Fig. 1 · Structure
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7-Hydroxymethotrexate
Cat. No.
A70151
CAS
5939-37-7
Drug Metabolite
7-Hydroxymethotrexate is a key metabolite of Methotrexate, primarily produced through the hepatic metabolism of the drug. It is involved in the inhibition of dihydrofolate reductase, thereby blocking the conversion of folic acid to tetrahydrofolate and subsequently disrupting DNA synthesis. This compound is significant in pharmacokinetic studies and therapeutic monitoring of Methotrexate, aiding in understanding its efficacy and safety profiles in various treatment regimens.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 5939-37-7 |
| Applications | Drug Metabolite |
| Formula | C20H22N8O6 |
| Molecular Weight | 470.44 |
| SMILES | O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3NC2=O)C)C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.