Catalog No.
Product Name
Application
Product Information
Citations
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elastogenesis inhibitor
L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. -
anti-cancer agent
Ginsenoside Rc, isolated from Panax ginseng, may exert various activities including anti-cancer, anti-inflammatory, antiobesity, and anti-diabetic effects. -
antiinflammatory agent
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation. -
anti-cancer agent
Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules. Falnidamol is a pyrimido-pyrimidine compound with anti-cancer activity. -
anti-bacterial agent
Pogostone is isolated from patchouli with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 ?g/ml . Pogostone induces cell apoptosis and autophagy. -
anti-inflammatory agent
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation. -
endothelial barrier enhancer
Ginsenoside Rk1, one of the main elements of Sung Ginseng, has been confirmed as a new endothelial barrier enhancer recently and has anti-cancer activity. -
antitumor agent
Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest. -
micronutrient
Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. -
Apoptosis Inducer
Thonningianin A is an ellagitannin that serves as an apoptosis inducer. Isolated from the methanolic extract of the African medicinal herb Thonningia sanguinea, this compound demonstrates significant antioxidant properties, including radical scavenging, anti-superoxide formation, and metal chelation. Thonningianin A is recognized for its potential anti-cancer activities, making it relevant for research in oncology and cellular signaling pathways related to apoptosis. -
Apoptosis Inducer
Hirsutine, an indole alkaloid derived from Uncaria rhynchophylla, serves as an apoptosis inducer with notable anti-cancer properties. It effectively triggers apoptotic pathways while demonstrating significant inhibitory effects against Dengue virus, all with low cytotoxicity. This compound is valuable for research in cancer biology and virology, enabling studies on apoptotic mechanisms and antiviral strategies. -
Apoptosis Inducer
Ganoderic Acid D is a tetracyclic triterpenoid derived from Ganoderma lucidum, known for its role as an apoptosis inducer. This compound facilitates the upregulation of SIRT3 protein expression, leading to enhanced deacetylation of cyclophilin D (CypD). Ganoderic Acid D effectively disrupts energy metabolism in colon cancer cells by inhibiting glucose uptake, lactate production, and the synthesis of pyruvate and acetyl-CoA. Additionally, it demonstrates potent apoptotic effects in HeLa human cervical carcinoma cells, making it a valuable reagent for cancer research applications. -
RIPK1 Binder
Ponicidin is a selective RIPK1 binder with an affinity of 135 nM for mouse RIPK1, functioning primarily as an apoptosis inducer and cell growth inhibitor. This compound modulates the JAK2/STAT3 signaling pathway to promote apoptosis, activates the PI3K/Akt pathway, and enhances SIRT1 expression. Additionally, Ponicidin exerts neuroprotective effects by alleviating oxidative stress, inhibiting inflammatory responses, and blocking necroptosis, while also increasing ROS production for antiproliferative and antiviral activity. It has significant implications for research in hepatocellular carcinoma, Alzheimer's disease, and gastric cancer. -
Apoptosis Inducer/Autophagy Inhibitor
Kumatakenin is a potent apoptosis inducer and autophagy inhibitor that targets ATG5 with a Kd value of 2.94 μM. It effectively enhances the activity of caspases 3, 8, and 9, leading to caspase-dependent apoptosis in ovarian cancer cells while modulating chemokines and pro-oncogenic factors. Kumatakenin also reduces M2 macrophage polarization, inhibits tumor progression in esophageal cancer by targeting FASN, and interacts with Eno3 to mitigate ferroptosis and alleviate intestinal inflammation. This compound is valuable for studies in ovarian cancer, esophageal cancer, depression, and colitis research. -
Apoptosis
Custirsen is a targeted antisense oligonucleotide that inhibits the expression of clusterin, an antiapoptotic protein often upregulated in response to chemotherapy. By downregulating clusterin, custirsen enhances apoptosis in cancer cells, thereby overcoming treatment resistance. This compound is primarily utilized in cancer research, particularly in studies focused on improving therapeutic efficacy and understanding apoptotic mechanisms in tumor biology. -
Apoptosis Inducer
