7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of dehydroepiandrosterone (DHEA), generated through the action of intracellular steroid 7α-hydroxylases, notably P450 2A1. This compound exhibits biological activity akin to DHEA while lacking the potential for androgenic or estrogenic conversion. 7α-Hydroxy-DHEA enhances the activity of thermogenic enzymes, including mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, promoting heat production and decreasing food utilization efficiency. This metabolite presents a promising avenue for research in obesity, metabolic diseases, and adrenal carcinoma.
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of dehydroepiandrosterone (DHEA), generated through the action of intracellular steroid 7α-hydroxylases, notably P450 2A1. This compound exhibits biological activity akin to DHEA while lacking the potential for androgenic or estrogenic conversion. 7α-Hydroxy-DHEA enhances the activity of thermogenic enzymes, including mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, promoting heat production and decreasing food utilization efficiency. This metabolite presents a promising avenue for research in obesity, metabolic diseases, and adrenal carcinoma.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
