Catalog No.
Product Name
Application
Product Information
Citations
-
14-3-3 protein Inhibitor
Difopein, dimeric version of R18 peptide that binds to 14.3.3 proteins with high affinity.- William J Stone, .et al. , J Neurochem, 2025, Sep;169(9):e70228 PMID: 40931680
-
Apoptosis inducer
LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.- Yingzheng Xu, .et al. , JCI Insight, 2024, Jun 13:e174746 PMID: 38869957
- Ting TC, .et al. , Cell Rep, 2019, Nov 5;29(6):1499-1510.e6 PMID: 31693891
- Ting Han, .et al. , Science, 2017, Apr 28;356(6336). pii: eaal3755 PMID: 28302793
-
Apoptosis Inducer
Andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent. -
inhibitor of tubulin polymerization
4-Oxo-4-HPR is an inhibitor of tubulin polymerization, inducing marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. It is also a fenretinide metabolite. -
Apoptosis Inducer
epi-Eriocalyxin A is a diterpenoid compound that serves as an apoptosis inducer in colon cancer cells. It effectively inhibits the activation of ERK1/2 and JNK pathways, leading to the suppression of Bcl-2 expression. This compound is valuable for research focused on cancer treatment and the mechanisms of apoptosis. -
Apoptosis Inducer
Sanguinarine chloride is a benzophenanthridine alkaloid that functions as an apoptosis inducer primarily through the generation of reactive oxygen species (ROS). This compound is known to activate key signaling pathways, specifically JNK and NF-κB, facilitating programmed cell death. Sanguinarine chloride is widely utilized in cancer research and studies investigating apoptotic mechanisms. -
Apoptosis Inducer
Dimethyl tetrasulfide (1,4-Dimethyltetrasulfane) is an apoptosis inducer that specifically targets leukemia cells. It demonstrates cytotoxic effects by promoting the production of intracellular reactive oxygen species (ROS) and activating the caspase-3 enzyme. This compound is valuable for research into cancer therapies, particularly in the context of leukemia. -
Apoptosis Inducer
9-cis-Canthaxanthin is a carotenoid recognized for its pro-apoptotic properties, particularly in THP-1 macrophage cells. This compound induces apoptosis by enhancing the activity of caspase-3 and caspase-8, making it a valuable tool for studying apoptosis pathways and cellular responses in various research applications. -
Apoptosis Inducer
Euptox A (9-Oxo-10, 11-dehydroageraphorone) is a potent apoptosis inducer derived from the cadenine sesquiterpene found in Eupatorium adenophorum. It enhances the expression of apoptotic proteases, particularly caspase-10, in HeLa cells, leading to increased apoptotic activity. This compound is valuable for research into apoptosis mechanisms and potential therapeutic applications in cancer treatment. -
Apoptosis Inducer
MT-21 is an apoptosis inducer that functions as an inhibitor of adenine nucleotide translocase. It triggers apoptosis by activating c-Jun N-terminal kinase (JNK) through the Krs/MST signaling pathway and facilitates the activation of caspase-3 via caspase-9. Additionally, MT-21 promotes the release of cytochrome c from mitochondria, making it a valuable reagent for investigating tumor biology and apoptotic mechanisms in cancer research. -
Apoptosis Inducer
SM1044 is a dihydroartemisinin (DHA) dimer that serves as an apoptosis inducer. It activates caspase pathways to effectively trigger apoptosis in RL95-2 and KLE cancer cell lines. Additionally, SM1044 demonstrates potent antiproliferative activity, with IC50 values below 3.6 μM across multiple cancer cell lines, including HEC-50, HEC-1-A, HEC-1-B, and AN3CA. Furthermore, SM1044 has been shown to inhibit tumor growth in RL95-2 xenograft mouse models, highlighting its potential utility in cancer research. -
Apoptosis Inducer
Ly101-4B is an apoptosis inducer that primarily targets the regulation of key proteins involved in cell survival and proliferation. It exhibits significant antiproliferative and cytotoxic effects by reducing HSF1 expression and inhibiting microRNA-214 synthesis, leading to the downregulation of HSP27, HSP70, and HSP90. Additionally, Ly101-4B activates caspase 3/7-mediated apoptosis by impairing DNA synthesis and disrupting the cell cycle at the G1/S phase transition, while sparing RNA synthesis and avoiding necrosis. This compound is particularly effective against pancreatic ductal adenocarcinoma cells with distinct genotypes and levels of E2F dependence, making it valuable for research in epithelial ovarian cancer and pancreatic ductal adenocarcinoma. -