Mepazine is a selective inhibitor of MALT1 protease, demonstrating IC50 values of 0.83 and 0.42 μM for full-length GSTMALT1 and the GSTMALT1 325-760 fragment, respectively. This compound effectively enhances apoptosis and reduces the viability of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cells. Mepazine serves as a valuable tool for investigating apoptosis mechanisms and potential therapeutic applications in cancer research. -
σ2 Receptor Agonist
PB28 dihydrochloride is a potent σ2 receptor agonist, exhibiting high affinity with a Ki of 0.68 nM, and also acts as a σ1 antagonist with a Ki of 0.38 nM. This compound demonstrates significant biological activity by inhibiting electrically evoked twitch responses in guinea pig bladder and ileum, with EC50 values of 2.62 μM and 3.96 μM, respectively. PB28 dihydrochloride has been shown to modulate SARS-CoV-2-human protein-protein interactions, induce caspase-independent apoptosis, and display antitumor effects, making it a valuable tool for research in neuropharmacology and cancer biology. -
Apoptosis Inducer
Medicarpin is a flavonoid derived from Medicago sativa that functions as an apoptosis inducer. It has been shown to effectively induce apoptosis and counteract multidrug resistance in leukemia P388 cells by modulating the P-glycoprotein-mediated efflux of chemotherapeutic agents. This compound serves as a valuable tool for research into cancer treatment and the mechanisms underlying drug resistance. -
IAP Antagonist
Dasminapant is a bivalent SMAC mimetic that functions as an inhibitor of inhibitor of apoptosis proteins (IAPs), specifically targeting XIAP, cIAP-1, cIAP-2, and ML-IAP. This compound induces the degradation of cIAP-1 and XIAP, resulting in the activation of caspase-3 and subsequent PARP cleavage, ultimately leading to programmed cell death (apoptosis). Dasminapant is valuable in research applications concerning hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma, providing insights into novel therapeutic strategies. -
Apoptosis Inducer
Bromelain is an apoptosis inducer derived from pineapple stem that exhibits anti-inflammatory properties. It functions by down-regulating plasma kininogen, inhibiting Prostaglandin E2 expression, and degrading advanced glycation end product receptors, alongside modulating angiogenic biomarkers and displaying antioxidant activity in the COX pathway. Bromelain demonstrates fibrinolytic, antiedematous, and antithrombotic effects, while also showcasing potential anticancer activities through the promotion of apoptotic cell death, making it a valuable tool for cancer research and inflammation studies. -
Apoptosis Inducer
ATH686 is a potent apoptosis inducer that selectively inhibits the mutant FLT3 protein kinase. By targeting ATP-binding sites, ATH686 effectively disrupts the proliferation of cells harboring FLT3 mutations, leading to apoptosis and cell cycle arrest. This compound is particularly relevant for research applications in the study of leukemic cell signaling and therapeutic interventions for FLT3-mutant leukemias. -
Apoptosis Inducer
Pinoresinol is a lignan that acts as an apoptosis inducer through the sensitization of cancer cells. It has been shown to enhance the susceptibility of these cells to TNF-related apoptosis-inducing ligand (TRAIL), thereby promoting apoptotic cell death. This compound is widely used in cancer research, particularly in studies aimed at elucidating mechanisms of TRAIL-induced apoptosis and developing potential therapeutic strategies. -
Apoptosis Inducer
Cycloartenol, a phytosterol compound, functions as an apoptosis inducer, exerting significant influence on cellular processes. It has been shown to inhibit glioma cell migration and suppress p38 MAP kinase phosphorylation, making it valuable for cancer research. Additionally, cycloartenol exhibits diverse pharmacological activities, including anti-inflammatory, antioxidant, and anti-tumor properties, as well as potential applications in neurodegenerative disease studies. This compound also contributes to essential processes in plant growth and development. -
Apoptosis Inducer
Pulsatilla saponin D is an apoptosis inducer derived from the root of Pulsatilla chinensis. It exhibits potent anti-tumor activity by promoting programmed cell death in cancer cells. This compound is primarily used in research applications focused on understanding the mechanisms of apoptosis and evaluating potential therapeutic strategies in oncology. -
Apoptosis Inducer
Physalin F is a secosteroid that acts as an apoptosis inducer. It effectively induces apoptosis in peripheral blood mononuclear cells (PBMCs), leading to a reduction in spontaneous proliferation and cytokine production associated with Human T-lymphotropic virus type 1 (HTLV-1) infection. This compound demonstrates significant anti-inflammatory and immunomodulatory properties, making it valuable for research in viral pathogenesis and cellular immune responses. -
