Catalog No.
Product Name
Application
Product Information
Citations
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Apoptosis Inducer
Fexapotide is an apoptosis inducer that selectively targets prostate cells, resulting in a reduction of prostate volume at the cellular level. This compound is primarily applied in research related to lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), providing insights into potential therapeutic interventions for these conditions. -
Apoptosis Inducer
Anticancer Agent 71 is a potent apoptosis inducer that targets the regulation of cell cycle and apoptotic pathways. This compound effectively arrests cells at the G2/M phase and promotes apoptosis by upregulating Bax, IkB-α, and cleaved PARP, while simultaneously downregulating Bcl-2 expression levels. Anticancer Agent 71 demonstrates significant antiproliferative activity, making it a valuable tool for cancer research applications focused on programmed cell death. -
Apoptosis Inducer
TJ08 is a 1,2,5-trisubstituted benzimidazole derivative that acts as an effective apoptosis inducer. It efficiently induces G1/S phase arrest while promoting apoptosis in a variety of cancer cell types. This compound is valuable for research applications focused on cancer biology and therapeutic development targeting apoptotic pathways. -
Apoptosis Inducer
Apiole is an apoptosis inducer that targets and inhibits human colon cancer cells, primarily by promoting G0/G1 cell cycle arrest. This compound demonstrates significant anti-tumor activity, as evidenced by its ability to inhibit colon tumor development in various in vivo mouse xenograft models. Apiole is valuable for research applications focused on cancer biology and therapeutic development. -
Apoptosis Inducer
Apoptosis Inducer 46 targets apoptotic pathways to induce cell death selectively in metastatic triple-negative breast cancer (TNBC) cells. It demonstrates potent growth inhibitory effects, specifically causing G2/M phase cell cycle arrest and promoting apoptotic cell death in MDA-MB-231 cells. Additionally, Apoptosis Inducer 46 inhibits NF-κB nuclear translocation, highlighting its potential for research applications in the study of TNBC. -
Apoptosis Inducer
Kusunokinin is a natural product isolated from Piper nigrum, functioning primarily as an apoptosis inducer. It demonstrates significant anticancer activity by arresting the cell cycle at the G2/M phase, leading to the activation of apoptotic pathways in cancer cells. This compound is useful for research applications focused on cancer biology and the mechanisms underlying cell cycle regulation and apoptosis. -
Apoptosis Inducer
NC-001 is a selective apoptosis inducer that primarily targets renal proximal tubular cells and renal cancer cells. This compound has demonstrated the ability to inhibit tumor growth in clear cell renal cell carcinoma (CCRCC) xenograft models, making it a valuable tool for investigating metastatic renal cell carcinoma. Its mechanism of action positions NC-001 as a promising candidate for research focused on renal cancer therapies. -
Apoptosis Inducer
Antitumor agent-100 hydrochloride is a potent apoptosis inducer targeting PDE3A-SLFN12, exhibiting an IC50 of 0.3 μM. This compound binds to the enzyme pocket of PDE3A, facilitating the recruitment and stabilization of SLFN12, which inhibits protein translation and initiates apoptotic pathways. It serves as a valuable tool in oncology research, particularly in studies focused on apoptosis and antitumor mechanisms. -
ASK1 Inhibitor
ASK1-IN-4 is a selective inhibitor of Apoptosis Signal-regulating Kinase 1 (ASK1), demonstrating an IC50 of 0.2 μM. This compound effectively interacts with the ATP-binding site of ASK1, leading to the modulation of apoptotic signaling pathways. ASK1-IN-4 is primarily utilized in research focused on apoptosis regulation, oxidative stress response, and related therapeutic investigations. -
Apoptosis Inducer
2-Methoxyjuglone is a naphthoquinone that functions primarily as an apoptosis inducer. It activates caspase-9 and caspase-3 through the mitochondrial cytochrome c-dependent intrinsic apoptosis pathway, leading to increased pro-apoptotic Bax levels and decreased anti-apoptotic Bcl-2 levels. 2-Methoxyjuglone also induces apoptosis by promoting mitochondrial cytochrome c release and is associated with morphological changes of apoptosis, early apoptotic signals, cell cycle arrest in S-phase and G2/M-phase, as well as DNA double-strand breaks. Additionally, it exhibits antimicrobial properties against Gram-positive bacteria and pathogenic fungi, making it valuable in the research of various cancers, including hepatocellular carcinoma and breast cancer, as well as in studies of fungal and bacterial infections. -
Apoptosis Inducer