Apoptosis Inducer
Antitumor agent-72 is a potent apoptosis inducer targeting key apoptotic pathways. This compound effectively activates caspase-3 and induces PARP cleavage, leading to significant anticancer activity. Antitumor agent-72 is suitable for studies related to cancer research and the exploration of apoptosis mechanisms. -
Apoptosis Inducer
3-Methoxy-9H-Carbazole is a potent apoptosis inducer that primarily targets caspase-3 activity. This compound enhances the generation of reactive oxygen species, leading to the inhibition of cancer cell proliferation and the initiation of apoptotic pathways. Its biological activity makes it a valuable tool for research into cancer mechanisms and apoptosis-related studies. -
Apoptosis Inducer
cRIPGBM is a proapoptotic derivative of RIPGBM that selectively induces apoptosis in glioblastoma (GBM) cancer stem cells by targeting receptor-interacting protein kinase 2 (RIPK2). It demonstrates an EC50 of 68 nM in GBM-1 cells, making it a valuable tool for studying apoptosis mechanisms in cancer research. This compound has potential applications in investigating therapeutic strategies for GBM by promoting cell death in cancer stem cell populations. -
Apoptosis Inducer
Xanthoangelol is an apoptosis inducer derived from Angelica keiskei, known for its ability to trigger programmed cell death in neuroblastoma and leukemia cells. It also exhibits anti-inflammatory properties by suppressing obesity-related inflammatory responses and demonstrates antibacterial activity. Additionally, Xanthoangelol inhibits monoamine oxidases, contributing to its diverse biological effects, making it suitable for research in cancer therapeutics and inflammatory disease models. -
Apoptosis Inducer
28-Deoxonimbolide is a limonoid derived from Azadirachta indica, functioning as an apoptosis inducer. This compound exhibits significant anticancer activity by inducing apoptotic cell death in HL60 cells through both mitochondrial and death receptor-mediated pathways. Its ability to trigger these mechanisms makes it a valuable tool for research in cancer biology and apoptosis. -
Apoptosis Inducer
Gomisin N, a lignan compound derived from Schisandra chinensis, functions primarily as an apoptosis inducer. It has demonstrated the ability to activate key signaling pathways such as AMPK, Akt, MAPK/ERK, and Nrf2, while also promoting the activation of caspase-3 and PARP-1. Gomisin N exhibits a range of biological activities including anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis effects, and has shown potential in inhibiting proinflammatory cytokines. Additionally, it possesses anti-tumor properties, particularly against cervical and liver cancers, and may offer benefits in the context of Alzheimer’s disease research. -
Apoptosis Inducer
Hellebrigenin is an apoptosis inducer that selectively inhibits the MAPK signaling pathway, including ERK, p38, and JNK, as well as XIAP. It plays a critical role in activating intrinsic apoptosis mechanisms, including mitochondrial membrane potential disruption, activation of the Caspase family, PARP cleavage, and modulation of pro- and anti-apoptotic protein levels. Hellebrigenin also induces DNA double-strand breaks, thereby activating the ATM pathway. This compound is primarily utilized in cancer research, particularly in the study of oral squamous cell carcinoma, liver cancer, and other malignancies, due to its capacity to inhibit tumor cell proliferation and clonogenicity. -
Apoptosis Inducer
α-Santalol, a naturally occurring sesquiterpene, functions as an apoptosis inducer through the activation of caspase-3, leading to enhanced apoptotic processes. This compound has demonstrated the ability to reduce cell viability, induce PARP cleavage, and trigger apoptosis in human prostate cancer cells. Additionally, α-Santalol inhibits the Akt/Survivin signaling pathway to promote cellular death. This reagent is valuable for research focused on prostate cancer and diabetes mellitus. -
Apoptosis Inducer
