Catalog No.
Product Name
Application
Product Information
Citations
-
Endogenous Metabolite
Sulforhodamine 101 DHPE is a fluorescent probe that targets endogenous metabolites through its unique conjugation of the phospholipid 1,2-dipalmitoyl-sn-glycero-3-PE with sulforhodamine 101, a red fluorescent dye exhibiting excitation/emission maxima of 586/605 nm. This reagent is well-suited for applications including imaging of solid-supported lipid bilayers, detection of protein-ligand interactions on bilayer surfaces, and monitoring the colocalization of lipid probes in liposomes using resonance energy transfer (RET) techniques. Its ability to integrate into phospholipid bilayers enhances its utility in membrane biophysics research. -
Endogenous Metabolite
6-Methyluracil, an endogenous metabolite of uracil, serves as an indicator for acetoacetyl-CoA (AACoA) accumulation in metabolic studies. This compound has demonstrated antiradiation effects in vivo, making it valuable for research in cellular protection mechanisms and metabolic regulation. Its unique properties enable applications in investigations of nucleic acid metabolism and oxidative stress responses. -
Endogenous Metabolite
AMC Arachidonoyl Amide (AMC-AA) is a synthetic substrate for fatty acid amide hydrolase (FAAH), enabling the assessment of FAAH activity. Upon hydrolysis by FAAH, AMC-AA releases aminomethyl coumarin, which exhibits fluorescence, specifically absorbing at 360 nm and emitting at 465 nm. This property makes AMC-AA an effective tool for the rapid and convenient quantification of FAAH activity in biological samples, facilitating research in lipid metabolism and neurobiology. -
Endogenous Metabolite
α-D-Xylose, an endogenous metabolite, serves as a critical component of the five-carbon fraction of biomass and a precursor of hemicellulose. This sugar participates in various enzyme-catalyzed reactions and is involved in multiple metabolic pathways. In research applications, α-D-Xylose is also utilized in the tanning and dyeing industries, as well as in formulations for diabetic food products. -
Endogenous metabolites
Clopidogrel carboxylic acid, an inactive metabolite of the antiplatelet drug Clopidogrel, primarily interacts with endogenous metabolites in human serum. This compound is significant for biochemical studies focused on metabolic pathways and drug metabolism. Its role in examining the pharmacokinetics of antiplatelet therapies makes it a valuable reagent for research in cardiovascular pharmacology. -
Endogenous Metabolite
Vitamin B12 hydrate, also known as Cyanocobalamin, acts as an endogenous metabolite crucial for neurological health and hematopoiesis. This compound supports normal brain and nervous system function, while also contributing to the formation of red blood cells. Additionally, Vitamin B12 hydrate demonstrates potential benefits in managing inflammatory diseases and offers protective effects against oxidative-stress-related conditions. Its diverse biological activities make it valuable for various research applications in neuroscience and immunology. -
Endogenous Metabolite
CE(20:3(8Z,11Z,14Z)) is a cholesterol ester that serves as an endogenous metabolite. This compound accumulates in the adrenal gland and has been observed to decrease in concentration, correlating with cognitive decline in HIV-infected individuals. Research applications include studies of cholesterol metabolism, adrenal function, and cognitive health. -
Endogenous Metabolite
L-Lysine acetate is an essential amino acid that functions as an endogenous metabolite. It is implicated in various biological processes and has been studied for its potential effects on vascular calcification and acute pancreatitis. This compound serves as a valuable tool for researchers investigating these pathological conditions and their underlying mechanisms. -
Endogenous Metabolite
γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) is an endogenous metabolite synthesized by Bacillus amyloliquefaciens and Aspergillus oryzae. This compound is known for enhancing umami flavor profiles, making it a valuable addition in food science for improving the sensory qualities of soy sauce and chicken broth. Its applications extend to research in flavor chemistry and metabolomic studies. -
Endogenous Metabolite
Moschamine is an endogenous metabolite that functions as an inhibitor of excessive superoxide production in mitochondria. This compound has been shown to modulate oxidative stress, making it a valuable tool for research on mitochondrial dysfunction and related metabolic disorders. Its biological activity has implications for studies investigating the roles of reactive oxygen species in cellular injury and age-related diseases. -
Endogenous Metabolite
11-dehydro-2,3-dinor Thromboxane B2 is an endogenous metabolite derived from the inactive metabolite TXB2 through the action of cytosolic aldehyde dehydrogenase and β-oxidation pathways. This compound plays a crucial role in the regulation of thromboxane biosynthesis and is implicated in various physiological and pathological processes. Elevated levels of 11-dehydro-2,3-dinor TXB2, observed in surgery-induced rat models of tendon overuse, suggest its potential utility in research related to inflammation and tissue repair mechanisms. -
Endogenous Metabolite