Griffipavixanthone is an apoptosis inducer that targets the mitochondrial apoptotic pathway, leading to increased reactive oxygen species (ROS) production within cells. Its primary biological activity is the induction of cell apoptosis, making it a valuable agent in anti-cancer research. Additionally, Griffipavixanthone exhibits weak inhibitory activity against sucrase, with an IC50 of 4.58 mM, suggesting potential implications in metabolic studies. -
Neural Apoptosis Inducer
NTR 368 is a peptide derived from the p75 neurotrophin receptor (p75NTR), specifically corresponding to residues 368-381 of the human protein. This compound exhibits a propensity to form alpha-helices in the presence of micellar lipids, enhancing its interaction with cellular membranes. NTR 368 serves as a potent inducer of neural apoptosis, making it a valuable tool for studying neurodegenerative processes and the mechanisms underlying neuronal cell death in research applications. -
Apoptosis Inducer
Asparanin A is an apoptosis inducer that exhibits significant anticancer activity. It triggers cell cycle arrest in the G0/G1 phase by targeting mitochondrial pathways and the PI3K/AKT signaling cascade, ultimately inhibiting the proliferation of cancer cells. Additionally, Asparanin A has showcased in vivo efficacy in a mouse xenograft model of Ishikawa endometrial carcinoma, where it substantially reduced tumor growth. -
Apoptosis Inducer
Amiloride is an inhibitor of epithelial sodium channels (ENaC) and the urokinase-type plasminogen activator receptor (uPAR). This compound has been shown to induce apoptosis through its modulation of sodium ion transport and intracellular signaling pathways. Research applications include studies on renal function, cancer cell metabolism, and the investigation of ion channel-related diseases. Additionally, Amiloride has been explored as a potential therapeutic agent in various pathophysiological conditions. -
Apoptosis Inducer
Silybin is a flavonolignan derived from the seeds of milk thistle (Silybum marianum) with a primary mechanism as an apoptosis inducer. It exhibits notable hepatoprotective, antioxidant, and anti-inflammatory properties, making it a valuable compound for cancer research. This compound's multifaceted biological activities support its potential applications in studies focused on cell death pathways and liver health. -
Apoptosis Inducer
Pyridinium bisretinoid A2E TFA is an apoptosis inducer primarily involved in the study of retinal degenerative diseases. Isolated from lipofuscin in the retinal pigment epithelium, A2E TFA serves as a fluorophore that facilitates blue-light-induced apoptosis. Upon photoactivation, it mediates autophagy and stimulates the production of reactive oxygen species, making it a valuable tool in the investigation of cellular processes linked to retinal health and disease. -
Apoptosis Inducer
Procyanidin C1 is a natural polyphenol that functions as an apoptosis inducer. It induces DNA damage and induces cell cycle arrest, promoting apoptotic pathways by reducing Bcl-2 levels while enhancing BAX, caspase 3, and caspase 9 expression in cancer cells. Additionally, Procyanidin C1 exhibits senotherapeutic activity and has been shown to increase lifespan in murine models, making it a valuable tool for cancer research and studies on aging. -
Survivin Inhibitor
FL118, a potent survivin inhibitor, is a synthetic analogue of camptothecin (10,11-(Methylenedioxy)-20(S)-camptothecin). It functions by binding to the oncoprotein DDX5 (p68), leading to its dephosphorylation and degradation. FL118 is instrumental for cancer research, providing valuable insights into therapeutic strategies targeting survivin-related pathways. -
Apoptosis Inducer
Bruceine D is an apoptosis inducer that targets the Notch signaling pathway, demonstrating significant anti-cancer activity in various human cancer cell lines. This compound effectively induces cell death, making it a valuable tool for cancer research. Additionally, Bruceine D exhibits potent anthelmintic properties against D. intermedius, with an EC50 value of 0.57 mg/L, highlighting its potential applications in both cancer biology and parasitology. -
p53 Stabilizer/MDM2 PROTAC Degrader
Seldegamadlin is a selective p53 stabilizer and an MDM2 PROTAC degrader with a DC50 of 0.4 nM. It effectively inhibits the proliferation of RS4;11 cancer cells, demonstrating an IC50 of 0.3 nM, and induces cell cycle arrest at the G2/M phase while promoting apoptosis. By upregulating p53 activity, Seldegamadlin overcomes the p53-MDM2 feedback loop, making it a valuable tool for research in hematologic and solid tumors, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). -
Apoptosis Inducer