Polyporenic acid C is a lanostane-type triterpenoid that functions as an apoptosis inducer. Isolated from Poria cocos, this compound activates key apoptotic pathways by cleaving caspase-8, caspase-3, and PARP, while modulating the phosphorylation status of Akt, PTEN, and p53. Additionally, Polyporenic acid C enhances JNK activation and exhibits significant anticancer activity against non-small cell lung cancer. This makes it a valuable reagent for research into cancer therapies and apoptotic mechanisms. -
Apoptosis Inducer
3-O-Methylgallic acid, a potent apoptosis inducer, is an anthocyanin metabolite known for its significant antioxidant properties. It effectively inhibits the proliferation of Caco-2 cells with an IC50 value of 24.1 μM, demonstrating its potential in cancer research. This compound is valuable for studying apoptotic pathways and therapeutic strategies in oncology. -
Apoptosis Inducer
Diffractaic acid is a proapoptotic compound primarily derived from Usnea longissima. It is recognized for its ability to induce apoptosis in various cellular models, making it relevant for research in cell death and related disorders. Additionally, diffractaic acid exhibits analgesic and antipyretic properties, contributing to its potential applications in neurobiology and anti-inflammatory studies. -
Apoptosis Inducer
Rabeprazole-d4 is a deuterated derivative of Rabeprazole, primarily acting as an apoptosis inducer through its irreversible inhibition of gastric H+/K+-ATPase. This second-generation proton pump inhibitor also functions as a uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole-d4 is valuable for research focused on gastric ulcerations and gastroesophageal reflux diseases, facilitating studies on its mechanisms of action and therapeutic potential. -
Apoptosis Inducer
XL44 is an apoptosis inducer that targets hRpn13, facilitating hRpn13-dependent programmed cell death. This compound reduces cell viability through a PCLAF-dependent mechanism, promoting the ubiquitin-dependent degradation of hRpn13Pru and the ubiquitin-independent degradation of specific proteins containing KEN boxes. XL44 is utilized in research applications focused on understanding apoptosis pathways and protein degradation mechanisms. -
Apoptosis Inducer
Chrysosplenol D is a methoxy flavonoid that functions as an apoptosis inducer, specifically targeting ERK1/2 signaling pathways in triple-negative human breast cancer cells. In addition to its pro-apoptotic effects, Chrysosplenol D displays anti-inflammatory properties and moderate antitrypanosomal activity, making it a valuable candidate for cancer research and studies focused on inflammation and parasitic infections. -
Apoptosis Inducer
Genistein 8-c-glucoside (G8CG) acts as an apoptosis inducer by promoting mitochondrial membrane depolarization. This compound facilitates programmed cell death, making it a valuable tool for research applications focused on cancer biology and therapeutic interventions. G8CG’s mechanisms can be explored in various cellular models to better understand apoptosis and its regulation. -
Apoptosis Inducer
Phellamurin is a plant flavonoid glycoside derived from the leaves of Phellodendron amurense, primarily functioning as an apoptosis inducer. It has been shown to inhibit intestinal P-glycoprotein and demonstrates anti-tumor activity by promoting programmed cell death in various cancer cell lines. Additionally, Phellamurin affects the reproductive behavior of Papilio protenor by inhibiting egg-laying, indicating its potential applications in biological research related to apoptosis and cancer therapy. -
Apoptosis Inducer
Ganglioside GD3 disodium salt is an acidic glycosphingolipid that functions as an apoptosis inducer. It has been shown to inhibit the proliferation of cancer cells, influence the mitochondrial permeability transition pore (mPTP), and activate the caspase family, leading to programmed cell death. This compound is valuable for research applications focused on cancer biology and neurodegenerative diseases. -
Apoptosis Inducer
Zeylenone is a naturally occurring cyclohexene oxide that acts as an apoptosis inducer. It effectively inhibits cell proliferation and promotes apoptotic cell death in cervical carcinoma cells through the modulation of the PI3K/AKT/mTOR and MAPK/ERK signaling pathways. This compound serves as a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