5α-Androstenone is an endogenous metabolite primarily recognized for its role as an odorous compound found in porcine adipose tissue. This steroidal compound is utilized in biological research to study its effects on pheromonal signaling and its potential influence on social and sexual behaviors in mammals. Its unique properties make it a valuable tool for investigations into olfactory signaling pathways and the biology of pheromones. -
Endogenous Metabolite
Glycerophospho-N-palmitoyl ethanolamine (GP-NPEA) is an endogenous metabolite and a metabolic precursor of palmitoyl ethanolamide (PEA). Research indicates that GP-NPEA levels decline in the cortex of chronic unpredictable stress (CUMS) rats, suggesting a potential link to disruptions in the endocannabinoid system associated with depression. This compound is valuable for studies examining metabolic pathways and neurobiological influences in mood disorders. -
Endogenous Metabolite
(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate is an endogenous metabolite known for its role in various physiological processes. This compound is involved in modulating neurotransmission and may influence pathways associated with neuroprotection and synaptic plasticity. It is valuable for research applications focused on metabolic profiling and neurochemical studies. -
Endogenous Metabolite
Trigalacturonic acid is an endogenous metabolite primarily involved in promoting plant cell growth and enhancing cell wall stability. It is known to improve plants' resilience to environmental stressors and is extensively utilized as a nutrient in plant cell culture applications. Additionally, trigalacturonic acid serves as a food additive, exhibiting thickening and gelling properties that are valuable in the food industry. -
Endogenous Metabolite
Ganglioside sialidase (AuSialidase S) functions as an endogenous metabolite that acts on gangliosides, facilitating the removal of sialic acid residues. This enzymatic activity plays a significant role in neuronal differentiation and is crucial for processes such as neurite outgrowth. AuSialidase S is valuable in research applications focused on neurobiology, particularly studies investigating neuronal development and associated signaling pathways. -
Endogenous Metabolite
1,3-Dimethyluracil is a pyrimidone derivative of uracil, serving as an endogenous metabolite in humans. This compound exhibits inhibitory activity against human carbonic anhydrases I and II, with Ki values of 316.2 μM and 166.4 μM, respectively. Its enzymatic inhibition profile makes it valuable for research applications involving carbonic anhydrase-related pathways and metabolic studies. -
Endogenous Metabolite
KSD 2405 is an endogenous metabolite that plays a significant role in various biochemical pathways. This compound is involved in metabolic processes and may influence cellular function and signaling. Its application in research includes the study of metabolic disorders, physiological regulation, and potential therapeutic interventions. -
Fungal Metabolite
Cerebroside D is a glycoceramide compound known for its immunomodulatory properties. It has been shown to enhance recovery from experimental colitis in mouse models, primarily through the modulation of activated T lymphocytes. This compound is of particular interest in research related to autoimmune diseases and inflammation. -
Endogenous Metabolite
SEP-227900 is a potent and orally bioavailable inhibitor of D-amino acid oxidase (DAO). It exhibits significant biological activity that may benefit conditions related to vitamin D metabolism and sunlight exposure. This compound holds promise for enhancing cancer prognosis and is applicable in research focusing on metabolic pathways and related diseases. -
Endogenous Metabolite
5-Methoxysalicylic acid (5-MeOSA) is an endogenous metabolite known for its role as a matrix in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) analysis of oligonucleotides. When combined with spermine, 5-MeOSA enhances ionization efficiency, making it a valuable tool in biochemical research. Its applications extend to studying nucleic acid interactions and characterizing oligonucleotide structures, thereby facilitating advancements in genetic and molecular biology studies. -
Endogenous Metabolite
Dapagliflozin-3-O-β-D-glucuronide is an endogenous metabolite of Dapagliflozin, produced primarily by the enzyme uridine diphosphate glucuronosyltransferase-1A9 (UGT1A9) in the liver and kidney. This compound plays a crucial role in the pharmacokinetics of Dapagliflozin, a selective inhibitor of sodium-glucose co-transporter 2 (SGLT2), which is utilized for improving glycemic control in type 2 diabetes management. Its study is significant in understanding drug metabolism and therapeutic efficacy in diabetic conditions. -
Endogenous Metabolite
Dihomo-γ-linolenic acid sodium is an endogenous metabolite classified as a 20-carbon ω-6 fatty acid. It exhibits notable anti-inflammatory and anti-proliferative activities, making it relevant for research involving lipid metabolism and cellular signaling. Notably, DGLA sodium has been shown to attenuate atherosclerosis in apolipoprotein E-deficient mouse models, highlighting its potential in cardiovascular research and inflammation studies. -
Fungal Metabolite
(-)-Cyclopenol is a fungal metabolite derived from the Australian marine fungus Aspergillus versicolor (MST-MF495). This compound exhibits significant biological activity, particularly in the inhibition of specific fungal species. It serves as a valuable tool for studying fungal metabolism and exploring potential antifungal applications in research. -
Endogenous Metabolite
