Catalog No.
Product Name
Application
Product Information
Citations
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Autophagy Inducer
SMER10 is a small-molecule autophagy inducer that enhances the formation of autophagosomes. This compound promotes the conversion of LC3-I to the autophagosome-associated form, LC3-II, thereby increasing the number of EGFP-LC3 positive structures in COS-7 and HeLa cells. SMER10 has been shown to facilitate the degradation of autophagic substrates such as the mutant huntingtin protein (EGFP-HDQ74) linked to Huntington's disease and A53T α-synuclein associated with Parkinson's disease, demonstrating its neuroprotective properties in relevant cellular models. -
Autophagy Inducer
Isodunnianol is a novel autophagy inducer that enhances autophagic activity by increasing the expression of pAMPK172 and pULK1555 while simultaneously reducing levels of pULK1757 and SQSTM2. This compound has demonstrated the ability to mitigate doxorubicin-induced cardiotoxicity, making it a valuable tool for research in cardioprotection and autophagy-related pathways. Its application can further advance studies related to cancer therapy and cellular stress responses. -
Autophagy Inducer
Amsacrine (gluconate) is an inhibitor of topoisomerase II, primarily functioning as an autophagy inducer. This compound exhibits significant antineoplastic activity by intercalating into the DNA of tumor cells, disrupting their replication and promoting cell death. Amsacrine (gluconate) is commonly utilized in cancer research to explore mechanisms of tumor growth inhibition and the roles of autophagy in cancer treatment. -
Autophagy Inducer
Chromomycin A2 is an autophagy inducer known for its cytotoxic properties. This compound exhibits significant anti-tumor activity, making it a valuable tool in cancer research. Its ability to modulate autophagy pathways allows for investigation into cancer cell survival and proliferation, facilitating studies focused on therapeutic interventions. -
Autophagy Activator
AR493 is an autophagy activator that targets AMPK (adenosine monophosphate-activated protein kinase). It modulates pathways involved in cellular energy sensing, leading to increased levels of autophagy. This compound is valuable for research into aging-associated disorders, including diabetes and neurodegenerative diseases, as well as for studies on autophagy regulation. -
Autophagy Inhibitor
Autophagy-IN-C1 is a potent autophagy inhibitor that effectively inhibits the autophagic process in hepatocellular carcinoma (HCC) cells. In addition to its role in blocking autophagy, this compound also induces apoptosis, making it a valuable tool for investigating cell death mechanisms and therapeutic strategies in cancer research. Its dual activity provides insights into the interplay between autophagy and apoptosis in tumor biology. -
Autophagy Inhibitor
Autophagy-IN-7 is an autophagy inhibitor that targets the autophagic process in cells. It is primarily utilized in cancer research to investigate the effects of autophagy modulation on tumor progression and treatment response. This compound serves as a valuable tool for elucidating the role of autophagy in various cellular mechanisms and cancer biology. -
Autophagy
(1R)-cis-Bifenthrin is a synthetic pyrethroid that targets autophagy pathways, particularly affecting motor coordination. Research indicates that (1R)-cis-Bifenthrin exposure leads to decreased motor function in ParKin-/- mice, evidenced by prolonged pole climbing times and reduced wheel running activity. The compound significantly decreases the number of tyrosine hydroxylase-positive cells and alters protein expression levels. Notably, (1R)-cis-Bifenthrin promotes the expression of mitophagy-related proteins, including LC3B and p62, while demonstrating enhanced binding affinity for transferrin and transferrin receptor 2. These interactions underscore its role in mitophagy and ferroptosis-related signaling pathways. -
Autophagy Inducer
8-Nitro-cGMP is an electrophilic second messenger involved in redox signaling that acts through the formation of protein-S-cGMP adducts via the s-guanylation process. This compound serves as an inducer of autophagy, demonstrating significant biological activity in promoting RANKL-induced osteoclast differentiation from macrophages. Additionally, 8-Nitro-cGMP exhibits vasodilatory effects and has been shown to improve vascular endothelial dysfunction in diabetic mouse models, making it a valuable tool for research in cellular signaling and metabolic disorders. -
Autophagy
