N-Deschlorobenzoyl indomethacin is a primary metabolite of indomethacin that lacks the N-p-chlorobenzoyl group. This alteration results in a significant reduction of its inhibitory activity against the enzymes AKR1C2 and AKR1C3, with an IC50 of 100 μM for AKR1C2 and an IC50 greater than 100 μM for AKR1C3, indicating no selectivity. This compound serves as a useful tool for studying the metabolic pathways and pharmacokinetics of indomethacin in various research applications.
N-Deschlorobenzoyl indomethacin is a primary metabolite of indomethacin that lacks the N-p-chlorobenzoyl group. This alteration results in a significant reduction of its inhibitory activity against the enzymes AKR1C2 and AKR1C3, with an IC50 of 100 μM for AKR1C2 and an IC50 greater than 100 μM for AKR1C3, indicating no selectivity. This compound serves as a useful tool for studying the metabolic pathways and pharmacokinetics of indomethacin in various research applications.
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