Apoptosis Inducer
Mepazine hydrochloride is a potent apoptosis inducer that selectively inhibits MALT1 protease, exhibiting IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 325-760. This compound effectively enhances apoptosis in ABC-DLBCL cells, making it a valuable tool for research into apoptotic mechanisms and therapeutic strategies in cancer biology. -
Apoptosis Inducer
SW106065 is an apoptosis inducer that targets malignant peripheral nerve sheath tumors (MPNST). It effectively inhibits ATP consumption in sMPNST models with an EC50 of 1 µM. This compound is a valuable tool for investigating the molecular mechanisms of MPNST and evaluating potential therapeutic strategies. -
Apoptosis Inducer
Furanodienone is an apoptosis inducer derived from the bioactive constituents of Rhizoma Curcumae. It has been shown to effectively promote programmed cell death in various cell types, making it a candidate for research in cancer therapy and related fields. Its ability to modulate apoptotic pathways highlights its potential in studies exploring therapeutic interventions and cancer treatment strategies. -
Apoptosis Inducer
2'-Aminoacetophenone is an apoptosis inducer that functions primarily by disrupting mitochondrial activity through the induction of oxidative stress. This compound has demonstrated efficacy in regulating autophagy by inhibiting the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR. Additionally, it serves as a respiratory biomarker for detecting Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients, providing valuable insights into disease mechanisms. Its ability to induce apoptosis signals also contributes to its utility in investigating skeletal muscle dysfunction in murine models. -
Apoptosis Inducer
(E)-Flavokawain A is a chalcone derived from Kava that functions as an apoptosis inducer. It has demonstrated anticarcinogenic properties by inducing apoptosis in bladder cancer cells through a Bax protein-dependent and mitochondria-dependent pathway. Additionally, (E)-Flavokawain A has been shown to suppress tumor growth in murine models, making it a valuable compound for cancer research and therapeutic studies. -
Apoptosis Inducer
7,8-Dihydroneopterin is an apoptosis inducer that enhances the expression of inducible nitric oxide synthase (iNOS) in astrocytes and neurons. This compound plays a significant role in the study of neurodegenerative diseases by promoting cellular apoptosis. Its biological activity provides valuable insights into mechanisms underlying neuroinflammation and neurodegeneration. -
Apoptosis Inducer/Insecticide
Dihydrorotenone is an irreversible inhibitor of mitochondrial complex I and serves as an apoptosis inducer. It demonstrates significant cytotoxicity to human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. Dihydrorotenone's insecticidal properties position it as a valuable tool in studies on neurodegenerative diseases, such as Parkinson's disease, as well as in safety assessments of natural pesticides and cancer chemoprevention research. -
Apoptosis Inducer
Prostaglandin A2 (PGA2) is a cyclopentenone prostaglandin that functions as an apoptosis inducer by activating caspase pathways and modulating the p53 signaling pathway. It also activates ERK2 and JNK1/SAPK pathways, contributing to its role in cell death and differentiation. Prostaglandin A2 exhibits antiviral properties against HSV-1 and demonstrates anti-tumor effects, making it relevant in research applications related to colorectal cancer, breast carcinoma, and herpetic keratitis. -
Apoptosis Inducer
Kahweol is a compound derived from Coffea arabica, functioning primarily as an apoptosis inducer. It exhibits anti-inflammatory, anti-angiogenic, and anti-cancer properties. Kahweol activates AMP-activated protein kinase (AMPK), leading to inhibition of adipogenesis and promotion of glucose uptake. Its biological activities make it valuable for research into cancer biology and metabolic disorders. -
Apoptosis Inducer
Ingenol 3,20-dibenzoate is a selective agonist of specific protein kinase C (PKC) isoforms, primarily targeting nPKC-delta, -epsilon, -theta, and PKC-mu. This compound induces morphologically characteristic apoptosis through the de novo synthesis of macromolecules and facilitates the translocation of these PKC isoforms from the cytosolic to the particulate fraction. Additionally, Ingenol 3,20-dibenzoate enhances interferon-gamma production and promotes the degranulation of natural killer (NK) cells, particularly in the context of non-small cell lung cancer (NSCLC) cell stimulation. Its applications are valuable in research focused on apoptosis and immune response modulation. -