SW063058 is an autophagy inducer that selectively disrupts the interaction between Beclin 1 and Bcl-2, while preserving the binding of Bcl-2 to pro-apoptotic proteins such as Bax and BIM. This selective inhibition relieves the negative regulatory effects of Bcl-2 on Beclin 1, thereby enhancing autophagic activity. SW063058 promotes autophagy in vitro without inducing cytotoxicity, apoptosis, or other forms of cell death, making it a valuable tool for studying autophagic processes in various biological contexts. -
Autophagy Inhibitor
CP 53631 is an autophagy inhibitor that demonstrates anticancer activity by disrupting the autophagic process in cancer cells. This compound can also serve as an internal standard in studies examining selective serotonin reuptake inhibitors (SSRIs) such as Sertraline, making it valuable for research in antidepressant mechanisms and effects. Its dual applications in oncology and neuropharmacology underscore its significance in advancing both fields. -
Autophagy Activator
Autophagy activator-1 is an autophagy enhancer that promotes the autophagic process by downregulating significant members of the HSP70 family while simultaneously activating the unfolded protein response. This compound serves as a valuable tool in research focused on cellular degradation pathways, protein homeostasis, and conditions associated with autophagy dysregulation. Its application extends to studies involving neurodegenerative diseases, cancer biology, and metabolic disorders. -
Autophagy Inducer
SR-3677 dihydrochloride is a selective inhibitor of Rho-associated coiled-coil containing protein kinase I (ROCK-I) and II (ROCK-II), exhibiting IC50 values of 56 nM and 3 nM, respectively. This compound serves as an autophagy inducer, promoting cellular degradation pathways that can enhance cell survival and homeostasis. It is particularly useful in research focused on cancer, neurodegenerative diseases, and metabolic disorders, where modulation of autophagy may offer therapeutic benefits. -
Autophagy Inducer
Dehydropachymic acid is a triterpene derived from Poria cocos, functioning primarily as an autophagy inducer. It has demonstrated enhanced efficacy in promoting the autophagy-lysosome pathway in cells with impaired autophagic processes compared to normal cells. This compound is valuable for research applications focused on autophagy modulation and cellular homeostasis. -
Autophagy Inhibitor/Purinergic Receptors Antagonist
Indophagolin is a potent autophagy inhibitor targeting purinergic receptors, demonstrating an IC50 of 140 nM. It effectively antagonizes the P2X4, P2X1, and P2X3 receptors with IC50 values of 2.71, 2.40, and 3.49 μM, respectively. Additionally, Indophagolin inhibits Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors, with IC50s ranging from 3.4 to 15.4 μM. It exhibits strong antagonistic effects on the serotonin receptor 5-HT6 (IC50=1.0 μM) and moderate effects on multiple serotonin receptors, making it a valuable tool for research into autophagy and neurological pathways. -
Autophagy Inhibitor
Autogramin-1 is a potent autophagy inhibitor that effectively suppresses autophagic processes triggered by nutrient deprivation or mTORC1 inhibition. With an IC50 of 0.17 μM against starvation-induced autophagy and 0.44 μM against Rapamycin-induced autophagy, it serves as a valuable tool for researching the role of autophagy in cellular processes and disease models. This compound provides insights into autophagic regulation and its implications in various cancer and neurodegenerative studies. -
Autophagy Inhibitor
NEO214 is an autophagy inhibitor that acts by preventing autophagy-lysosome fusion, effectively blocking autophagic flux. This compound, a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol, exhibits anti-cancer activity and is capable of penetrating the blood-brain barrier. Its mechanism involves the activation of mTOR and aggregation of the transcription factor EB (TFEB), promoting the death of glioma cells. NEO214 may provide a strategy to combat chemotherapy resistance in glioblastoma. -
Autophagy Inducer
(Rac)-BL-918 is a potent autophagy inducer that activates UNC-51-like kinase 1 (ULK1). This compound facilitates cytoprotective autophagy, making it a valuable tool for research focused on neurodegenerative diseases, particularly Parkinson's disease. Its ability to modulate autophagy pathways offers insights into therapeutic strategies for enhancing neuronal survival and function. -
Autophagy Inducer
Autophagy Inducer 4 is a Mannich base derivative of Magnolol that promotes autophagy. This compound exhibits significant anticancer properties by enhancing autophagy, leading to suppression of cancer cell viability, particularly with a 76-fold increase in cytotoxicity against T47D cells compared to Magnolol. Additionally, Autophagy Inducer 4 demonstrates inhibitory effects on the migration of T47D and HeLa cancer cells, making it a valuable reagent for cancer research. -
Peptide
