Catalog No.
Product Name
Application
Product Information
Citations
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Apoptosis Inducer
2-Deoxy-L-ribose functions as an apoptosis inducer by inhibiting the anti-apoptotic effects of its stereoisomer, 2-Deoxy-D-ribose. This compound has been shown to suppress the metastasis of tumor cells that overexpress thymidine phosphorylase, making it a valuable reagent for research in cancer biology and therapeutic applications targeting apoptosis pathways. -
Apoptosis Inducer
c-Met/MEK1/Flt-3-IN-1 functions as an apoptosis inducer through the inhibition of key signaling pathways involved in cell proliferation and survival. It demonstrates significant antiproliferative effects, exhibiting IC50 values of 0.21 µM in HeLa cells, 0.39 µM in A549 cells, and 0.33 µM in MCF-7 cells. This compound also induces apoptosis in A549 cells in a dose-dependent manner by causing cell cycle arrest at the G1 phase, making it a valuable tool for cancer research and therapeutic studies targeting apoptosis. -
Apoptosis Inducer
Apoptosis Inducer 6 is an agent that promotes apoptosis in cancer cells, serving as a valuable tool in anticancer research. It effectively initiates cell death by activating apoptotic pathways, demonstrating broad-spectrum anticancer activity across various cancer types. This compound is essential for studies investigating mechanisms of cell death and the development of novel cancer therapies. -
Apoptosis Inducer
Antitumor agent-100 (compound A6) is an orally bioavailable apoptosis inducer targeting PDE3A and SLFN12, with an IC50 value of 0.3 μM. This compound functions by binding to the PDE3A enzyme pocket, effectively recruiting and stabilizing SLFN12, which disrupts protein translation and promotes apoptosis. Antitumor agent-100 demonstrates significant potential in cancer research applications, particularly in programs focusing on apoptosis regulation and tumor suppression mechanisms. -
Apoptosis Inducer
β-Apopicropodophyllin is a natural product known for its role as an apoptosis inducer. It exerts its effects through mechanisms that include microtubule disruption, DNA damage, cell cycle arrest, and endoplasmic reticulum stress. This compound is particularly relevant for research applications in cancer biology, facilitating studies on apoptotic pathways and potential therapeutic strategies. -
Apoptosis Inducer
JR5-26B is an orally bioavailable apoptosis inducer that mediates cell death through copper-dependent mechanisms, including apoptosis and necroptosis. It demonstrates significant antiproliferative effects on various pancreatic cancer cell lines, including MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2, with IC50 values of 0.6 μM, 4.4 μM, 8.0 μM, 1.1 μM, and 3.4 μM, respectively. This compound serves as a valuable tool for investigating apoptotic pathways and the treatment of malignancies. -
Apoptosis Inducer
Momordicoside G is a cucurbitane-type triterpene glycoside that functions as an apoptosis inducer. It selectively triggers apoptosis in M1-like macrophages while sparing M2-like macrophages, thereby modulating immune responses. Additionally, Momordicoside G reduces intracellular reactive oxygen species (ROS) and promotes autophagy, contributing to its anticancer properties by inhibiting the growth of various cancer cell lines. Furthermore, it stimulates repair mechanisms in M2-associated lung injury and provides protective effects against inflammatory lung cancer damage. -
Apoptosis Inducer
Digallic acid is an apoptosis inducer that demonstrates antioxidant, antimutagenic, and antigenotoxic properties. This compound acts as a reverse transcriptase inhibitor and inhibits xanthine oxidase (XOD) and URAT1, with an IC50 of 5.34 μM. Additionally, digallic acid effectively scavenges DPPH· and O2·− radicals, making it valuable in cancer research and oxidative stress studies. It can be isolated from the fruits of Pistacia lentiscus, highlighting its natural sources. -
Apoptosis Inducer
Anticancer agent 173 is a potent thioxodihydroquinazolinone analog that functions as an apoptosis inducer. This compound enhances the efficacy of platinum-based chemotherapeutics, promoting apoptotic cell death in various cancer cell lines. Its ability to potentiate anticancer effects makes it a valuable tool for research in cancer biology and therapeutic development. -
MDM2/4 Inhibitor