Selumetinib sulfate is a selective, non-ATP-competitive inhibitor of MEK1/2, exhibiting an IC50 of 14 nM against MEK1. By inhibiting the phosphorylation of ERK1/2, Selumetinib sulfate induces apoptosis in cancer cells. Additionally, its ability to penetrate the blood-brain barrier enhances its potential for therapeutic applications in brain tumors and other central nervous system malignancies. -
Apoptosis Inducer
Bacopaside II is an apoptosis inducer derived from the medicinal herb Bacopa monnieri. It functions as an inhibitor of AQP1 and demonstrates anti-angiogenesis activity. Bacopaside II exhibits significant cytotoxicity, effectively inducing apoptosis in cancer cells, making it a valuable tool for cancer research and therapeutic exploration. -
PKD/PIM2 Inhibitor
CRT0066101 is a potent and orally active inhibitor of Protein Kinase D (PKD) with IC50 values of 1 nM, 2.5 nM, and 2 nM for PKD1, PKD2, and PKD3, respectively. Additionally, it serves as an effective PIM2 inhibitor with an IC50 of approximately 135.7 nM. This compound exhibits notable anti-inflammatory activity demonstrated in LPS-induced lung injury models in mice, as well as anticancer effects, making it a valuable tool for research in cancer and inflammation-related studies. -
Apoptosis Inducer
SM-164 hydrochloride is a potent Smac mimetic compound that functions as an apoptosis inducer by targeting the X-linked inhibitor of apoptosis protein (XIAP). It binds with high affinity to the BIR2 and BIR3 domains of XIAP, exhibiting an IC50 value of 1.39 nM. This compound is primarily utilized in research applications focused on dissecting apoptotic pathways and exploring therapeutic strategies for cancers that evade cell death mechanisms. -
MDM2 Inhibitor
D-CopA3 functions as an MDM2 inhibitor, promoting the activation of the p53 signaling pathway. It demonstrates significant cytotoxicity against colorectal cancer cell lines HCT-116, LoVo, and RKO, with an IC50 ranging from 15 to 18 μM, and induces JNK/Beclin-1-mediated autophagy. Additionally, D-CopA3 reduces the expression of the cell cycle inhibitor p21Cip1/Waf1, enhances mucosal barrier function, and exhibits anti-inflammatory properties in models of acute enteritis and chronic colitis. Furthermore, it has shown anti-tumor efficacy in HCT-116 mouse xenograft models. -
Anti-p53 Agent
PK11007 is an anti-p53 agent that functions as a mild thiol alkylator, exhibiting significant anticancer activity. It selectively alkylates two surface-exposed cysteines on the p53 protein, leading to its stabilization without interfering with its DNA binding capabilities. Additionally, PK11007 promotes cell death in mutant p53 cancer cells by elevating reactive oxygen species (ROS) levels, making it a valuable compound for cancer research applications targeting p53 pathways. -
PROTAC GPX4 Degrader
PROTAC GPX4 degrader-5 is a selective degrader targeting GPX4, with a DC50 of 28 nM. This compound effectively induces ferroptosis and enhances reactive oxygen species (ROS) levels while exhibiting low toxicity to normal cells. PROTAC GPX4 degrader-5 demonstrates significant anti-proliferative effects in various tumor cell lines, making it a valuable tool for cancer research. -
ROCK Inhibitor
3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine is a selective inhibitor of Rho-associated protein kinase (ROCK), exhibiting IC50 values of 0.092 μM for PKC-α, 0.26 μM for ROCK, and 0.77 μM for ASK1. This compound demonstrates significant cytotoxic activity against human prostate cancer PC-3 cells, with an IC50 value of 0.16 μM. Its efficacy in inhibiting kinase activity makes it a valuable tool for research in cancer therapeutics and related signaling pathways. -
Caspase-3/Caspase-7 Inhibitor
Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7, targeting the proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site. This compound is crucial for studying apoptosis and cellular signaling mechanisms by selectively modulating caspase activity. Its application extends to research areas involving cell death regulation and disease models where caspase-mediated pathways play a pivotal role. -
Glutathione Peroxidase Inhibitor
4-Methylesculetin is a coumarin derivative that functions as a potent inhibitor of glutathione peroxidase. This compound exhibits significant antioxidant and anti-inflammatory properties, effectively inhibiting myeloperoxidase activity. In research applications, 4-Methylesculetin demonstrates the ability to attenuate bone resorption by downregulating elevated levels of bone-related exoglycosidases, cathepsin D, and tartrate-resistant acid phosphatases. Additionally, it reduces the expression of pro-inflammatory markers such as TNF-α, IL-1β, IL-6, COX-2, and PGE2, making it a valuable tool for studying inflammatory diseases. -
Apoptosis Inducer