Apoptosis Inducer
Bixin is a carotenoid derived from the seeds of Bixa orellana that acts as an apoptosis inducer. It has been shown to effectively induce cell death in cancer cells while also exhibiting notable anti-inflammatory, anti-tumor, and antioxidant properties. Additionally, Bixin treatment has demonstrated a protective effect on cardiac function by reducing fibrosis, inflammation, and the generation of reactive oxygen species (ROS), making it a valuable compound for research in cancer and cardiovascular diseases. -
Apoptosis Inducer
Euphorbia Factor L2 is a lathyrane diterpenoid that acts as an apoptosis inducer. Isolated from the seeds of Euphorbia lathyris L., it demonstrates potent cytotoxicity and triggers apoptosis through the mitochondrial pathway. This compound is a valuable tool for cancer research, providing insights into mechanisms of cell death and potential therapeutic applications in oncology. -
Apoptosis Inducer
Falcarindiol is an orally active polyacetylenic oxylipin that functions as an apoptosis inducer by activating PPARγ and enhancing the expression of the cholesterol transporter ABCA1 in cells. This compound exhibits significant biological activities, including anti-inflammatory, antifungal, anticancer, and antidiabetic effects. Additionally, as a click chemistry reagent, Falcarindiol contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it valuable for various research applications. -
Apoptosis Inducer
Ethylene dimethanesulfonate is a pro-apoptotic compound that functions as a mild alkylating agent. It selectively induces apoptosis in lymphocytes, making it a valuable tool for studying programmed cell death. This reagent is useful in research applications involving cancer biology, immunology, and cellular stress response mechanisms. -
Apoptosis Inducer
Delphinidin 3-rutinoside chloride is an active anthocyanin that functions as an apoptosis inducer, primarily targeting B cell chronic lymphocytic leukemia (B CLL). This compound demonstrates pro-apoptotic effects by promoting cell death in B CLL cells. Additionally, it exhibits phytoestrogen activity through its binding affinity for estrogen receptor beta (ERβ), with an IC50 value of 2.3 μM, making it a valuable tool for cancer research and apoptosis studies. -
Apoptosis Inducer
Leachianone A is a potent apoptosis inducer derived from Radix Sophorae. This compound exhibits notable anti-malarial, anti-inflammatory, and cytotoxic properties. Leachianone A effectively triggers apoptosis through both extrinsic and intrinsic pathways, making it a valuable reagent for research in therapeutic applications aimed at programmed cell death and disease modulation. -
Apoptosis Inducer
Polygalacin D (PGD) is an apoptosis inducer derived from Platycodon grandiflorum, exhibiting significant anticancer and anti-proliferative effects. It effectively downregulates inhibitor of apoptosis (IAP) proteins, including survivin, cIAP-1, and cIAP-2, while inhibiting the PI3K/Akt signaling pathway through the dephosphorylation of GSK3β and Akt, along with reduced expression of PI3K. PGD serves as a valuable reagent for research in cancer biology and therapeutic investigations targeting apoptosis mechanisms. -
Apoptosis Inducer
δ-Cadinene is a sesquiterpene primarily known for its role as an apoptosis inducer. It exhibits significant antiproliferative and pro-apoptotic effects specifically in human ovarian cancer (OVCAR-3) cells. Additionally, δ-Cadinene demonstrates broad-spectrum bioactivity, including trichomonacidal, antimicrobial, antifungal, and anticancer properties, making it a valuable compound for various research applications in cancer biology and infectious disease studies. -
Apoptosis Inducer
(E/Z)-E64FC26 is a mixture of E-E64FC26 and Z-E64FC26, functioning as a potent pan-inhibitor of the protein disulfide isomerase (PDI) family. It exhibits significant biological activity with IC50 values of 1.9 μM for PDIA1, 20.9 μM for PDIA3, 25.9 μM for PDIA4, 16.3 μM for TXNDC5, and 25.4 μM for PDIA6. This compound is particularly valuable in research related to apoptosis induction and has demonstrated anti-myeloma properties. -
ASK1 Inhibitor
ASK1-IN-2 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), demonstrating a potent inhibitory activity with an IC50 of 32.8 nM. This compound is valuable for research applications related to ulcerative colitis, as it modulates inflammatory pathways mediated by ASK1. Its orally active nature makes it suitable for in vivo studies aimed at exploring the therapeutic potential in gastrointestinal diseases.