MDM2/4-p53-IN-2 is a potent dual inhibitor of MDM2 and MDM4, functioning as an activator of p53. With IC50 values of 70.7 nM and 81.4 nM for the MDM2-p53 and MDM4-p53 complexes, respectively, this compound effectively regulates the cell cycle and induces apoptosis. It demonstrates significant anticancer activity, making it a valuable tool for research focused on cancer therapeutics and the modulation of p53 signaling pathways. -
Apoptosis Inducer
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol is an apoptosis inducer that demonstrates significant antitumor activity across various tumor types. This compound, derived from medicinal mushrooms, inhibits the growth of HT29 colon cancer cells by inducing the expression of CDKN1A, leading to cell cycle arrest and subsequent apoptosis. Its unique mechanism makes it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
GKK1032B is an alkaloid compound derived from the endophytic fungus Penicillium sp. It functions as an apoptosis inducer, activating the caspase pathway to effectively induce cell death in human osteosarcoma MG63 cells. This compound holds potential for research applications in cancer studies and the exploration of therapeutic strategies targeting apoptotic mechanisms. -
Apoptosis Inducer
Telomerase-IN-5 is a selective inhibitor of telomerase, a key enzyme involved in cellular immortality and proliferation. This compound exhibits significant antiproliferative activity and effectively induces apoptosis in cancer cells. It serves as a valuable tool for research into telomerase-targeted therapies and the mechanisms underlying cell death and tumor suppression. -
Apoptosis Inducer
Apoptosis Inducer 12 (Compound 3z) is a potent inducer of apoptosis via the mitochondrial pathway. It effectively triggers programmed cell death, making it a valuable tool for cancer research. This compound is particularly useful for studying mechanisms of tumor cell apoptosis and evaluating potential therapeutic strategies. -
Apoptosis Inducer
Apoptosis Inducer 9 targets the apoptotic pathway to effectively promote cell death via the mitochondrial mechanism. It displays an IC50 value of 4.21 μM, leading to the activation of key apoptotic markers including cleaved caspase-3, cleaved caspase-9, and cleaved PARP. This compound offers substantial potential for the development of novel anti-proliferative agents, making it valuable for cancer research and studies focused on cell death mechanisms. -
Apoptosis Inducer
NSC308848 is a potent apoptosis inducer that operates through the inhibition of Myc transactivation. It disrupts the DNA-binding activity of Myc family proteins, leading to increased apoptosis in various cell types. This compound is valuable for research applications targeting Myc-dependent tumorigenesis and cellular stress responses. -
Apoptosis Inducer
Asperindole A is an indole-diterpene alkaloid that acts as an apoptosis inducer. This compound demonstrates cytotoxic properties and effectively induces apoptosis along with cell cycle arrest specifically at the S-phase. Asperindole A shows potential for research applications in the study of prostate cancer. -
Apoptosis Inducer
CIL-102 is an apoptosis inducer that functions as a MMP-2 and MMP-9 inhibitor, effectively reducing both protein expression and mRNA levels of these matrix metalloproteinases. This compound exhibits significant anti-cancer activity, making it a valuable tool for research focused on apoptosis mechanisms and cancer therapy development. Its ability to modulate MMP expression alters cellular environments, contributing to the understanding of tumor progression and metastasis. -
Apoptosis Inducer
L-2,5-Dihydrophenylalanine is an apoptosis inducer known for its ability to trigger programmed cell death in HL-60 human myeloblastoid leukemia cells. This compound facilitates research into mechanisms of apoptosis and may contribute to the development of therapeutic strategies for leukemia and other apoptosis-related disorders. Its role in cancer cell line studies makes it a valuable reagent for researchers focused on understanding cell death pathways. -
Apoptosis Inducer
TrxR1-IN-B19 is a covalent inhibitor of the enzyme thioredoxin reductase 1 (TrxR1). By inhibiting TrxR1 activity, it elevates oxidative stress, which triggers reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress and mitochondrial dysfunction. This cascade of events ultimately leads to cell cycle arrest and apoptosis, making TrxR1-IN-B19 a valuable tool for investigating apoptotic pathways in cellular models of disease. -
Apoptosis Inducer
