Fig. 1 · Structure
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7α-Hydroxy-DHEA
Cat. No.
A69986
CAS
53-00-9
Drug Metabolites
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of dehydroepiandrosterone (DHEA), generated through the action of intracellular steroid 7α-hydroxylases, notably P450 2A1. This compound exhibits biological activity akin to DHEA while lacking the potential for androgenic or estrogenic conversion. 7α-Hydroxy-DHEA enhances the activity of thermogenic enzymes, including mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, promoting heat production and decreasing food utilization efficiency. This metabolite presents a promising avenue for research in obesity, metabolic diseases, and adrenal carcinoma.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 53-00-9 |
| Applications | Drug Metabolites |
| Formula | C19H28O3 |
| Molecular Weight | 304.42 |
| Synonyms | 7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one |
| SMILES | C[C@@]12[C@]3([H])[C@]([C@@H](C=C1C[C@H](CC2)O)O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.