Fig. 1 · Structure
Documents & Downloads
N-Deschlorobenzoyl indomethacin
Cat. No.
A70130
CAS
2882-15-7
Drug Metabolite
N-Deschlorobenzoyl indomethacin is a primary metabolite of indomethacin that lacks the N-p-chlorobenzoyl group. This alteration results in a significant reduction of its inhibitory activity against the enzymes AKR1C2 and AKR1C3, with an IC50 of 100 μM for AKR1C2 and an IC50 greater than 100 μM for AKR1C3, indicating no selectivity. This compound serves as a useful tool for studying the metabolic pathways and pharmacokinetics of indomethacin in various research applications.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2882-15-7 |
| Applications | Drug Metabolite |
| Formula | C12H13NO3 |
| Molecular Weight | 219.24 |
| SMILES | CC(N1)=C(C2=C1C=CC(OC)=C2)CC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.