2,2′-Dihydroxychalcone is a potent apoptosis inducer primarily targeting glutathione S-transferase (GST) with an IC50 of 28.9 μM in human colon cancer cells. This flavonoid has been shown to induce cell cycle arrest and apoptosis specifically in prostate cancer cells, highlighting its potential in cancer therapeutics. Additionally, 2,2′-Dihydroxychalcone exhibits significant anticancer and anti-inflammatory properties, making it a valuable reagent for cancer research and inflammation studies. -
ASK1 Inhibitor
ASK1-IN-5 is a selective inhibitor of apoptosis signal-regulated kinase 1 (ASK1). This compound plays a crucial role in regulating cellular stress responses and apoptosis, making it valuable in the investigation of autoimmune and neurodegenerative diseases. Its application in research can help elucidate the mechanisms underlying these conditions and potentially guide therapeutic development. -
Apoptosis Inducer
Formoxanthone A is an apoptosis inducer that effectively reduces cell viability in HeLa cells at a concentration of 25 μM. Its mechanism of action involves the activation of apoptotic pathways, making it a valuable tool for studying cell death processes. This compound can be utilized in research applications focused on cancer biology and therapeutic strategies targeting apoptosis. -
Apoptosis Inducer
γ-Eudesmol is a mitochondrial-mediated apoptosis inducer that effectively binds to mitochondrial membrane proteins, leading to depolarization of the mitochondrial membrane potential and the activation of caspase cascades. This compound exhibits significant cytotoxic effects against various tumor cell lines, including HepG2 and B16-F10, with IC50 values between 8.86 and 15.15 μg/mL. γ-Eudesmol is of particular interest for research applications in cancer biology, specifically in studies related to hepatocellular carcinoma and melanoma. -
Apoptosis Inducer
Flaccidoside II is a potent apoptosis inducer that targets malignant peripheral nerve sheath tumors (MPNSTs). This active triterpenoid saponin, derived from the rhizome of Anemone flaccida, effectively inhibits proliferation and triggers apoptotic pathways in cancer cell lines. Additionally, Flaccidoside II demonstrates therapeutic potential in mitigating collagen-induced arthritis in murine models, making it a valuable reagent for research in cancer and inflammatory diseases. -
Apoptosis Inducer
Mel56 is an apoptosis inducer that acts on human melanoma cells. This melanogenin analogue demonstrates cytotoxicity by promoting melanin production and facilitating apoptosis in cancerous cells. It serves as a valuable reagent for research applications aimed at understanding melanoma progression and therapeutic strategies. -
Apoptosis Inducers
C8 D-threo Ceramide (d18:1/8:0) is a sphingolipid analog that serves as an apoptosis inducer. It effectively triggers apoptotic pathways in U937 cells, leading to the fragmentation of nucleosomal DNA. This compound is utilized in research focused on understanding ceramide-mediated apoptosis and its implications in cancer biology. -
Apoptosis Inducer
Sarcosinamide chloroethylnitrosourea is an orally active alkylating agent that induces apoptosis through the promotion of DNA alkylation. This compound plays a significant role in cancer research by facilitating cell death in malignant cells, making it valuable for studies focused on tumor biology and therapeutic strategies. Its mechanism of action may provide insights into the development of novel anticancer therapies. -
Apoptosis Inducer
LQB-118 is an orally active apoptosis inducer with a primary mechanism of regulating the AKT/GSK3β pathway. This compound exhibits significant potential in oncology research by inhibiting the migration of glioblastoma and prostate cancer cells, as well as inducing cell death through ROS-triggered and mitochondrial-dependent pathways. Additionally, LQB-118 has demonstrated efficacy in suppressing inflammation induced by yeast polysaccharides in both in vivo and in vitro models. Its diverse applications include investigations related to inflammation, cancer, and infectious diseases. -
MDM2 Antagonist
(Rac)-Nutlin-3 is a potent antagonist of the murine double minute protein 2 (MDM2), with an IC50 of 90 nM. This compound effectively disrupts the interaction between MDM2 and p53, leading to stabilization of the p53 protein. Additionally, (Rac)-Nutlin-3 promotes cell autophagy and apoptosis, making it a valuable tool for investigating the roles of MDM2 in TP53 wild-type ovarian carcinomas and other related cancer research applications. -