6-Dehydroprogesterone is an endogenous metabolite derived from the microbial dehydrogenation of progesterone. This steroid compound is significant for studying steroid metabolism pathways, including microbial dehydrogenase activity and steroid biotransformation. Its unique properties make it a valuable tool for researchers investigating the biochemical roles of steroid metabolites. -
Endogenous Metabolite
13-cis-Retinyl acetate is a metabolite of vitamin A, specifically an active isomer derived from Retinyl acetate. This compound is known to play a significant role in various biological processes, including vision and cellular growth regulation. Its unique structure and activity make it a valuable tool for research applications studying vitamin A metabolism and its physiological effects. -
Endogenous Metabolite
Cyclanilide, an endogenous metabolite, acts as a plant growth regulator primarily used in cotton cultivation. It influences various growth stages by modulating physiological processes, which can enhance crop yield and quality. Its applicability in agricultural research makes it a valuable tool for exploring plant growth dynamics and metabolism. -
Endogenous Metabolite
4,4'-Disulfanediylbis(2-aminobutanoic acid) is an endogenous metabolite that plays a crucial role in various biochemical pathways. It serves as a potential biomarker in metabolic studies, enabling researchers to investigate redox states and sulfur metabolism. This compound is valuable for research applications focused on metabolic regulation and cellular signaling. -
Endogenous Metabolite
18-Hydroxycorticosterone is a corticosteroid and an endogenous metabolite derived from corticosterone. It plays a crucial role in the regulation of electrolyte balance and blood pressure. This compound is essential for research into adrenal gland function, mineralocorticoid activity, and conditions associated with electrolyte disturbances, such as hyperaldosteronism. -
Endogenous Metabolite
1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine is an endogenous metabolite that plays a crucial role in lipid metabolism. It is primarily involved in signaling pathways related to obesity and metabolic disorders. This compound can be utilized in research to investigate the biological mechanisms underlying obesity and its potential impact on health. -
Endogenous Metabolite
Cortisol sulfate, also known as Cortisol 21-sulfate, is an endogenous metabolite of cortisol. As a specific ligand for intracellular transcortin, it plays a crucial role in regulating corticosteroid activity within the body. This compound is instrumental in research applications focused on stress response, glucocorticoid signaling, and metabolic pathways related to endocrine function. -
Endogenous Metabolite
Triarachidin is an endogenous metabolite that plays a significant role in the biosynthesis of lipids and other cellular functions. As a bioactive compound, it contributes to various metabolic pathways and cellular signaling mechanisms. Triarachidin is essential for research related to lipid metabolism, cellular physiology, and the exploration of metabolic disorders. -
Endogenous Metabolite
Lucidenic acid LM1 is a natural triterpenoid derived from the fungus Ganoderma lucidum. It is an endogenous metabolite that exhibits various biological activities, including anti-inflammatory and antioxidant properties. This compound has potential applications in research focused on oxidative stress, inflammation, and the exploration of fungal bioactive substances. -
Endogenous Metabolite
Phenylacetyl CoA is an endogenous metabolite that serves as an acyl-CoA derivative in metabolic pathways. It functions as a substrate for acceptor oxidoreductases, playing a critical role in the anaerobic metabolism of phenylalanine in denitrifying bacteria, such as Thauera aromatica. This compound is essential for studies on microbial metabolism and can be applied in research investigating the enzymatic processes of anaerobic organisms. -
Endogenous Metabolite
Urolithin M7 is an endogenous metabolite derived from gut microbiota metabolism. It exhibits significant inhibitory effects on oxidative stress and modulates inflammatory signaling pathways. Urolithin M7 is a valuable reagent for research applications focused on gut microbiota metabolism and cardiovascular disease mechanisms. -
Endogenous Metabolite
2,3-Diaminopropanoic acid hydrochloride is an endogenous metabolite known for its role as a biochemical building block and regulator in various metabolic pathways. It has been implicated in amino acid metabolism and can serve as a substrate in the synthesis of bioactive peptides. This compound is useful in research applications focusing on cellular metabolism, neurobiology, and the study of metabolic disorders. -
Endogenous Metabolite
11-Oxo etiocholanolone, also known as 11-Ketoetiocholanolone, is an endogenous metabolite that serves as a crucial marker for the detection of cortisol metabolites in feces and urine. This steroid plays a significant role in studies related to stress response and hormone metabolism. Its potential function as a pheromone further enhances its relevance in neuroendocrine research and behavioral studies. -
Endogenous Metabolite
Pteridine-2,4(1H,3H)-dione is an endogenous metabolite with a significant role in various biochemical pathways. This compound is involved in the regulation of cellular processes and may influence cellular responses to oxidative stress. Research applications include studies on metabolic pathways, enzyme activity, and the biological implications of pteridine derivatives in health and disease. -
