Apoptosis

Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity.

BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.

Iberdomide (CC-220) is a cereblon (CRBN) modulator with an IC50 of 60 nM.

Bz-423 is an F1F0-ATPase modulator. It acts by selectively killing autoimmune lymphocytes.