PHF6 (VQIVYK) is a peptide that facilitates the self-assembly and aggregation of the full-length tau protein, specifically targeting the third microtubule-binding repeat region of tau. This peptide is instrumental in studies of tau pathology associated with neurodegenerative diseases, particularly in understanding the mechanisms underlying tau aggregation and its implications in tau-related disorders. Its unique structure makes it a valuable tool for investigating tau fibrillogenesis and potential therapeutic interventions. -
Antioxidant/Autophagy Enhancer
Thonningianin B is an antioxidant that enhances autophagy. This compound is known for its role in mitigating oxidative stress and promoting cellular renewal processes. Its ability to modulate autophagy pathways makes it a valuable reagent for research in fields such as neuroprotection, cancer biology, and age-related diseases. Thonningianin B may facilitate studies aimed at understanding the interplay between oxidative stress and cellular homeostasis. -
Autophagy Inducer
Desethylamiodarone hydrochloride is a significant active metabolite of Amiodarone, primarily functioning as an autophagy inducer. It is produced through the action of CYP3A isoenzymes and plays a critical role in cellular processes affecting autophagy. This compound is utilized in research applications focusing on cardiovascular pharmacology and cellular stress responses, due to its influence on potassium channels and potential therapeutic implications in arrhythmias. -
Autophagy Inducer
Glaucocalyxin B is an ent kaurane diterpenoid that acts as an autophagy inducer. This compound has demonstrated significant anticancer and antitumor properties, effectively reducing the growth of HL-60 cells with an IC50 of approximately 5.86 μM after 24 hours. Its mechanism and biological activity make it a valuable tool for research in cancer biology and therapeutic development. -
Autophagy Inhibitor
CUR5g is a selective autophagy inhibitor that targets the fusion of autophagosomes and lysosomes. By inhibiting the recruitment of STX17 to autophagosomes through a UVRAG-dependent mechanism, CUR5g effectively disrupts the degradation of autophagic substrates in cancer cells. This compound enhances the anticancer efficacy of Cisplatin in both in vitro and in vivo models, making it a valuable tool for studying autophagy's role in cancer treatment and potential therapeutic synergies. -
Autophagy Inducer
Atorvastatin-d5 sodium is a deuterium-labeled analog of atorvastatin, an oral HMG-CoA reductase inhibitor. This compound effectively lowers blood lipid levels and acts as an autophagy inducer. It has been shown to inhibit human smooth muscle cell proliferation and invasion, with IC50 values of 0.39 μM and 2.39 μM, respectively. Atorvastatin-d5 sodium is valuable for research applications related to lipid metabolism and cellular growth regulation. -
REV-ERB/Autophagy Inhibitor
ARN5187 is a lysosomotropic ligand targeting REV-ERBβ, known for its dual inhibitory effects on REV-ERB-mediated transcriptional regulation and autophagy. This compound exhibits significant lysosomotropic potency and has cytotoxic properties, leading to the induction of apoptosis. ARN5187 serves as a valuable tool for research into the mechanisms of autophagy and the role of REV-ERBβ in cellular processes. -
Autophagy Inducer
SGI-1776 is a selective inhibitor of Pim kinases, exhibiting IC50 values of 7 nM for Pim-1, 363 nM for Pim-2, and 69 nM for Pim-3. This compound has been identified as an autophagy inducer, showcasing potential mechanisms in cellular pathways associated with cancer and metabolic disorders. SGI-1776 is employed in research applications focusing on the modulation of cell survival and proliferation, making it a valuable tool for investigating therapeutic strategies targeting the Pim kinase signaling network. -
Autophagy Inhibitor
IITZ-02 is a lysosomotropic autophagy inhibitor that disrupts lysosomal function, leading to impaired autophagosomal degradation and increased autophagosome accumulation. This compound induces apoptosis through a mitochondria-mediated pathway by abolishing mitochondrial membrane potential. IITZ-02 exhibits potent antitumor activity in MDA-MB-231 xenograft mouse models, making it a valuable tool for cancer research applications focusing on the regulation of autophagy. -
Autophagy Inhibitor
Erythrabyssin II is a potent late-stage autophagy inhibitor that selectively inhibits the fusion of autophagosomes and lysosomes. This compound promotes the accumulation of autophagic substrates without disrupting lysosomal pH or enzyme activity. Erythrabyssin II has demonstrated efficacy in suppressing ovarian cancer organoid growth and inducing apoptosis, making it a valuable tool for research in ovarian cancer studies. -
Autophagy Inhibitor
