ASK1 ligand 1

Catalog No.: A53662
ASK1 Ligand
ASK1 Ligand 1 is a selective binding ligand for Apoptosis Signal-Regulating Kinase 1 (ASK1). This compound facilitates the development of PROTACs, including dASK1-VHL, enabling targeted protein degradation. Its primary applications lie in studies of apoptosis and signal transduction pathways, making it a valuable tool in cancer research and therapeutic development.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionASK1 Ligand 1 is a selective binding ligand for Apoptosis Signal-Regulating Kinase 1 (ASK1). This compound facilitates the development of PROTACs, including dASK1-VHL, enabling targeted protein degradation. Its primary applications lie in studies of apoptosis and signal transduction pathways, making it a valuable tool in cancer research and therapeutic development.
Product Information
Catalog NumA53662
FormulaC17H16F2N6O
Molecular Weight358.35
CAS Number3064087-54-0
SMILESO=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N)=C(F)C=C3F
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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