Fig. 1 · Structure
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N-Desmethyl imatinib
Cat. No.
A70095
CAS
404844-02-6
Drug Metabolite
N-Desmethyl imatinib is an active metabolite of Imatinib, primarily targeting the c-Abl kinase by binding to its catalytic domain, thus inhibiting substrate phosphorylation. This compound exhibits significant biological activity by inhibiting c-Abl-mediated α-synuclein activation and modulating downstream inflammatory signaling pathways, which leads to apoptosis in K562 human leukemia cells. Research applications include the investigation of pediatric gastrointestinal stromal tumors, chronic myeloid leukemia, and potential implications in neurodegenerative disorders such as Parkinson's disease. Elevated plasma levels of N-Desmethyl imatinib following certain viral infections can offer insights into its therapeutic roles.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 404844-02-6 |
| Applications | Drug Metabolite |
| Formula | C28H29N7O |
| Molecular Weight | 479.59 |
| Synonyms | Norimatinib; Imatinib metabolite N-Desmethyl imatinib; CGP 74588 |
| SMILES | O=C(NC1=CC=C(C)C(NC2=NC(C3=CC=CN=C3)=CC=N2)=C1)C4=CC=C(CN5CCNCC5)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.