EAD1 TFA is an autophagy inhibitor that plays a critical role in the regulation of plant growth and development, particularly in maize. This compound is preferentially expressed in the xylem of immature corn ears, where it facilitates the transport of malic acid. Its function is essential for proper ear length and kernel development, with alterations in EAD1 TFA expression correlating with changes in malic acid content. EAD1 TFA represents a valuable tool for researchers investigating the genetic basis of crop yield improvement. -
Autophagy Inducer
Imipramine-d4-1 is a deuterated derivative of Imipramine, primarily targeting autophagy induction. It exhibits significant antitumor activity through inhibition of Fascin1 and has a notable effect on serotonin transporter with an IC50 value of 32 nM. In cellular assays, Imipramine-d4-1 has been shown to stimulate autophagy in U-87MG glioma cells and induce apoptosis in HL-60 cells. Additionally, it demonstrates neuroprotective and immunomodulatory properties, making it valuable for various research applications in cancer biology and neurobiology. -
Autophagy Enhancer
IR-58 is a mitochondria-targeting near-infrared fluorophore that enhances autophagy. It effectively induces apoptosis in tumor cells by promoting excessive autophagy through the activation of the reactive oxygen species (ROS)-Akt-mTOR signaling pathway. This compound is valuable for research applications focused on cancer biology, autophagy modulation, and therapeutic development. -
Anticancer Agent
Tubulosine is an alkaloid that functions as a selective inhibitor of the Janus kinase 3 (JAK3) with an IC50 of 9.9 nM. It exhibits enhanced inhibition of JAK3 compared to other JAK family members, with IC50 values of 69.5 nM for JAK1, 84.9 nM for JAK2, and 76.3 nM for TYK2. Tubulosine induces both apoptotic and necrotic/autophagic cell death in cancer cells and disrupts peptide chain elongation in eukaryotic polysomes. This compound demonstrates promising anticancer activity, particularly in breast cancer cell lines, making it a valuable tool for cancer research. -
Autophagy Inducer
Autophagy Inducer 2 is a potent activator of autophagy, primarily targeting cellular mechanisms involved in this critical survival process. It demonstrates significant antiproliferative effects on MCF-7 breast cancer cells, with an IC50 value of 1.31 μM, and markedly reduces colony formation in these cells. By modulating cell-cycle-related proteins such as Cdk-1 and Cyclin B1, Autophagy Inducer 2 effectively induces cell cycle arrest in the G2/M phase. This compound offers valuable insights for research in breast cancer therapy and the regulation of autophagy. -
Autophagy Inhibitor/Ionic Compound
Ammonium chloride is an ionic compound known for its role as an autophagy inhibitor. By inducing intracellular alkalization, it can disrupt lysosomal function and alter enzymatic activity, leading to metabolic acidosis. This compound is widely utilized in research applications focused on autophagy modulation and lysosomal pathway studies. -
Autophagy Inhibitor; p62 ZZ Domain Inhibitor
XRK3F2 is a selective inhibitor of the p62 (sequestosome-1) ZZ domain, demonstrating potent inhibition of autophagy processes. This compound effectively blocks TNFα-induced signaling in bone marrow stromal cells and promotes apoptosis in multiple myeloma cells. XRK3F2 is valuable for research applications targeting multiple myeloma bone disease and acute myeloid leukemia, providing insights into cell survival mechanisms and autophagic regulation in hematological malignancies. -
Autophagy Inducer
Eupatilin is a lipophilic flavonoid extracted from Artemisia argyi Lévl. et Van. that acts as an autophagy inducer and PPARα agonist. It demonstrates significant anti-apoptotic, anti-oxidative, and anti-inflammatory activities. This compound is valuable for research in cellular stress responses, inflammation, and neuroprotection studies. -
Cytokinin Nucleoside/Autophagy Inhibitor
N6-Isopentenyladenosine, a cytokinin nucleoside, acts primarily as an autophagy inhibitor. This compound, derived from the mevalonate pathway, has demonstrated notable anti-melanoma activity. Additionally, it plays a critical role in RNA modification, enhancing the efficiency and accuracy of translation in certain tRNAs and regulating plant growth and differentiation. Research applications include investigations into autophagy-related mechanisms and the development of therapeutic strategies for melanoma. -
Autophagy Inducer
Oxyresveratrol is a potent autophagy inducer with significant antioxidant properties, exhibiting an IC50 of 28.9 µM against DPPH free radicals. It serves as a noncompetitive inhibitor of tyrosinase, demonstrating an IC50 value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol has been shown to exhibit antiviral activity against HSV-1, HSV-2, and varicella-zoster virus, as well as providing neuroprotective effects. This compound is valuable for research into cellular protection mechanisms and the regulation of metabolic processes. -