Mepazine acetate is an apoptosis inducer that inhibits the protease activity of MALT1, making it a valuable tool for investigating the role of MALT1 in various biological processes. In studies with mouse bone marrow precursor cells, treatment with mepazine acetate significantly reduced RANK ligand (RANKL)-induced osteoclast formation and suppressed the expression of key osteoclast markers, including TRAP and feline hepsin K. Notably, its protective effects were found to be independent of MALT1 deficiency, suggesting the involvement of alternative mechanisms. This compound is essential for research focused on apoptosis, osteoclast differentiation, and related signaling pathways. -
Apoptosis Inducer
Vitamin K2 is an apoptosis inducer that exerts its effects by promoting autophagy and inhibiting cell proliferation. It has demonstrated the ability to reduce proinflammatory cytokine levels, including IL-1β, TNF-α, and IL-6, making it relevant in studies related to inflammatory processes. Vitamin K2 is valuable for research into conditions such as involutional osteoporosis, non-alcoholic fatty liver disease, ulcerative colitis, acute myeloid leukemia, myelodysplastic syndromes, and hepatocellular carcinoma. -
Apoptosis Inducer
Pyridinium bisretinoid A2E is an apoptosis inducer primarily found in lipofuscin within the retinal pigment epithelium. This compound triggers blue-light-induced apoptosis, facilitating autophagy and generating reactive oxygen species upon photoactivation. A2E is employed in research to investigate mechanisms underlying retinal degenerative diseases. -
Apoptosis Inducer
Resistomycin is a pentacyclic polyketide antibiotic that serves as an apoptosis inducer. It exhibits significant anticancer activity by promoting programmed cell death in various cancer cell lines. This compound is valuable for research applications focused on understanding apoptotic mechanisms and developing cancer therapeutics. -
Apoptosis Inducer
Secalonic acid D is a potent apoptosis inducer that targets GSK3-β, leading to the degradation of β-catenin. Isolated from the metabolites of Aspergillus aculeatus, this compound effectively down-regulates c-Myc expression and induces cell cycle arrest at the G1 phase. Its mechanism of action makes Secalonic acid D valuable for research on tumor cell apoptosis and cell cycle regulation in cancer studies. -
Apoptosis Inducer
Icariside D2 is an apoptosis inducer isolated from Annona glabra fruit that inhibits angiotensin-converting enzyme. It exhibits notable cytotoxicity against the HL-60 cell line with an IC50 value of 9.0 ± 1.0 μM. This compound is valuable in research focused on cancer biology, particularly in studies exploring mechanisms of programmed cell death and potential therapeutic interventions. -
Apoptosis Inducer
Girinimbine is a carbazole alkaloid recognized for its ability to induce apoptosis. This compound exhibits a range of biological activities including antitrypanosomal, antibacterial, antiplatelet, anti-inflammatory, antioxidant, and antitumor effects. It is valuable in research applications focused on cell death mechanisms and potential therapeutic strategies against various diseases. -
Apoptosis Inducer
Rotundifuran is a labdane-type diterpene isolated from Vitex rotundifolia, known for its role as an apoptosis inducer. This compound has been demonstrated to inhibit cell cycle progression and promote apoptosis in human myeloid leukemia cells, making it a valuable tool for cancer research. Its effects on cell viability and mechanisms of action provide insight into potential therapeutic applications targeting cancer cell survival. -
Apoptosis Inducer
Ganoderenic acid D is a triterpene that acts as an apoptosis inducer. Isolated from the extract of Ganoderma lucidum, this compound effectively inhibits the proliferation of cancer cells by promoting cell cycle arrest and triggering apoptotic pathways. It serves as a valuable tool in cancer research, particularly in studies focused on mechanisms of cell death and therapeutic interventions in oncology. -
Apoptosis Inducer
QN523 is an innovative apoptosis inducer that exhibits potent cytotoxicity across a diverse panel of 12 cancer cell lines. This compound facilitates programmed cell death and autophagy, making it a valuable tool for cancer research. Utilizing QN523 can enhance the understanding of apoptotic pathways and contribute to the development of targeted cancer therapies. -
