inducer
Phellamurin is a plant flavonoid glycoside derived from the leaves of Phellodendron amurense, primarily functioning as an apoptosis inducer. It has been shown to inhibit intestinal P-glycoprotein and demonstrates anti-tumor activity by promoting programmed cell death in various cancer cell lines. Additionally, Phellamurin affects the reproductive behavior of Papilio protenor by inhibiting egg-laying, indicating its potential applications in biological research related to apoptosis and cancer therapy. -
Apoptosis Inducer
Ganglioside GD3 disodium salt is an acidic glycosphingolipid that functions as an apoptosis inducer. It has been shown to inhibit the proliferation of cancer cells, influence the mitochondrial permeability transition pore (mPTP), and activate the caspase family, leading to programmed cell death. This compound is valuable for research applications focused on cancer biology and neurodegenerative diseases. -
Apoptosis Inducer
Zeylenone is a naturally occurring cyclohexene oxide that acts as an apoptosis inducer. It effectively inhibits cell proliferation and promotes apoptotic cell death in cervical carcinoma cells through the modulation of the PI3K/AKT/mTOR and MAPK/ERK signaling pathways. This compound serves as a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Mepazine acetate is an apoptosis inducer that inhibits the protease activity of MALT1, making it a valuable tool for investigating the role of MALT1 in various biological processes. In studies with mouse bone marrow precursor cells, treatment with mepazine acetate significantly reduced RANK ligand (RANKL)-induced osteoclast formation and suppressed the expression of key osteoclast markers, including TRAP and feline hepsin K. Notably, its protective effects were found to be independent of MALT1 deficiency, suggesting the involvement of alternative mechanisms. This compound is essential for research focused on apoptosis, osteoclast differentiation, and related signaling pathways. -
Apoptosis Inducer
Vitamin K2 is an apoptosis inducer that exerts its effects by promoting autophagy and inhibiting cell proliferation. It has demonstrated the ability to reduce proinflammatory cytokine levels, including IL-1β, TNF-α, and IL-6, making it relevant in studies related to inflammatory processes. Vitamin K2 is valuable for research into conditions such as involutional osteoporosis, non-alcoholic fatty liver disease, ulcerative colitis, acute myeloid leukemia, myelodysplastic syndromes, and hepatocellular carcinoma. -
Mdm2-MdmX Inhibitor
MMRi64 is a selective inhibitor of the Mdm2-MdmX protein interactions. This compound downregulates Mdm2 and MdmX levels in leukemia cells, leading to increased accumulation of p53 and activation of the apoptotic pathways associated with p53. MMRi64 is a valuable tool for cancer research, particularly in the study of leukemias and lymphomas, where modulation of the p53 signaling axis is critical. -
Apoptosis Inducer
Pyridinium bisretinoid A2E is an apoptosis inducer primarily found in lipofuscin within the retinal pigment epithelium. This compound triggers blue-light-induced apoptosis, facilitating autophagy and generating reactive oxygen species upon photoactivation. A2E is employed in research to investigate mechanisms underlying retinal degenerative diseases. -
Apoptosis Inducer
Resistomycin is a pentacyclic polyketide antibiotic that serves as an apoptosis inducer. It exhibits significant anticancer activity by promoting programmed cell death in various cancer cell lines. This compound is valuable for research applications focused on understanding apoptotic mechanisms and developing cancer therapeutics. -
Apoptosis Inducer
Secalonic acid D is a potent apoptosis inducer that targets GSK3-β, leading to the degradation of β-catenin. Isolated from the metabolites of Aspergillus aculeatus, this compound effectively down-regulates c-Myc expression and induces cell cycle arrest at the G1 phase. Its mechanism of action makes Secalonic acid D valuable for research on tumor cell apoptosis and cell cycle regulation in cancer studies. -
Apoptosis Inducer
Icariside D2 is an apoptosis inducer isolated from Annona glabra fruit that inhibits angiotensin-converting enzyme. It exhibits notable cytotoxicity against the HL-60 cell line with an IC50 value of 9.0 ± 1.0 μM. This compound is valuable in research focused on cancer biology, particularly in studies exploring mechanisms of programmed cell death and potential therapeutic interventions. -
Apoptosis Inducer
Girinimbine is a carbazole alkaloid recognized for its ability to induce apoptosis. This compound exhibits a range of biological activities including antitrypanosomal, antibacterial, antiplatelet, anti-inflammatory, antioxidant, and antitumor effects. It is valuable in research applications focused on cell death mechanisms and potential therapeutic strategies against various diseases. -
Apoptosis Inducer