Endogenous Metabolite
PNU-100440 is an endogenous metabolite of Linezolid, which primarily functions as an antibiotic targeting bacterial ribosomal protein synthesis. This compound is used in research to study the pharmacological profile of Linezolid and its metabolic pathway, providing insights into its therapeutic and side effects. The analysis of PNU-100440 can contribute to a better understanding of antibiotic metabolism and resistance in microbial organisms. -
Endogenous Metabolite
Hydroxy bosentan is an endogenous metabolite derived from Bosentan, primarily processed by the cytochrome P450 system in the liver. This compound retains 10%-20% of Bosentan's pharmacological activity, serving as a significant contributor to the overall therapeutic effects of the parent compound. Hydroxy bosentan is useful in research focused on metabolic pathways and the pharmacokinetics of endothelin receptor antagonists. -
Endogenous Metabolite
Cholesterol glucuronide is an endogenous metabolite that acts primarily through its role as a conjugate of cholesterol. It is produced in the liver by the enzyme UDP-glucuronosyltransferase and plays a significant role in cholesterol metabolism and transport. This compound is valuable for research applications focusing on lipid metabolism, cholesterol homeostasis, and related metabolic disorders. -
Endogenous Metabolite
Vitamin D3 octanoate, an octanoate ester of cholecalciferol, serves as an endogenous metabolite. It is known to induce cellular differentiation and inhibit the proliferation of cancer cells, making it a valuable compound for cancer research. This reagent is also applicable in studies focusing on vitamin D metabolism and its broader implications in cellular health. -
Endogenous Metabolite
3-(3-Hydroxyphenyl)propionic acid (3HPPA) functions as an endothelium-dependent promoter of nitric oxide (NO) release and an activator of endothelial nitric oxide synthase (eNOS). This compound facilitates vascular smooth muscle relaxation by enhancing NO synthesis in endothelial cells, leading to vasodilation and decreased peripheral vascular resistance. In studies, 3HPPA has shown a dose-dependent ability to lower systolic and diastolic blood pressure in spontaneously hypertensive rats without affecting cardiac contractility or heart rate. Its antihypertensive and vascular protective properties make it a valuable reagent for investigating cardiovascular disease prevention and treatment. -
Endogenous Metabolite
Hexokinase, Yeast is an enzyme that catalyzes the phosphorylation of glucose, playing a crucial role in the glycolytic pathway. This enzyme is vital for cellular energy production, contributing to the maintenance of mitochondrial integrity and promoting cell survival. It serves as an important reagent for studies focused on metabolic regulation and energy dynamics within yeast models. -
Endogenous Metabolite
NSC 16590 is an inhibitor of endogenous ethylene synthesis. This compound has been shown to effectively suppress the production of ethylene in cotyledonary segments of cocklebur, making it a valuable tool for studies on plant physiology and development. Its application in research can elucidate the roles of ethylene in growth processes and stress responses in plants. -
Endogenous Metabolite
O-Desmethylangolensin is an endogenous metabolite derived from the soy isoflavone daidzein, which is metabolized by gut microbiota. This compound exhibits notable antioxidant activity, making it a valuable biomolecule for research focused on oxidative stress and related pathologies. Its role in studying metabolic processes and the impact of dietary components on health further highlights its significance in biochemical investigations. -
Endogenous Metabolite
4-Hydroxyphenylpyruvic acid is an endogenous metabolite involved in the metabolic pathway of phenylalanine. It serves as a substrate for the enzyme 4-hydroxyphenylpyruvic acid dioxygenase (HPPA), which plays a critical role in amino acid catabolism. This compound is valuable for investigating HPD-related disorders, including type III tyrosinemia and hawkinsinuria, providing insights into their biochemical mechanisms and potential therapeutic approaches. -
Endogenous Metabolite
D-(+)-Malic acid is an endogenous metabolite that acts as a competitive inhibitor of L(-)-malic acid transport. This compound is involved in various metabolic pathways and plays a critical role in cellular energy production. D-(+)-Malic acid is utilized in research applications focused on metabolic disorders, mitochondrial function, and the study of energy metabolism in various biological systems. -
Endogenous Metabolite
Octadecanedioic acid is an endogenous metabolite with implications in metabolic research. It plays a role in cellular processes and has been investigated in the context of Reye's syndrome, contributing to understanding the disease's biochemical pathways. This compound is useful for studies focused on lipid metabolism and associated disorders. -
Endogenous Metabolite
α-Tocotrienol is an isoform of vitamin E that functions primarily as an endogenous antioxidant. It exhibits significant biological activity in reducing cholesterol and lipid levels, offering neuroprotective effects, and demonstrating anticancer properties. This compound is widely utilized in research focused on cardiovascular disease, oxidative stress, and potential therapeutic interventions for various health disorders.