p53 Activator
TDP-665759 is a p53 activator that functions by inhibiting the HDM2:p53 complex, thereby promoting p53 activity. It exhibits significant inhibition of the STAT3 signaling pathway with an EC50 of 5.90 μM and reduces cell viability in p53-expressing A549R cells, demonstrating an IC50 of 7.02 μM. TDP-665759 has also been shown to induce apoptosis in HepG2 cells and displays antitumor efficacy in mouse models, making it a valuable tool for cancer research and therapeutic development. -
Apoptosis Inducer
27-Methyl withaferin A is an apoptosis inducer that exhibits significant anticancer properties. This compound demonstrates potent antiproliferative effects against various human tumor cell lines, including HeLa, A-549, and MCF-7, with respective IC50 values of 3.2 μM, 4.2 μM, and 1.4 μM. Its ability to promote programmed cell death makes it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
27-O-(tert-Butyldimethylsilyl)withaferin A is a natural withanolide that acts as an apoptosis inducer. This compound exhibits potent antiproliferative effects across various human cancer cell lines, including HeLa, A-549, and MCF-7, while demonstrating a selective profile against normal Vero cells. Its unique mechanism of action makes it a valuable tool for research into cancer therapeutics and the regulation of programmed cell death. -
Apoptosis Inducer
MXC-017 is a potent apoptosis inducer that effectively penetrates the blood-brain barrier (BBB) and selectively targets Vimentin (VIM). This compound has demonstrated the ability to inhibit radiation-induced glioma stem cell formation while promoting G0/G1 cell cycle arrest and apoptosis. With minimal off-target effects and negligible cytotoxicity, MXC-017 has been shown to significantly enhance median survival in glioblastoma mouse models when used in conjunction with radiation therapy, making it a valuable tool for cancer research. -
p53-MDM2 Inhibitor
p53-MDM2-IN-6 is a selective inhibitor of the p53-MDM2 interaction, demonstrating an IC50 of 11.08 µg/mL. This compound effectively induces cell cycle arrest in the S phase and promotes both early and late apoptosis in HT29 colorectal cancer cell lines, with an IC50 of 10.44 µg/mL. Its ability to elevate p53 levels while decreasing GST enzyme expression highlights its potential as a valuable tool for investigating therapeutic strategies in colorectal cancer research. -
Apoptosis Inducer
Apoptosis Inducer 14 is a potent chemotherapeutic agent that initiates both intrinsic and extrinsic apoptosis pathways through the activation of P53. Exhibiting IC50 values of 193.93 μg/mL in A549 cells, 6.76 μg/mL in HCT116 cells, and 222.67 μg/mL in HF84 cells, this compound is a valuable tool for research focusing on cancer cell apoptosis and therapeutic efficacy. Applications include investigating mechanisms of cancer cell death and developing novel cancer treatments. -
p53-MDM2 Inhibitor
p53-MDM2-IN-5 is a potent inhibitor of the p53-MDM2 interaction. This compound induces apoptosis, promotes autophagy, and causes DNA damage in cells, contributing to its anti-tumor efficacy. Additionally, p53-MDM2-IN-5 effectively induces cell cycle arrest at both the S and G2/M phases, making it a valuable tool for cancer research applications focused on therapeutic strategies targeting the p53 pathway. -
Apoptosis Inducer
Apoptosis Inducer 24 targets the apoptosis pathway to inhibit proliferation in gastric cancer cells, with an IC50 ranging from 1.2 to 4.8 μM. This compound causes cell cycle arrest at the G2/M phase, induces apoptosis in the BGC-823 cell line, and disrupts mitochondrial function. Additionally, Apoptosis Inducer 24 demonstrates significant antitumor efficacy in murine models, exhibiting a favorable safety profile with an LD50 of 91.2 mg/kg. -
Apoptosis Inducer
Antitumor agent-44 is an apoptosis inducer that disrupts mitochondrial homeostasis, leading to cell cycle arrest and programmed cell death in human adenocarcinoma cells. This compound demonstrates significant anti-tumor activity in a lung cancer cell xenograft mouse model, making it a valuable tool for cancer research and therapeutic studies in oncology. -
Apoptosis Inducer
Apoptosis Inducer 3 is a potent compound that selectively initiates apoptosis in target cells, promoting both early and late apoptotic processes. It exhibits significant cytotoxic effects against various cancer cell lines, making it a valuable tool in cancer research and therapeutic studies. This reagent is crucial for investigating apoptotic mechanisms and developing novel cancer treatments. -