Apoptosis Inducer
Soyasaponin III is a monodesmodic oleanane triterpenoid that acts as an apoptosis inducer. Derived from soy (Glycine max), this bioactive saponin demonstrates significant cytotoxicity in Hep-G2 cells, making it a valuable tool for research into cancer biology and therapeutic strategies targeting apoptosis. Its unique mechanism provides insights into the modulation of cell death pathways and potential applications in developing anticancer agents. -
Apoptosis Inducer
Kauran-16,17-diol is a natural diterpene that functions as an apoptosis inducer. This compound demonstrates significant anti-tumor activity, exhibiting an IC50 of 17 μM in inhibiting nitric oxide production in LPS-stimulated RAW 264.7 macrophages. Kauran-16,17-diol is valuable for research focused on cancer biology and mechanisms of apoptosis. -
Apoptosis Inducer
Dehydroleucodine, a sesquiterpene lactone derived from Artemisia douglasiana, acts as an apoptosis inducer. This compound exhibits significant antileukemic activity and has been shown to inhibit gastric ulcer formation. Additionally, Dehydroleucodine stabilizes mast cells by preventing degranulation triggered by compound 48/80, making it a valuable reagent for exploring mechanisms of cell death and inflammation in research applications. -
Apoptosis Inducer
OTS514 hydrochloride is a potent inhibitor of the TOPK kinase, exhibiting an IC50 value of 2.6 nM. This compound effectively suppresses the proliferation of TOPK-positive cancer cells by inducing cell cycle arrest and apoptosis. OTS514 hydrochloride is a valuable tool for research focusing on cancer biology and potential therapeutic strategies targeting apoptotic pathways. -
Apoptosis Inducer
AlbA-DCA is a novel apoptosis inducer formed by conjugating Albiziabioside A (AlbA) with dichloroacetate acid (DCA). This compound triggers a significant increase in intracellular reactive oxygen species (ROS) while reducing lactic acid buildup in the tumor microenvironment (TME). AlbA-DCA selectively targets and eliminates cancer cells, effectively inducing apoptosis and making it a valuable tool for research in cancer biology and therapeutic development. -
Apoptosis Inducer
VDR Agonist 1 is a nonsteroidal agonist of the Vitamin D receptor (VDR), exhibiting an IC50 of 690 nM in MCF-7 cells. This compound induces apoptosis by enhancing the expression of pro-apoptotic protein BAX while reducing anti-apoptotic protein Bcl-2 levels. Additionally, VDR Agonist 1 triggers cell cycle arrest through the up-regulation of cyclin-dependent kinase inhibitors p21 and p27, making it a valuable tool for studies related to cancer biology and therapeutic interventions targeting apoptotic pathways. -
Apoptosis Inducer
Fexapotide is an apoptosis inducer that selectively targets prostate cells, resulting in a reduction of prostate volume at the cellular level. This compound is primarily applied in research related to lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), providing insights into potential therapeutic interventions for these conditions. -
Apoptosis Inducer
Anticancer Agent 71 is a potent apoptosis inducer that targets the regulation of cell cycle and apoptotic pathways. This compound effectively arrests cells at the G2/M phase and promotes apoptosis by upregulating Bax, IkB-α, and cleaved PARP, while simultaneously downregulating Bcl-2 expression levels. Anticancer Agent 71 demonstrates significant antiproliferative activity, making it a valuable tool for cancer research applications focused on programmed cell death. -
Apoptosis Inducer
TJ08 is a 1,2,5-trisubstituted benzimidazole derivative that acts as an effective apoptosis inducer. It efficiently induces G1/S phase arrest while promoting apoptosis in a variety of cancer cell types. This compound is valuable for research applications focused on cancer biology and therapeutic development targeting apoptotic pathways. -
Apoptosis Inducer
Apiole is an apoptosis inducer that targets and inhibits human colon cancer cells, primarily by promoting G0/G1 cell cycle arrest. This compound demonstrates significant anti-tumor activity, as evidenced by its ability to inhibit colon tumor development in various in vivo mouse xenograft models. Apiole is valuable for research applications focused on cancer biology and therapeutic development.