Enniatin A1 is a cyclic hexadepsipeptide that functions as an apoptosis inducer. Isolated from Fusarium mycotoxins, this compound exhibits anticarcinogenic properties primarily through the induction of apoptosis and disruption of the ERK signaling pathway. In addition, Enniatin A1 demonstrates inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) with an IC50 of 49 μM in rat liver microsomes, making it a valuable tool for research in cancer biology and lipid metabolism. -
Apoptosis Inducer
Apoptosis Inducer 42 is a potent agent that triggers late-stage apoptosis and inhibits interleukin-6 (IL-6) secretion. This compound demonstrates significant cytotoxic effects against various cancer cell lines, making it a valuable tool for cancer research, particularly in the study of colon cancer. Its mechanism of action and ability to modulate key cytokines enhance its utility in investigating apoptotic pathways and therapeutic strategies in oncology. -
Apoptosis Inducer
Actisomide is a potent apoptosis inducer that primarily targets mitochondrial pathways to initiate programmed cell death. This compound demonstrates significant biological activity in various cellular models, making it a valuable tool for research on apoptosis and related signaling pathways. Its pH-dependent absorption in animal models and in vitro uptake in CaCo-2 cells highlight its relevance in pharmacological studies and drug development. Researchers can utilize Actisomide to elucidate mechanisms of apoptosis and investigate potential therapeutic applications in cancer and other diseases characterized by dysregulated cell death. -
ASK1 Inhibitor
Selonsertib hydrochloride is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1). This compound exerts anti-inflammatory, anti-tumor, and anti-fibrotic effects by blocking the phosphorylation and activation of ASK1 through its binding to the catalytic kinase domain. It also attenuates the production of inflammatory cytokines and decreases the expression of fibrosis-related genes, thereby inhibiting excessive apoptosis and limiting cell proliferation. These properties make selonsertib hydrochloride a valuable tool for research in inflammation and fibrotic diseases. -
p53 Stabilizer
p53 Stabilizer 2 (Compound 17a16) is a potent p53 stabilizer that enhances the stability and function of the p53 protein. This compound induces S-phase arrest and apoptosis in both p53-proficient and p53-deficient cancer cells, demonstrating its broad therapeutic potential. Mechanistically, p53 Stabilizer 2 triggers mitochondrial stress and activates critical checkpoint pathways, including NA-PKcs-dependent p53 stabilization and ATR-Chk1 axis activation. Additionally, it has shown efficacy in inhibiting tumor growth in p53-deficient xenograft models, making it a valuable tool for cancer research. -
Apoptosis Inducer
Uvarigrin is a potent apoptosis inducer targeting multidrug-resistant tumor cells. Isolated from the roots of Uvaria calamistrata, it effectively activates Caspase-9, leading to programmed cell death. This compound holds potential for research in cancer therapy and the mechanisms underlying drug resistance. -
Apoptosis Inducer
Ginsenoside Rs3 is a natural diol-type ginseng saponin that functions as an apoptosis inducer. It selectively enhances the protein levels of p53 and p21WAF1, leading to the induction of apoptosis in SK-HEP-1 cells. Ginsenoside Rs3 is utilized in cancer research to explore mechanisms of tumor cell death and the regulation of apoptosis-related pathways. -
Apoptosis Inducer
ABL-L is an apoptosis inducer that targets the p53-dependent pathway. This compound effectively promotes apoptosis in human laryngocarcinoma cells, making it a valuable tool for cancer research. Its ability to modulate apoptotic mechanisms supports investigations into therapeutic strategies for treating laryngeal cancer and related malignancies. -
Apoptosis Inducer
Telomerase-IN-4 is a potent telomerase inhibitor that induces apoptosis in targeted cells. It demonstrates significant antiproliferative activity, making it a valuable tool for research in cancer biology and therapeutic development. This compound can be utilized to explore mechanisms of cell death and the role of telomerase in tumor progression. -
Apoptosis Inducer
Apoptosis Inducer 4 (Compound 12b) primarily functions as an apoptosis inducer, targeting the apoptotic pathway to initiate programmed cell death. This compound exhibits significant anticancer activity, making it a valuable tool for research focused on cancer therapeutics and the mechanisms of apoptosis. Its role in triggering apoptosis positions it as a potential candidate for investigating treatments aimed at tumor cell eradication and understanding the underlying processes of cell death in various cancer types. -
Apoptosis Inducer
