Tubulysin H is a potent apoptosis inducer that functions as an anti-microtubule toxin by inhibiting tubulin polymerization. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin H exhibits exceptional cytotoxicity in mammalian cells, including those that are multidrug-resistant, with low nanomolar IC50 values. Its ability to disrupt microtubule dynamics results in cell cycle arrest and subsequent induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development.
Tubulysin H is a potent apoptosis inducer that functions as an anti-microtubule toxin by inhibiting tubulin polymerization. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin H exhibits exceptional cytotoxicity in mammalian cells, including those that are multidrug-resistant, with low nanomolar IC50 values. Its ability to disrupt microtubule dynamics results in cell cycle arrest and subsequent induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development.
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