Rotundifuran is a labdane-type diterpene isolated from Vitex rotundifolia, known for its role as an apoptosis inducer. This compound has been demonstrated to inhibit cell cycle progression and promote apoptosis in human myeloid leukemia cells, making it a valuable tool for cancer research. Its effects on cell viability and mechanisms of action provide insight into potential therapeutic applications targeting cancer cell survival. -
Apoptosis Inducer
Ganoderenic acid D is a triterpene that acts as an apoptosis inducer. Isolated from the extract of Ganoderma lucidum, this compound effectively inhibits the proliferation of cancer cells by promoting cell cycle arrest and triggering apoptotic pathways. It serves as a valuable tool in cancer research, particularly in studies focused on mechanisms of cell death and therapeutic interventions in oncology. -
Apoptosis Inducer
QN523 is an innovative apoptosis inducer that exhibits potent cytotoxicity across a diverse panel of 12 cancer cell lines. This compound facilitates programmed cell death and autophagy, making it a valuable tool for cancer research. Utilizing QN523 can enhance the understanding of apoptotic pathways and contribute to the development of targeted cancer therapies. -
Apoptosis Inducer
Soyasaponin III is a monodesmodic oleanane triterpenoid that acts as an apoptosis inducer. Derived from soy (Glycine max), this bioactive saponin demonstrates significant cytotoxicity in Hep-G2 cells, making it a valuable tool for research into cancer biology and therapeutic strategies targeting apoptosis. Its unique mechanism provides insights into the modulation of cell death pathways and potential applications in developing anticancer agents. -
Apoptosis Inducer
Kauran-16,17-diol is a natural diterpene that functions as an apoptosis inducer. This compound demonstrates significant anti-tumor activity, exhibiting an IC50 of 17 μM in inhibiting nitric oxide production in LPS-stimulated RAW 264.7 macrophages. Kauran-16,17-diol is valuable for research focused on cancer biology and mechanisms of apoptosis. -
Apoptosis Inducer
Dehydroleucodine, a sesquiterpene lactone derived from Artemisia douglasiana, acts as an apoptosis inducer. This compound exhibits significant antileukemic activity and has been shown to inhibit gastric ulcer formation. Additionally, Dehydroleucodine stabilizes mast cells by preventing degranulation triggered by compound 48/80, making it a valuable reagent for exploring mechanisms of cell death and inflammation in research applications. -
Apoptosis Inducer
OTS514 hydrochloride is a potent inhibitor of the TOPK kinase, exhibiting an IC50 value of 2.6 nM. This compound effectively suppresses the proliferation of TOPK-positive cancer cells by inducing cell cycle arrest and apoptosis. OTS514 hydrochloride is a valuable tool for research focusing on cancer biology and potential therapeutic strategies targeting apoptotic pathways. -
Apoptosis Inducer
AlbA-DCA is a novel apoptosis inducer formed by conjugating Albiziabioside A (AlbA) with dichloroacetate acid (DCA). This compound triggers a significant increase in intracellular reactive oxygen species (ROS) while reducing lactic acid buildup in the tumor microenvironment (TME). AlbA-DCA selectively targets and eliminates cancer cells, effectively inducing apoptosis and making it a valuable tool for research in cancer biology and therapeutic development. -
p53-MDM2 Inhibitor
DS-5272 is an orally active inhibitor of the p53-MDM2 interaction, demonstrating an IC50 of 20 nM. This compound effectively inhibits the proliferation of SJSA-1 cells (wildtype p53, IC50 = 0.17 μM) as well as DLD-1 cells (mutant p53). DS-5272 induces cell cycle arrest and promotes apoptosis in SJSA-1 cells, while also exhibiting antitumor efficacy in vivo in mouse models. This makes DS-5272 a valuable tool for research in cancer therapeutics targeting the p53 pathway. -
Apoptosis Inducer
VDR Agonist 1 is a nonsteroidal agonist of the Vitamin D receptor (VDR), exhibiting an IC50 of 690 nM in MCF-7 cells. This compound induces apoptosis by enhancing the expression of pro-apoptotic protein BAX while reducing anti-apoptotic protein Bcl-2 levels. Additionally, VDR Agonist 1 triggers cell cycle arrest through the up-regulation of cyclin-dependent kinase inhibitors p21 and p27, making it a valuable tool for studies related to cancer biology and therapeutic interventions targeting apoptotic pathways. -
MDM2-NFAT1 Inhibitor
MA242 free base is a targeted inhibitor of MDM2 and NFAT1, effectively disrupting their interaction. By binding with high affinity, MA242 promotes degradation of both proteins and suppresses NFAT1-mediated transcription of MDM2. This compound has demonstrated the ability to induce apoptosis in pancreatic cancer cell lines, providing a valuable tool for research in cancer biology and therapeutic applications, particularly in contexts where p53 is either mutated or absent.