Carubicin, a potent apoptosis inducer, is derived from microbial sources. This compound effectively inhibits the proliferation of VHL-deficient clear cell renal cell carcinoma (CCRCC) cells. Notably, Carubicin induces apoptosis through mechanisms that are independent of p53 and hypoxia-inducible factor 2 (HIF2), highlighting its unique mode of action. Its specific biological activity makes Carubicin a valuable tool for research into cancer therapeutics. -
ASK1 Inhibitor
ASK1-IN-3 is a selective inhibitor of the apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 33.8 nM. This compound demonstrates significant apoptotic induction in HepG2 cancer cells and exhibits effective cell cycle arrest. Its ability to modulate the activity of several cell cycle regulating kinases renders ASK1-IN-3 valuable for research applications related to cancer therapy and cell cycle regulation studies. -
Apoptosis Inducers
Antiangiogenic Agent 7 is an apoptosis inducer known for its ability to stimulate cell death through increased production of Reactive Oxygen Species and inhibition of thioredoxin reductase, an intracellular enzyme. This compound exhibits notable anti-cancer properties, displaying an IC50 range of 0.08-3.5 μM against various cancer cell lines, including HeLa (cervical), PC-3 (prostate), and A549 (non-small cell lung cancer). Additionally, Antiangiogenic Agent 7 demonstrates the potential to inhibit tumor growth in mouse xenograft models, making it a valuable tool for cancer research. -
PKD Inhibitor
CRT0066101 trihydrochloride is a potent inhibitor of Protein Kinase D (PKD), exhibiting IC50 values of 1 nM, 2.5 nM, and 2 nM against PKD1, PKD2, and PKD3, respectively. In addition to its PKD-inhibitory properties, it also targets PIM2 with an IC50 of approximately 135.7 nM. This compound demonstrates significant anti-inflammatory effects in lipopolysaccharide (LPS)-induced lung injury models in mice and exhibits potential anticancer activity, making it a valuable reagent for research in oncology and inflammation. -
Apoptosis Inducer
2-Deoxy-L-ribose functions as an apoptosis inducer by inhibiting the anti-apoptotic effects of its stereoisomer, 2-Deoxy-D-ribose. This compound has been shown to suppress the metastasis of tumor cells that overexpress thymidine phosphorylase, making it a valuable reagent for research in cancer biology and therapeutic applications targeting apoptosis pathways. -
Apoptosis Inducer
c-Met/MEK1/Flt-3-IN-1 functions as an apoptosis inducer through the inhibition of key signaling pathways involved in cell proliferation and survival. It demonstrates significant antiproliferative effects, exhibiting IC50 values of 0.21 µM in HeLa cells, 0.39 µM in A549 cells, and 0.33 µM in MCF-7 cells. This compound also induces apoptosis in A549 cells in a dose-dependent manner by causing cell cycle arrest at the G1 phase, making it a valuable tool for cancer research and therapeutic studies targeting apoptosis. -
Apoptosis Inducer
Apoptosis Inducer 6 is an agent that promotes apoptosis in cancer cells, serving as a valuable tool in anticancer research. It effectively initiates cell death by activating apoptotic pathways, demonstrating broad-spectrum anticancer activity across various cancer types. This compound is essential for studies investigating mechanisms of cell death and the development of novel cancer therapies. -
Apoptosis Inducer
Antitumor agent-100 (compound A6) is an orally bioavailable apoptosis inducer targeting PDE3A and SLFN12, with an IC50 value of 0.3 μM. This compound functions by binding to the PDE3A enzyme pocket, effectively recruiting and stabilizing SLFN12, which disrupts protein translation and promotes apoptosis. Antitumor agent-100 demonstrates significant potential in cancer research applications, particularly in programs focusing on apoptosis regulation and tumor suppression mechanisms. -
Apoptosis Inducer
β-Apopicropodophyllin is a natural product known for its role as an apoptosis inducer. It exerts its effects through mechanisms that include microtubule disruption, DNA damage, cell cycle arrest, and endoplasmic reticulum stress. This compound is particularly relevant for research applications in cancer biology, facilitating studies on apoptotic pathways and potential therapeutic strategies. -
Apoptosis Inducer
JR5-26B is an orally bioavailable apoptosis inducer that mediates cell death through copper-dependent mechanisms, including apoptosis and necroptosis. It demonstrates significant antiproliferative effects on various pancreatic cancer cell lines, including MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2, with IC50 values of 0.6 μM, 4.4 μM, 8.0 μM, 1.1 μM, and 3.4 μM, respectively. This compound serves as a valuable tool for investigating apoptotic pathways and the treatment of malignancies.