Autophagy Inducer
BGT226 is a dual inhibitor targeting PI3K and mTOR, demonstrating IC50 values of 4 nM, 63 nM, and 38 nM against PI3Kα, PI3Kβ, and PI3Kγ, respectively. This compound effectively induces autophagy, showcasing significant growth-inhibitory effects in human head and neck cancer cells. BGT226 is valuable for research in cancer biology and drug development focused on autophagy modulation and PI3K/mTOR signaling pathways. -
Autophagy Inhibitor
DC-LC3in-D5 functions as an autophagy inhibitor by inhibiting the lipidation of LC3B. It effectively binds to LC3B and disrupts the interaction with LBP2, exhibiting an IC50 value of 200 nM. This compound is valuable in research focused on the modulation of autophagy, contributing to investigations of anti-HCV therapies and potential cancer treatments through autophagy inhibition. -
Autophagy Inducer
Sedanolide is a natural compound recognized for its role as an autophagy inducer. This compound exhibits significant anti-inflammatory and antioxidant properties, making it valuable in various biological research applications. Its ability to modulate cellular processes associated with autophagy allows researchers to explore its potential therapeutic effects in diseases linked to autophagic dysfunction. -
Autophagy Activator
Ginkgolide K is an autophagy activator derived from Ginkgo biloba. It stimulates protective autophagy by modulating the AMPK/mTOR/ULK1 signaling pathway, thereby promoting cellular survival. Additionally, Ginkgolide K exhibits neuroprotective properties, making it a valuable tool for research in neurobiology and cellular stress responses. -
Autophagy Inducer
Pyriproxyfen acts as a juvenile hormone analog, primarily targeting larval development by inhibiting the transition to adulthood. This mechanism effectively reduces reproductive capabilities in various insect species. Pyriproxyfen is widely utilized in chemical research to study autophagy induction and its implications in pest control and developmental biology. -
Autophagy Inhibitor
ATG7-IN-1 is a selective inhibitor of the autophagy-related protein ATG7, exhibiting an IC50 of 62 nM. This compound interferes with autophagy processes by disrupting the function of ATG7, making it a valuable tool for research in autophagy regulation. It is particularly useful for studies investigating the role of autophagy in various diseases, including cancer and neurodegenerative disorders. -
Autophagy Inducer
Pemetrexed disodium heptahydrate is an innovative antifolate that serves as an autophagy inducer. It effectively inhibits key enzymes including thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with Ki values of 1.3, 7.2, and 65 nM, respectively. This compound is valuable in research applications targeting metabolic pathways and autophagic processes in cancer and other diseases. -
Autophagy Inhibitor
Autogramin-2 is a potent autophagy inhibitor that effectively blocks autophagy triggered by nutrient deprivation, demonstrating an IC50 of 0.27 μM, as well as autophagy induced by mTORC1 inhibition with Rapamycin, with an IC50 of 0.14 μM. This compound is valuable for studying the role of autophagy in cellular processes and various diseases, including cancer and neurodegeneration. Its ability to modulate autophagic pathways makes it an essential tool for researchers investigating autophagy's impact on cell survival and metabolism. -
Autophagy Inducer
XIE62-1004-A is a potent inducer of p62-LC3 interaction, specifically targeting the ZZ-domain of p62. Its binding induces p62 oligomerization, thereby activating p62-dependent autophagy processes. This compound is valuable for research applications investigating the mechanisms of autophagy and its role in cellular homeostasis and disease. -
Autophagy Inducer
AMDE-1 is a potent autophagy inducer that activates the AMPK-mTORC1-ULK1 signaling pathway. While promoting autophagy, AMDE-1 also disrupts lysosomal function, thereby inhibiting autophagy-mediated degradation. This dual mechanism makes AMDE-1 a valuable tool for investigating autophagy-related processes in cancer research. -
Autophagy Inducer
Paroxetine hydrochloride hemihydrate is a selective serotonin reuptake inhibitor that also functions as an autophagy inducer. With an IC50 of 14 μM for GRK2 inhibition, it demonstrates potential in neuroprotective research and the study of mood disorders. This compound is suitable for investigations into its effects on cellular processes such as autophagy, neurobiology, and therapeutic applications for depression.