Apoptosis Inducer
Xanthoxyletin is a coumarin compound recognized for its role as an apoptosis inducer. Isolated from plants in the Genus Zanthoxylum and Clausena, it demonstrates significant antioxidant and anti-inflammatory properties. Xanthoxyletin exhibits cytotoxic effects on cancer cells, effectively inducing both apoptosis and necrosis. This compound is valuable for research focused on cancer therapies and the mechanisms underlying inflammation. -
Apoptosis Inducer
d-Sophoridine is a quinolizidine alkaloid derived from the Leguminous plant Sophora flavescens, acting as a potent apoptosis inducer. This compound demonstrates significant antitumor activity, particularly as a candidate for pancreatic cancer treatment, while exhibiting favorable toxicity profiles. d-Sophoridine is valuable for research aimed at understanding apoptosis mechanisms and developing targeted cancer therapies. -
Apoptosis Inducer
Aspergillus giganteus α-sarcin is a ribosome-inactivating protein that functions as an apoptosis inducer. It effectively promotes programmed cell death in rhabdomyosarcoma cells by inhibiting protein synthesis. This compound is valuable for research applications focused on cancer biology and the mechanisms of apoptosis. -
Apoptosis Inducer
R24 is a flavonoid derivative that functions as an apoptosis inducer. It exhibits significant anti-angiogenic and anti-proliferative properties, effectively inducing apoptosis in cancer cells while promoting the production of reactive oxygen species (ROS). R24 is particularly useful in research applications focused on cancer biology, including studies on lung cancer and colorectal cancer. -
p53 Activator
p53 Activator 14 is a potent activator of the p53 tumor suppressor pathway. This compound induces DNA damage, resulting in the activation of p53 and subsequent inhibition of proliferation in various cancer cell lines, with an IC50 of 7.21 μM in HCT116 cells. Additionally, it demonstrates the ability to inhibit cell adhesion, migration, and invasion, while also inducing cell cycle arrest and apoptosis. Its anti-angiogenic properties and antitumor efficacy have been validated using the chick chorioallantoic membrane (CAM) model, showcasing its potential for cancer research applications. -
Apoptosis Inducer
TBP-134 is an apoptosis inducer that primarily targets the death receptor DR5, leading to G2/M phase cell cycle arrest. This compound is particularly relevant for research applications in pancreatic tumor studies, facilitating investigations into apoptotic pathways and therapeutic strategies. Its ability to selectively trigger apoptosis makes TBP-134 a valuable tool for cancer research. -
MDM2-p53 Interaction Inhibitor
MI-773 TFA is a selective inhibitor of the MDM2-p53 interaction, demonstrating a Ki of 0.88 nM for MDM2. By disrupting the MDM2-TP53 interaction, MI-773 TFA effectively activates the p53 tumor suppressor pathway, leading to apoptotic cell death. This compound has shown significant anticancer activity, inducing tumor regression in xenograft models of adenoid cystic carcinoma and exhibiting therapeutic potential in neuroblastoma. MI-773 TFA serves as a valuable tool for research focused on p53-related cancer therapies. -
Apoptosis Inducer
Galgravin is an apoptosis inducer derived from Nectandra megapotamica, exhibiting potent cytotoxic effects in vitro. This compound triggers programmed cell death in leukemia cells, making it a valuable tool for studying cancer biology and therapeutic applications. Its anti-inflammatory properties further emphasize its potential in cancer research and drug development. -
Apoptosis Inducer
Anticancer agent 136 is a C17-triazole analogue of Geldanamycin that functions as an apoptosis inducer by targeting Hsp90. It demonstrates an IC50 of 3.38 μM in human dermal fibroblasts (HDF) and a dissociation constant (Kd) of 3.86 μM for Hsp90. This compound is useful for research investigating apoptosis pathways and the therapeutic potential of Hsp90 inhibition in cancer treatment. -
Apoptosis Inducer
Antitumor agent-110 is an imidazotetrazine compound that functions as an apoptosis inducer primarily by arresting the cell cycle at the G2/M phase. This reagent exhibits favorable permeability properties and is suitable for applications in cancer research. Additionally, Antitumor agent-110 contains an alkyne functional group, facilitating its use in click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
